Global Harmonization Research Articles

Global policy harmonization in creative commons licensing: A roadmap for balancing creator and user rights

This paper examines the necessity for global policy harmonization in Creative Commons (CC) licensing to prevent legal exploitation and ensure equitable protection for both creators and users. It highlights the challenges posed by inconsistent copyright laws across different jurisdictions, which often lead to vulnerabilities and copyright trolling. Through a detailed analysis of various legal systems, this paper identifies key inconsistencies and proposes international policy standards that balance creator and user rights. A comprehensive roadmap is outlined, featuring phased goals, an implementation framework, and mechanisms for monitoring and evaluation. The paper concludes with recommendations for future research and a call to action for policymakers to collaborate internationally, aiming to create a cohesive and fair digital content-sharing ecosystem.

Enhancing ethical standards in clinical trials: A deep dive into regulatory compliance, informed consent, and participant rights protection frameworks

This study critically examines the ethical standards governing clinical trials, focusing on regulatory compliance, informed consent, and the protection of participant rights. The purpose is to assess the current ethical frameworks and explore emerging trends that shape the evolving landscape of clinical research. Through a detailed review of existing literature, this paper analyzes how global regulatory bodies and ethical guidelines, such as Good Clinical Practice (GCP) and the Declaration of Helsinki, guide the ethical conduct of trials while identifying gaps that have emerged due to advances in technology and the globalization of clinical research. Key findings reveal that while informed consent remains central to participant autonomy, challenges persist in ensuring true comprehension across diverse populations, particularly in the context of complex interventions and digital tools. The growing use of artificial intelligence (AI), decentralized trial designs, and precision medicine introduces both opportunities and ethical dilemmas, especially regarding data privacy, participant selection, and regulatory harmonization in multinational trials. Conclusions emphasize the need for adaptive ethical frameworks that address the unique risks and benefits associated with these emerging trends. Recommendations include strengthening global regulatory harmonization, enhancing transparency in AI-driven research, and ensuring that participant rights, particularly data security and informed consent, are prioritized in evolving clinical trial designs. These steps are crucial for maintaining public trust and advancing medical research ethically and responsibly.

Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures

Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample size. These efforts unveil new questions about how to integrate data across distinct sources and instruments. The goal of this study was to link scores across common auditory verbal learning tasks (AVLTs). This international secondary analysis aggregated multisite raw data for AVLTs across 53 studies totaling 10,505 individuals. Using the ComBat-GAM algorithm, we isolated and removed the component of memory scores associated with site effects while preserving instrumental effects. After adjustment, a continuous item response theory model used multiple memory items of varying difficulty to estimate each individual’s latent verbal learning ability on a single scale. Equivalent raw scores across AVLTs were then found by linking individuals through the ability scale. Harmonization reduced total cross-site score variance by 37% while preserving meaningful memory effects. Age had the largest impact on scores overall (− 11.4%), while race/ethnicity variable was not significant (p > 0.05). The resulting tools were validated on dually administered tests. The conversion tool is available online so researchers and clinicians can convert memory scores across instruments. This work demonstrates that global harmonization initiatives can address reproducibility challenges across the behavioral sciences.

TCM-Centric Innovations in WHO's International Standard Terminologies: A Qualitative Exploration

Abstract: Traditional Chinese medicine (TCM) is increasingly recognized worldwide as a valuable complementary and alternative medicine. To facilitate global research and collaboration in this field, the World Health Organization (WHO) introduced the International Standard Terminologies on Traditional Chinese Medicine on March 3, 2022. This international terminology translation standard, IST 2022, goes beyond conventional translation by embracing three innovative features: 1) It reflects TCM's foundational philosophy of unity and opposition, emphasizing the interconnectedness among TCM terms during translation. This approach transcends individual term translations to explore the interrelationships among them. 2) It meticulously preserves the integrity of TCM theory. It achieves this by retaining transliterations for unique TCM terms that possess distinct features, thus upholding the essence of TCM. 3) It employs innovative Xiang (Image) cognition, a concept rooted in traditional Chinese thought by helping readers grasp visual and mental imagery associated with each term. This study presents a qualitative analysis based on interviews with 11 TCM translation experts, examining their perspectives on these features and their translational preferences across IST 2007 and 2022 versions. The findings contribute to the standardization and global harmonization of TCM terminology, advocating for clarity, precision, and the advancement of TCM in the international healthcare arena.

Legal Complications on Patenting Crossbreed Animals: A Comparative Discussion on India and Abroad

The patentability of cross-breed animals is a complex area facing constant evolution. The intellectual property law varies significantly in this domain between various jurisdictions. The study focuses mainly on a comparative analysis between IPR rights of India and abroad, where. This paper aims to provide a comparative discussion on the legal frameworks that govern rights of patentability of cross-bred animals in India and abroad, focusing on the lacunas that are highlighted to understand where the Indian legislation, despite being quite robust in plant cloning and breeding, falls short in animal cross breeding. The paper takes a dive into the international standards and practices and then tallies it in the Indian context. All the major and key jurisdictions such as the United States, European Union, and Australia are taken into consideration for the purpose of discussion, to understand what remedies could be generated on the basis of the comparative analysis. The Indian legislation, precedents and policies are considered to draw conclusions. It also tries to pass remarks on the implications on innovation, animal welfare, and efforts for global harmonization in IPR. To draft this paper, the authors have taken help from various primary and secondary resources.

A Review on Advancement in Analytical Quality by Design (AQbD)

Analytical Quality by Design (AQbD) represents a transformative methodology in pharmaceutical development, anchored in a systematic, risk-based, and data-driven framework. This approach optimizes analytical methods, fostering heightened product quality, efficient regulatory compliance, and informed decision-making. The industry's increasing acceptance of AQbD principles signifies a paradigm shift towards enhanced efficiency, sustainability, and global harmonization. This review comprehensively explores AQbD principles, regulatory perspectives, and its applications, particularly in analytical method development, including high-performance liquid chromatography (HPLC) and high-performance thin-layer chromatography (HPTLC). Emphasis is placed on the symbiotic relationship between AQbD and analytical method validation (AMV), elucidating their collective role in ensuring reliable and accurate analytical results. Integrating AQbD in method transfer, automation, and control strategies underscores its pivotal role in achieving robust, efficient, and compliant analytical processes. The review delves into lifecycle management and continuous improvement, coupled with AQbD principles, ensuring sustained method reliability throughout the pharmaceutical product lifecycle. AQbD's significant contribution to pharmaceutical lifecycle management, optimization, and change control is explored, emphasizing its systematic, data-driven, and risk-based approach to method development, validation, and ongoing enhancement. This review illuminates AQbD's transformative impact on pharmaceutical analysis, aligning with industry trends toward quality, efficiency, and regulatory compliance.

In silico occupational exposure banding framework for data poor compounds in biotechnology.

Occupational exposure limits (OELs) and occupational exposure bands (OEBs) provide quantitative benchmarks for worker health protection. If empirical toxicology data are insufficient to derive an OEL, an OEB is often assigned using partial toxicology data along with other relevant hazard information. There is no consensus methodology to assign OEBs for chemicals lacking any empirical toxicology data. Thus, this study developed an in silico framework for OEB assignment of data poor compounds. It relies upon computational tools to evaluate standard toxicological end points and to assign reliability ratings, which are then used to assign Global Harmonization System (GHS) hazard categories. Subsequently, the hazard categories are entered into the National Institute for Occupational Safety and Health (NIOSH) occupational exposure banding tool to assign bands for individual end points as well as an overall OEB. As a proof-of-concept, five compounds with established OELs (i.e., "knowns") were evaluated. The knowns were assigned to overall OEBs C, D, or E, four of which were equal to or lower than the OEBs based on actual harmonized GHS categories as well as established OELs, indicating that the OEBs assigned using this framework are likely to be protective. Subsequently, five compounds with little to no experimental data and no established OELs from any U.S. agency or consensus OEL-setting organizations were evaluated (i.e., "unknowns"). The unknowns were assigned to overall OEBs D or E. It was concluded that the proposed framework can be used to assign protective OEBs to compounds with little to no toxicology testing data. As additional data become available, the compound may be de-risked, and a precautionary OEB (or an OEL) can be assigned. The proposed framework provides an example of a practical methodology to evaluate data poor compounds and shows that the output of this framework is expected to be protective of worker health.

Advancing food safety standards through technology integration and policy development

Food safety is a critical global concern, directly impacting public health, economic stability, and international trade. With the complexity of modern food supply chains and the rising incidence of foodborne illnesses, traditional food safety measures are often insufficient to address the growing risks. This review explores how integrating advanced technologies and developing robust policies can significantly enhance food safety standards. Technological innovations, including the Internet of Things (IoT), blockchain, artificial intelligence (AI), and automation, offer promising solutions for real-time monitoring, traceability, and predictive analytics in food production and distribution. IoT and sensors enable constant monitoring of environmental conditions like temperature and humidity, while blockchain ensures transparency and traceability across supply chains. AI and machine learning are transforming food safety by predicting contamination risks and optimizing inspection processes, while robotics and automation reduce human error in food processing plants. Alongside technological advancements, policy development plays a crucial role in reinforcing food safety standards. Global harmonization of food safety regulations, stronger enforcement mechanisms, and public-private partnerships are essential for ensuring widespread compliance. Incorporating technology into regulatory frameworks is key to addressing new challenges and maintaining food safety across borders. Governments must also prioritize consumer education and awareness through policies that leverage technology platforms to promote food safety knowledge. Case studies demonstrate the successful application of these technologies in sectors like dairy and meat processing, showcasing the potential for broader industry adoption. However, challenges such as high implementation costs, regulatory lag, and data security concerns remain. This review argues that a synergistic approach combining technological integration with forward-thinking policy development is essential for advancing global food safety standards and safeguarding public health in the future.

Monitoring macroplastics in aquatic and terrestrial ecosystems: Expert survey reveals visual and drone-based census as most effective techniques

Anthropogenic litter, such as plastic, is investigated by the global scientific community from various fields employing diverse techniques. The goal is to assess and finally mitigate the pollutants' impacts on the natural environment. Plastic litter can accumulate in different matrices of aquatic and terrestrial ecosystems, impacting both biota and ecosystem functioning. Detection and quantification of macroplastics, and other litter, can be realized by jointly using visual census and remote sensing techniques. The primary objective of this research was to identify the most effective approach for monitoring macroplastic litter in riverine and marine environments through a comprehensive survey based on the experiences of the scientific community. Researchers involved in plastic pollution evaluated four litter occurrence and flux investigation methods (visual census, drone-based surveys, satellite imagery, and GPS/GNSS trackers) through a questionnaire. Traditional visual census and drone deployment were deemed as the most popular approaches among the 46 surveyed researchers, while satellite imagery and GPS/GNSS trackers received lower scores due to limited field validation and short performance ranges, respectively. On a scale from 0 to 5, visual census and drone-based surveys obtained 3.5 and 2.0, respectively, whereas satellite imagery and alternative solutions received scores lower than 1.2. Visual and drone censuses were used in high, medium and low-income countries, while satellite census and GPS/GNSS trackers were mostly used in high-income countries. This work provides an overview of the advantages and drawbacks of litter investigation techniques, contributing i) to the global harmonization of macroplastic litter monitoring and ii) providing a starting point for researchers and water managers approaching this topic. This work supports the selection and design of reliable and cost-effective monitoring approaches to mitigate the ambiguity in macroplastic data collection, contributing to the global harmonization of macroplastic litter monitoring protocols.

Strong reasons make strong actions: What Shakespeare’s ‘King John’ can teach us about the Internet of Things

The rapid proliferation of Internet of Things (IoT) devices in modern societies brings forth unprecedented opportunities for convenience and connectivity but also poses significant cyber security challenges. This paper examines the risks associated with these devices and the regulatory frameworks governing them in key regions including the US, the EU, China and India. Through a comprehensive analysis, it becomes evident that while efforts are being made to address IoT cyber security concerns, discrepancies in approaches and regulations hinder global harmonisation and create obstacles for industry compliance. Drawing from insights into existing cyber security frameworks and industry practices, the paper proposes actionable recommendations to enhance consumer IoT cyber security. These recommendations include defining baseline security requirements, promoting expertise within IoT workforces, advocating for the independent involvement of conformity assessment bodies (CABs), leveraging the quality infrastructure ecosystem, and launching an international awareness campaign. By implementing these measures, stakeholders can foster a safer and more secure IoT environment, mitigating the risks posed by cyber threats and ensuring the trust and resilience of connected devices. As society continues to navigate the complexities of IoT adoption, it is imperative to recognise the urgency of addressing cyber security challenges. By heeding the lessons from Shakespeare’s ‘King John’ — ‘Strong reasons make strong actions’ — and taking decisive steps to fortify IoT cyber security, we can safeguard individuals, businesses and critical infrastructure from the evolving threat landscape.

Tracing the Evolution: A Comprehensive Bibliometric Analysis of Drug Interaction Clinical Studies.

This study aims to meticulously map the bibliometric landscape of drug-drug interactions (DDIs) in clinical research. This represents the first use of bibliometric analysis to comprehensively highlight the evolutionary trends and core themes in this critical field of pharmacology. An exhaustive bibliometric search was performed within the Web of Science Core Collection, aiming to comprehensively gather literature on DDIs in clinical settings. A combination of sophisticated analytical tools including DIKW, VOSviewer, and Citespace was utilized for an in-depth exploration of bibliometric patterns and trends. Of the 3421 initially identified articles, 2622 were considered relevant. The analysis revealed a marked escalation in DDIs publications, with a peak observed in 2020. Five principal thematic clusters emerged: Safety and Adverse Reactions, Drug Metabolism and Efficacy, Disease and Drug Treatment, Research Methods and Practices, and Special Populations and Combined Medication. Key insights included the escalating significance of drug metabolism in pharmacokinetics, heightened focus on cardiovascular and antiviral therapeutics, and the advancing frontier of personalized medicine. Additionally, the analysis underscored the necessity for strategic attention to vulnerable populations and innovative methodological approaches. This study calls for the global harmonization of research methods in DDIs clinical investigations, advocating for the integration of personalized medicine paradigms and the implementation of cutting-edge computational analytics. It highlights the imperative for inclusive and collaborative research approaches to adeptly address the intricate challenges of contemporary pharmacotherapy.

An Investigation of the Third Harmonic Power Line Emission in the Topside Ionosphere During the Recent Solar Minimum Period

AbstractPower line harmonic radiation (PLHR) events are radiated by electric power systems on the ground at harmonics of the base power system frequency (50 or 60 Hz, depending on the region). We analyze the global third harmonics PLHR at 150 and 180 Hz using electric field data collected by China Seismo‐Electromagnetic Satellite during the recent solar minimum between January 2019 and December 2022. The average frequency spectrum over industrialized areas shows that the third harmonic has a high occurrence rate in the U.S. region, as well as in western China and northern India, but is very low in the European region. In particular, in the China region and the U.S. region, more than 11,000 and 24,000 dayside and nightside third harmonic PLHR events have been detected from 2019 to 2022, respectively. Compared to the 150 Hz PLHR occurrence rate detected above the China region, the 180 Hz PLHR occurrence rate above the U.S. region is higher, which reveals a significant regional difference. In addition, both at nighttime and daytime, the PLHR electric field intensities at 180 Hz are higher than that at 60 Hz above the U.S. region, which is also different from the result above the China region.

Illuminator: Image-based illumination editing for indoor scene harmonization

Illumination harmonization is an important but challenging task that aims to achieve illumination compatibility between the foreground and background under different illumination conditions. Most current studies mainly focus on achieving seamless integration between the appearance (illumination or visual style) of the foreground object itself and the background scene or producing the foreground shadow. They rarely considered global illumination consistency (i.e., the illumination and shadow of the foreground object). In our work, we introduce “Illuminator”, an image-based illumination editing technique. This method aims to achieve more realistic global illumination harmonization, ensuring consistent illumination and plausible shadows in complex indoor environments. The Illuminator contains a shadow residual generation branch and an object illumination transfer branch. The shadow residual generation branch introduces a novel attention-aware graph convolutional mechanism to achieve reasonable foreground shadow generation. The object illumination transfer branch primarily transfers background illumination to the foreground region. In addition, we construct a real-world indoor illumination harmonization dataset called RIH, which consists of various foreground objects and background scenes captured under diverse illumination conditions for training and evaluating our Illuminator. Our comprehensive experiments, conducted on the RIH dataset and a collection of real-world everyday life photos, validate the effectiveness of our method.

Advancing Pharmacovigilance: Safeguarding Drug Safety and Enhancing Public Health

Pharmacovigilance is integral to ensuring the safety and efficacy of pharmaceutical products throughout their lifecycle. This review explores the essential components of pharmacovigilance, highlighting its role in monitoring adverse drug reactions (ADRs), detecting safety signals, and managing risks associated with medications. Key components include adverse event reporting systems, advanced signal detection methodologies utilizing artificial intelligence and real-world data, rigorous data management and evaluation processes, and compliance with regulatory requirements. Effective communication strategies ensure dissemination of safety information to healthcare professionals and the public, promoting informed decisionmaking and enhancing patient safety. Challenges such as data quality, regulatory adaptation, and global harmonization are discussed, alongside future directions aimed at improving pharmacovigilance practices. By continuously evolving to integrate technological advancements and global collaboration, pharmacovigilance contributes significantly to public health by maintaining the integrity and safety of pharmaceutical therapies worldwide.

The future perspectives of the European Unified Patent Court in the light of the existing intellectual property courts in the United States and Japan

AbstractThe entering into force of Europe's Unified Patent Court (UPC) on 1 June 2023 shifts the question on whether and how a specialised and unified court should be designed to the question on how the already conceived court shall function to meet the set institutional and substantive goals for the European patent adjudication. Despite the contextual legal and economic differences, the examples of the US Court of Appeals for the Federal Circuit (CAFC) and the Tokyo Intellectual Property High Court (IPHC) can serve as guidance for the new European court, especially in its early days of operation. This article, outlining both the differences and similarities in the origins of the three courts, articulates upon the challenges as well as the achievements of the United States and Japanese examples to shed light on the future perspectives of the UPC and wherever relevant, provide policy‐oriented and practical recommendations for those in charge of shaping the UPC's jurisprudence. To this end, it is submitted that particular attention should be paid to ensuring the wide range of competences of the UPC judges; the interinstitutional dialogue between the UPC and the Court of Justice of the European Union (CJEU) as well as the dialogue among the UPC judges, including the encouragement of dissenting opinions; consultation of public, if possible in the form of amicus curiae briefs; and international cooperation with existing specialised IP courts worldwide. Based on evidenced foreign practices, these mechanisms are argued to serve the objectives of avoiding ‘overspecialisation’, achieving uniformity while maintaining accuracy, securing the new court's legitimacy and, finally, fostering global judicial harmonisation.

Philosophical Interpretation of Article 24 of the Medicines Act: Drug Safety, Efficacy, and Quality Control

Article 24 of the Medicines Act serves as a cornerstone in the regulatory framework governing pharmaceuticals in the United Kingdom. This article emphasizes the rigorous evaluation of drug safety, efficacy, and quality through a structured, multi-phase process involving pre-clinical studies, clinical trials, and post-marketing surveillance. This paper explores the philosophical underpinnings of Article 24, delving into its ethical, epistemological, and regulatory dimensions. The ethical analysis focuses on balancing public health and individual rights, the principle of informed consent, and equitable access to high-quality medicines. The epistemological discussion highlights the commitment to evidence-based medicine, scientific rationalism, and the critical role of regulatory bodies like the Medicines and Healthcare products Regulatory Agency (MHRA). The regulatory perspective examines the comprehensive and precautionary approach to drug approval and quality control, emphasizing global harmonization and collaboration. By integrating these perspectives, the paper underscores the significance of Article 24 in ensuring that only safe, effective, and high-quality medicinal products are available in the UK, thereby setting a model for global regulatory practices.

P445 A journey to achieve global harmonisation for physiotherapy outcome measures

P445 A journey to achieve global harmonisation for physiotherapy outcome measures

Microbial pesticides – challenges and future perspectives for testing and safety assessment with respect to human health

Plant protection measures are necessary to prevent pests and diseases from attacking and destroying crop plants and to meet consumer demands for agricultural produce. In the last decades the use of chemical pesticides has largely increased. Farmers are looking for alternatives. Biopesticides should be considered a sustainable solution. They may be less toxic than chemical pesticides, be very specific to the target pest, decompose quickly, and be less likely to cause resistance. On the other hand, lower efficacy and higher costs are two disadvantages of many biopesticides. Biopesticides include macroorganisms, natural compounds and microorganisms. Microbial pesticides are the most widely used and studied class of biopesticides. The greatest difference between microbial and chemical pesticides is the ability of the former to potentially multiply in the environment and on the crop plant after application. The data requirements for the European Union and the United States Environmental Protection Agency are highlighted, as these regulatory processes are the most followed in regions where local regulations for biopesticide products are not available or vague. New Approach Methods already proposed or harmonized for chemical pesticides are presented and discussed with respect to their use in evaluating microbial pesticide formulations. Evaluating the microbials themselves is not as simple as using the same validated New Approach Methods as for synthetic pesticides. Therefore, the authors suggest considering New Approach Method strategies specifically for microbials and global harmonization with acceptability with the advancements of such approaches. Further discussion is needed and greatly appreciated by the experts.

Relationship Between Cerebrospinal Fluid Alzheimer's Disease Biomarker Values Measured via Lumipulse Assays and Conventional ELISA: Single-Center Experience and Systematic Review.

Although Lumipulse assays and conventional ELISA are strongly correlated, the precise relationship between their measured values remains undetermined. To determine the relationship between Lumipulse and ELISA measurement values. Patients who underwent cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarker measurements and consented to biobanking between December 2021 and June 2023 were included. The relationship between values measured via Lumipulse assays and conventional ELISA were evaluated by Passing-Bablok analyses for amyloid-β 1-42 (Aβ42), total tau (t-tau), and phospho-tau 181 (p-tau 181). Studies using both assays were systematically searched for in PubMed and summarized after quality assessment. Regression line slopes and intercepts were 1.41 (1.23 to 1.60) and -77.8 (-198.4 to 44.5) for Aβ42, 0.94 (0.88 to 1.01) and 98.2 (76.9 to 114.4) for t-tau, and 1.60 (1.43 to 1.75) and -21.1 (-26.9 to -15.6) for p-tau181. Spearman's correlation coefficients were 0.90, 0.95, and 0.95 for Aβ42, t-tau, and p-tau181, respectively. We identified 13 other studies that included 2,117 patients in total. Aβ42 slope varied among studies, suggesting inter-lab difference of ELISA. The slope and intercept of t-tau were approximately 1 and 0, respectively, suggesting small proportional and systematic differences. Conversely, the p-tau181 slope was significantly higher than 1, distributed between 1.5-2 in most studies, with intercepts significantly lower than 0, suggesting proportional and systematic differences. We characterized different relationship between measurement values for each biomarker, which may be useful for understanding the differences in CSF biomarker measurement values on different platforms and for future global harmonization.

P21 Advancing dermatological care: a comprehensive evaluation of the steroid-free GL-1 formulation

Abstract Introduction and aims The prolonged use of topical steroids introduces notable dermatological risks, including the onset of permanent stretch marks, bruising, discoloration and vascular abnormalities. This study presents an innovative strategy by formulating GL-1, a steroid-free treatment amalgamating seaweed bioactives, sesame oil and naturally occurring salts and minerals. The objective of this study was to address the limitations of conventional topical steroids and introduce pioneering solutions to dermatological care. Methods To assess the safety and efficacy of GL-1 (product 1), a comprehensive battery of in vitro tests was employed. The skin corrosion test (OECD 431) established the noncorrosive nature of GL-1, validating its safety on reconstructed human epidermis. The skin irritation test (OECD 439) demonstrated the nonirritating attributes of GL-1, aligning with the United Nations Globally Harmonized System of Classification and Labelling guidelines. Additionally, the bovine corneal opacity and permeability test (OECD 437) affirmed the noninducing nature of GL-1 in relation to eye irritation or serious eye damage. Results Preliminary outcomes from dermal clinical trials indicate promising Results for GL-1. In vitro experiments on HaCaT and human dermal fibroblasts, adult (HDFa) cell lines highlighted the noncytotoxicity of GL-1, contrasting with the ‘Cortopin’, which exhibited cytotoxicity. GL-1 exhibited a proliferative effect in HDFa cells, signifying its potential for regenerative applications. Furthermore, both GL-1 and ‘Cortopin’ displayed antioxidant activity in HaCaT cells, underscoring the additional merits of our formulation. Conclusions Our steroid-free formulation, GL-1, demonstrates exceptional safety and efficacy through a meticulous series of in vitro assessments and initial clinical trials. These findings position GL-1 as a promising candidate for diverse dermal applications, offering a secure alternative to traditional topical steroids. The potential impact of GL-1 transcends its therapeutic efficacy, emphasizing its robust safety profile validated through multiple in vitro evaluations.