Global Harmonization Research Articles

ChemESI (Chemical Environmental Sustainability Index)—A KPI (Key Performance Indicator) for Standardizing Environmental Metrics for Chemical Sustainability

As part of the ESG (Environmental, Social, and Governance) dynamics, chemical environmental sustainability, i.e., the impact from chemicals and how to measure it across hundreds of products, is a daunting, but necessary task. Although methods are available to measure the effects and impacts of a single chemical, most enterprises do not focus on a single chemical, let alone produce “pure” chemicals for sale. Nearly all chemicals in commerce are chemical products, i.e., mixtures, while assessment methods for mixtures are few and far between. What is needed is a metric that tracks the potential risk of an enterprise's total product inventory while monitoring its improvements as it greens in coming years. The Chemical Environmental Sustainability Index (ChemESI) metric measures both risk (as the product of exposure and hazard) and hazard across numerous chemicals as a single metric/KPI. The ChemESI's for chemicals, products and facilities are expressed such that they can be summed across facilities to wrap up into a single corporate ChemESI KPI for either hazard or risk. But what about growth—if growth occurs using greener chemical inventory, a company can both grow and improves its ChemESI KPI. Given the lead-time for developing more, true green alternatives to existing chemicals, intermediate substitution of less hazardous “analogs” may drive initial ChemESI reduction. To achieve a representative risk estimate, a primary data need is chemical characterization data for products. SDS's (Safety Data Sheets) unfortunately make poor substitutes for true constituent analyses. A definite need exists for better, more detailed chemical characterization data for both mixtures and individual chemicals, as the latter most often are not 100 % “pure.” However, these SDS's are available universally, across the globe, and provide GHS (UN Globally Harmonized System) classifications for single endpoint chemical hazard assessment. GHS classifications are near universal and here used to derive chemical hazard scores over multiple endpoints for each chemical. A ChemESI Risk metric can be derived by multiplying the hazard score by the exposure, here using inventory as a surrogate. The ChemESI Hazard metric is then derived as an inventory weighted hazard score.

A Computational Approach for Respiratory Hazard Identification of Flavor Chemicals in Tobacco Products.

Flavor chemicals contribute to the appeal and toxicity of tobacco products, including electronic nicotine delivery systems (ENDS). The assortment of flavor chemicals available for use in tobacco products is extensive. In this study, a chemistry-driven computational approach was used to evaluate flavor chemicals based on intrinsic hazardous structures and reactivity of chemicals. A large library of 3012 unique flavor chemicals was compiled from publicly available information. Next, information was computed and collated based on their (1) physicochemical properties, (2) global harmonization system (GHS) health hazard classification, (3) structural alerts linked to the chemical's reactivity, instability, or toxicity, and (4) common substructure shared with FDA's harmful and potentially harmful constituents (HPHCs) flavor chemicals that are respiratory toxicants. Computational analysis of the constructed flavor library flagged 638 chemicals with GHS classified respiratory health hazards, 1079 chemicals with at least one structural alert, and 2297 chemicals with substructural similarity to FDA's established and proposed list of HPHCs. A subsequent analysis was performed on a subset of 173 chemicals in the flavor library that are respiratory health hazards, contain structural alerts as well as flavor HPHC substructures. Four general toxicophore structures with an increased potential for respiratory toxicity were then identified. In summary, computational methods are efficient tools for hazard identification and understanding structure-toxicity relationship. With appropriate context of use and interpretation, in silico methods may provide scientific evidence to support toxicological evaluations of chemicals in or emitted from tobacco products.

25 JAHRE ZONENEINTEILUNG IN DEN USA

n the area of explosion protection, the publication of Article 505 in the 1996 National Electrical Code (NEC®) was seen as a giant step toward global harmonization. It allowed for the implementation of the Zone system for explosive gas atmospheres (gases, flammable liquid-produced vapors, and combustible liquid-produced vapors) in the United States to co-exist with the traditional North American Class/Division system.

Contiguous Governance of Synchronic and Diachronic Changes for the Use of Genome Editing Technologies

Genome editing technologies are increasingly coming under scrutiny, based on various social value judgments in biomedical research, clinical care, and public health. A central cause of this sociotechnical tension is that these technologies are capable of precisely and easily creating genome-modified organisms and human cells and tissues. To exemplify a general framework for a national governance system of genome editing technologies, we first look at the regulatory dynamics in Japan. Second, we expose the potential tension between national and international debates and directions for the global harmonization of genome editing technologies. Third, underpinning these two perspectives, we propose contiguous governance as a novel model of the governance of emerging biotechnologies from both synchronic and diachronic perspectives. These perspectives, derived from genome editing technologies, can contribute to a better understanding and consideration of future regulations and governance systems.

Review on Stability and Power Quality Problem and Mitigation on Renewable Energy Penetration in Grid System

Abstract: An increase in the production and integration of renewable energy sources to the power grid system have begun to have an impact on the stability and security of the power grid. As renewable energy sources (RESs) like solar PV array plant and wind plant begin to displace traditional power plants, grid integration requirements have become an important issue. To ensure grid stability, additional criteria and technological constraints have been implemented. An updated assessment of current integration criteria and compliance control techniques for renewable power plant integration into the electric grid is being conducted as part of this study to close the knowledge gap. There is a comparison of the most important criterion for grid stability, including frequency stability and voltage stability, quality of power, voltage ride-through (VRT), reactive and active power controls. To meet these standards, a variety of control techniques have recently been proposed. As a result, cutting-edge options for compliance technologies and control techniques are analysed and evaluated in this paper. Additionally, a thorough examination of the benefits, challenges, and drawbacks of global harmonisation of integration requirements is included. Even though current incorporation necessities may enhance grid security, stability, operation, and dependability, a thorough assessment concludes that further improvements to shielding legislation, optimization of control system and international harmonisation are still required. There are a number of recommendations for further research into the integration and technical limitations of RESs that follow this. This study's findings could help to create a seamless and stable grid integration of RESs, as well as aid researchers in the development of new design methods and control systems based on current requirements. Educate and support operators in power system for creating or cultivating their individual standards that differ from the international norms that remain in place. Keywords: fault ride-through, Current limitation, grid forming control, grid connection, voltage-source converter

Labelling Assessment of Greek "Quality Label" Prepacked Cheeses as the Basis for a Branded Food Composition Database.

A labelling assessment study of Greek prepacked “quality label” cheeses was conducted with a view to provide an overview of the whole category. In total, 158 prepacked products belonging to 19 “quality label” cheeses were identified in the Greek market. Among them, Feta had the highest share followed by Kasseri, Graviera Kritis, Kefalograviera and Ladotyri Mitilinis with 81, 16, 15, 11 and 9 products found in the market, respectively. For the rest of the 14 cheeses, the share was limited, ranging from 1 to 4. All labelling indications, nutritional information, claims and other labelling data were recorded and analysed in relation to their compliance against European food law requirements. The results of the analysis showed that for only 6 of the 19 cheeses, all products fully complied with EU labelling legislation. Among the 14 mandatory labelling requirements, the lowest overall compliance was observed for allergens declaration (65%). The analysis of the nutritional data showed a remarkable variability between cheeses and products. Differences in the nutritional characteristics were more pronounced among soft, semi-hard, hard and whey cheese. The above data were entered into an archival database. Application of global harmonisation and standardisation guidelines and tools lead to the initialisation of a branded food composition database (BFCD), conceptualising a specialised database for “quality label” foods.

Current status of global harmonization of GMP standards in PIC/S and future prospects of effective GMP inspection by PMDA

Current status of global harmonization of GMP standards in PIC/S and future prospects of effective GMP inspection by PMDA

A Literature Review on the Global Burden and Impact of Substandard and Falsified Medicine

Abstract Substandard and falsified medicines are a global health concern negatively affecting individuals, the public, the pharmaceutical industry and governments all over the world. This review aims to examine the global prevalence of substandard and falsified medicines, its impact on health and the health system, including socio-economic impacts and strategies for curbing this menace. A literature review of published articles between January 2000 and May 2020 was done with keywords “substandard”, “counterfeit”, and “falsified medicines”. Articles were sourced from PubMed, World Health Organization (WHO) databases and Google Scholar. There are reports of substandard and falsified medicines from all WHO Regions with noticeable prevalence in the African Region. These medicines have been reported to cause death, antimicrobial resistance, increase prevalence of diseases, and loss of confidence in the health system. Increased patients spending, loss of productivity, strain of limited health systems resources, and loss of government revenue are major socio-economic implications of substandard and falsified medicines. An increase in criminal sanctions, global harmonization of drug regulatory authorities, and appropriate education of healthcare professionals and patients on how to prevent, detect, and respond to reported cases of substandard and falsified medicines are strategies that can be implemented to curb the menace of these medicines. Registered pharmacists and pharmacy students play critical roles in addressing this global health issue.

Toward Global Harmonization of Training and Certification of Specialists in Laboratory Animal Veterinary Medicine

Laboratory animal medicine (LAM) is a corner stone of animal-based research and has been a veterinary specialty for over 60 y. Today 5 Colleges of LAM (American, European, Japanese, Korean, and Indian) that certify specialists (Diplomates) in LAM are members of the International Association of Colleges of LAM (IACLAM). Goals of IACLAM are to support the development of new Colleges of LAM, to harmonize expectations for the knowledge and skills of newly certified LAM Diplomate, and to harmonize the standards (best practices) for training and examination of candidates among the member Colleges. IACLAM recently conducted an in-depth review and comparison of oversight, training, credentialing, and examination standards in the 5 Colleges as part of an initiative to create a framework for harmonization and consistency for these activities across the 5 Colleges. The process has led to an agreement on recommendations for knowledge and skill requirements for a newly certified Diplomate, as described by each College in a detailed role delineation document (RDD). The RDD is based on task analyses of the work responsibilities of laboratory animal veterinary Diplomates. This agreement is an important step toward the goal of global harmonization of LAM Diplomate training. Further efforts are planned for areas such as training, research, publication, and examination. This paper describes the role and content of the RDD and lists the differences and similarities among the RDDs of 5 Colleges of LAM.

Evaluation of Norfloxacin Acute Toxicity in Five Day old Broiler Chicken

Background: Norfloxacin is a second generation fluoroquinolone, used widely against sensitive organisms. After the withdrawal of enrofloxacin by the U.S. FDA for its use in poultry, the importance of Norfloxacin is getting increased and already some veterinary formulations were introduced by pharmaceutical companies in the market. The present study was undertaken to evaluate the acute toxicity of Norfloxacin IP, a member of fluoroquinolone in five day old broiler chicken. Materials and Methods: Healthy 60 COBB broiler a day old chicks, with an average body weight of 45±5g were acclimatized to the laboratory condition for five days. Six groups; each group consisting 10 experimental birds were used for determining LD50 safety value. Clinical observations were made. The tissue samples from concerned organs of all the birds were collected for histopathological study. Findings: The maximum dose of Norfloxacin, where no mortality occurred was 1.4 g /kg. The dose at which 100 percent mortality observed was calculated to be 1.8 g/kg /body weight. The clinical signs of toxicity observed before death were dullness, excitability, and drowsiness, circling, oozing of fluid from mouth and gasping for breath with beaks wide open. The calculated LD50 value for Norfloxacin was found to be 1.55 g/kg for 24 h observation period. The histopathological findings observed in concerned organs were: hemorrhage, congestion and tubular epithelium degeneration and necrosis in kidney, Hemorrhage, edema and infiltration of few inflammatory cells in heart. Congestion of vessels and dilatation of sinusoidal space were observed. Perivascular hepatocytes were degenerated with infiltration of few inflammatory cells on liver and sever lymphocytolysis in spleen. Conclusion: Norfloxacin can be classified as a moderately toxic drug according to Global Harmonization System (GHS) for classification of toxic compounds as per given protocol.

Global Harmonization of Urbanization Measures: Proceed with Care.

By 2050, two-thirds of the world's population is expected to be living in cities and towns, a marked increase from today's level of 55 percent. If the general trend is unmistakable, efforts to measure it precisely have been beset with difficulties: the criteria defining urban areas, cities and towns differ from one country to the next and can also change over time for any given country. The past decade has seen great progress toward the long-awaited goal of scientifically comparable urbanization measures, thanks to the combined efforts of multiple disciplines. These efforts have been organized around what is termed the "statistical urbanization" concept, whereby urban areas are defined by population density, contiguity and total population size. Data derived from remote-sensing methods can now supply a variety of spatial proxies for urban areas defined in this way. However, it remains to be understood how such proxies complement, or depart from, meaningful country-specific alternatives. In this paper, we investigate finely resolved population census and satellite-derived data for the United States, Mexico and India, three countries with widely varying conceptions of urban places and long histories of debate and refinement of their national criteria. At the extremes of the urban-rural continuum, we find evidence of generally good agreement between the national and remote sensing-derived measures (albeit with variation by country), but identify significant disagreements in the middle ranges where today's urban policies are often focused.

Probabilistic Linear Inversion of Satellite Gravity Gradient Data Applied to the Northeast Atlantic

AbstractWe explore the mantle density structure of the northeast Atlantic region using constrained linear inversion of the satellite gravity gradient data based on statistical prior information and assuming a Gaussian model. The uncertainty of the residual gravity gradient signal is characterized by a covariance matrix obtained using geostatistical analysis of controlled‐source seismic data. The forward modeling of the gravity gradients in the 3D reference crustal model is performed using a global spherical harmonics analysis. We estimate the model covariance function in the radial and angular directions using a variogram method. We compute volumetric gravity gradient kernels for a spherical shell covering the northeast Atlantic region down to the mantle transition zone (410 km depth). The solution of the linear inverse problem in the form of the mean density model and the posterior covariance matrix follows a least squares approach. The results indicate that on average the seismic velocity variation is proportional to the density variation in the northeast Atlantic region. However, a noticeable mismatch or anti‐correlation exists in some areas, such as the Greenland‐Iceland‐Faroe ridge and southwestern Norway. The predicted low‐density anomalies at depths of 100–150 km underneath the northeast Atlantic Ocean are correlated with the distribution of Cenozoic submarine volcanoes and seamount‐like features of the seafloor.

The Inter-Agency Committee on Radiation Safety—30 years of international coordination of radiation protection and safety matters

The Inter-Agency Committee on Radiation Safety (IACRS) was constituted in 1990, as a forum for collaboration and coordination between international bodies with regards to radiation safety. It consists today of representatives of eight intergovernmental member organizations (the European Commision, Food and Agriculture Organization, International Atomic Energy Agency (IAEA), International Labour Office, Organisation for Economic Co-operation and Development/ Nuclear Energy Agency (OECD/NEA), Pan American Health Organization, United Nations Scientific Committee on the Effects of Atomic Radiation and the World Health Organization) and five observer non-governmental organizations (International Commission on Radiological Protection, International Commission on Radiation Units & Measurements, International Electrotechnical Commission, International Radiation Protection Association and International Organization for Standardization). The IACRS provides a platform for interaction between these relevant international bodies to contribute to a common understanding of the scientific basis and legal framework for the application of the system of radiation protection, towards global harmonisation of radiation safety standards. The IACRS played a key role in the development of the International Basic Safety Standards (BSS) in 1996 and in its revision in 2014. Further, an IACRS specific Task Group—chaired by the IAEA—fosters the implementation of the BSS in a consistent and coherent manner in all Member States of the United Nations. The IACRS operates via a standing secretariat jointly provided by the IAEA and OECD/NEA and is chaired by one of its member organizations on a rotating basis for periods of about 18 months. This approach has proved to be effective and was the foundation for ensuring continuity of the work of the committee and at the same time allowing a rotating leadership for all member organizations. Currently, the IACRS is chaired by the WHO. The International Radiation Safety Framework under which the IACRS works is structured around four main areas: (a) science; (b) principles; (c) standards; and (d) practice. This paper presents briefly the mandates, roles and functions of the various international bodies that are relevant to the four above mentioned areas of work, discusses how these bodies coordinate their actions and complement each other to enhance radiation protection and safety worldwide and describes their contribution to the achievement of the Sustainable Development Goals. The paper also provides an overview of the main accomplishments of the IACRS since its inception 30 years ago, and an outlook on key challenges for its future activities.

Search for dark-photon dark matter in the SuperMAG geomagnetic field dataset

In our recent companion paper [arXiv:2106.00022], we pointed out a novel signature of ultralight kinetically mixed dark-photon dark matter. This signature is a quasi-monochromatic, time-oscillating terrestrial magnetic field that takes a particular pattern over the surface of the Earth. In this work, we present a search for this signal in existing, unshielded magnetometer data recorded by geographically dispersed, geomagnetic stations. The dataset comes from the SuperMAG Collaboration and consists of measurements taken with one-minute cadence since 1970, with $\mathcal{O}(500)$ stations contributing in all. We aggregate the magnetic field measurements from all stations by projecting them onto a small set of global vector spherical harmonics (VSH) that capture the expected vectorial pattern of the signal at each station. Within each dark-photon coherence time, we use a data-driven technique to estimate the broadband background noise in the data, and search for excess narrowband power in this set of VSH components; we stack the searches in distinct coherence times incoherently. Following a Bayesian analysis approach that allows us to account for the stochastic nature of the dark-photon dark-matter field, we set exclusion bounds on the kinetic mixing parameter in the dark-photon dark-matter mass range $2\times10^{-18}\,\text{eV} \lesssim m_{A'} \lesssim 7\times10^{-17}\,\text{eV}$ (corresponding to frequencies $6\times 10^{-4}\,\text{Hz}\lesssim f_{A'} \lesssim 2\times 10^{-2}\,\text{Hz}$). These limits are complementary to various existing astrophysical constraints. Although our main analysis also identifies a number of candidate signals in the SuperMAG dataset, these appear to either fail or be in tension with various additional robustness checks we apply to those candidates. We report no robust and significant evidence for a dark-photon dark-matter signal in the SuperMAG dataset.

Good Financial Grant Practice: A Tool for Developing and Demonstrating Institutional Financial and Grant Management Capacity in Global Health.

The administration and governance of grant funding across global health organizations presents enormous challenges. Meeting these challenges is crucial to ensuring that funds are used in the most effective way to improve health outcomes, in line with the United Nations’ Sustainable Development Goal 3, “Ensure healthy lives and promote well-being for all at all ages.” The Good Financial Grant Practice (GFGP) Standard (ARS 1651) is the world’s first and, currently, only international standard for the financial governance and management of grant funding. Through consensus building and global harmonization between both low- and middle-income and high-income country players, the GFGP Standard has achieved a leveling impact: GFGP applies equally to, and can be implemented by, all types of organization, regardless of location, size, or whether they predominantly give or receive funding.GFGP can be used as a tool for addressing some of the challenges of the current funding model. Here, we describe our experiences and lessons learned from implementing GFGP across 4 diverse research institutions in India, Nigeria, Colombia, and the Philippines as part of our National Institute for Health Research Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance.

Isomorphic dynamics in national action plans on antimicrobial resistance

AbstractThe article investigates isomorphic dynamics in the development and implementation of national action plans (NAPs) on antimicrobial resistance (AMR) following the World Health Assembly's adoption of a Global Action Plan on AMR in 2015. Through a nested approach, we conduct a quantitative cross‐country analysis of this policy process with particular emphasis on form (the NAP design) and function (their implementation). The qualitative component consists of three illustrative examples from Japan, Myanmar, and Denmark, which represent different types of responses to this internationally driven policy process. The analysis reveals tendencies of isomorphic mimicry characterized by a clear rift between the drafting of NAPs and their implementation, particularly in low‐income and lower‐middle‐income countries. Interestingly, there is also evidence of typically high‐income member states with substantial leverage deviating from global guidelines when compiling their NAPs—a trend we term “isomorphic posturing.” We argue that both types of isomorphic behaviors inhibit global harmonization around best practices and conclude that the mismatch between policy design and policy implementation in the AMR field can best be solved by establishing international, legally binding agreements that adhere to the benefit principle and individualized responsibilities.

Use of LC50 in aquatic regulatory toxicology-Disharmony in global harmonization of hazard classification of chemicals

In regulatory aquatic toxicology, acute toxicity studies with chemicals are conducted with a species of fish, crustacea, and or alga. The LC50/EC50 obtained from these studies is used for the hazard classification and labeling of the chemicals. The methods like probit or logit analysis and Litchfield and Wilcoxon method are prescribed in the OECD guidelines to determine the LC50. In the present study, LC50s were calculated using probit analysis, Litchfield & Wilcoxon method, and also using the method by Trevan (the inventor of median lethal dose) using three sets of concentration-mortality data of fish acute toxicity tests. The slopes of the concentration-mortality curves, fiducial limits (95% confidence interval) of LC50s, and ‘mode’ of the concentration-mortality curves were compared. Though the methods used in the study resulted in more or less similar LC50s, the LC10 and LC90, slopes and ‘mode’ differed considerably, indicating that LC50 does not reveal the exact toxicity profile of a chemical. The LC50 calculated using Finney’s probit analysis provides better information on the toxicity profile of a chemical than the LC50calculated by Litchfield & Wilcoxon method. While interpreting LC50, the mortality occurred below 16 % (eg.,LC10) and above 84 % (eg.,LC90), slope and ‘mode’ of the concentration-mortality curve may also be considered. It is worth having a relook at the current practice of hazard classification and labeling of the chemicals based only on LC50 in regulatory aquatic toxicology.

The First WHO International Standard for Harmonizing the Biological Activity of Bevacizumab.

Several Bevacizumab products are approved for clinical use, with many others in late-stage clinical development worldwide. To aid the harmonization of potency assessment across different Bevacizumab products, the first World Health Organization (WHO) International Standard (IS) for Bevacizumab has been developed. Two preparations of a Bevacizumab candidate and comparator were assessed for their ability to neutralize and bind vascular endothelial growth factor (VEGF) using different bioassays and binding assays in an international collaborative study. Relative potency estimates were similar across different assays for the comparator or the duplicate-coded candidate sample. Variability in relative potency estimates was reduced when the candidate standard was used for calculation compared with various in-house reference standards, enabling harmonization in bioactivity evaluations. The results demonstrated that the candidate standard is suitable to serve as an IS for Bevacizumab, with assigned unitages for VEGF neutralization and VEGF binding activity. This standard coded 18/210 was established by the WHO Expert Committee on Biological Standardization, which is intended to support the calibration of secondary standards for product development and lifecycle management. The availability of IS 18/210 will help facilitate the global harmonization of potency evaluation to ensure patient access to Bevacizumab products with consistent safety, quality and efficacy.

A Retrospective Analysis of Chemical Constituents in Regulated and Unregulated E-Cigarette Liquids.

E-cigarette or vaping use-associated lung injury (EVALI) was identified with the incidents of a multi-state outbreak of acute lung injuries associated with the use of electronic cigarettes (e-cigs) and attributed to vitamin E acetate in off-market cannabis-based e-liquids. Aside from EVALI, hypersecretion of mucus, irritated nasal passages, and watery, red eyes have been defined as complaints associated with vaping standard nicotine-based e-liquids. The chemical composition of e-liquids varies between manufacturers and robust oversight of ingredients is lacking. Manufacturers use chemicals deemed “generally recognized as safe” (GRAS) by the FDA, a designation for chemicals used in foodstuffs to be ingested. Most “GRAS” chemicals are associated with at least one Global Harmonization System (GHS) warning class, ranging from irritant to toxic. Untargeted chemical analysis is critical to evaluate e-liquid products to determine chemical composition; equally important is the quantitation of components to help elucidate the potential harms from exceeding recommended exposure limits. Untargeted screening of e-liquids was accomplished using gas chromatography-mass spectrometry (GC-MS) and Direct Analysis in Real Time-AccuTOF™ mass spectrometry (DART-ToF-MS) and has identified 350 chemical constituents from 241 products analyzed. Nicotine, caffeine, menthol, and vitamin E were confirmed and quantitated by GC-MS, ethanol was confirmed and quantitated by headspace-gas chromatography-dual flame ionization detection (HS-GC-FID), and olivetol and cannabinoids were confirmed and quantitated by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Maximum identified concentrations of nicotine, caffeine, menthol, vitamin E, ethanol, olivetol, Δ9-tetrahydrocannabinol, and cannabidiol were 56.4, 26.9, 4.28, 307.9, 217.2, 399.6, 497.7, and 332.6 mg/ml, respectively. Evaluation of untargeted analysis and quantitation of unlabeled chemical components of e-liquids is essential to improving etiology of acute lung injury and less severe impacts of vaping, both short-term and long-term. The historical documentation of unlabeled ingredients can provide some insight for a retrospective analysis of health consequences and inform policy discussions.

Performance Statistics of Defined Approaches for Eye Hazard Identification of Non-Surfactant Liquids to Distinguish Between the Three United Nations Globally Harmonized System Categories

Introduction: Cosmetics Europe develops two defined approaches (DAs) for eye hazard identification, that is, addressing serious eye damage (Cat. 1), eye irritation (Cat. 2), and the absence thereof (No Cat.), for nonsurfactant liquid test substances. DAL-1 combines four physicochemical properties, the reconstructed human cornea-like epithelium (EpiOcular™ eye irritation test [EIT]: VRM1 and SkinEthic™ human corneal epithelium EIT: VRM2) test method (OECD test guideline [TG] 492), and bovine corneal opacity and permeability (BCOP) test method (OECD TG 437). DAL-2 combines the short time exposure test method (OECD TG 491) and the BCOP test method (OECD TG 437). In both DAs, the BCOP with the laser light-based opacitometer is used, however, only opacity is used to identify liquids that cause serious eye damage. Materials and Methods: The performance of the DAs to distinguish between the three United Nations Globally Harmonized System of Classification (UN GHS) categories was compared against the minimum performance values proposed by Cosmetics Europe to the Organisation for Economic Co-operation and Development expert Group on eye/skin irritation/corrosion and phototoxicity and agreed upon by the experts. Furthermore, the class-specific performance metrics are also provided for each DA. Results: The balanced accuracy of DAL-1 with validated reference method—EpiOcular EIT (VRM1), DAL-1 with validated reference method—SkinEthic HCE EIT (VRM2), and DAL-2 was 69.2%, 75.2%, and 74.3%, respectively. DAL-1 with VRM1 identified 76.5% of Cat. 1 (N = 17), 59.1% of Cat. 2 (N = 22), and 72.1% of No Cat. (N = 55) correctly. DAL-1 with VRM2 identified 76.5% of Cat. 1 (N = 17), 68.7% of Cat. 2 (N = 23), and 80.4% of No Cat. (N = 46) correctly. DAL-2 identified 81.2% of Cat. 1 (N = 17), 56.3% of Cat. 2 (N = 24), and 85.3% of No Cat. (N = 123) correctly. Conclusion: The percentage of correct predictions was greater than the proposed minimum performance values of 75% for Cat. 1, 50% for Cat. 2, and 70% for No Cat. Therefore, DAL-1 and DAL-2 have shown to successfully distinguish between the three UN GHS categories for eye hazard identification.