Hemophilia Group Research Articles

血友病Ａ患者におけるＯＫＴ４／８比の検討 ＩＩ

Reduced T-helper to T-suppressor cell ratio in asymptomatic hemophiliacs has been reported in recent papers relating to the similar findings in patients with acquired immunodeficiency syndrome (AIDS). It is not clear yet the causative agent(s) of these abnormalities of T-cell subpopulation in non-AIDS hemophiliacs exposed to pooled clotting factor concentrates. This paper describes the analysis of laboratory data in non-AIDS hemophiliacs (n=92) treated by the single brand concentrate through at least three years in our laboratory. Objective data include lymphocyte subpopulation with monoclonal antibodies, immune comlex, complements, coagulation factors, liver function test, viral antibodies, amounts infused per year, age, etc. Each group of hemophilia A received factor VIII concentrates, hemophilia A with inhibitor treated by PCC or APCC and hemophilia B showed significantly low T-cell ratio than normal control. From these statistical studies it was considered that reduced T-cell ratio was derived from the depressed absolute T-helper cell level and the elevated absolute T-suppressor cell count. T-cell ratio showed the statistically significant correlation of platelet count, serum IgG level and age and not of the amount of factor VIII concentrates infused per year.

Dr. Stanley Wins Hollenback Award / European Dental Leader Dies at 73 / AFDH Names New Board Members, Advisors / Dr. Stucky, Lecturer, Consultant, Dies at 74 / Dr. Phillips Wins First Black Award / Dental Behavior Assessment Project Wins Award for Baylor Investigator / Hemophilia Group Funds Baylor Study / ‘Dental Peace Corps’ Reaches Out to Israel’s Needy /

Dr. Stanley Wins Hollenback Award / European Dental Leader Dies at 73 / AFDH Names New Board Members, Advisors / Dr. Stucky, Lecturer, Consultant, Dies at 74 / Dr. Phillips Wins First Black Award / Dental Behavior Assessment Project Wins Award for Baylor Investigator / Hemophilia Group Funds Baylor Study / ‘Dental Peace Corps’ Reaches Out to Israel’s Needy /

Immunoradiometric assay of procoagulant factor VIII antigen (VIIICAG)

An immunoradiometric assay of procoagulant factor VIII antigen was developed using a human antibody to the procoagulant activity of factor VIII (VIII:C). The assay measures specifically the antigen related to factor VIII procoagulant activity (VIIICAG) both in plasma and in serum. VIII:C and VIIICAG were measured in a group of healthy individuals and in a group of haemophilia A patients. In haemophilia A at least four groups can be recognised on the basis of the presence or absence of VIII:C and VIIICAG and the VIII:C/VIIICAG ratio.

Inhibitor-neutralisation assay and electro-immuno assay of human factor IX (Christmas factor)

A rabbit antibody specifically precipitating human factor IX has been used in the assay of factor IX antigen. The results obtained with two different methods (inhibitor-neutralisation assay and electro-immunoassay) have been compared in a group of healthy individuals and in a group of hemophilia B patients and carriers. In general, identical results are obtained with both methods, except in some hemophilia B + carriers and patients, where the electroimmuno assay gives 1.5–2.0 times higher levels. Results obtained by electroimmuno assay are more accurate and reproducible than those obtained by inhibitor-neutralisation assay, which is of importance for its potential use in carrier detection.

Hereditary Hemorrhagic Disorders Excluding Hemophilia Group

Hereditary Hemorrhagic Disorders Excluding Hemophilia Group