The article presents a collaboration and communication architecture for disaster stressed areas where communication losses restrain disaster response and perplex rescue operations. In these areas, the fragile access networks such as cellular or Wi-Fi systems become congested or inaccessible, requiring a reliable emergency communication infrastructure. The proposed architecture involves Unmanned Aerial Vehicles (UAVs), equipped with wireless technologies i.e., 3G/4G/5G/Wi-Fi systems, and manifestly Software Defined Radios (SDRs), enabling self-forming, self-organizing, and self-healing capabilities. The architecture uses a Hybrid Connectivity Module (HCM) which empowers cooperative communication capacities and abridge the technologies to achieve reliable communication link between UAVs, mobile-to-UAV, and UAV-to-mobile towards Ground Control Station (GCS) in catastrophic areas. The seamless connectivity via next generation SDR waveforms and designed algorithms ensure an implementation of versatile multi-user UAVs network. This enables the formation of a backbone network assisting ground devices to communicate GCS. For cooperative communication, the architecture provides a MAC-centric cross-layer protocol which offers efficient multihop routing between UAVs. The data (i.e., text, images, or voice) is routed to devices or GCS via UAVs, which can notify rescue services reliably and help to trace the catastrophic zones. Furthermore, the protocol helps to allocate network resources by creating virtual sub-nets for simultaneous interference-free data transmissions which maximizes the network throughput. The experimental results show the data latency far better than any other existing ad hoc routing protocol (e.g., OLSR or AODV) based designs which usually add delays in the emergency response operations.