Golden Goose Research Articles

Extracellular vesicles in cancer: golden goose or Trojan horse.

Intercellular communication can be mediated by direct cell-to-cell contact and indirect interactions through secretion of soluble chemokines, cytokines, and growth factors. Extracellular vesicles (EVs) have emerged as important mediators of cell-to-cell and cell-to-environment communications. EVs from tumor cells, immune cells, and stromal cells can remodel the tumor microenvironment and promote cancer cell survival, proliferation, metastasis, immune evasion, and therapeutic resistance. Most importantly, EVs as natural nanoparticles can be manipulated to serve as a potent delivery system for targeted cancer therapy. EVs can be engineered or modified to improve their ability to target tumors and deliver therapeutic substances, such as chemotherapeutic drugs, nucleic acids, and proteins, for the treatment of cancer. This review provides an overview of the biogenesis and recycling of EVs, discusses their roles in cancer development, and highlights their potential as a delivery system for targeted cancer therapy.

Killing the Golden Goose: A Resource-Based Theory Perspective on Hedge Fund Activism

Killing the Golden Goose: A Resource-Based Theory Perspective on Hedge Fund Activism

Men Becoming Gods in “Style”

Men Becoming Gods in “Style”

Direct-to-Video (On Demand): New Industrial and Cultural Valuations of Nontheatrical Film Releases

Direct-to-Video (On Demand): New Industrial and Cultural Valuations of Nontheatrical Film Releases

Plucking the ‘golden goose’, alive: The impacts of ‘supercity’ governance on a small island community

Plucking the ‘golden goose’, alive: The impacts of ‘supercity’ governance on a small island community

White Elephant or Golden Goose? An Assessment of Middle Route of the South-to-North Water Diversion Project from the Perspective of Regional Water Use Efficiency

White Elephant or Golden Goose? An Assessment of Middle Route of the South-to-North Water Diversion Project from the Perspective of Regional Water Use Efficiency

“Killing the Golden Goose?”: FDI in Poland 2022

This article is a follow up on recent events that relate to participation in foreign direct investment (FDI) activities in Poland in light of the Law on Freedom of Economic Activity (LFEA), the Act on Control of Certain Investments and the Amendments thereto, which provide for the rules on foreign participation in the Polish market and later restrictions on the purchase of Polish assets by discrete categories of investors. The article builds on research published in 2021 relating to the existence and importance of FDI in the Polish economy that had been negatively affected by a series of challenges and paradoxes in Polish society.

Data and Computation Reuse in CNNs Using Memristor TCAMs

Exploiting computational and data reuse in CNNs is crucial for the successful design of resource-constrained platforms. In image recognition applications, high levels of input locality and redundancy present in CNNs have become the golden goose for skipping costly arithmetic operations. One promising technique for this consists in storing function responses of some input patterns into offline lookup tables and replacing online computation with search operations, which are highly efficient when implemented by emerging non-volatile memory technologies. In this work, we rethink both algorithm and architecture for exploiting locality and reuse opportunities by replacing entire convolutions with searches on Content-addressable Memories. By previously calculating convolution results and building compact lookup tables with our novel clustering algorithm, one can evaluate activations at constant time complexity, also requiring a single read operation of the current input tensor. Then, we devise a reconfigurable array of processing elements based on memristive Ternary Content-addressable Memories to efficiently implement the algorithmic solution and meet the flexibility requirements of several CNN architectures. Results show that our design reduces the number of multiplications and memory accesses proportionally to the number of convolutional layer channels. The average performance is 1,172 and 82 FPS for AlexNet and VGG-16 models, thus outperforming state-of-the-art works by 13×.

Starving the golden goose? Access to finance for innovators in the creative industries

This paper extends research on innovating firms’ access to finance in the creative industries. While we know that entrepreneurial firms experience barriers to applying for funding and difficulties in securing positive outcomes, prior studies have shown that firms may use patents to signal innovative quality to potential investors. Yet these studies typically focus on R&D-oriented innovation in ‘traditional’ technological sectors. Creative industries firms have different innovation characteristics that may influence the funding process, including the uncertainty of content-based product markets, the highly-imbalanced information asymmetries between creative entrepreneurs and conservative investors, and the symbolic and intangible nature of their innovations. Using the UK‘s Creative Industries Council‘s unique cross-sectional survey data of 575 firms we analyse the extent to which innovating firms seek to apply to and achieve funding from a wide range of potential sources. We find little evidence that prior innovative activities provide a meaningful signal, positive or negative, to potential funders for creative industries firms. This suggests that the highly intangible and symbolic nature of innovation in creative industries businesses is unreliable as an indicator of quality. The reliance of owners on personal capital is congruent with recent literature on the high levels of social and personal capital among workers in the creative industries. We suggest that the specific challenges creative firms face may be addressed through new financial and policy instruments to feed and sustain these high-growth, innovating industries.

Is Holothuria tubulosa the golden goose of ecological aquaculture in the Mediterranean Sea?

The use of detritivores under sea farms is a promising avenue to mitigate the benthic impacts of marine fish farms. Sea cucumbers are interesting candidates for integrated multi-trophic aquaculture (IMTA) due to their prevalence in the marine environment, their diversified diet and their economic value. Yet limited information is available regarding their capacities to be stocked and reared underneath aquaculture cages and the associated effects on their survival, growth rate and body composition. This study focused on Holothuria tubulosa, a Mediterranean sea cucumber species candidate for rearing in the vicinity to marine fish cages. We investigated its potential for co-culture on the seabed more or less influenced by marine fish cages. The farm's waste footprint was predicted using a dispersion model (NewDEPOMOD) to estimate the farm's influence along a transect where we also sampled sediment at four distances from the cages (0 m, 25 m, 100 m from the cages, plus a reference site at 150 m). Organic composition of the sediment was analysed (TOC, TON, TOP, OM, stable isotope signature) and linked to the results from the dispersion model. Based on the model simulation, the maximum flux of matter reached almost 17 kg solids.m−2.year−1 below the cages, and gradually decreased with distance from the cages. An isotopic gradient was also found in the sediments according to the distance from the farm, with an enrichment in δN15 and a depletion in δC13 with increasing proximity to the farm. In parallel we investigated the response of adult sea cucumbers placed at varying distances from the fish cages for a period of one month, measuring their proximate composition, isotopic concentration, and fatty acid and protein composition. We found that despite good survival, growth was null over the experiment. While the isotope signature of the sea cucumbers was significantly affected by distance from the cage, this did not follow the pattern found in sediment. There was a clear difference in fatty acid composition between sites, with sea cucumbers closer to the cages having lower levels of short-chain fatty acids. The protein content was also lower in sea cucumbers reared right below the cages. These results suggest that while adult H. tubulosa can survive the environmental conditions below marine aquaculture cages, they do not nutritionally benefit from fish waste over short periods in the stocking conditions we tested. Their use in IMTA requires further investigation to find optimal stocking conditions.

Nigeria: a narrative of competing needs between shifting global trend, sustainable transportation, and economic growth

ABSTRACT Nigeria is the biggest economy in Africa and a significant player in the geopolitics of the continent. The country's ability to command so much relevance is based partly on its status as an oil exporter. It is, therefore, imperative that the country's government protects its golden goose, oil. In this paper, we argue that the recent act of the Nigerian government to resist the promotion of electric vehicles (EV) in the country as a way to protect its economic goose is ill advised. We contend that global transportation and energy phenomena suggest that for Nigeria to remain relevant in the future of the world economy, it is pertinent that it pursues a shift from its current economic model. To buttress our claim, we show how embracing sustainable transportation systems like adopting EV promoting policies, can give Nigeria a rare opportunity to be a big player in the future world economy.

Killing the golden goose? A framework for regulating disruptive technologies

ABSTRACT Core precepts of the Silicon Valley technology culture include disruption, breaking things, and profiting from the results. As technologies run ahead of regulatory regimes, a great deal of attention has been paid to the organization and evaluation of regulatory processes, from corporate self-regulation, to direct state intervention, and multiple stakeholder governance. However, it is less clear what values or principles should animate these approaches. Public discussions and academic literatures have identified at least four critical areas that require attention: data market and business monopolies; moral dilemmas of AI, such as surveillance and behavioral engineering; a variety of environmental harms; and the spread of hate, disinformation and attacks on liberal democratic values. This analysis develops a holistic framework of guiding principles to address these different problem areas. Without a set of widely shared guiding principles, regulatory approaches will remain fragmentary and weak. Policies in one area may miss or even create problems in others. The aim is not to impose a priori solutions on complex problems, but to offer scholars, regulators, and stakeholders a heuristic framework to guide policy thinking.

Wavelet-based analysis of guar futures in India: did we kill the golden goose?

PurposeGuar Gum (GG) is used in Shale oil exploration. Excessive price increase in the Guar futures market had a spillover impact on Guar spot prices and affected Guar export from India as Shale oil producers started exploring alternate sources. In this paper, the role of excessive speculation in the futures market, and its adverse impact on the guar-based agri-business ecosystem have been empirically explored.Design/methodology/approachVolatility spillover dynamics between WTI crude oil and Guar futures have been explored using bivariate-Granger Causality, BEKK–GARCH models with Wavelet multi-resolution analysis. The wavelet-based models capture the multi-scale features of mean and volatility spillover to identify the effect of heterogenous investment behavior in the time and frequency domain.FindingsThe results provide evidence that excessive speculation in futures markets increases spot market volatility. The results also suggest that the excess presence of short-term investors can destabilize the futures market.Research limitations/implicationsThe purpose of the commodity futures market is to support price discovery and risk management. However, speculative practices can destabilize these purposes leading to the failure of the business ecosystem.Originality/valueThe novelty of this paper is twofold. First, it explores the economic linkages between the spot and futures market and tests whether the presence of heterogeneous traders affects the economic linkages. Second, it models the impact of short-term speculative investment on the destabilization of the spot market.

Taxing the Golden Goose: Reforming Taxation of the Oil Sector in Putin’s Russia

There has been one defining characteristic of Russia’s approach to taxing the oil sector during the Putin era. Successive governments have illustrated an inbuilt resistance to adopting a comprehensive tax regime that would take into account the sector’s costs and profitability. This has defied international trends among a growing number of oil-rich countries. This article centres on three explanations. The concentration of power around the executive branch, the organisational setup of the oil industry and ‘path dependence’ have all made Russia less likely to shift away from its adherence to more traditional means of taxation and ad hoc policy solutions.

Golden Goose prize recognizes serendipitous discoveries

Roots of the immune system, cell communication, and implicit bias are honored in the 2018 awards

Move Last and Take Things: Facebook and Predatory Copying

Facebook’s now decade-long dominance of the social media landscape stands in start contrast with the industry’s early history of dynamism and disruption. The company played a key role in growing the social media industry from the small, niche communities of the early 2000s into the omnipresent societal force it is today. Capitalizing on this growth, Facebook pioneered a business model that now transforms the attention of billions of users into billions of dollars of advertising revenue. But for all of Facebook’s success, perhaps its greatest triumph has been in defending its golden goose from a swarm of competitors eager to claim a share of the profits. Countless challenges from Snapchat, Twitter, Google, and dozens of social network startups have all failed to break Facebook’s hold of the market. This Note argues that Facebook has exploited its market dominance to exclude competitors in the social media market. Despite complaints from competitors and business commentators, Facebook has so far avoided serious antitrust inquiry. By examining Facebook’s history, its business model, and the structural incentives of the social media market, one can see how Facebook leverages its position toward anticompetitive ends. In particular, this Note explores how Facebook copies the popular apps and features developed by its rivals in order to prevent those rivals from establishing a foothold in the social media market. This copycat strategy causes significant non-monetary consumer harms, such as product degradation and stifled innovation, currently neglected by antitrust doctrine. Facebook’s copying campaign highlights the need for courts o consider new frameworks and theories that help identify new forms of anticompetitive conduct.

The add value of laboratory diagnostics: the many reasons why decision-makers should actually care

The role and responsibilities of laboratory professionals are impressively changing. Clinical and technical background is no longer sufficient, since laboratory activity is now increasingly committed to manage organizational, administrative and economic concerns. Although the relationship between costs, revenues and profits is indeed straightforward for public laboratories, with much larger profitability than many other industries, laboratory professionals are still struggling to survive. While most public hospitals are besieged to reach the break-even and stay afloat, public laboratories only receive a fraction of what they bill, but are largely contributing to generate economic revenues that will ultimately contribute to offset the hospital losses. Whatever profitability analyst would hence see as quite masochistic to kill the golden goose. In this dissertation, we are hence aiming to provide some useful elements to convince decision-makers that laboratory medicine is not a deadwood, but is probably the key for a patient-centered and sustainable future of health care.

The decline of science in corporate R&D

Research summary: In this article, we document a shift away from science by large corporations between 1980 and 2006. We find that publications by company scientists have declined over time in a range of industries. We also find that the value attributable to scientific research has dropped, whereas the value attributable to technical knowledge (as measured by patents) has remained stable. These trends are unlikely to be driven principally by changes in publication practices. Furthermore, science continues to be useful as an input into innovation. Our evidence points to a reduction of the private benefits of internal research. Large firms still value the golden eggs of science (as reflected in patents), but seem to be increasingly unwilling to invest in the golden goose itself (the internal scientific capabilities).Managerial summary: There is a widespread belief among commentators that large American corporations are withdrawing from research. Large corporations may still collaborate with universities and acquire promising science‐based start‐ups, but their labs increasingly focus on developing existing knowledge and commercializing it, rather than creating new knowledge. In this article, we combine firm‐level financial information with a large and comprehensive data set on firm publications, patents and acquisitions to quantify the withdrawal from science by large American corporations between 1980 and 2006. This withdrawal is associated with a decline in the private value of research activities, even though scientific knowledge itself remains important for corporate invention. We discuss the managerial and policy implications of our findings.

Chasing the Golden Goose: What is the path to effective anonymisation?

Chasing the Golden Goose: What is the path to effective anonymisation?

Guest Editorial: Lessons for a Downturn

Guest editorial Downturns offer you a choice: panic and shut down all but breathing or make use of the opportunities that desperation has handed you. What? In the good times of a price boom, we have no time, and usually no impetus, to alter the way we work and how we apply science and technology. This activity breeds inefficiency and waste, but the flow of easy profits is like an opioid drug, blinding forward-looking senses that should warn us that a price bust may be around the next corner with a demand reduction, manufacturing slowdown, renewable energy advance, or an upset in political alignments. The world currently needs the energy density and reliability of fossil fuels, but high cost and inefficient use will eventually kill this golden goose. Often, when the good times end, we pull back, believing all the while that the next boom and easy profits are just around the corner if we can just hold on. This is the recipe for bankruptcy. Every wave of a technology powerful enough to alter the economic landscape in any industry has a life span divided into three parts: an often rough beginning, a period of growth where the technology reaches a zenith of efficiency, and the inevitable plateau where we think it cannot be exceeded or replaced. All the while, a new technology is often quietly building that can upset our comfortable operations world. The history of the oil field is littered with the memories of companies that ignored developments by overreaching only for the profits made available by a boom and ignoring the future. While some would like to believe that wildcatters’ luck will drive the next upturn, the promises of unconventional formations will not be unlocked by chance. An attempt to express the problem might start with a small modification to the proverb, “There are none so deaf as those who will not listen.” Better Practices So, what is to be done in a downturn? Those on the science side of production companies can use the time to review each part of well performance with the objective of looking for better practices than the “best” practices that we have unconsciously limited ourselves to. Operators accepting this path often come out stronger after a slump. Gains in efficiency, generated from a better understanding of a company’s well-development practices, remain after oil prices rebound and supplier discounts disappear. The enablers are keeping and supporting a technological staff that is capable of learning prior to and while in survival mode, plus a management team that is wiser about how and where to invest before and after prices rebound. Most of all, it requires tearing down some barriers that “successful experience” has erected to the abandoning of methods with which we have become accustomed.