Hardness Uniformity Research Articles

Formulation and evaluation of pH activated dosage form as minitablets in capsule for delivery of fesoterodine

ObjectivesIn the present study, an attempt is made to develop novel multifunctional sustained-release minitablets in a capsule system by film coating Fesoterodine for the treatment of urinary incontinence (increased urinating frequency). MethodologyThe direct compression technique was used to formulate the minitablets, and coating was applied using hydroxypropyl methylcellulose (HPMC) phthalate. The pre-formulation study was performed using tools like differential scanning calorimetry (DSC), infrared spectroscopy (IR) and post-formulation parameters such as hardness, thickness, weight variation, uniformity, and drug release. Drug release kinetics were studied for the formulations F1–F11. ResultsAll the pre- and post-formulation parameters were found to be within the limits. F1 and F2 result in burst release of the drug within 30 minutes. For the F3, F4, and F5 formulations, HPMC phthalate-coated minitablets show almost 100% drug release in 3, 4, and 5 hours, respectively. F6, F7, and F8 (2.5%, 5%, and 10% formaldehyde-coated minitablets, respectively) show drug releases in the small intestine, and the release was prolonged for 24 hours, whereas F9, F10, and F11 (2.5%, 5%, and 10% glutaraldehyde-coated minitablets, respectively) release in the small intestine, but drug release takes more than 20 hours. ConclusionFilm-coated minitablets were satisfactorily developed in terms of various post-compression parameters like hardness, thickness, friability, weight variation, and content uniformity. IR and DSC studies revealed no significant drug excipient interactions. HPMC phthalate-coated minitablets released in the buffer, and it was supposed that the drug releases in the intestine, which leads to better absorption and follows Korsmeyer-Peppas release kinetics.

Ultra-precision grinding of 4H-SiC wafer by PAV/PF composite sol-gel diamond wheel

To eliminate the deep scratches on the 4H-SiC wafer surface in the grinding process, a PVA/PF composite sol-gel diamond wheel was proposed. Diamond and fillers are sheared and dispersed in the polyvinyl alcohol-phenolic resin composite sol glue, repeatedly frozen at a low temperature of −20°C to gel, then 180°C sintering to obtain the diamond wheel. Study shows that the molecular chain of polyvinyl alcohol-phenolic resin is physically cross-linked to form gel under low-temperature conditions. Tested by mechanical property testing machines, microhardness tester, and SEM. The results show that micromorphology is more uniform, the strength of the sol-gel diamond wheel is higher, the hardness uniformity is better than that of the hot pressing diamond wheel. Grinding experiments of 4H-SiC wafer were carried out with the prepared sol-gel diamond wheel. The influence of grinding speed, feed rate, and grinding depth on the surface roughness was investigated. The results showed that by using the sol-gel diamond wheel, the surface quality of 4H-SiC wafer with an average surface roughness Ra 6.42 nm was obtained under grinding wheel speed 7000 r/min, grinding feed rate 6 µm/min, and grinding depth 15 µm, the surface quality was better than that of using hot pressing diamond wheel.

Optimasi Kombinasi Asam Sitrat dan Asam Tartrat sebagai Zat Pengasam pada Tablet Effervescent Ekstrak Ubi Jalar Ungu (Ipomoea batatas L)

Purple sweet potato has the content of anthocyanin compounds that are efficacious as antioxidants. To deliver these efficacious compounds, formulations of effervescent tablets are required as antioxidants with a combination of citric acid and tartrate acid to accelerate the solubility of the drug. The research aims to optimize the combination of citric acid and tartrate acid as a sourgent on effervescent tablets of purple sweet potato extract using the simplex lattice design method. The manufacture of tablets using a direct pumping method with effervescent powder evaluation includes flow rate test, silent angle, compressibility, and powder moisture. Evaluation of tablets includes organoleptic tests, uniformity of tablet weight, hardness, fragility, and soluble time of tablets—data analysis using simplex lattice design software design expert version 10. The results of effervescent powder evaluation include a test of flow rate, quiet angle, compressibility, and moisture of powder in each formula that already meets the requirements. The physical evaluation results on the effervescent tablet weight uniformity test on F3, F4, and F5 have met the requirements. The evaluation of tablet hardness F1 and F2 also meet the requirements. The results of the evaluation of fragility and time dissolve tablets have met the requirements of all formulas. The simplex lattice design analysis results obtained F5 as the most optimal formula with a concentration of citric acid 103.25 mg and tartrate acid 44.25 mg. The combination of citric acid and tartaric acid affects the evaluation of hardness, fragility, and time-soluble effervescent tablets of purple sweet potato extract. The optimal concentration based on simplex lattice design analysis was obtained in F5 with a citric acid concentration of 103.25 mg and tartrate acid of 44.25 mg.

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LANSOPRAZOLE BY SOLUBILITY ENHANCEMENT TECHNIQUE

The present study was focused on preparation and evaluation of Lanzoprazole fast dissolving tablets. Lansoprazole (LAN) is a proton pump inhibitor drug and used for the treatment of gastric ulcer. Lansoprazole is acid labile drug and to avoid the acidic pH of the stomach LAN is formulated as oral fast dissolving tablets. Lansoprazole is the class II drug of the BCS classification and has a low aqueous solubility. Hence, to improve the solubility of the drug we have prepared Lansoprazole solid dispersion with poly ethylene glycol and complex with β cyclodextrin. Fast Dissolving tablets of LAN were formulated using different superdisintegrants like Sodium Starch Glycolate, Cross Povidone, Cross Carmellose Sodium by direct compression method. The prepared fast dissolving tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content, wetting time, in-vitro drug release and short term stability studies. Percentage weight variation, hardness, friability and drug content uniformity were found to be within the approved range for all the formulations. The in-vitro release studies showed that 99.6% of LAN within 90 sec. Overall, in the formulations prepared by the direct compression method, F3, which contains 6% CCS as super disintegrants release 99% of (LAN) in 2 min was found to be the best formulation. The results concluded that fast dissolving tablets of LAN showing enhanced dissolution might lead to improved bioavailability and effective therapy for gastric ulcer. KEYWORDS: β cyclodextrin, Cross Povidone, Fast dissolving tablets, Gastric ulcer, Lanzoprazole, Solid dispersion

Pharmaceutical quality of antimalarial drugs: quinine sulfate and Artemether/Lumefantrine tablets sold on Bukavu Market

BackgroundGeneric antimalarial drugs sold in sub-Saharan Africa require tighter control as counterfeiting has grown more and more out of control. The study aimed to analyze the pharmaceutical quality of quinine sulfate (QS) and Artemether/Lumefantrine(AL) tablets marketed in Bukavu city compared to the current trends in other African cities.ResultsThe samples were purchased in community pharmacies or from ambulatory street vendors and analyzed using a set of thirteen simple tests, including visual inspection, UV spectrometry, TLC, and conventional quality control procedures. More than 93% of AL samples had an acceptable global quality score of > 90%. Around 16.6% of QS batches did not satisfy the requirements about hardness, friability, and mass uniformity. Only 33.3% met the disintegration quality; 33.3% did not contain quinine; 8.33% had an active ingredient other than quinine.ConclusionThe findings strongly alert the circulation of fake antimalarial medicines observed in many countries. Simple TLC procedures may help to detect any low-quality generics to avoid microbial resistance and guarantee the health of the population. Pharmacists and regulatory authorities are alerted to the circulation of low-quality generic quinine preparations in the country.

Potential and Comparative Tablet Disintegrant Properties of Pectin Obtained from Five Okra Genotypes in Ghana.

Okra pectin has been studied as a potential excipient in tablet formulations for pharmaceutical industries. Okra is widely grown and available in Ghana and other parts of the world. The prospective use of pectin from okra genotypes grown in Ghana as tablet disintegrants has not been reported. This study aims to determine the potential and comparative disintegrating properties of pectin from five okra genotypes (Abelmoschus esculentus L.) in Ghana using uncoated immediate release paracetamol tablet formulations. The yield of the pectin from the various genotypes ranged between 6.12 and 18.84% w/w. The extracted pectins had pH ranging from slightly acidic to almost neutral (6.39–6.92). Pectin from the various genotypes exhibited good swelling indexes (˃200%), varying solubility in different solvents, and low moisture content (˂20%). Elemental analysis of the extracted pectin from the various genotypes revealed very low levels of toxic metals and micronutrients. Pectin from the various genotypes was evaluated as disintegrants within concentrations of 5–10% w/w (F1–F18). Their disintegrating properties were compared to that of maize starch BP. All the formulated batches of uncoated immediate release paracetamol tablets (F1–F18) passed the following: uniformity of weight test, uniformity of dimensions, hardness, friability (˂1%), and drug content (95–105%). Significant differences (p ≤ 0.05) were observed between the hardness of the maize starch tablets and tablets formulated from pectin of the various genotypes. Pectin from all genotypes other than PC5 exhibited good disintegrating properties (DT ˂ 15 min) and subsequently passed the dissolution profile test (≥70% release in 45 minutes). Tablets formulated with PC5 as disintegrants at all concentrations (5% w/w (F5), 7.5% w/w (F11), and 10% w/w (F17)) failed the disintegration and dissolution tests. Ultimately, pectins extracted from PC1, PC2, PC3, and PC4 can be commercially exploited as disintegrants in immediate release tablets.

Formulation of Metformin Sustained Release Tablet Using Natural Polymer

The overall objective of the present work was to develop an oral sustained-release (SR) Metformin tablet that is prepared by the direct compression method by using hydrophilic hydroxyl propyl methyl cellulose (HPMC) and Guar gum polymer alone as well as in combination at different concentrations. Metformin is a biguanide that has a relatively short plasma half-life. It has low absolute bioavailability. All the properties were evaluated for thickness, weight variation, hardness and drug content uniformity and in vitro drug release. The mean dissolution time is used to characterize the drug release rate from a dosage form that indicates the drug release-retarding efficiency of the polymer. The hydrophilic matrix of HPMC alone could not control the Metformin release effectively for 12 h but when combined with Guar gum, it could slow down the release of drug and, thus, can be successfully employed for formulating Sustain Release matrix tablets.
 Keywords: Guar gum, hydroxylpropylmethylcellulose, matrix tablets, release kinetics,

COMPARATIVE STUDY OF SEVEN BRANDS OF LEVOFLOXACIN 500 MG FILM-COATED TABLET MARKETED IN YEMEN

Objective: The objective of the current study was to evaluate the quality control parameters of seven brands of levofloxacin 500 mg film-coated tablet available in the Yemeni market.
 Methods: Physicochemical parameters assay was performed for seven brands of levofloxacin 500 mg film-coated tablet. Each brand was subjected to official and unofficial in vitro quality control tests, including weight variation, thickness, hardness, friability, disintegration, dissolution, and content uniformity assay by High-Performance Liquid Chromatography (HPLC).
 Results: Out of seven, six brands of levofloxacin 500 mg film-coated tablet passed official specified assay tests according to the United States Pharmacopeia (USP) specifications. They showed a similar profile of thickness ranged between±0.01 and 0.10%, friability ranged between 0.01% and 0.34%, disintegration time ranged between 3.00 and 15.00 min, dissolution percentage ranged between 90.650 and 103.05 and content uniformity ranged between 93.62 and 107.12%. Regarding weight variation and hardness, six brands passed the weight variation test and only three brands showed optimum range (10-20 kg) of hardness test. Only one brand failed to pass the weight variation test, and four brands failed to pass the optimum range (10-20 kg) of hardness.
 Conclusion: There are no remarkable differences between the seven brands regarding in vitro quality control tests of content uniformity, thickness, friability, disintegration, and dissolution. Even though four brands were above the optimum range of hardiness, they showed complete disintegration and dissolution within the acceptable limit. Regular assessment of marketed drugs is required to ensure bioequivalent to their innovators.

Development and Evaluation of Goat Milk Tablet Using Dry Granulation Techniques for Nutraceutical Purposes

There are several problems for the school children to take the pure milk especially the goat milk every day because of the unpleasant taste and smell of the goat milk are not so good. Besides, the pure milk has a short life time. It is difficult to store the goat milk in a long period of time at room temperature. The solution for this problem is change the goat milk from liquid form into the chewable milk tablet that can be easily consume by the school children. Goat milk in the form of tablet formulation will increase the shelf life of the product. Therefore, the chewable goat milk tablet can be stored in a long period of time, convenience, and suitable for distribution to remote areas. In this project, the focusing was more into the optimization of the weight adjustment of the tableting machine before and after the dry granulation to form good chewable tablet. The pre-evaluation had been done for the goat milk powder and granule after dry granulation process. It can be concluded that goat milk tablet can be an alternative to the pure goat milk. The poorly flowing properties of goat milk powder can be improved by using dry granulation techniques. Based on this study, F4D shows the best setting to produce the goat milk tablet using dry granulation technique. F4D successfully improved the flow ability and compressibility of goat milk tablet. It also produce the best goat milk tablet as it possess uniformity of weight, low friability and good hardness

Evaluasi Pengaruh Konsentrasi Pati Biji Cempedak (Artocarpus champeden) sebagai Bahan Pengisi pada Formulasi Tablet Paracetamol

Cempedak plants are widely distributed in Indonesia, one of which is Kalimantan. Cempedak is a tropical plant, so its potential can be used as an additive in the manufacture of pharmaceutical preparations. Previous studies used cempedak seed starch as a binding agent in tablet formulations. This study aims to determine the effect of variations in concentration and optimum concentration of Cempedak seed starch (Artocarpus champeden) as a filler for Paracetamol tablets. The study used a True Experimental Design design with a posttest-only control group design. Making tablets using the wet granulation method. Data analysis used the one-way ANOVA test followed by the LSD test and the Kruskal-Wallis H test which continued with the Mann Whitney Test as a derivative test of the one-way ANOVA. Granule evaluation includes organoleptic, flow properties, tapping test, and stationary angle test. The results of the evaluation of the granules produced granules produced from each formulation are in accordance with the requirements. Tablet evaluation included organoleptic, uniformity in weight, the hardness of tablet, friability, and disintegration time. The results of the tablet evaluation showed that the maximum concentration of cempedak seeds was found in F1 because it showed the evaluation results that were in accordance with the requirements. In evaluating the uniformity of weight and hardness of tablets with the Kruskal Wallis H test and the Mann Whitney test, the results show that there are differences in each formula with a P-value <0.05. The results of the evaluation of tablet friability and disintegration time with one-way ANOVA test and LSD test showed differences in each formula with a P-value <0.05. Cempedak seed starch (Artocarpus champeden) can be used as a filler in the loading of Paracetamol tablets by the wet granulation method.

Effect of phase dispersivity and grain size on hardness of steel vessels at outlet of rolling-press line

The hot production technology of round vessels made of 50 steel on rolling-press line is studied. It is shown that processing by cooled deforming tool leads to uneven distribution of temperature and phase composition along the height of the vessels metal. Oil quenching did not allow the uniformity of structure and hardness to be formed in the unevenly heated metal of the vessels. The study of the microstructure and its phase components made it possible to establish the reasons for the deviations of the hardness along the height, measured by Rockwell method in the bottom and top parts of vessel about 32 and 24 HRC respectively.

Evaluation of the matrix-forming ability of Chrysophyllum albidum Linn fruit gum in sustained-release tablet formulations

Background: Plant gums are extensively being exploited as pharmaceutical excipients due to the ease of availability, biodegradability, and reduced costs. Aim: This study investigated the application of the fruit gum of Crysophyllum albidum (CFG) as a matrix former in the formulation of chlorpheniramine maleate and theophylline hydrochloride tablets. Materials and Methods: The gum was extracted using acetone and evaluated for flow, swelling, and hydration capacity. Effects of temperature on CFG and drug compatibility were evaluated using differential scanning calorimetry (DSC). Granules containing CFG at 10, 20, and 30% w/w were prepared using the wet granulation method and evaluated for flow properties. Compressed tablets were evaluated for uniformity of weight, hardness, friability, and drug content. In vitro drug release studies were carried out in simulated gastric (pH 1.2) and simulated intestinal (pH 6.8) fluids. Pearson’s similarity correlations were used to analyze results. Results: CFG had a swelling capacity of 22% and hydration capacity of 1.44 with an angle of repose of 30o and Carr’s index of 7.6 signifying good flow. DSC thermogram returned an endothermic glass transition peak at 72.1oC with no appreciable shifts in the peak when CFG was incorporated into the drug. Tablet hardness and friability were concentration dependent with values of 6.5–8.5kg F and 0.04–0.4%, respectively; drug content was within official specifications. Formulations containing 30%w/w CFG sustained drug release for over 12 h and showed better ability to control drug release than HPMC at same concentration. Conclusion: This study shows the propensity of CFG to be used in the formulation of sustained-release tablet formulations.

Assessment of physicochemical properties and comparison of the dissolution profile of amoxicillin caplets

Background: Marketed drugs must meet the required standards to guarantee product quality. Amoxicillin is a generic compound marketed under various trademarks as copy drugs. Amoxicillin caplets are an immediate release dosage form of BCS class I. An essential aspect of evaluating copy drugs is to assess the equivalence for their treatment to the innovator drugs to ensure the safety and effectiveness of the circulating copy drugs. Objective: The study aims to evaluate the physicochemical properties and compare the dissolution profile of amoxicillin caplets available in the market. Methods: Five amoxicillin caplet products, four test products, and one reference product were tested for their physicochemical properties and dissolution. The dissolution test was carried out with a type II device at a speed of 75 rpm in 900 mL of media buffered at pH 1.2, 4.5, and 6.8 and at a temperature of 37 +/- 0.5degrees celcius. The dissolution profile was analyzed by comparing it with the similarity factor (f2) parameters. Results: Two of the four amoxicillin caplet products had a similar dissolution profile to the reference products, namely products A and B. Products C and D were dissimilar because f2 was lower than 50 at pH 4.5. The caplets tested had almost the same dimensions, and all caplets met the requirements for uniformity of content, hardness, disintegration time, and dissolution. Conclusion: Not all of the amoxicillin caplets in the market have a similar dissolution profile to the reference products. Keywords: caplets, amoxicillin, dissolution, similarity factor

Formulation and Evaluation of Hydrocortisone Sodium Succinate Mucoadhesive Buccal Tablet

Background: The present study involves the formulation and in-vitro assessment of mucoadhesive tablets of hydrocortisone sodium succinate. Local treatment for buccal inflammatory injuries such as aphthous wounds relies on the fact that a high amount of drug can be delivered at the target site, as well as reduction or avoidance of steroidal adverse effects seen by systemic administration routes. Methods: Tablets contained acacia as the mucoadhesive component with different concentrations (10, 20 and 30%w/w). To this, lactose, magnesium stearate and active pharmaceutical ingredient were added and mixed thoroughly. These tablets were prepared by direct compression technique. Buccal tablets were tested for thickness, hardness, weight and content uniformity, surface pH and mucoadhesive strength. Kinetic of drug release was also calculated for the best formulation. Dissolution parameters were also measured in-vitro for the selected formulation and compared with Corlan® as the standard reference tablet. Results: All of the tests confirmed the proper formulation according to the standards of conventional oral tablets. Mucoadhesive strength of one of formulations was about 50% more than the reference tablet. The optimized formulation that was made by 10% acacia provided adequate release comparable to Corlan®. Release profile was best fitted to Hixson-Crowell model. Conclusion: We concluded that our formulated buccal tablet was comparable and similar in-vitro bioequivalent) to the reference tablets.

Improving the distribution uniformity of surface hardness of the cured CFRP molniezaschita coating during processing in a microwave field elektromagnitnom

In the structural elements of advanced air transport and wind turbines are widely used fiber-reinforced polymer composite materials: carbon and fiberglass. In order to increase the resistance of materials to static electricity and lightning discharges, lightning-proof coatings are included in the structure of the polymer composite materials. In the process of operation, there may be collisions of the plumage and planes of aircraft, as well as large-sized blades of wind turbines with solid objects. Therefore, along with the strength and resistance to high-amplitude low-cycle loads, one of the important characteristics of polymer composite materials that determine their performance properties is hardness. Strength and endurance of polymer composite materials products can be increased by short-term exposure to microwave electromagnetic field. The presence of a built-in metal structure introduces additional uncertainty in the perception of anisotropic polymer composite materials operating loads, as well as in the process of interaction with the electromagnetic field of ultrahigh frequency. The studies of the hardness distribution on the surface of carbon plastics with built-in lightning-proof coatings under different schemes of exposure to microwave electromagnetic field: from the lightning-proof coatings, from the side opposite to the lightning-proof coatings, sequential processing on both sides compared with the starting material. It is found that processing in a microwave electromagnetic field with an energy flux density (17-18) ×104 mW/cm2 for 2 minutes leads to a significant increase in the uniformity of the initial hardness of the surface of the samples.

Field experimental investigation on filling the soda residue soil with liquid soda residue and liquid fly ash

In order to reuse waste soda residue, the feasibility of utilizing liquid soda residue and liquid fly ash to prepare soda residue soil was investigated. The mechanical properties of the soda residue soil were studied and analyzed through laboratory tests and field tests. The raw materials preparation process and liquid-liquid mixing method in the field were determined, and the optimal mixing proportion of the soda residue soil was investigated by compaction test and micro penetration test. And the filling quality of the liquid-liquid mixing and solid-liquid soda residue soil was measured by micro penetration test, light dynamic penetration test, and variable energy dynamic penetration test. The test results showed that the optimal mass ratio of soda residue to fly ash is 7:3. The optimal water content and maximum dry density of the soda residue soil with the optimal mix ratio are 63.5% and 0.88 g/cm3, respectively. After 5 months of natural drying, the soda residue soil filled by liquid soda residue and liquid fly ash has higher strength and better uniformity of hardness. The water content of the soda residue soil is between 160% to 180%, and drainage consolidation is the effective method to reduce the water content and improve the strength of the soda residue soil. Compared with the method of preparing the soda residue soil by solid mixing, the method used in this experiment is simple, efficient and feasible.

Design, Development and Evaluation of Gliclazide Tablets for Non-Insulin Dependent Diabetes Mellitus

The goal of the present work was to formulate the oral tablets of gliclazide for non-insulin dependent diabetes and provide a dosage form for prolonged period of time, in order to improve efficacy, reduce the frequency of total dose and better patient compliance. The powders were evaluated for angle of repose, bulk density, compressibility index and hausner’s ratio. All the tests revealed that powders showed excellent flow properties. The resulting tablets were evaluated for thickness, diameter, and uniformity of weight test, hardness, friability and drug content. In-vitro release of drug was performed using 7.4 pH phosphate buffers and dissolution was done. All the tablet formulations showed acceptable pharmacological properties and complied with pharmacopoeias standards.
 

Research of the excipients quantitative characteristics influence on the basic quality indicators of amlodipine with enalapril tablets

Topicality. Arterial hypertension remains one of the most common diseases in Ukraine. Pharmaceutical development provides creating effective, high-quality and safe medicines.Aim. To study the influence of quantitative factors on pharmacotechnological parameters of amlodipine with enalapril tablets.Materials and methods. We selected excipients grouped in 7 factors and studied them at the lower and upper levels. A random balance method used for the plan of the experiment. The obtained tablets have been analyzed according to the requirements of the State Pharmacopoeia of Ukraine. Significant factors have been determined by the scatter plots.Results and discussion. The excipients quantity influence on the pharmacotechnological characteristics of the granulate (loss on drying), tablet mass (flowability, angle of repose, bulk density, tapped density) and amlodipine with enalapril tablets (uniformity of mass, hardness, friability and disintegration) studied.Conclusions. It has been selected the number of excipients providing the pharmacotechnological properties of the granulate, tablet mass and amlodipine with enalapril tablets according to current pharmacopoeia requirements.

Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet.

BackgroundSevere bleeding and perforation of the colon and rectum are complications of ulcerative colitis which can be treated by a targeted drug delivery system.PurposeDevelopment of colon-targeted delivery usually involves a complex formulation process and coating steps of pH-sensitive methacrylic acid based Eudragit®. The current work was purposefully designed to develop dicalcium phosphate (DCP) facilitated with Eudragit-S100-based pH-dependent, uncoated mesalamine matrix tablets.Materials and MethodsMesalamine formulations were compressed using wet granulation technique with varying compositions of dicalcium phosphate (DCP) and Eudragit-S100. The developed formulations were characterized for physicochemical and drug release profiles. Infrared studies were carried out to ensure that there was no interaction between active ingredients and excipients. Artificial neural network (ANN) was used for the optimization of final DCP-Eudragit-S100 complex and the experimental data were employed to train a multi-layer perception (MLP) using quick propagation (QP) training algorithm until a satisfactory root mean square error (RMSE) was reached. The ANN-aided optimized formulation was compared with commercially available Masacol®.ResultsCompressed tablets met the desirability criteria in terms of thickness, hardness, weight variation, friability, and content uniformity, ie, 5.34 mm, 7.7 kg/cm2, 585±5 mg (%), 0.44%, and 103%, respectively. In-vitro dissolution study of commercially available mesalamine and optimized formulation was carried out and the former showed 100% release at 6 h while the latter released only 12.09% after 2 h and 72.96% after 12 h which was fitted to Weibull release model with b value of 1.3, indicating a complex release mechanism.ConclusionDCP-Eudragit-S100 blend was found explicative for mesalamine release without coating in gastric and colonic regions. This combination may provide a better control of ulcerative colitis.

Mempelajari Pengaruh Konsentrasi Maltodekstrin dan Polivinil Pirolidon (PVP) terhadap Karakteristik Sifat Fisik Tablet Effervescent Kopi Robusta (Coffea robusta Lindl)

Effervescent tablets are soft drink products that contain organic acids such as citric acid and sodium bicarbonate, which react quickly in water by releasing carbon dioxide. The purpose of this research is to increase the empowerment of coffee plants, namely Robusta coffee as a popular commodity, with Robusta coffee diversification into functional food products in the form of effervescent tablets. This study aims to determine whether there are variations in the concentration of maltodextrin and polyvinyl pyrrolidone (PVP) on the physical characteristics of robusta coffee effervescent tablets. The method / design used in this study is a Randomized Group Design pattern with each factor of three levels with three replications with variations in the addition of maltodextrin (10%, 15%, 20%) and PVP (2%, 3 %, 4%). The results showed that the concentration of maltodextrin as a filler had an effect on the physical response, namely hardness, dissolution time and weight uniformity of effervescent tablets of robusta coffee. Concentration of polyvinyl pyrrolidone (PVP) as a binder gives effect to the physical response, namely hardness and soluble time of effervescent tablets of robusta coffee. The interaction between maltodextrin concentration and polyvinyl pyrrolidone (PVP) concentration influences the physical response, namely hardness and soluble time of effervescent tablets of Robusta coffee. Based on the results of the study, the best treatment was obtained at 15% maltodextrin concentration and 4% PVP concentration.