This paper presents a Multi-Echelon Inventory Optimization (MEIO) framework, based on the Guaranteed-Service Model (GSM), to allocate safety stocks across a supply chain with several locations and products, minimizing costs while meeting service level objectives. Extending previous work by Achkar et al. (2023), this paper enhances the Mixed-Integer Quadratically Constrained Program (MIQCP) with a highly efficient solution approach. The model introduces a piecewise linear approximation, significantly improving computational efficiency and the accuracy of the approximation for the fill rate function. It also introduces a different and more efficient approach to account for stochastic lead times using a discrete function. Moreover, an extension of the approach to account for non-normally distributed demands is proposed. The model is applied to several instances of a real-world case study from a pharmaceutical company, with more than 7300 product-location combinations, showing that optimal solutions can be obtained within few seconds of computational time.
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