In the present study, water and methanol extracts of hawthorn (Creatagus monogyna) were studied for antioxidant and antimicrobial properties. The antioxidant properties of fruits and leaves were evaluated by determining 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. The water and methanol extracts of both fruits and leaves have antioxidant potential, ranging from 3.7 % to 44 %. Antimicrobial activities of above extracts were also tested against clinical isolates of human pathogenic strains belonging to 4 bacteria, Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and 3 yeast species, Candida albicans, Candida glabrata and Candida parapsilosis, by disk-diffusion method. The minimal inhibition concentration (MIC) value of each active extracts was also determined. The most effective antibacterial activity was expressed by methanol extract of hawthorn leaves against Gram-positive bacteria S. aureus with 12mm inhibition zone and 0.625 mg/ml MIC value. None of the extracts had antifungal activity against tested human pathogenic clinical isolates