Hamilton Depression Rating Scale Research Articles

Relationship between anhedonia, separation anxiety, attachment style and suicidality in a large cohort of individuals with mood and anxiety disorders.

Relationship between anhedonia, separation anxiety, attachment style and suicidality in a large cohort of individuals with mood and anxiety disorders.

DNA methylation of core clock genes in patients with major depressive disorder: Association with air pollution exposure and disease severity.

DNA methylation of core clock genes in patients with major depressive disorder: Association with air pollution exposure and disease severity.

Screening for depressive disorders: Validation of the Patient Health Questionnaire for Adolescents (PHQ-A) in a population-based multi-ethnic Asian sample.

Screening for depressive disorders: Validation of the Patient Health Questionnaire for Adolescents (PHQ-A) in a population-based multi-ethnic Asian sample.

Alterations in magnetic susceptibility correlate with higher cerebral blood flow in the right amygdala of patients with major depressive disorder.

Alterations in magnetic susceptibility correlate with higher cerebral blood flow in the right amygdala of patients with major depressive disorder.

Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease.

Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease.

A randomized controlled Trial of telerehabilitation intervention for acute ischemic stroke patients Post-Discharge.

A randomized controlled Trial of telerehabilitation intervention for acute ischemic stroke patients Post-Discharge.

Glymphatic system dysfunction and its impact on seizure severity, cognitive function, and affective symptoms in patients with generalized tonic-clonic seizures alone.

Glymphatic system dysfunction and its impact on seizure severity, cognitive function, and affective symptoms in patients with generalized tonic-clonic seizures alone.

Investigation of the relationship between biological rhythm pattern and eating attitude in patients diagnosed with bipolar disorder.

Investigation of the relationship between biological rhythm pattern and eating attitude in patients diagnosed with bipolar disorder.

The differential impact of processing speed and cognitive flexibility on cognitive emotion regulation strategies and depression.

The differential impact of processing speed and cognitive flexibility on cognitive emotion regulation strategies and depression.

Measuring suicidal behavior in the era of rapid-acting antidepressants: A systematic review of ketamine studies.

Measuring suicidal behavior in the era of rapid-acting antidepressants: A systematic review of ketamine studies.

Altered cerebellar activity and cognitive deficits in Type 2 diabetes: Insights from resting-state fMRI.

Altered cerebellar activity and cognitive deficits in Type 2 diabetes: Insights from resting-state fMRI.

Altered resting-state brain activity in patients with major depression disorder and bipolar disorder: A regional homogeneity analysis.

Altered resting-state brain activity in patients with major depression disorder and bipolar disorder: A regional homogeneity analysis.

Anxiety and depression moods is involved in the pathogenesis of postural tachycardia syndrome.

Anxiety and depression moods is involved in the pathogenesis of postural tachycardia syndrome.

Modulation of cerebellar homotopic connectivity by modified electroconvulsive therapy at rest: Study of first-episode, drug-naive adolescent major depressive disorder.

Modulation of cerebellar homotopic connectivity by modified electroconvulsive therapy at rest: Study of first-episode, drug-naive adolescent major depressive disorder.

Brain activity differences between difficulty in falling asleep and early awakening symptoms in major depressive disorder: A resting-state fMRI study.

Brain activity differences between difficulty in falling asleep and early awakening symptoms in major depressive disorder: A resting-state fMRI study.

Efficacy, safety, and tolerability of JNJ-61393215 (tebideutorexant), a selective orexin-1 receptor antagonist, as adjunctive treatment for major depressive disorder with anxious distress: A double-blind, placebo-controlled, randomized phase 2a study.

Efficacy, safety, and tolerability of JNJ-61393215 (tebideutorexant), a selective orexin-1 receptor antagonist, as adjunctive treatment for major depressive disorder with anxious distress: A double-blind, placebo-controlled, randomized phase 2a study.

Exploring the prospective association of serum interleukin-1β and brain-derived neurotrophic factor with antidepressant treatment response.

Exploring the prospective association of serum interleukin-1β and brain-derived neurotrophic factor with antidepressant treatment response.

Cognitive function in physically healthy, unmedicated individuals with major depression: Relationship with depressive symptoms and antidepressant response.

Cognitive function in physically healthy, unmedicated individuals with major depression: Relationship with depressive symptoms and antidepressant response.

Characteristic alterations of dynamic amplitude of low-frequency fluctuation in patients with post-stroke depression.

The abnormalities in static brain activity in patients with post-stroke depression (PSD) have been widely reported; the abnormal alterations and characterized clustering model of the dynamic neural activity in PSD remain enigmatic. We investigated dynamic neural activity abnormalities in patients with PSD with the dynamic amplitude of low-frequency fluctuation (dALFF) method. Imaging and clinical data from 25 patients with PSD and 28 without PSD collected from April 2020 to June 2023 were evaluated. The between-group comparisons of dALFF variance and state properties were conducted using a combined approach of sliding window and clustering analysis. The correlation coefficients between abnormal dALFF variance and ALFF in the distinguished regions (DRs) and depression severity of PSD were calculated. Compared with that in patients without PSD, decreased dALFF variance in patients with PSD was mainly located in lower dALFF variance in multiple emotion-related brain regions. The dALFF was clustered into four states in all patients. In particular, state 3 was the remarkably distinct state that dwelled for more time in the PSD group. There was a negative correlation between decreased dALFF variance in the right parietal cortex and Hamilton Rating Scale for Depression (HAMD) scores in patients with PSD. ALFF values in the DRs showed no correlation with the HAMD score. Our results suggest that patients with PSD showed characteristic alterations in dynamic regional neural activity, which might be regarded as potential neural mechanisms of PSD. This study demonstrates the dynamic features of neural activity in PSD, which may advance future neuroimaging studies.

Brain-derived neurotrophic factor as predictor of early-onset poststroke depression.

BackgroundPoststroke depression (PSD) with an approximately one third prevalence in stroke patients is associated with increased morbidity and mortality. This study aimed to investigate the potential relationship between brain-derived neurotrophic factor (BDNF) levels in serum and early-onset PSD as well as clinical variables.MethodsClinical data and radiological images of 88 patients diagnosed with acute ischemic stroke were examined. Serum BDNF levels were measured within the first 72hours following stroke diagnosis. On the 14th day following stroke diagnosis, Montreal Cognitive Assessment (MoCA), Hamilton Depression Rating Scale (HAM-D17), and National Institutes of Health Stroke Scale (NIHSS) were applied to the patients.ResultsSerum BDNF levels (P = 0.022) and MoCA values (P = 0.004) of patients with early-onset PSD were significantly lower, and NIHSS values (P = 0.027) were significantly higher compared to patients without early-onset PSD. There was a significantly negative correlation between BDNF value and HAMD-17 score and lymphocytes. Receiver operating characteristic (ROC) analysis was used to investigate the extent the BDNF level could predict the occurrence of early-onset PSD and cut-off values were determined. For a BDNF cut-off value of 361.51, sensitivity and specificity values were 75% and 56.2%, respectively, which indicated that BDNF may be a useful indicator associated with early-onset PSD.ConclusionLower serum BDNF levels are associated with early-onset PSD and may serve as a potential biomarker, although causal or predictive conclusions are limited due to the study's cross-sectional design.