Goal-directed Cognition Research Articles

Major depression symptom severity associations with willingness to exert effort and patch foraging strategy.

Individuals with major depressive disorder (MDD) can experience reduced motivation and cognitive function, leading to challenges with goal-directed behavior. When selecting goals, people maximize 'expected value' by selecting actions that maximize potential reward while minimizing associated costs, including effort 'costs' and the opportunity cost of time. In MDD, differential weighing of costs and benefits are theorized mechanisms underlying changes in goal-directed cognition and may contribute to symptom heterogeneity. We used the Effort Foraging Task to quantify cognitive and physical effort costs, and patch leaving thresholds in low effort conditions (reflecting perceived opportunity cost of time) and investigated their shared versus distinct relationships to clinical features in participants with MDD (N=52, 43 in-episode) and comparisons (N=27). Contrary to our predictions, none of the decision-making measures differed with MDD diagnosis. However, each of the measures were related to symptom severity, over and above effects of ability (i.e., performance). Greater anxiety symptoms were selectively associated with lower cognitive effort cost (i.e. greater willingness to exert effort). Anhedonia and behavioral apathy were associated with increased physical effort costs. Finally, greater overall depression was related to decreased patch leaving thresholds. Markers of effort-based decision-making may inform understanding of MDD heterogeneity. Increased willingness to exert cognitive effort may contribute to anxiety symptoms such as worry. Decreased leaving thresholds associations with symptom severity is consistent with reward rate-based accounts of reduced vigor in MDD. Future research should address subtypes of depression with or without anxiety, which may relate differentially to cognitive effort decisions.

26 Apathy in Korsakoff Patients with and without Neurovascular Comorbidity

Objective:People with Korsakoff syndrome (KS) experience severe neuropsychological and neuropsychiatric complications following vitamin B1 deficiency predominantly due to alcoholism. KS often presents itself with neuropsychological symptoms such as problems in episodic memory, executive functioning, and social cognition. Common neuropsychiatric symptoms in KS are disorders of affect, confabulations, anosognosia, and apathy. Apathy can be defined by a pathological lack of goal-directed behaviors, goal-directed cognitions, and goal-directed emotions. Patients with KS have an increased risk of cerebrovascular comorbidity. Cerebrovascular accidents are known to increase the risk for developing apathy. Apathy in KS patients can negatively influence the ability to live an autonomous life, often making 24-hour care a necessity. Limited research on apathy in KS patients has been published to this day. Our aim was to assess apathy in Korsakoff patients with and without neurovascular comorbidity.Participants and Methods:General apathy and related subconstructs, such as judgment and decision-making skills, emotional blunting, and the intentions to perform pleasurable activities, were studied in fifteen KS patients, fifteen KS patients with additional cerebrovascular comorbidity, and fifteen healthy controls. The first responsible caregiver of each patient filled in the Apathy Evaluation Scale and Scale for Emotional Blunting. An examiner administered the interview-based Judgement scale of the Neuropsychology Assessment Battery with the KS patients and each KS patient filled in the self-report section of the Pleasurable Activities List. Both KS patient groups receive 24-hour care in a specialized facility for Korsakoff Syndrome.Results:Our study found higher levels of general apathy in both KS patient groups, when rated by their caregiver compared to healthy controls. No difference was found between the KS patient groups and the healthy control group on the self-reported section of the Pleasurable Activities List, which might suggest the presence of intrinsic motivation in KS patients. However, a discrepancy was found between the self-reported activity levels and proxy reported levels of apathy. KS patients with cerebrovascular comorbidity showed increased levels of emotional blunting compared to KS patients without cerebrovascular comorbidity and healthy controls. Decreased judgment and decision-making skills were found in both patient groups compared to healthy controls, with no difference found between KS patients with cerebrovascular comorbidity and KS patients without.Conclusions:Our findings suggest that people with Korsakoff syndrome experience more general apathy compared to healthy controls. Both patient groups showed decreased judgement and decision-making skills and increased emotional blunting. Intrinsic motivation was found to be intact in KS patients. Experiencing cerebrovascular comorbidity in KS carries a risk for developing emotional blunting. Our findings show that apathy greatly affects people with KS. Future scientific research is warranted to further benefit the care for this complex patient population.

Computational modeling of attractor-based neural processes involved in the preparation of voluntary actions

AbstractVolition is conceived as a set of orchestrated executive functions, which can be characterized by features, such as reason-based and goal-directedness, driven by endogenous signals. The lateral prefrontal cortex (LPFC) has long been considered to be responsible for cognitive control and executive function, and its neurodynamics appears to be central to goal-directed cognition. In order to address both associative processes (i.e. reason-action and action-outcome) based on internal stimuli, it seems essential to consider the interconnectivity of LPFC and the anterior cingulate cortex (ACC). The critical placement of ACC as a hub mediates projection of afferent expectancy signals directly from brain structures associated with emotion, as well as internal signals from subcortical areas to the LPFC. Apparently, the two cortical areas LPFC and ACC play a pivotal role in the formation of voluntary behaviors. In this paper, we model the neurodynamics of these two neural structures and their interactions related to intentional control. We predict that the emergence of intention is the result of both feedback-based and competitive mechanisms among neural attractors. These mechanisms alter the dimensionalities of coexisting chaotic attractors to more stable, low dimensional manifolds as limit cycle attractors, which may result in the onset of a readiness potential (RP) in SMA, associated with a decision to act.

Embodied and embedded ecological rationality: A common vertebrate mechanism for action selection underlies cognition and heuristic decision-making in humans.

The last common ancestor shared by humans and other vertebrates lived over half a billion years ago. In the time since that ancestral line diverged, evolution by natural selection has produced an impressive diversity-from fish to birds to elephants-of vertebrate morphology; yet despite the great species-level differences that otherwise exist across the brains of many animals, the neural circuitry that underlies motor control features a functional architecture that is virtually unchanged in every living species of vertebrate. In this article, we review how that circuitry facilitates motor control, trial-and-error-based procedural learning, and habit formation; we then develop a model that describes how this circuitry (embodied in an agent) works to build and refine sequences of goal-directed actions that are molded to fit the structure of the environment (in which the agent is embedded). We subsequently review evidence suggesting that this same functional circuitry became further adapted to regulate cognitive control in humans as well as motor control; then, using examples of heuristic decision-making from the ecological rationality tradition, we show how the model can be used to understand how that circuitry operates analogously in both cognitive and motor domains. We conclude with a discussion of how the model encourages a shift in perspective regarding ecological rationality's "adaptive toolbox"-namely, to one that views heuristic processes and other forms of goal-directed cognition as likely being implemented by the same neural circuitry (and in the same fashion) as goal-directed action in the motor domain-and how this change of perspective can be useful.

Unraveling the cognitive correlates of heart rate variability with the drift diffusion model

The Neurovisceral Integration Model posits a link between resting vagally mediated heart rate variability (vmHRV) and cognitive control. Empirical support for this link is mixed, potentially due to coarse performance metrics such as mean response time (RT). To clarify this issue, we tested the relationships between resting vmHRV and refined estimates of cognitive control- as revealed by the ex-Gaussian model of RT and, to a greater extent, the drift diffusion model (DDM, a computational model of two-choice performance). Participants (N = 174) completed a five-minute resting baseline while ECG was collected followed by a Simon spatial conflict task. The root mean square of successive differences in interbeat intervals was calculated to index resting vmHRV. Resting vmHRV was unrelated to Simon mean RT and accuracy rates, but was inversely related to the ex-Gaussian parameter reflecting slow RTs (tau); however, this finding was attenuated after adjustment for covariates. High resting vmHRV was related to faster drift rates and slower non-decision times, DDM parameters reflecting goal-directed cognition and sensorimotor processes, respectively. The DDM effects survived covariate adjustment and were specific to incongruent trials (i.e., when cognitive control demands were high). Findings suggest a link between vmHRV and cognitive control vis-a-vis drift rate, and potentially, a link between vmHRV and motoric inhibition vis-a-vis non-decision time. These cognitive correlates would have been missed with reliance on traditional performance. Findings are discussed with respect to the inhibitory processes that promote effective performance in high vmHRV individuals.

Effects of temporally regular versus irregular distractors on goal-directed cognition and behavior

Human environments comprise plenty of task-irrelevant sensory inputs, which are potentially distracting. Auditory distractors often possess an inherent temporal structure. However, it is largely unknown whether and how the temporal regularity of distractors interferes with goal-directed cognitive processes, such as working memory. Here, we tested a total sample of N = 90 participants across four working memory tasks with sequences of temporally regular versus irregular distractors. Temporal irregularity was operationalized by a final tone onset time that violated an otherwise regular tone sequence (Experiment 1), by a sequence of tones with irregular onset-to-onset delays (Experiment 2), and by sequences of speech items with irregular onset-to-onset delays (Experiments 3 and 4). Across all experiments, temporal regularity of distractors did not modulate participants’ primary performance metric, that is, accuracy in recalling items from working memory. Instead, temporal regularity of distractors modulated secondary performance metrics: for regular versus irregular distractors, recall of the first item from memory was faster (Experiment 3) and the response bias was more conservative (Experiment 4). Taken together, the present results provide evidence that the temporal regularity of task-irrelevant input does not inevitably affect the precision of memory representations (reflected in the primary performance metric accuracy) but rather the response behavior (reflected in secondary performance metrics like response speed and bias). Our findings emphasize that a comprehensive understanding of auditory distraction requires that existing models of attention include often-neglected secondary performance metrics to understand how different features of auditory distraction reach awareness and impact cognition and behavior.

Pupillary correlates of individual differences in long-term memory.

The present study is the first to examine individual differences in long-term memory, arousal dysregulation, and intensity of attention within the same experiment. Participants (N = 106) completed 28 lists of an immediate free-recall task while their pupil diameter was recorded via an eye-tracker during the encoding period. Two main pupillary measures were extracted: intraindividual variability in pre-list pupil diameter and evoked pupillary responses during item encoding. Variability in pre-list pupil diameter served as a measure of arousal dysregulation, and evoked pupillary responses served as a measure of intensity of attention. Based on prior work, we hypothesized that there would be a positive association between intensity of attention and recall ability, and that there would be a negative association between arousal dysregulation and recall ability. Collectively these two measures accounted for 19% of interindividual variance in recall, with 5% attributable uniquely to intensity of attention and 12% attributable uniquely to arousal regulation. The findings demonstrate that there are sources of individual differences in long-term memory that can be revealed via pupillometry, notably the amount of effort deployed during item encoding and the degree to which people exhibit dysregulated arousal. Both findings are consistent with recent theorizing regarding the role of the locus coeruleus (LC)-norepinephrine (NE) system's role in goal-directed cognition. Specifically, the LC governs both moment-to-moment arousal and NE release to cortical regions subserving cognitive processing. Among people for whom this system operates most optimally, long-term memory retention is superior.

Assessing the relationship between maternal risk for attention deficit hyperactivity disorder and functional connectivity in their biological toddlers.

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with increased risk for poor educational attainment and compromised social integration. Currently, clinical diagnosis rarely occurs before school-age, despite behavioral signs of ADHD in very early childhood. There is no known brain biomarker for ADHD risk in children ages 2-3years-old. The current study aimed to investigate the functional connectivity (FC) associated with ADHD risk in 70 children aged 2.5 and 3.5years via functional near-infrared spectroscopy (fNIRS) in bilateral frontal and parietal cortices; regions involved in attentional and goal-directed cognition. Children were instructed to passively watch videos for approximately 5min. Risk for ADHD in each child was assessed via maternal symptoms of ADHD, and brain data was evaluated for FC. Higher risk for maternal ADHD was associated with lower FC in a left-sided parieto-frontal network. Further, the interaction between sex and risk for ADHD was significant, where FC reduction in a widespread bilateral parieto-frontal network was associated with higher risk in male, but not female, participants. These findings suggest functional organization differences in the parietal-frontal network in toddlers at risk for ADHD; potentially advancing the understanding of the neural mechanisms underlying the development of ADHD.

Spontaneous and deliberate modes of creativity: Multitask eigen-connectivity analysis captures latent cognitive modes during creative thinking

Despite substantial progress in the quest of demystifying the brain basis of creativity, several questions remain open. One such issue concerns the relationship between two latent cognitive modes during creative thinking, i.e., deliberate goal-directed cognition and spontaneous thought generation. Although an interplay between deliberate and spontaneous thinking is often implicated in the creativity literature (e.g., dual-process models), a bottom-up data-driven validation of the cognitive processes associated with creative thinking is still lacking. Here, we attempted to capture the latent modes of creative thinking by utilizing a data-driven approach on a novel continuous multitask paradigm (CMP) that widely sampled a hypothetical two-dimensional cognitive plane of deliberate and spontaneous thinking in a single fMRI session. The CMP consisted of eight task blocks ranging from undirected mind wandering to goal-directed working memory task, while also included two widely-used creativity tasks, i.e., alternate uses task (AUT) and remote association task (RAT). Using eigen-connectivity (EC) analysis on the multitask whole-brain functional connectivity (FC) patterns, we embedded the multitask FCs into a low-dimensional latent space. The first two latent components, as revealed by the EC analysis, broadly mapped onto the two cognitive modes of deliberate and spontaneous thinking, respectively. Further, in this low-dimensional space, both creativity tasks were located in the upper right corner of high deliberate and spontaneous thinking (creative cognitive space). Neuroanatomically, the creative cognitive space was represented by not only increased intra-network connectivity within executive control and default mode network, but also by higher coupling between the two canonical brain networks. Further, individual differences reflected in the low-dimensional connectivity embeddings were related to differences in deliberate and spontaneous thinking abilities. Altogether, using a continuous multitask paradigm and a data-driven approach, we provide initial empirical evidence for the contribution of both deliberate and spontaneous modes of cognition during creative thinking.

Internal manipulation of perceptual representations in human flexible cognition: A computational model

Executive functions represent a set of processes in goal-directed cognition that depend on integrated cortical-basal ganglia brain systems and form the basis of flexible human behaviour. Several computational models have been proposed for studying cognitive flexibility as a key executive function and the Wisconsin card sorting test (WCST) that represents an important neuropsychological tool to investigate it. These models clarify important aspects that underlie cognitive flexibility, particularly decision-making, motor response, and feedback-dependent learning processes. However, several studies suggest that the categorisation processes involved in the solution of the WCST include an additional computational stage of category representation that supports the other processes. Surprisingly, all models of the WCST ignore this fundamental stage and they assume that decision making directly triggers actions. Thus, we propose a novel hypothesis where the key mechanisms of cognitive flexibility and goal-directed behaviour rely on the acquisition of suitable representations of percepts and their top-down internal manipulation. Moreover, we propose a neuro-inspired computational model to operationalise this hypothesis. The capacity of the model to support cognitive flexibility was validated by systematically reproducing and interpreting the behaviour exhibited in the WCST by young and old healthy adults, and by frontal and Parkinson patients. The results corroborate and further articulate the hypothesis that the internal manipulation of representations is a core process in goal-directed flexible cognition.

Electrophysiological Decoding of Spatial and Color Processing in Human Prefrontal Cortex

The prefrontal cortex (PFC) plays a pivotal role in goal-directed cognition, yet its representational code remains an open problem with decoding techniques ineffective in disentangling task-relevant variables from PFC. Here we applied regularized linear discriminant analysis to human scalp EEG data and were able to distinguish a mental-rotation task versus a color-perception task with 87% decoding accuracy. Dorsal and ventral areas in lateral PFC provided the dominant features dissociating the two tasks. Our findings show that EEG can reliably decode two independent task states from PFC and emphasize the PFC dorsal/ventral functional specificity in processing the where rotation task versus the what color task.

A cortical circuit mechanism for structural knowledge-based flexible sensorimotor decision-making

Making flexible decisions based on prior knowledge about causal environmental structures is a hallmark of goal-directed cognition in mammalian brains. Although several association brain regions, including the orbitofrontal cortex (OFC), have been implicated, the precise neuronal circuit mechanisms underlying knowledge-based decision-making remain elusive. Here, we established an inference-based auditory categorization task where mice performed within-session flexible stimulus re-categorization by inferring the changing task rules. We constructed a reinforcement learning model to recapitulate the inference-based flexible behavior and quantify the hidden variables associated with task structural knowledge. Combining two-photon population imaging and projection-specific optogenetics, we found that auditory cortex (ACx) neurons encoded the hidden task rule variable, which requires feedback input from the OFC. Silencing OFC-ACx input specifically disrupted re-categorization behavior. Direct imaging from OFC axons in the ACx revealed task state-related feedback signals, supporting the knowledge-based updating mechanism. Our data reveal a cortical circuit mechanism underlying structural knowledge-based flexible decision-making.

Unraveling Apathy in Korsakoff Syndrome Patients Receiving Long-Term Care With and Without Cerebrovascular Comorbidity.

BackgroundKorsakoff syndrome (KS) is a severe neuropsychiatric disorder caused by acute deficiency of vitamin B1 and concomitant alcoholism. Patients with KS are particularly vulnerable for cerebrovascular comorbidity. KS is characterized by cognitive and neuropsychiatric symptoms, one of which is apathy. Apathy is a pathological lack of goal‐directed behaviors, goal‐directed cognitions, and goal‐directed emotions. Cerebrovascular accidents are known to carry a risk for developing apathy. Apathy has a dramatic effect on the autonomy and daily lives of patients suffering from this condition.MethodsWe assessed general apathy and related subconstructs in fifteen patients with KS, fifteen patients with KS and cerebrovascular comorbidity who reside in a 24‐hour care facility, and fifteen healthy controls.ResultsCompared with healthy controls, both KS patient groups showed higher levels of apathy as rated by a close informant. We found no difference between both KS patient groups and the healthy control group on the self‐report section of the Pleasant Activities List, suggesting that motivation is still intact in KS patients. It is important to note a discrepancy was found between self‐reporting and proxy reporting on this list. KS patients with cerebrovascular comorbidity showed more severe emotional blunting compared to both KS patients without cerebrovascular comorbidity and healthy controls. The competency to consent was lower in patients compared with healthy controls, but no difference was found between KS patients with cerebrovascular comorbidity and those without.ConclusionsOur results suggest that KS patients show increased levels of general apathy compared with healthy controls. Patients show a diminished competency to consent and increased emotional blunting, while motivation is not compromised. Cerebrovascular comorbidity in KS forms a high risk for emotional blunting. The results of this study suggest that apathy is a severe problem in KS. More attention in both the literature and clinical practice would benefit this complex patient population.

Flexible Coordinator and Switcher Hubs for Adaptive Task Control.

Functional connectivity (FC) studies have identified at least two large-scale neural systems that constitute cognitive control networks, the frontoparietal network (FPN) and cingulo-opercular network (CON). Control networks are thought to support goal-directed cognition and behavior. It was previously shown that the FPN flexibly shifts its global connectivity pattern according to task goal, consistent with a "flexible hub" mechanism for cognitive control. Our aim was to build on this finding to develop a functional cartography (a multimetric profile) of control networks in terms of dynamic network properties. We quantified network properties in (male and female) humans using a high-control-demand cognitive paradigm involving switching among 64 task sets. We hypothesized that cognitive control is enacted by the FPN and CON via distinct but complementary roles reflected in network dynamics. Consistent with a flexible "coordinator" mechanism, FPN connections were varied across tasks, while maintaining within-network connectivity to aid cross-region coordination. Consistent with a flexible "switcher" mechanism, CON regions switched to other networks in a task-dependent manner, driven primarily by reduced within-network connections to other CON regions. This pattern of results suggests FPN acts as a dynamic, global coordinator of goal-relevant information, while CON transiently disbands to lend processing resources to other goal-relevant networks. This cartography of network dynamics reveals a dissociation between two prominent cognitive control networks, suggesting complementary mechanisms underlying goal-directed cognition.SIGNIFICANCE STATEMENT Cognitive control supports a variety of behaviors requiring flexible cognition, such as rapidly switching between tasks. Furthermore, cognitive control is negatively impacted in a variety of mental illnesses. We used tools from network science to characterize the implementation of cognitive control by large-scale brain systems. This revealed that two systems, the frontoparietal (FPN) and cingulo-opercular (CON) networks, have distinct but complementary roles in controlling global network reconfigurations. The FPN exhibited properties of a flexible coordinator (orchestrating task changes), while CON acted as a flexible switcher (switching specific regions to other systems to lend processing resources). These findings reveal an underlying distinction in cognitive processes that may be applicable to clinical, educational, and machine learning work targeting cognitive flexibility.

Foraging in Mind

People and other animals can search for information inside their heads. Where does this ability come from, and what does it enable cognitive systems to do? In this article, we address the behavioral and cognitive similarities between search in external environments and internal environments (e.g., memory). These require both maplike representations and the means to navigate them, and the latter involves modulation between exploitation and exploration analogous to a foraging process called area-restricted search. These findings have implications for understanding a number of cognitive abilities commonly considered to be hallmarks of the human species, such as well-developed executive control and goal-directed cognition, autonoetic consciousness (i.e., self-awareness), deliberation, and free will. Moreover, this research extends our conception of what organisms may share these abilities and how they evolved.

Functions of spontaneous and voluntary future thinking: evidence from subjective ratings.

Future thinking is defined as the ability to withdraw from reality and mentally project oneself into the future. The primary aim of the present study was to examine whether functions of future thoughts differed depending on their mode of elicitation (spontaneous or voluntary) and an attribute of goal-relatedness (selected-goal-related or selected-goal-unrelated). After producing spontaneous and voluntary future thoughts in a laboratory paradigm, participants provided ratings on four proposed functions of future thinking (self, directive, social, and emotional regulation). Findings showed that spontaneous and voluntary future thoughts were rated similarly on all functions except the directive function, which was particularly relevant to spontaneous future thoughts. Future thoughts classed as goal-related (selected-goal-related) were rated higher across all functions, and there was largely no interaction between mode of elicitation and goal-relatedness. A higher proportion of spontaneous future thoughts were selected-goal-related compared with voluntary future thoughts. In general, these results indicate that future thinking has significant roles across affective, behavioural, self and social functions, and supports theoretical views that implicate spontaneous future thought in goal-directed cognition and behaviour.

Common mechanisms of executive attention underlie executive function and effortful control in children.

Executive Function (EF) and Effortful Control (EC) have traditionally been viewed as distinct constructs related to cognition and temperament during development. More recently, EF and EC have been implicated in top-down self-regulation - the goal-directed control of cognition, emotion, and behavior. We propose that executive attention, a limited-capacity attentional resource subserving goal-directed cognition and behavior, is the common cognitive mechanism underlying the self-regulatory capacities captured by EF and EC. We addressed three related questions: (a) Do behavioral ratings of EF and EC represent the same self-regulation construct? (b) Is this self-regulation construct explained by a common executive attention factor as measured by performance on cognitive tasks? and (c) Does the executive attention factor explain additional variance in attention deficit hyperactivity disorder (ADHD) problems to behavioral ratings of self-regulation? Measures of performance on complex span, general intelligence, and response inhibition tasks were obtained from 136 preadolescent children (M=11years, 10months, SD=8months), along with self- and parent-reported EC, and parent-reported EF, and ADHD problems. Results from structural equation modeling demonstrated that behavioral ratings of EF and EC measured the same self-regulation construct. Cognitive tasks measured a common executive attention factor that significantly explained 30% of the variance in behavioral ratings of self-regulation. Executive attention failed to significantly explain additional variance in ADHD problems beyond that explained by behavioral ratings of self-regulation. These findings raise questions about the utility of task-based cognitive measures in research and clinical assessment of self-regulation and psychopathology in developmental samples.

Baseline brain structural and functional predictors of clinical outcome in the early course of schizophrenia.

Although schizophrenia is considered a brain disorder, the role of brain organization for symptomatic improvement remains inadequately defined. We investigated the relationship between baseline brain morphology, resting-state network connectivity and clinical response after 24-weeks of antipsychotic treatment in patients with schizophrenia (n=95) using integrated multivariate analyses. There was no significant association between clinical response and measures of cortical thickness (r=0.37, p=0.98) and subcortical volume (r=0.56, p=0.15). By contrast, we identified a strong mode of covariation linking functional network connectivity to clinical response (r=0.70; p=0.04), and particularly to improvement in positive (weight=0.62) and anxious/depressive symptoms (weight=0.49). Higher internal cohesiveness of the default mode network was the single most important positive predictor. Key negative predictors involved the functional cohesiveness of central executive subnetworks anchored in the frontoparietal cortices and subcortical regions (including the thalamus and striatum) and the inter-network integration between the default mode and sensorimotor networks. The present findings establish links between clinical response and the functional organization of brain networks involved both in perception and in spontaneous and goal-directed cognition, thereby advancing our understanding of the pathophysiology of schizophrenia.

Just above Chance: Is It Harder to Decode Information from Prefrontal Cortex Hemodynamic Activity Patterns?

The prefrontal cortex (PFC) is central to flexible, goal-directed cognition, and understanding its representational code is an important problem in cognitive neuroscience. In humans, multivariate pattern analysis (MVPA) of fMRI blood oxygenation level-dependent (BOLD) measurements has emerged as an important approach for studying neural representations. Many previous studies have implicitly assumed that MVPA of fMRI BOLD is just as effective in decoding information encoded in PFC neural activity as it is in visual cortex. However, MVPA studies of PFC have had mixed success. Here we estimate the base rate of decoding information from PFC BOLD activity patterns from a meta-analysis of published MVPA studies. We show that PFC has a significantly lower base rate (55.4%) than visual areas in occipital (66.6%) and temporal (71.0%) cortices and one that is close to chance levels. Our results have implications for the design and interpretation of MVPA studies of PFC and raise important questions about its functional organization.

Hoarding disorder and difficulties in emotion regulation

The present study aimed to examine self-reported deficits in emotion regulation (ER) among individuals with hoarding disorder (HD). Seventy-seven adult outpatients with HD and 45 age- and gender-matched healthy control (HC) participants received a diagnostic assessment and completed self-report measures of hoarding severity, depression, and anxiety. In addition, participants completed the Difficulties in Emotion Regulation Scale (DERS), which measures lack of emotional clarity (Clarity), difficulty regulating behavior when distressed (Impulse), difficulty engaging in goal-directed cognition and behavior when distressed (Goals), unwillingness to accept emotional responses (Accept), and lack of access to strategies for feeling better when distressed (Strategies). The HD group scored higher on all DERS subscales than did the HC group; self-reported ER deficits remained evident when controlling for baseline depression, anxiety, and stress. The DERS correlated significantly with hoarding severity in the HD group: acquiring was significantly correlated with DERS Impulse, Strategies, and Accept; saving was significantly correlated with DERS Accept. Correlations remained significant when controlling for depression, anxiety, and stress. Results suggest that HD is characterized by self-reported deficits in ER, and that this relationship is not solely attributable to high levels of depression and anxiety.