The Cd accumulating difference in edible parts of leafy vegetables were involvement with the cultivar-dependent oxidation resistance of plants. According to the transcriptomic results, the total expression of the 4 major antioxidase genes in Cd pollution-safe cultivars (Cd-PSCs) under control condition were higher than in high-Cd-accumulating cultivars (HCCs) of the 4 tested leafy vegetables, indicating the cultivar-dependent high oxidation resistance of Cd-PSCs. Simultaneously, expression of superoxide dismutase (SOD) and peroxidase (POD) genes in Cd-PSCs were all higher than in HCCs under control condition. The real detection of SOD activities in Cd-PSCs under control condition were higher than in HCCs, which verified the transcriptomic results. What’s more, there were no uniform response mechanisms of antioxidase genes to cope with Cd stress among the 4 tested leafy vegetables, even 3 of them were native from the same genus Brassica. Meanwhile, expression of the 4 major antioxidase genes were difference from genus, such as the polyphenol oxidase (PPO) genes were hardly expression in genus Brassica. These results would contribute to the understanding the inherent difference between Cd-PSCs and HCCs, and the cultivar-dependent Cd oxidation resistance related to Cd-PSCs might a easy signal for in vitro catching and screening.