Harrison's Principles Research Articles

Harrison's Principles of Internal Medicine.

Harrison's Principles of Internal Medicine.

Response to Article by Gross et al.

To the Editor—In the recent article by Gross, et al., “Pernicious Anemia in the Demented Patient without Anemia or Macrocytosis,'” published in the Journal August 1986, the point was made that Vitamin B12 deficiency with neurological abnormalities could exist in the absence of anemia and macrocytosis. It is noteworthy that both cases were reported to have normal folic acid levels. It has been known for a long time that the hematological manifestations of Vitamin B12 deficiency may be masked by folic acid. As noted in the 10th Edition of Harrison's Principles of Internal Medicine, “folate, particularly in large doses, can correct the megaloblastic anemia of Vitamin B12 deficiency without altering the neurological abnormalities. The neurological manifestations may even be aggravated by folate therapy.” It is therefore possible that even though these patients may not have received folic acid as tablets, they may have had dietary practices which included foods, (ie, fresh lettuce and corn) which have significant amounts of folic acid. In patients who consume large amounts of dietary folate, it is conceivable that Vitamin B12 deficiency may be manifested by the psychoneurological symptoms of B12 deficiency, without the hematological findings. It might be worthwhile not only measuring folate levels in these patients, but also evaluating their dietary practices to determine whether they have a relatively large intake of folic acid containing foods.

Diagnostic Imaging in Internal Medicine

Perhaps no specialty in medicine is evolving as rapidly as radiology. In the past five years, magnetic resonance imaging (MRI), digital subtraction angiography, and positron emission tomography, along with significant improvements in ultrasound, computed tomography, and nuclear medicine technology, have revolutionized noninvasive imaging. Similarly dramatic changes have occurred in interventional radiology with the development of percutaneous biliary and renal drainage, abscess and pseudocyst drainage, transluminal angioplasty, and dilatation of gastrointestinal strictures. To the author's credit, this explosion of new diagnostic and therapeutic techniques is smoothly and intelligently integrated with classic, albeit more prosaic, radiographs of bone diseases, pneumonias, infection, metabolic and immunologic disorders, ulcers, and polyps. This book lacks a section on obstetric radiology and, save for this one intentional omission, this work is comprehensive. Although written as an imaging complement to Harrison's Principles and Practice of Internal Medicine , it is actually an all-purpose review of contemporary radiology, propelling it

Book Review: Harrison's Principles of Internal Medicine: Update 5

Book Review: Harrison's Principles of Internal Medicine: Update 5

Harrison's Principles of Internal Medicine

The first modern textbook of internal medicine was Osler'sThe Principles and Practice of Medicine, published in 1892. This was made possible by the development of bacteriology in the last third of the 19th century, and the consequent assignment of specific causes to the illnesses most patients were initially seen with in those days. For the first time it was practical to have a nosography based on etiology. Osler's breadth of knowledge, clinical orientation, and mastery of English prose made the book a tremendous success. New editions appeared every two or three years. In 1927, an entirely new textbook of medicine came out, edited by Dr Russell Cecil, but written by 130 contributors. It soon replacedOsler(by then edited by McCrae) as the standard American medical text. Cecil retained Osler's format, with discrete descriptions of disease entities grouped by etiology or by systems affected. In 1950, another textbook was

Update IV Harrison's Principles of Internal Medicine

This is the last of the four “Updates” expected to appear between the publications of the ninth and tenth editions of Harrison's Principles of Internal Medicine. Of the 15 topics discussed all will be of great interest to the internist and family practitioner, but of these only seven are likely to fall within the scope of Tropical Medicine. These latter are “Toxic-Shock Syndrome,” “The Expanding Spectrum of Chlamydia trachomatis Infections,” “The Gram-Negative Bacillary Pneumonias,” “Diagnosis and Prevention of Viral Hepatitis,” “Assessment of the New Immune-Complex Assay Technology,” “Implications of Recombinant DNA Technology for Medicine,” and “Decision Theory and Medical Practice.”Each topic is thoroughly covered and well written, the previous high standards of the publication being upheld.The toxic-shock syndrome, which received so much attention in the lay news media 2 or 3 years ago is not a phenomenon only of menstruating women using tampons.

Harrison's Principles of Internal Medicine.

Harrison's Principles of Internal Medicine.

Harrison's Principles of Internal Medicine with CME Examination. Update IV.

Harrison's Principles of Internal Medicine with CME Examination. Update IV.

Harrison's principles of internal medicine update I with CME examination Edited by K. J. Isselbacher, R. D. Adams, E. Braunwald, J. B. Martin, R. G. Petersdorf, and J. D. Wilson. McGraw‐Hill Book Company, New York, 1981 284 pp, illustrated, $30.00

Harrison's principles of internal medicine update I with CME examination Edited by K. J. Isselbacher, R. D. Adams, E. Braunwald, J. B. Martin, R. G. Petersdorf, and J. D. Wilson. McGraw‐Hill Book Company, New York, 1981 284 pp, illustrated, $30.00

Disorders of Voluntary Muscle

ABSTRACT Walton's Disorders of Voluntary Muscle, like Harrison's Principles of Internal Medicine or the Davis-Christopher Textbook of Surgery, become a classic in its field.This fourth edition (the first was published in 1964, the third six years ago) is a welcome response to the almost exponential growth of the investigation of neuromuscular disease over the past five years and, like all of Professor Walton's publications, reflects a high standard of excellence, both in conception and execution.The present volume undergone numerous alterations and modifications. Its format is totally different from the previous edition. This has allowed extensive revision and restructuring of many of the chapters, with complete rewriting of others. Also new is a short section on the involvement of human muscle by parasites, as well as a chapter on drug-induced neuromuscular disorders.Like its first edition, this book is aimed primarily at the clinician, whether he be a

Update I—Harrison's Principles of Internal Medicine with CME Examination

Update I—Harrison's Principles of Internal Medicine with CME Examination

Harrison's Principles of Internal Medicine.

Harrison's Principles of Internal Medicine.

Harrison's Principles of Internal Medicine

Every three or four years the conscientious physician must again answer the recurrent question of whether to buy the newest edition of Harrison's textbook of medicine. The physician may ask, Are there substantial changes in the text? Are there important additions? Although the changes in the newest edition are mostly not substantive, they are indeed numerous and of some importance. For example, infectious mononucleosis is now discussed with diseases of viral origin rather than being included in the section Diseases of Uncertain Etiology, a section that has now shrunk from four to just three listings. As another example, in the eighth edition, the discontinuation of cold baths in treatment of heat stroke is recommended when the rectal temperature falls below 101 F (38.3 C), while in the seventh edition, the recommendation is made to do so when the temperature falls below 103 F (39.5 C). I personally care more what

Harrison's Principles of Internal Medicine.

Harrison's Principles of Internal Medicine.

On the role of the orthogonalization hole potential in Harrison's first principles pseudopotential theory

An analysis is made of the exact treatment for the orthogonalization hole potential, denoted by nu OPW*, in Harrison's first principle pseudopotential theory (1966, 1969). A corrected form of Harrison's expression for the approximation of nu OPW* is given and its effect on the calculation of phonon spectra for lithium, sodium and zinc are discussed. To demonstrate the effect of using the 'exact' formulation for the orthogonalization hole potential, the nu OPW* and an exact orthogonalization hole density are used in the calculation of a nonlocal pseudopotential and phonon dispersion curves for zinc.

On the influence of electronic exchange and correlation on pseudopotential calculations

AbstractThe influence of different local statistical exchange and correlation approximations for the core‐core and conduction band‐core interactions on a calculation of binding energies and stable crystal structures within Harrison's first principles pseudopotential formalism is discussed. It is shown that with a convenient choice of the exchange parameters it is possible to calculate the binding energies with high accuracy and to predict the correct crystal structure in each case. These exchange parameters agree well with those yielding the best form factors and effective interionic pair potentials in a previous paper [1].

On the Influence of Electronic Exchange and Correlation on Pseudopotential Calculations I. Form Factors, Energy‐Wave Number Characteristics, and Effective Interionie Pair Potentials

AbstractThe influence of electronic exchange and correlation on pseudopotential calculations is discussed within the framework of Harrison's first principles pseudopotential formalism. The Xα local exchange and correlation approximation is used for the calculation of the core states and for the conduction band–core exchange interaction. Exchange and correlation between the conduction electrons are taken into account using different modified forms of the dielectric function. The influence of these approximations on the form factors, normalized energy‐wave number characteristics, and effective interionie pair potentials of 14 simple metals is discussed.

Bear Meat and Hypervitaminosis A

To the Editor.— The EDITORIAL, Dangers of Eating Bear Meat, (220:274, 1972) triggered recall of information acquired as a medical student and unused to date. In the seventh (1943) edition of Cecil's Medicine (p 662), there is a report of the pathology attributed to hypervitaminosis A, over the signature of Tom D. Spies. Severe illness from the ingestion of polar bear liver by dogs and men has long been known to Eskimos, and has been reported by members of arctic expeditions. Signs and symptoms include complete loss of hair, peeling of the skin, drowsiness, severe headache, and vomiting. In 1940, Douty reported development of violent headaches, nausea, and torpor the morning after he and several others ate freshly killed polar bear liver. Harrison's Principles of Internal Medicine (sixth edition, 1970, p 419) lists among the effects of an excess of vitamin A in adults, headache, blurred vision or diplopia, nausea,

Principles of Diagnostic Radiology

This is an excellent book. It is a companion volume in radiology to Harrison's Principles of Internal Medicine . To quote from the preface, This book is not intended to teach the details of radiologic interpretation, which are better left for more specialized monographs in radiologic diagnosis, rather we wish to present a rational and systematic approach to the use of Radiology as a tool to augment other forms of clinical diagnosis in patient care. Thus, it is this emphasis that makes Principles of Diagnostic Radiology ideally suited as a companion volume to the comprehensive Harrison's Principles of Internal Medicine which presents a unique and logical approach to medicine through systematic recapitulation of the thinking process by which a physician reaches a diagnosis. The editors and authors are to be congratulated for having succeeded so well. They have divided coverage of various topics into two basic compartments. The first part, entitled

Roentgenologic Diagnosis: A Complement in Radiology to the Beeson and McDermott Textbook of Medicine

Principles of Diagnostic Radiology: Companion Volume to Harrison Principles of Internal Medicine, by E. James Potchen, P. Ruben Koehler, and David O. Davis, 571 pp, with illus, $29.50, New York: McGraw-Hill Book Co., 1971. Roentgenologic Diagnosis , which appeared a little more than four years ago, has been entirely rewritten in its second edition, with 400 pictures added, together with a new section dealing with the environmental causes of disease. It is a mark of the authors' skill that they could do this while adding very little to the weight of two comprehensive and lavishly illustrated volumes. The range of this atlas by Teplick and Haskin sweeps from the most ordinary lesions to the most exotic— from the Empty Sella to the Madura Foot. Nothing is swept under the rug. As the authors sensibly point out, rarities that open our eyes deserve more space than warts. Drs. Teplick and Haskin were