Based on the analysis of coupling mechanism between socio-economic growth and the growth of service economy, this paper reconstructed the evaluation index system of regional socio-economic development and service economic growth, then obtained comprehensive evaluation index of regional socio-economic development and the growth of service economy by using entropy method. On the use of coupling coordination model, this paper measured the coupling development of socio-economic development and the growth of service economy in Zhejiang Province, and carried out spatial econometric analysis of coupling coordination degree of different regions. Main conclusions are as follows: the coupling coordination degree of socio-economic growth and service economic growth in Zhejiang Province was growing during 2002-2012. At the meantime, the spatial region variation of coupling coordination degree was changing constantly. The internal constitution of high level and low-level areas were changing obviously. In addition, the coupling coordination degree of socio-economic growth and the growth of service economy in Zhejiang Province shows agglomeration trend, and clearly showing the stepped spatial pattern of “high in northeast and low in southwestâ€.