Golden Era Research Articles

The Evolution of Narratives on the Oslo Process among Palestinian-Arab Political Elites in Israel

Abstract The signing of the Oslo Accords in the 1990s between Israel and the PLO has had significant implications for the Palestinian-Arab community in Israel. From a three-decade perspective it becomes clear that the debate on Oslo continues to resonate among the various political and ideological circles in Israel's Arab community. While the members of the Arab-Jewish current consider the Oslo period the Golden Era of Arab parties in Israeli politics, the Palestinian nationalists in the Arab community sharply criticize not only the outcome of the Oslo Accords but also the Palestinian leadership that endorsed them as well. The Islamists greeted the Oslo Accords with mixed reactions but over time began to criticize their outcome as well. This article sheds light on the evolving narratives of Oslo among the various ideological currents in Israel's Arab society from the early 1990s to the present.

Congestion and Energy Aware Multipath Load Balancing Routing for LLNs

The Internet of Things (IoT) is presently in its golden era with its current technological evolution towards digital transformation. Low-power and Lossy Networks (LLNs) form the groundwork for IoT, where the IPv6 Routing Protocol for Low-Power and Lossy Networks (RPL) is designated by Internet Engineering Task Force as the benchmark protocol for routing. Although RPL, with its unique capabilities, has addressed many IoT routing requirements, Load balancing and Congestion control are the outliers. This paper builds on the RPL protocol and proposes a multipath Congestion and Energy Aware RPL (CEARPL) that alleviates the load balancing and congestion concerns associated with RPL and improves the network performance. For congestion avoidance, a Congestion and Energy Aware Objective Function (CEA-OF) is suggested during parent selection that considers multiple metrics like Child Count metric, Estimated Lifetime metric, and Queue Occupancy metric, to equally distribute the traffic in LLNs. The Queue Occupancy metric is used to detect congestion in the network, and a Multipath routing strategy is utilized to mitigate the congestion in the network. A comparison of the performance of CEA-RPL was made against the existing Objective Functions of RPL, OFO, and MRHOF, as well as COM-OF, utilizing Contiki OS 3.0's Cooja emulator. CEA-RPL projected superior results with power consumption lowering by 33%, end-to-end delay decreasing by 30%, queue loss ratio reducing by 49%, and packet receiving rate and network lifetime improving by 7% and 49%, on an average, respectively.

Once upon a time in Turkey: the sex influx, gender inequality, and revisiting past pornographies

ABSTRACT In Turkish cinema culture, something akin to a ‘golden era’ dates to the years 1974–1980. During this time, some of the most prominent figures in mainstream Turkish cinema, directors included, shot various sorts of sex films: almost half of the 1091 features shot during these years were designated as sex films. This article asks: how did this era end? What happened to its performers? What kinds of gendered realities appeared on-screen and off-screen? In what ways have these films reappeared in popular memory? In order to address these questions, the article introduces debates and testimonies concerning the sex influx and discusses how its materials are revisited today. In conclusion, the article points out some future research directions.

बलम्वु क्षेत्रका लिच्छवीकालिन शिलालेखहरुको वर्तमान अवस्था {The Contemporary State of the Lichhavi Inscriptions of Balmbu}

This article is based on the present situation of stone inscription at ward no. 12 Chandragiri Municipality of Balambu area as referenced in the title. The article seeks to discuss the past and present situation of nine different stone inscriptions found at Balambu area. These inscriptions are valuable sources for the writing of Nepali’s history. These inscriptions were issued by various kings such as Basanta Deva, Kramalil, Ravi Gupta, Bhauma Gupta, Amsu Varma, Gana Deva, Bhimarjuna Deva, Jishnu Gupta, Narendra Deva, Shiva Deva II play an important role to write the history of Nepal. This research is a qualitative and comparative study of the differences in the physical condition of these inscriptions that were looked into and researched fifty years ago. These inscriptions which are witnesses of Nepalese long history has not caught the attention of the related institutions. Thus, the main objective of this research is to look into the physical condition of these inscriptions at various places of the ward no 12, Balambu area Chandragiri municipality. What was the physical condition of these inscriptions fifty years ago? In what ways are they different? How many have been lost? What is there physical condition at present? This research article seeks to unfold the how and why of these present conditions of these inscription. The Department of Archaeology the local municipality and community are the major stakeholder for the conservation and preservation of the cultural heritages. This article also investigates about: Who is responsible for the conservation of these Ancient inscriptions which belong to the Lichhavi period considered to be the golden era of Nepali history. Loss and damage of the inscription create problems for verification or correction against previous researches. This research will facilitate students, researchers and others to gather information about the status and present conditions of these stone inscription.

Overcoming Obstacles to Agriculture Finance in India: A Vibrant Prospect of Agri-Entrepreneurship

The traditional agriculture in India used to be affected adversely by the delay in monsoon, drought, inferior quality of seeds and insufficiency of fertilizer and shortage of skilled labour etc. A clear vision of the Government, since independence, changed the environment of agriculture in the country to a great extent. Constant initiatives, in the form of promoting agri-financing by rural credit, infrastructural development, upliftment of standard of living of the farmers, supervisory role of regulatory bodies to provide banking services, strengthening rural financial institutions, have created a healthy ecosystem of agri-entrepreneurship. The increase in demand due to change in food habits of the people, combined with better purchasing power, is encouraging the entrepreneurs to come up with innovative products. The development of financial markets in India, to provide better financial services in the form of insurance and risk management etc., is bringing agrientrepreneurship on the threshold of a golden era.

Chinese Super League: Missing Out Aspects on Service Quality and Brand Equity

Chinese sports market gained tremendous attention in recent days as China held the 2022 Winter Olympic Games successfully. However, in contrast to other sports markets, the attention given to the Chinese Super League (CSL), the top-division soccer league in China, seems to have decreased catastrophically. The CSL was once popular among the public in its golden era but met a recession in recent years. Service quality and brand equity were two of the major factors that directly influenced spectators' experiences in the western market, followed by previous studies. The study from Grönroos suggests that service quality has three dimensions: functional, technical, and image. The study from Keller suggests that brand equity was built by consumers based on their knowledge and experience of a brand. From former empirical research, it is unsure if those models fit different occasions in China, and whether the depression of the CSL can be explained by the missing aspects of service quality and brand equity. The results from review actions by CSL revealed that both thrive of the CSL and the recession of the CSL followed by brand equity and service quality model. Meanwhile, several suggestions have been raised based on the two models that can be implemented to help the CSL out of catastrophe.

SOHO State of the Art Updates and Next Questions: Novel Therapeutic Strategies in Development for Myelofibrosis.

Development of myelofibrosis (MF) therapeutics has reached fruition as the transformative impact of JAK2 inhibitors in the MPN landscape is complemented/expanded by a profusion of novel monotherapies and rational combinations in the frontline and second line settings. Agents in advanced clinical development span various mechanisms of action (eg, epigenetic or apoptotic regulation), may address urgent unmet clinical needs (cytopenias), increase the depth/duration of spleen and symptom responses elicited by ruxolitinib, improve other aspects of the disease besides splenomegaly/constitutional symptoms (eg, resistance to ruxolitinib, bone marrow fibrosis or disease course), provide personalized strategies, and extend overall survival (OS). Ruxolitinib had a dramatic impact on the quality of life and OS of MF patients. Recently, pacritinib received regulatory approval for severely thrombocytopenic MF patients. Momelotinib is advantageously poised among JAK inhibitors given its differentiated mode of action (suppression of hepcidin expression). Momelotinib demonstrated significant improvements in anemia measures, spleen responses, and MF-associated symptoms in MF patients with anemia; and will likely receive regulatory approval in 2023. An array of other novel agents combined with ruxolitinib, such as pelabresib, navitoclax, parsaclisib, or as monotherapies (navtemadlin) are evaluated in pivotal phase 3 trials. Imetelstat (telomerase inhibitor) is currently evaluated in the second line setting; OS was set as the primary endpoint, marking an unprecedented goal in MF trials, wherein SVR35 and TSS50 at 24 weeks have been typical endpoints heretofore. Transfusion independence may be considered another clinically meaningful endpoint in MF trials given its correlation with OS. Overall, therapeutics are at the cusp of an exponential expansion and advancements that will likely lead to the golden era in treatment of MF.

Intrinsic ferromagnetic half-metal: Non-equivalent alloying compounds CrMnI6 monolayer

Spintronics, the golden era of modern magnetism.Nowadays, intrinsic two-dimensional (2D) half-metal materials with pure spin sources possess a broad prospect in the practical application of modern spintronics. Therefore, based on first-principles calculations, we systematically predict the electronic structures and magnetic properties of non-equivalent alloying compounds CrMnI6 monolayer and fortunately find that the monolayer is a dynamically and thermally stable half-metal with a large in-plane magnetic anisotropy energy (MAE) of 36.75 meV/cell. Its Curie temperature is 145 K, significantly higher than that of CrI3 monolayer. In addition, the half-metallicity of monolayer CrMnI6 can be remained in almost the entire range of carrier doping and strain. Moreover, the in-plane MAE can be further improved to 68.41 and 60.58 meV/cell under 0.1 hole doping and 6% tensile strain, respectively. Simultaneously, according to the second-order perturbation theory, the larger in-plane MAE of CrMnI6 monolayer mainly originates from the couplings of 〈pxLxpz〉 in the different spin channel of I atom and the couplings of 〈dx2-y2Lzdxy〉 in the same spin channel of Mn and Cr atoms. Our prediction of such a novel 2D FM half-metal CrMnI6 monolayer may serve as a good candidate for the next-generation high-performance spintronic nanodevices and high- density magnetic recording and sensors.

Doctor sahab: Doctors and the public in the 'golden era' of the Indian medical profession.

This essay analyses and historicises a contemporary dominant narrative among India's biomedical doctors, that the early post-independence period (1940s-1970s) was characterised by immense public trust and confidence in the biomedical profession, with the patient-doctor relationship experiencing a 'golden era'. By exploring people's experiences with and perceptions of doctors during these decades, I show that contrary to contemporary understanding, public dissatisfaction with doctors was substantial even in the early post-independence period. I argue that the dominance of privileged-caste and -class Indians in the medical profession nurtured a caste privilege-based elitist outlook within the mainstream profession and its leadership and created an insurmountable socioeconomic distance between doctors and the large majority of the public. What doctors deemed as people's 'trust' in them and their profession was often simply a manifestation of people's general deference towards the elites of the society. This incorrect interpretation of patient-doctor dynamics in the past has been a constant feature of mainstream narratives around the doctor-society relationship in post-independence India and has remained largely under-explored and under-historicised in the medical, scholarly and public discourses.

Ecosystem services research: From golden era to next crossing

Ecosystem services has been widely explored in various theoretical or practical studies since its emergence more than 20 years ago. The two big issues in the past golden era of ecosystem services research were: ecosystem services valuing and ecosystem services trade-offs. We analyzed advantages of ecosystem services in promoting the attention that government and the public pay to the natural capital and the management of ecosystem services, together with summarizing the shortcomings. It was found that ecosystem services valuing made the public aware of the importance of natural capital from an economic perspective, while ecosystem services trade-offs highlighted the relationship between various ecosystem services from an ecological perspective, which could be better applied to ecosystem services-based ecosystem management. With an increasing number of papers focusing on ecosystem services flows, it is believed that ecosystem services flows integrating ecology, economy, sociology and geography disciplines will become a new key direction after ecosystem services valuing and trade-offs. To further promote the study of ecosystem services flows that link human and nature within geographical context, we need to focus on the value of ecosystem services flows with payment and benefit accounting, the relationship of ecosystem services flows by trade-off and synergy analysis, and the direction of ecosystem services flows by spatial and temporal assessment. In addition, a more efficient and widely recognized method is also essential for the development of quantifying ecosystem services flow. This study contributes to understanding the development stage of ecosystem services research and highlights the importance of ecosystem services flow research.

Review: Cruisy, Sleepy, Melancholy: Sexual Disorientation in the Films of Tsai Ming-liang, by Nicholas de Villiers

Review: <i>Cruisy, Sleepy, Melancholy: Sexual Disorientation in the Films of Tsai Ming-liang</i>, by Nicholas de Villiers

The Effect of Covid-19 Pandemic on Indian Cinema: The Rise of OTT Viewership

The Indian cinema industry happens to be biggest producer of films in a variety of languages that entertain millions of audiences across the globe. It has shown an impeccable record of recognition and quality entertainment that is being delivered for decades and is now a cultural element that is embed within the country’s heritage and pride. Although, the year 2020 put a striking hit on this industry’s golden era of rejoicing it’s religious followers with a global pandemic that is caused by a respiratory virus called as the Corona 2 (SARS-CoV-2). This virus had not only impacted the overall wellbeing of the populace but also has disrupted economies and industries. One such devastated industry happens to be the Indian cinema industry that has faced massive downfall on its overall growth due to the lockdown shutting down theatres causing millions of workers from this industry to lose their livelihoods. Although, one industry in specific that is the OTT industry bloomed and took over the opportunity of self-isolation and rose to show it’s true potential in the Indian market which has indeed stuck and taken over the true essence of Indian cinema by affecting the number of theatre-going audiences even today. This empirical paper examines this very thought and highlights the understanding of how the global Covid-19 pandemic has changed the Indian cinema industry and the studies the mindset of Indian audiences to see if the culture of visiting the theatres still exist as the OTT platform is on its exponential rise. The study uses a descriptive analysis tool in order to analyses and identify patterns to categories the data collection process and provide conclusions and recommendations on the effects the OTT platforms has on the Indian cinema industry as the collective OTT viewership rises.

Diversity and taxonomic distribution of bacterial biosynthetic gene clusters predicted to produce compounds with therapeutically relevant bioactivities.

This paper combines several bioinformatics workflows to identify which genera of bacteria are most likely to produce novel natural products with useful bioactivities such as antibacterial, antitumor, or antifungal activity.

Three Innovations of Next-Generation Antibiotics: Evolvability, Specificity, and Non-Immunogenicity

Antimicrobial resistance is a silent pandemic exacerbated by the uncontrolled use of antibiotics. Since the discovery of penicillin, we have been largely dependent on microbe-derived small molecules to treat bacterial infections. However, the golden era of antibiotics is coming to an end, as the emergence and spread of antimicrobial resistance against these antibacterial compounds are outpacing the discovery and development of new antibiotics. The current antibiotic market suffers from various shortcomings, including the absence of profitability and investment. The most important underlying issue of traditional antibiotics arises from the inherent properties of these small molecules being mostly broad-spectrum and non-programmable. As the scientific knowledge of microbes progresses, the scientific community is starting to explore entirely novel approaches to tackling antimicrobial resistance. One of the most prominent approaches is to develop next-generation antibiotics. In this review, we discuss three innovations of next-generation antibiotics compared to traditional antibiotics as specificity, evolvability, and non-immunogenicity. We present a number of potential antimicrobial agents, including bacteriophage-based therapy, CRISPR-Cas-based antimicrobials, and microbiome-derived antimicrobial agents. These alternative antimicrobial agents possess innovative properties that may overcome the inherent shortcomings of traditional antibiotics, and some of these next-generation antibiotics are not merely far-fetched ideas but are currently in clinical development. We further discuss some related issues and challenges such as infection diagnostics and regulatory frameworks that still need to be addressed to bring these next-generation antibiotics to the antibiotic market as viable products to combat antimicrobial resistance using a diversified set of strategies.

A History of ARNOVA at Fifty

To mark the 50th anniversary of the Association for Research on Nonprofit Organizations and Voluntary Action (ARNOVA), this article reviews the association’s history, from its 1971 founding by a small group of scholars interested in voluntary action to the current association of more than 1,000 members who study a broad range of nonprofit, civil society, voluntary action, and philanthropic topics. To inform the history, we recorded oral histories and reviewed the ARNOVA collection of historical records at the Ruth Lilly Archives and internal files provided by ARNOVA. Our article is divided into three important junctures of change: 1971–1989, the founding period; 1990–2006, the golden era of philanthropic support; and 2007–2020, a maturing field and strategic directions. Through our analysis, we identify recurring themes and tensions and how ARNOVA navigated through a changing environment and growing field. We conclude the article with forward-looking questions.

Novel algorithms for pair and pixel selection and atmospheric error correction in multitemporal InSAR

Entering the SAR's golden era began with the launch of Sentinel-1A/B satellites in 2014 and 2016 with 6–12 day revisit time, much larger stacks of high-resolution SAR images are available over a given area to perform time series analysis. Algorithms that deal with large stack sizes face several challenges, including interferometric phase quality degradation due to signal decorrelations, phase closure error caused by applied multilooking, and tropospheric phase delay. Here, we present an improved SBAS-type algorithm suitable for processing a large stack of SAR images at an arbitrary resolution. We develop a new pair selection strategy that applies dyadic downsampling combined with widely used Delaunay Triangulation to identify an optimal set of interferometric pairs that minimize systematic errors due to short-lived signals and closure errors. We develop and apply a novel statistical framework that selects elite pixels accounting for distributed and permanent scatterers. Also, we implement a new tropospheric error correction that takes advantage of smooth 2D splines to identify and remove error components with fractal-like structures. We demonstrate the effectiveness of the algorithms by applying them to 3 large datasets of Sentinel-1 SAR images measuring non-linear surface deformation over various terrains. Compared with independent GNSS observations, we find that over the rural/natural terrains adjacent to San Andreas fault in southern California, our approach yields a standard deviation of 0.48 cm for time series differences in both ascending and descending tracks. While in urban areas, such as Los Angeles, standard deviation difference with GNSS time series is 0.30 cm.

Antibiotic sensitivity profile of bacterial isolates from stool samples among children below five years in Murang'a County, Kenya.

the discovery of antibiotics led to the optimistic belief of completely eradicating infectious diseases during the golden era following their discovery. Countries are grappling with the burden of microbial resistance bringing a near paralysis of all facets of mankind. Enterobacteriaceae and other hard-to-treat Gram-negative bacteria have become resistant to nearly all antibiotic options available, and this is a bad taste in the fight against microbial resistance. during the months of April-October 2017, 163 children below five years presenting with diarrhea were randomly selected in Murang´a and Muriranja´s Hospitals. Bacterial agents were identified and antibiotic susceptibility profile was determined. Design: a cross-sectional study approach was used. Statistical analyses were performed using STATA v. 13. a total of 188 bacteria belonging to 11 genera were isolated, and identified and their antibiotic susceptibility profiles were determined. Susceptibility testing showed that almost all the Enterotoxigenic Escherichia coli (ETEC), Enteropathogenic Escherichia coli (EPEC), Enteroaggregative Escherichia coli (EAEC), Salmonella, Klebsiella, Shigella, Vibrio, Enterobacter, Proteus, Pseudomonas, Aeromonas, Citrobacter and Yersinia species were resistant to the following antibiotics: ampicillin, amoxicillin, chloramphenicol, ciprofloxacin, ceftriaxone and kanamycin. Other than ETEC (90.9%), all the rest of the isolates were resistant to nalidixic acid. Other than ETEC (9.1%), EAEC (33.3%) and Salmonella species (95.2%), all the rest of the isolates were resistant to gentamicin. Other than V. cholerae, all the other isolates were resistant to trimethoprim-sulfamethoxazole. Isolates were sporadically resistant to erythromycin, streptomycin, doxycycline, and ofloxacin. the high resistance rate of enteric Gram-negative bacterial pathogens in Murang´a County is alarming. The need for urgent, efficient, and sustainable actions and interventions, such as culture and susceptibility testing, is needed and must be taken into account to minimize and prevent the establishment and spread of enteric pathogenic bacteria.

Britain’s China policy after Brexit: Based on pragmatism or values first?

After Brexit, Britain has vowed to build a “Global Britain”. Guided by this strategy, the Great Britain’s policy towards People’s Republic of China is undergoing a more dramatic adjustment, which has brought the relations between China and the United Kingdom from a “golden era” to a more turbulent and unpredictable period of today. Overall, Britain’s current policy toward China is based on a range of policy tools, such as investment screening, Indo-Pacific Policy, as well as bilateral mechanisms, to catch the Chinese market for economic gain, while politically following the United States and provoking China on ideological and sovereignty matters in order to maintain its alliance with the West. Given in general the increase of negative perceptions of British public opinion of China, as well as the dramatic changes in the international situation (including the occurrence of major geopolitical events such as the Russian-Ukrainian military conflict), adjustments in the UK’s policy toward China will continue for some time, which will impact the stability of Sino-British relations. In the future, based on pragmatism, Britain’s China policy will maintain a flexible balance between maintaining selective cooperation with China in economy and global governance and deepening confrontation with China in the political sphere.

Filamentous temperature sensitive mutant Z: a putative target to combat antibacterial resistance.

In the pre-antibiotic era, common bacterial infections accounted for high mortality and morbidity. Moreover, the discovery of penicillin in 1928 marked the beginning of an antibiotic revolution, and this antibiotic era witnessed the discovery of many novel antibiotics, a golden era. However, the misuse or overuse of these antibiotics, natural resistance that existed even before the antibiotics were discovered, genetic variations in bacteria, natural selection, and acquisition of resistance from one species to another consistently increased the resistance to the existing antibacterial targets. Antibacterial resistance (ABR) is now becoming an ever-increasing concern jeopardizing global health. Henceforth, there is an urgent unmet need to discover novel compounds to combat ABR, which act through untapped pathways/mechanisms. Filamentous Temperature Sensitive mutant Z (FtsZ) is one such unique target, a tubulin homolog involved in developing a cytoskeletal framework for the cytokinetic ring. Additionally, its pivotal role in bacterial cell division and the lack of homologous structural protein in mammals makes it a potential antibacterial target for developing novel molecules. Approximately 2176 X-crystal structures of FtsZ were available, which initiated the research efforts to develop novel antibacterial agents. The literature has reported several natural, semisynthetic, peptides, and synthetic molecules as FtsZ inhibitors. This review provides valuable insights into the basic crystal structure of FtsZ, its inhibitors, and their inhibitory activities. This review also describes the available in vitro detection and quantification methods of FtsZ-drug complexes and the various approaches for determining drugs targeting FtsZ polymerization.

“I Dreamed of an Alliance between the Authority of Dogma and Political Liberty”: Mormonism and Socialism in France in the Nineteenth Century

“I Dreamed of an Alliance between the Authority of Dogma and Political Liberty”: Mormonism and Socialism in France in the Nineteenth Century