Guaiacum Officinale Research Articles

A saponin from the stem bark of Guaiacum officinale

A new nortriterpenoid saponin isolated from the stem bark of Guaiacum officinale was characterized as the 3-O-[α-l-arabinopyranosyl]-30-norolean-12,20(29)-dien-28-oic acid. Sitosterol-d-glucoside was also isolated.

Sapogenins from Guaiacum officinale

Acid hydrolysis of the saponins from the stem bark of Guaiacum officinale yielded the new sapogenin 3β,20η-dihydroxy-30-norolean-12-en-28-oic acid and the artifacts 3β-hydroxy-30-norolean-12,19-dien-28-oic acid and its methyl ester. Larreagenin, sitosterol and oleanolic acid were also isolated.

Furoguaiaoxidin—a new enedione lignan of Guaiacum officinale L: a novel method of sequential introduction of alkoxy functions in the 3- and 4-methyl groups of 2,5-diaryl-3,4-dimethylfurans

Thestructure of furoguaiaoxidin, a new enedione lignan of Guaiacum officinale has been elucidated and a novel method of sequential introduction of alkoxy functions in the 3- and 4-methyl groups of 2,5-diaryl-3,4-dimethylfurans is described.

Toxicological tests on flavouring matters

Short-term feeding studies in rats have been carried out on the following 23 flavouring matters: Methyl N-methylanthranilate; methyl β-naphthyl ketone; methyl octanoate; α-amylcinnamaldehyde; tolualdehydes; α-ionone; β-ionone; α-irone; α-isomethylionone; β-naphthyl ethyl ether; musk ambrette; γ-nonalactone; γ-undecalactone; γ-valerolactone; 1-( p-methoxyphenyl)-1-penten-3-one; m-dimethoxybenzene; patchouly, oil; davana, oil; guaiac wood, oil; costus root, oil; walnut hull, extract; yerba santa, fluid extract; mountain maple, solid extract. These compounds appear in the ‘GRAS’ (“generally recognized as safe”) list compiled by the Expert Panel of the Flavouring Extract Manufacturers' Association of the United States (FEMA). Administration of any one of these flavouring matters for 90 days at a level in excess of at least 100 times the maximum estimated daily dietary intake in man evoked no adverse effect on growth, food consumption, haematology, blood chemistry, liver and kidney weights or on gross and microscopic appearance of major organs at autopsy.