We aimed to investigate the prevalence and genotype distribution of human papillomavirus (HPV) among Korean males and explore implications for targeted vaccination strategies. A total of 44,065 males underwent HPV testing between March 2014 and February 2022 using the Anyplex™ II HPV 28 system, detecting 19 high-risk (HR) and 9 low-risk (LR) HPV types. Additionally, data from 507 male patients at local clinic (2017-2022) were analyzed to compare genotype prevalence between those with (WAT group) and without (WAT X group) genital warts. Overall HPV positivity was 59.1%. HPV 6 (33.3%) and HPV 11 (11.0%) were the most prevalent LR genotypes, while HPV 16 (5.2%) dominated HR infection. Multiple HPV genotype co-infection occurred in 49.3% of positive cases, with 11.3% involving multiple HR types. Younger males (teens, 20s) exhibited higher HR-HPV positivity, although total HPV positivity peaked in the 40s (60.1%). Non-9-valent HR genotypes (HPV 53, 51, 39, 66) accounted for 27.6%-35.0% of infections annually. At local clinic, HPV 43 was significantly associated with genital warts (p=0.017). These data support including males in national HPV vaccination strategies using the current 9-valent vaccine and underscore the need for ongoing genotype surveillance to monitor non-vaccine high-risk types and inform public health policy, and support inclusion of males in national HPV vaccination strategies using the current 9-valent vaccine.

Verruciform xanthoma is a rare, benign mucocutaneous growth, usually seen in the oral cavity, but uncommonly also seen on genital skin. It presents as a flat or raised skin lesion, varying in colour with an irregular surface. These lesions can mimic stigmata of sexually transmitted infections such HPV-genital warts, condyloma latum or cause concern for inflammatory or malignant conditions, with histopathology being crucial for diagnosis and to avoid anxiety or invasive procedures. Underlying cause of these lesions remains uncertain, but no link to HPV has been identified. We present an 89 year old male referred to the sexual health service for concern of genital wart, despite low risk sexual history. Following removal and analysis to ensure non-malignant, the patient has been well since, with no recurrence.

ABSTRACT This study assessed the impact and cost-effectiveness of gender-neutral immunization with the nonavalent human papillomavirus (HPV) vaccine in South Korea. An established dynamic transmission model of HPV epidemiology was adapted to the South Korean population. Vaccinating both girls and boys with the nonavalent HPV vaccine was compared to the currently administered program of vaccinating girls only with the quadrivalent vaccine. Compared to vaccination of girls only with the quadrivalent HPV vaccine, gender-neutral vaccination with the nonavalent HPV vaccine was projected to prevent 1,282,415 cases of cervical intraepithelial neoplasia grade 1 (CIN1), 918,384 cases of CIN2/3, 36,248 cases of cervical cancer, and 9,313 cervical cancer deaths in females over 100 years. Gender-neutral vaccination was projected to reduce HPV-related vaginal, vulvar, anal, and head & neck cancers in females by 4.8–8.2%, in addition to reductions of 14.6% and 15.8% in genital warts and recurrent respiratory papillomatosis, respectively. In males, gender-neutral vaccination was projected to prevent 666,182 cases of genital warts, 7,422 cases of RRP, 995 cases of anal cancer, 2,441 cases of head & neck cancer, and 122 cases of penile cancer. The incremental cost-effectiveness ratio (ICER) was ₩38.9 million per quality-adjusted life year (QALY), which is below the accepted cost-effectiveness threshold in South Korea. These findings suggest that gender-neutral vaccination with the nonavalent HPV vaccine would reduce the public health burden of HPV disease in both females and males in South Korea and would be cost-effective under base case assumptions about vaccine price and coverage of boys.

Low-risk human papillomaviruses HPV-6 and HPV-11 impose a substantial global burden of benign disease. While genomically similar to high-risk HPV types, their codon usage patterns remain uncharacterized. This study systematically deciphers these patterns in HPV-6 and HPV-11. Analysis included 214 HPV-6 and 100 HPV-11 genomes from the NCBI GenBank database. Genomic analysis identified a strong preference for A/U-ending synonymous codons (over 85% of preferred codons) and low GC content at third codon positions (<35%). Relative dinucleotide abundance analysis further revealed underrepresentation of ApA, CpG, and UpC, and overrepresentation of CpA and UpG, which critically shaped synonymous codon selection in both genotypes. While Effective Number of Codons (ENC) values >49 indicated limited overall codon bias, multi-method analyses (Parity Rule 2, ENC-plot, neutrality plot) established natural selection as the dominant evolutionary force over mutational pressure. Despite moderate host adaptation, a strategic mismatch exists between viral codon preferences and human tRNA abundance, potentially moderating translational efficiency to favor immune evasion and persistence. The Relative Codon Deoptimization Index (RCDI) values approaching 2 further support a moderate adaptation to human codon usage patterns.These findings provide crucial insights into the molecular evolution of low-risk HPVs and inform the development of codon-optimized therapeutic strategies, including vaccines targeting pathologies like genital warts and recurrent respiratory papillomatosis.

Depression is associated with a higher prevalence of self-reported risky sexual behaviors, potentially increasing susceptibility to sexually transmitted infections (STIs). However, epidemiological evidence linking depression to genital herpes or genital warts remains limited. This cross-sectional analysis utilized data from the National Health and Nutrition Examination Survey. Depressive symptoms were assessed using the validated Patient Health Questionnaire-9. STIs were self-reported via audio computer-assisted self-interview in private rooms at the Mobile Examination Center. Multivariable logistic regression models were employed to evaluate associations between depression and genital herpes/warts-related outcomes, supplemented by subgroup analyses to identify vulnerable populations. Adults with depression demonstrated significantly elevated risks of genital herpes (odds ratio = 1.73, 95% confidence interval:1.22–2.45) and genital warts (odds ratio = 1.79, 95% confidence interval:1.36–2.35) compared with nondepressed individuals. Subgroup analyses revealed differential vulnerability across demographic and clinical strata, with females, individuals with postsecondary education, and hypertensive patients exhibiting heightened susceptibility to both infections. Depression was associated with higher odds of genital herpes and genital warts among US adults. These findings underscore the clinical importance of integrating STIs screening into mental health management protocols, particularly among females and individuals with higher educational attainment. Enhanced preventive strategies targeting high-risk sexual behaviors in depressed populations are warranted.

Human papillomavirus (HPV) is a leading cause of genital warts and cervical cancer (CC), which was reported as the second most common malignancy among women in Bangladesh in 2020. While vaccination against HPV stands out as the most effective strategy for preventing CC, however, misconceptions about its safety, effectiveness, and benefits may impact its prevalence. This study aimed to evaluate the knowledge of HPV infection, CC, and vaccination, as well as the attitudes and willingness to receive the vaccine among female university students in Bangladesh. A cross-sectional survey was conducted to collect primary data from 800 university students through face-to-face interviews. A well-structured questionnaire was administered to collect data on socio-demographic characteristics, knowledge of HPV infection, CC, and vaccination, as well as attitudes and willingness regarding vaccination. Multivariable logistic regression was used to identify factors influencing knowledge about HPV infection and CC. Moreover, Structural Equation Modeling (SEM) explored direct and indirect pathways affecting knowledge, attitudes, and willingness, validated by goodness-of-fit indices. Students with sexual health education demonstrated higher awareness of HPV infection and cervical cancer, with 23.4% having good knowledge, compared to only 11.0% without such education. Difficulty accessing healthcare increased the odds of poor knowledge in the unadjusted model (COR: 1.72. 95% CI: 1.01-2.93), whereas students from Khulna had higher odds (AOR: 4.45, 95% CI: 1.24-15.88). Moreover, 44.8% of participants recognized that the HPV vaccine prevents cervical cancer, and 64.7% were unsure of its effectiveness. The SEM highlights that attitude is the strongest predictor of vaccination willingness (0.61), while HPV vaccination knowledge has a moderate impact (0.46). University female students have limited knowledge about HPV, CC, and vaccination, yet they are willing to receive the HPV vaccine. This highlights the need for the government to implement educational initiatives and health counseling to increase awareness and empower informed health decisions.

Vaginal intraepithelial neoplasia (VaIN) is a rare premalignant lesion with the potential to progress to invasive vaginal carcinoma, yet its clinical characteristics and associated risk factors remain incompletely defined. This retrospective study evaluated the prevalence, human papillomavirus (HPV) genotype distribution, and clinical risk factors of VaIN in women undergoing colposcopy. A total of 8206 patients who received colposcopic examination and vaginal biopsy due to abnormal ThinPrep cytologic test results and/or high-risk HPV positivity between January 2021 and December 2023 were reviewed. Patients with cervical cancer, vulvar intraepithelial lesions, or condyloma acuminatum were excluded. Clinical characteristics, HPV genotypes, cytology findings, and histopathological results were analyzed. VaIN was diagnosed in 682 patients (8.22%). The most prevalent HPV genotypes were HPV16, HPV52, HPV58, and HPV53. High-grade VaIN (VaIN3) occurred more frequently in older and postmenopausal women. Concurrent VaIN and cervical intraepithelial neoplasia was significantly associated with advanced age, postmenopausal status, multiple HPV infections, and a history of cervical intraepithelial neoplasia. Among women with prior hysterectomy, VaIN was more commonly observed after hysterectomy for cervical lesions, although 24.7% of cases followed hysterectomy for non-cervical indications. In non-hysterectomized patients, 98.2% of VaIN lesions were located in the upper third of the vagina. Multivariate analysis identified older age, postmenopausal status, and multiple HPV infections as independent risk factors for VaIN. These findings underscore the importance of vigilant vaginal surveillance, particularly in women with persistent or multiple HPV infections and those with a history of hysterectomy.

ABSTRACT Against the backdrop of calling for nonfemale‐oriented promotion of vaccination against human papillomavirus (HPV), this study explored three potential names—“HPV Vaccine,” “Cervical Cancer Vaccine,” and “Genital Warts Vaccine”—to promote vaccination against HPV infection among heterosexual men. To assess the effect of vaccine names presented in promotional messages on heterosexual men's vaccination decisions, we drew on theories of label framing and reference points. Through a single‐factor between‐subjects experiment with 278 participants, we examined how these vaccine names, functioned as label frames, influenced men's vaccination intentions through their fear, and how this influence varied across men's relationship status. Moderated mediation analysis showed that men in relationships exposed to “Cervical Cancer Vaccine” experienced greater fear of spreading the virus to partners, which heightened vaccination intention compared to “Genital Warts Vaccine.” Single men exposed to “HPV Vaccine,” as opposed to “Cervical Cancer Vaccine,” had a higher fear of infecting future partners, boosting their vaccination intentions. Theoretical and practical implications were discussed.

Progression from infection with human papillomavirus (HPV) to cervical cancer in some women is thought to involve a permissive host environment, one in which immune response is mobilized in an inappropriate manner. Interleukin-2 (IL-2) is one of the most studied cytokines driving T-cell proliferation and survival. Soluble Interleukin-2 receptor (sIL2R) was found to play an immunoregulatory role and is detected in the serum of healthy individuals but increases in association with certain types of neoplasms. The aim of the current study was to assess the serum level of sIL2R in HPV infected female patients with genital warts compared to healthy control women and to correlate the results with cervical cytology (pap smear) results to determine the utility of measuring the serum sIL2R levels in screening of precancerous changes in cervix. The study was conducted on 90 Egyptian female patients with genital warts and 90 apparently healthy controls. Cervical brush samples were taken for both conventional Pap cytology and detection of HPV-DNA. Serum levels of sIL2R were measured by enzyme-linked immunosorbent assay (ELISA). Patients were divided into two groups according to the result of Pap smear: group 1 with Low-grade squamous intraepithelial lesion (LSIL) having flat condyloma on cervix and group 2 with normal pap smear having condyloma accuminata lesions. Serum sIL2R levels of HPV infected patients showed a statistically significant higher median when compared to controls (p value < 0.0001). Also, group 1 showed a statistically significant higher median compared to group 2 regarding sIL2R levels (p value < 0.0001). sIL2R was found to be perfect and reliable in differentiation between group 1 and group 2. Also, it may be useful to use serum sIL2R level for screening of HPV infections and cervical cancer.

Aim: The present study determines the patterns of sexually transmitted infections in Federal Medical Center Asaba in the past five years, with relation to their socio-demographic characteristics. Study Design: A five-year retrospective study. Place and Duration of Study: Federal Medical Centre, Asaba, Delta State, Nigeria between 1st of January 2019 to 31st of December 2023. Methodology: A retrospective study on sexually transmitted infections (syphilis, gonorrhea, and chlamydia) in the hospital, from 2019 – 2023, a review of the medical records from FMC Asaba to collect data on the socio-demographics of patients, prevalence of the infections reported over the past five years. Results: In a comprehensive analysis of 89 subjects, it was found that a substantial majority, specifically 62 individuals (69.7%), were identified as male, while the remaining 27 subjects (30.3%) were female. This demographic distribution indicated a significant male predominance, with a calculated male-to-female ratio of 2.8:1 throughout the examined period. Notably, this ratio was not static; rather, it exhibited fluctuations that varied from year to year, emphasizing the dynamic nature of the population under study. Delving deeper into the patient demographics, the mean age of male patients during the five-year assessment period was recorded at 32.3 years. In contrast, female patients presented with a slightly older average age of 38 years, suggesting potential differences in risk factors and health seeking behaviors between the genders. When examining the types of sexually transmitted infections (STIs) present in this study, Syphilis clearly emerged as the predominant infection, accounting for a striking 71 cases, which constituted 79.8% of the total infections documented, this was followed by Gonorrhea, with a total of 12 cases representing 13.5% of the population. Additionally, there was one case each (1.1%) of genital warts and mixed infections that involved both Syphilis and Chlamydia. Moreover, it is significant to note that four cases (4.5%) were identified as HIV positive individuals who also had concurrent Syphilis infections. Conclusion: The findings of our study indicate a discernible reduction in the number of patients diagnosed with STIs attending the healthcare facility in comparison to trends observed in preceding years. The reasons underlying this decline remain speculative; it may either reflect a genuine decrease in the prevalence of STIs within the community or lack of resources to carry out these tests. Enhanced access to diagnostic laboratories and treatment centers for STIs may have contributed to this observed decrease in patient visits, as individuals may now feel more empowered to seek care in alternative settings.

Background and aimHuman papillomavirus (HPV) is a common sexually transmitted infection and is the leading cause of genital warts and cervical cancer. However, research on HPV prevalence within the Iraqi population is limited, with only a few published studies. The aim of this study was to investigate the prevalence and genotype distribution of HPV among Iraqi women.MethodsIn this study, samples from 2,193 married women referred to PharmaGene laboratory for diagnostic evaluation between 2023 and 2025 were analyzed. HPV genotyping was performed using the HPV Direct Flow CHIP system.ResultThe overall positive rate was 12.7% (n = 279). Within the positive cases, 6.9% had only high-risk (HR-HPV) genotypes, 4.4% had only low-risk (LR-HPV) genotypes, and 1.4% were co-infected with both HR and LR-HPV genotypes. The most frequently detected HPV genotypes were HPV 18 (13.3%), HPV 11 (11.4%), HPV 16 (6.9%), HPV 62/81 (5.7%), HPV 39 (4.5%), HPV 51 (3.6%), and HPV 6 (3.6%). Among HPV-positive cases, the prevalence of single, double, triple, and quadruple or higher infections was 83.5%, 14%, 1.8%, and 0.7%, respectively.ConclusionThis study presents novel epidemiological data on the prevalence and genotype distribution of HPV infection in Iraq, offering a valuable basis for enhancing cervical cancer screening and HPV prevention strategies. Furthermore, understanding the distribution of HPV genotypes may support the implementation of targeted vaccination programs.

Urethral condyloma acuminatum, caused by human papillomavirus, is uncommon. This report details a unique case in a young, immunocompetent male lacking conventional risk factors, highlighting significant diagnostic and management challenges within a resource-constrained setting. A 26-year-old male from the Bakonzo tribe (Bantu ethnicity) reported to Kampala International University Teaching Hospital with a 3-week history of a painless, single urethral lesion. He denied sexually transmitted infections or HIV, and physical examination was otherwise unremarkable. While initial urinalysis suggested a urinary tract infection, the lesion's atypical nature (presenting as a solitary, painless mass without coexisting external lesions or high-risk history) significantly lowered suspicion for condyloma, compelling the team to prioritize the exclusion of a low-grade urethral neoplasm or papilloma. This clinical ambiguity, combined with resource constraints on advanced noninvasive diagnostics (such as cystoscopy), necessitated an excisional biopsy for definitive diagnosis and therapeutic clearance. Histopathological analysis confirmed condyloma acuminatum with characteristic koilocytosis but no dysplasia or malignancy. Notably, subsequent high-risk human papillomavirus genotyping (16, 18, 45) was negative. Following surgical excision, the patient experienced complete resolution and no recurrence during 1-year follow-up. This case compellingly demonstrates the essential requirement for increased clinical vigilance and diagnostic flexibility in the management of urethral condyloma, especially in resource-constrained settings. It demonstrates that atypical presentations, even without classic risk factors or high-risk human papillomavirus detection, mandate reliance on histopathological confirmation for accurate diagnosis and prognostication. The successful outcome via excisional biopsy underscores its practicality and effectiveness as a primary intervention for such complex cases in resource-constrained environments, offering valuable learning for similar global health contexts.

Human papillomavirus (HPV)-related diseases have risen in Japan since recommendations for the HPV vaccine were suspended in 2013. This study evaluated the public health benefit of extending the current 3-year nonavalent HPV (9vHPV) catch-up vaccination program for females 17-26 years of age to 6 years. A dynamic transmission model calibrated to Japanese specific demographic and epidemiological data compared the impact of different 9vHPV vaccination scenarios on female and male HPV-related diseases over a 100-year time horizon. The base-case analysis compared the routine vaccination in combination with the current 3-year catch-up program for females 17-26 years of age from 2022 to 2025 (status quo) to the routine vaccination in combination with an extended 6-year program from 2022 to 2028 (6-year catch-up scenario) for Japan. HPV-related disease incidence with the 6-year catch-up scenario decreased further than the status quo over 100 years. Extending catch-up vaccinations from three to six years in combination with routine vaccination prevented an additional 413,454 HPV-related disease cases and 7,184 deaths for both sexes. Anogenital warts had the highest number of averted cases (361,020 cases) and males (229,867 cases) had more total HPV-related disease cases averted than females (183,586 cases). Routine vaccination in combination with an extension of the catch-up HPV vaccination strategy for females 17-26 years of age from three to six years may expedite the decrease of morbidity and mortality due to HPV-related diseases in Japan.

Current treatments for pregnancy-associated genital warts (PGW) often fail to balance safety and efficacy, especially during gestation. In this study, we introduce GelPV-5-ALA-Matrine, a smart, photoresponsive hydrogel designed for localized photodynamic therapy (PDT) targeting HPV-infected tissues. Co-delivery of 5-ALA and matrine facilitates mitochondrial autophagy through reactive oxygen species (ROS) elevation and MAPK8 activation. Using Mendelian randomization, we identified mitochondrial DNA copy number as a risk factor for sexually transmitted infections, supporting mitochondrial pathways as viable therapeutic targets. The hydrogel demonstrated strong in vitro efficacy in HPV-positive HeLa cells and significantly reduced wart burden and viral load in vivo under near-infrared (NIR) light. Molecular docking and functional validation highlighted MAPK8's key role in mediating ROS-induced mitochondrial clearance and apoptosis. Importantly, no systemic toxicity or adverse biochemical responses were observed. This innovative hydrogel system provides a blueprint for next-generation, patient-safe therapies for PGW and may be adaptable to other HPV-related pathologies in reproductive health.

Epidemiologic, clinical, and economic burden of anogenital warts among adults: A global systematic review.

Abstract OP 34: Diseases and Interventions 2, B304 (FCSH), September 5, 2025, 10:15 - 11:15 International migrants are often disproportionately affected by HIV and other blood-borne viruses, particularly in high-income countries. However, evidence regarding the prevalence of sexually transmitted infections (STIs) more broadly among migrants is scattered. This study aimed to synthesise the global evidence on the prevalence of STIs among migrants and specific subgroups and summarise the risk of migrants having STIs compared to non-migrants. We conducted a systematic review and meta-analysis of peer-reviewed literature published since 2014. We searched MEDLINE, Embase, and Ovid Global Health without language limitations. The primary outcome was the prevalence of STIs namely chlamydia, gonorrhoea, syphilis, genital warts, genital herpes, trichomoniasis, mpox, lymphogranuloma venereum, chancroid and donovanosis, and associated clinical syndromes. We conducted a narrative synthesis of populations studied, study setting, and barriers and facilitators of migrants’ access to sexual health services; and used meta-analysis to calculate the pooled prevalence by infection and relative risk among migrants compared to non-migrant populations. We identified 2,529 records and included 79 studies from 30 countries covering ten infections/conditions. 74 studies were included in the pooled measures of prevalence and 27 in the pooled risk ratio. Of the 27 studies with a comparison group, two thirds reported a higher prevalence of the studied infection in migrants compared to non-migrants. Compared to non-migrants, migrants were twice as likely to have a current syphilis (4 studies, pooled RR = 2.39, 95% CI = 0.13-4.65) or chlamydia infection (8 studies, pooled RR = 2.02, 95% CI = 1.09-2.96) while the risk for gonorrhoea and HSV-2 was similar between groups. While STI prevalence and relative risk among migrants varies by setting, population, study type and infection, there is a clear need to address migrants’ unmet needs for sexual health information and services. This will not only improve health equity but is crucial to addressing the multiple epidemics of STIs.

Human Papillomavirus (HPV) is a sexually transmitted infection associated with genital warts and multiple cancers. HPV awareness and vaccine coverage remain low in mainland China. With the rise of digital social media, young people increasingly acquire knowledge and information online, influencing their perceptions and decisions. Impact of social media on HPV knowledge and vaccine hesitancy remains unclear. The study aimed to assess the knowledge and awareness of HPV and its vaccines hesitancy among young adults in China using an online structured questionnaire with implied consent. Our findings showed that 94.4% of respondents had heard of HPV, with most aware of its sexual transmission and risks to both men and women. However, gaps in knowledge and misconceptions were identified, particularly concerning the asymptomatic nature of HPV infections and the lack of effective antiviral treatments for HPV. Misconceptions about HPV and vaccine safety were notable, contributing to vaccine hesitancy. Yet 78.4% of participants believed in the effectiveness of HPV vaccine, and 83.5% expressed their willingness to receive vaccination if recommended by a doctor. Although overall awareness of HPV and HPV vaccination was high, significant knowledge gaps and misconceptions remain. Thereby reshaping public perception and enhancing awareness, trust and motivation for HPV vaccination are under challenge. Addressing misinformation through strategic educational initiatives could enhance trust in HPV vaccination and improve coverage, ultimately reducing the burden of HPV-related diseases in China.

Background: In 2022, the United States reported 207,255 syphilis cases, marking a 17.3% increase from 2021, and the highest incidence since 1950. In Indonesia, early and late-stage syphilis cases reached 2,981 and 1,144 cases respectively in the first quarter of 2023. Purpose: This study aims to describe the characteristics of syphilis patients at the Dermatology and Venereology Polyclinic at Prof. Dr. I.G.N.G Ngoerah General Hospital. Methods: A retrospective descriptive study was conducted using secondary data from medical records of syphilis patients between January 2021 to December 2023. Data were obtained from the Sexually Transmitted Infection divisions. The study examined patient characteristics, including age, sex, occupation, comorbid conditions, syphilis stage, HIV status, sexual orientation, and sexual behaviour. Result: Out of 346 cases, the highest new syphilis cases recorded in 2021 (133 cases, 86%). The majority of patients were diagnosed with late latent syphilis (211 cases, 61%). The majority of patients were male (59%). The most affected age group was 25–44 years (174 cases, 51%). Private-sector employees represented the largest occupational group (118 cases, 34%). The most common comorbid condition was condyloma acuminatum, 45 patients (50%). In terms of sexual behavior, 62 patients (36%) engaged in receptive sexual activity. Heterosexual orientation was the most frequently reported (176 cases, 51%). Additionally, 205 patients (60%) were HIV-positive. Conclusion: This study has provided important characteristic data in mapping the population to the stages of syphilis, especially in the Bali region.

Background: Sexually Transmitted Infections (STIs) have been considered a public health threat in all countries, both in developed and developing countries. STIs have a direct impact on sexual and reproductive health through stigmatization, infertility, cancer, and pregnancy complications that can increase the risk of HIV. Purpose: This study aims to identify cases of adolescent patients with STIs at Ngoerah Hospital, Denpasar, Bali in the period 2021 to 2023. Methods: This study uses a descriptive observational study with a cross-sectional design. The research was conducted at the Dermatology and Venereology Polyclinic and the Medical Record Installation of Ngoerah Hospital, Denpasar, Bali. After the data was collected, it was tabulated in tabular form and grouped descriptively. Result: A total of 46 patient samples were obtained, with an average age of 16.7 years. Adolescents with STIs were more commonly found in female (63%). Based on their last education, the highest number of patients were junior high school graduates (58.7%) with a history of multipartner sexual intercourse (56.5%). Only 15.2% claimed to be married. The most common type of STIs was syphilis (50%), followed by condyloma acuminata (45.6%). A total of 67.4% of adolescents were known to have HIV-positive status. Conclusion: The picture of STIs in teenagers is more common in female with a junior high school education. Most teenagers have multi-partner partners with a history of having sexual relations with commercial sex workers (CSWs). The most common type of STIs in teenagers is syphilis (50%), and 67.4% are infected with HIV.

A 71-year-old man with newly diagnosed plantar melanoma underwent 18F-FDG PET/CT for staging. In addition to the hypermetabolic primary lesion, intense FDG uptake was observed at the left penile shaft (SUVmax 14.3), raising suspicion for metastatic disease or primary penile malignancy. Physical examination revealed a papillomatous lesion suggestive of condyloma acuminatum. Histopathologic analysis following biopsy confirmed condyloma. This case highlights that condyloma acuminatum can present with intense FDG uptake and may mimic malignancy. Awareness of this potential false-positive finding is essential to avoid misdiagnosis and overtreatment in oncology patients.