Two experiments were conducted to evaluate the efficacy of carbohydrases and phytase to compensate three key nutrients (NE, DAA and avP) for growing-finishing pigs. In Exp. 1, 112 pigs with average live weight 20.7 kg were randomly allocated to 4 dietary treatments, fed on commercial multi-grain diets containing total NSPs 12-15% with added phytase (500 FTU/kg), to examine the effect of two types of carbohydrase enzymes (single xylanase or multi-carbohydrase complex) to compensate NE and DAA: T1, Positive Control (PC); T2, negative control (NC1, PC minus 2% NE and 3% DAA); T3, NC1+ Multi-carbohydrases; and T4, NC1 + Single xylanase. In Exp. 2, 72 pigs averaged 20.7 kg live weight were randomly allocated to 3 dietary treatments: T5, Positive Control (PC, with added phytase); T6, NC2 negative control (PC minus 2.5% NE, 3.2% DAA, and 0.17 pcu avP, without added phytase); T7, NC2 + Multi-enzyme complex (carbohydrases + phytase). The pigs of both studies were reared for 3 phases: Grower 1 20-50 kg, Grower 2 50-75 kg, and Finisher (76-100 kg). The key performance parameters were measured and compared. The results of Epx. 1 showed, the pigs (PC) grew from 20 kg to 100 kg at average daily gain (ADG) close to 1 kg and FCR 2.30, and the reduction of nutrients (NC1) impaired growth rate mostly during the finishing phase (feed intake P=0.07, FCR P=0.09), and supplementation with both NSPase preparations tended to improve FCR over the NC1 with no differences observed between the two types of NSPase. In Exp. 2, the reduction of the three key nutrients clearly suppressed performance, namely lower weight gain (P<0.05) and higher FCR (P<0.05). The supplementation of multi-enzyme preparation partially restored performance with no significant differences from PC and NC2. In conclusion, for high performing pigs, carbohydrases can play a positive role in diets that already contain added phytase, and the contribution of the NSPase and phytase complex appear to be age related, and can be extrapolated as NE 40, 50 and 60 kcal/kg, respectively for Post-weaning, Grower and Finisher phases, and digestible amino acids 2-3% and avP 0.17% are for all phases. The enzyme supplementation showed no impact on feed intake.