Gender Mismatch Research Articles

Analysis of the reasons for the decline in the marriage rate and fertility rate among women

In recent years, there has been a significant decline in marriage and fertility rates around the world, probably because women are more independent and reluctant to get involved in marriage and pregnancy. Therefore, this article delves into three reasons women are reluctant to marry. From the standpoint of gender mismatch in modern society, fewer men meet women’s needs, creating a mismatch between demand and supply. From the perspective of the contemporary working environment, the improvement of women’s intelligence makes women put more experience into work, and marriage and childbirth may ruin women’s careers. At the same time, sexual harassment in the workplace makes women resentful of men and reluctant to get married. From the perspective of social and cultural influences, the traditional conservative ideas of the past still exist in modern society, which has caused an imbalance in the gender division of labor and made women rebellious. Therefore, women may be reluctant to marry because it becomes a prudent issue and needs to be carefully considered before making a decision.

Afterload mismatch is associated with gender mismatch and negatively affect long-term outcome after heart transplant

Abstract Background Cardiac physiology changes after heart transplant (HT), resulting in a restrictive physiology with an increase in both arterial elastance (Ea) and ventricular elastance (Ees). This leads to a higher susceptibility to develop afterload mismatch, although the early identification of this phenomenon has not yet been explored. The aim of this study is to identify the presence of afterload mismatch after HT, its determinants, and its impact on cardiac mortality. Methods We conducted an observational, single-centre study based on the historical cohort of patients who underwent HT from 1985 to 2015 at our institution. We included patients who had survived the first year after HT with left ventricular ejection fraction (LVEF) ≥ 50%, International Society of Heart and Lung Transplantation (ISHLT) cardiac allograft vasculopathy of grade 0-1, and ISHLT acute cellular rejection of grade 0-1R at 1 year after HT. Ea and Ees were calculated using a non-invasive method based on blood pressure and end-systolic volume and end-diastolic volume measured at transthoracic echocardiography. Patients were grouped in 3 categories according to the presence of increased afterload and afterload mismatch as follows: low afterload (LA - Ea lower the median), matched high afterload (MHA - Ea higher of equal than the median, Ees higher or equal than the median), afterload mismatch (AM - Ea higher or equal than the median, Ees lower than the median). The impact of AM on long-term outcome, defined as cardiac mortality, was investigated, as well as predictors of AM. Results The study cohort consisted of 345 HT patients. The median of Ea and Ees were 4.0mmHg/mL and 6.75mmHg/mL, respectively. 49 patients (13%) developed AM, while LA and MHA groups accounted for 49% and 36% of the cohort, respectively. Patients with AM were mostly male (91%), with ischemic heart disease (45%) and a higher percentage of left ventricular assisted device prior to HT (8%). LVEF was lower in AM (57% vs 63% and 64% for LA and MHA respectively, p < 0.0001), while stroke volume was lower than LA and similar to MHA (27ml vs 35mL and 26mL for LA and MHA respectively, p = 0.0001). Predictors of AM were male recipient from male donor (Mr/Md) (β 015, p = 0.0067) and Mr from female donor (Mr/Fd) (β 0.6, p = 0.0078). After a median of 11.3-year follow-up, 59 (17%) HT recipients died. Cardiac mortality was higher in AM than in the other groups (AM median survival 17.2y vs 27.8y and 24.1y for LA and MHA respectively, log-rank p = 0.005). After adjusting for confounding variables, AM was a predictor of cardiac mortality (HR: 2.26; 95%CI 1.18 – 4.35), such as Mr/Fd (HR 2.94; 95%CI 1.18 – 4.35, p = 0.0358). Conclusion AM, in the context of a normal LVEF, is associated with male donor and sex mismatch, and negatively affects long-term outcome after HT.KM curvesCox proportional hazard model

Gender inequality in intergenerational contact after parental separation in the digital era

AbstractObjectiveThe goal of this brief report is to analyze parent‐adult child contact frequency in intact and non‐intact families by focusing on parent and child gender and the type of contact.BackgroundParental separation increases gender differences in parent–child relationships, with separated fathers having less frequent contact with their adult children compared to separated mothers. We investigate whether the father–mother gap in post‐separation contact varies according to parent–child gender mismatch and the type of contact, that is, face‐to‐face, phone, or digital (e.g., via video calls).MethodWe use data on Italian families from the Family and Social Subjects survey to examine parent–child contact frequency among 6770 adult children aged 30–55 (11,041 parent–child dyads). We estimate random and fixed effects models on the probability of having frequent contact with biological parents in intact and non‐intact families (parental separation before age 18).ResultsFathers' reduced contact frequency compared to mothers is particularly evident with daughters, more pronounced in face‐to‐face and phone contact than in digital contact, and greater among younger daughters at the time of separation. Gender differences in phone and digital contact are larger for fathers who have also less frequent face‐to‐face contact compared to mothers.ConclusionWe interpret these findings by focusing on the centrality of mother–daughter ties and the loyalty that children have with the same‐gender parent. We also suggest that different types of contact reinforce gender differences between parents and may lead to a polarization of older parents with “strong” and “weak” family ties.

Covariation in processing: grammar vs. context

In addition to referential uses, pronouns can have covarying interpretations, i.e., exhibit the behavior of a bound variable. The grammatical mechanism(s) behind such readings have been subject to longstanding debates: Some authors argue for a fairly flexible but unified semantic mechanism that is not tied closely to syntactic configurations. Others distinguish a core class of bona fidebinding with tight syntactic constraints from other mechanisms that give rise to ultimately parallel effects, but do so more indirectly. Psycholinguistic work has started to uncover the processing mechanisms involved in evaluating dependencies between covarying pronouns and (candidate) antecedents. Moulton and Han (2018) leverage the processing perspective to try to shed light on the theoretical question of what grammatical mechanism is at play for a given covarying pronoun. They argue that so-called Gender Mismatch Effects only arise for cases of bona fide binding, supporting the existence of distinct grammatical mechanisms. However, Kush and Eik (2019), looking at another construction involving the relevant other covariation mechanisms, do find Gender Mismatch Effects. These authors suggest that various contextual factors can make a covarying interpretation harder to obtain, and they propose adjustments to Moulton and Han’s stimuli that they think should lead to fast Gender Mismatch Effects even when no bona fide binding is involved. A series of self-paced reading experiments replicate the results from Moulton and Han, and then extend the paradigm to variations along the lines suggested by Kush and Eik. The adjustment of contextual factors indeed results in Gender Mismatch Effects for both environments. We discuss how the processing evidence informs the theoretical issues.  

Can DNA Methylation Profiling Classify Histologic Subtypes and Grades in Soft Tissue Sarcoma?

A clear classification of the subtype and grade of soft tissue sarcoma is important for predicting prognosis and establishing treatment strategies. However, the rarity and heterogeneity of these tumors often make diagnosis difficult. In addition, it remains challenging to predict the response to chemotherapy and prognosis. Thus, we need a new method to help diagnose soft tissue sarcomas and determine treatment strategies in conjunction with traditional methods. Genetic alterations can be found in some subtypes of soft tissue sarcoma, but many other types show dysregulated gene expression attributed to epigenetic changes, such as DNA methylation status. However, research on DNA methylation profiles in soft tissue sarcoma is still insufficient to provide information to assist in diagnosis and therapeutic decisions. (1) Do DNA methylation profiles differ between normal tissue and soft tissue sarcoma? (2) Do DNA methylation profiles vary between different histologic subtypes of soft tissue sarcoma? (3) Do DNA methylation profiles differ based on tumor grade? Between January 2019 and December 2022, we treated 85 patients for soft tissue sarcomas. We considered patients whose specimens were approved for pilot research by the Human Biobank of St. Vincent's Hospital, The Catholic University of Korea, as potentially eligible. Based on this, 41% (35 patients) were eligible; 1% (one patient) was excluded because of gender mismatch between clinical and genetic data after controlling for data quality. Finally, 39 specimens (34 soft tissue sarcomas and five normal samples) were included from 34 patients who had clinical data. All tissue samples were collected intraoperatively. The five normal tissue samples were from muscle tissues. There were 20 female patients and 14 male patients, with a median age of 58 years (range 19 to 82 years). Genomic DNA was extracted from frozen tissue, and DNA methylation profiles were obtained. Genomic annotation of DNA methylation sites and hierarchical cluster analysis were performed to interpret results from DNA methylation profiling. A t-test was used to analyze different methylation probes. Benjamini-Hochberg-adjusted p value calculations were used to account for bias resulting from evaluating thousands of methylation sites. The most common histologic subtypes were liposarcoma (n = 10) and leiomyosarcoma (n = 9). The tumor grade was Fédération Nationale des Centres de Lutte Contre Le Cancer Grades 1, 2, and 3 in 3, 15, and 16 patients, respectively. DNA methylation profiling demonstrated differences between soft tissue sarcoma and normal tissue as 21,188 cytosine-phosphate-guanine sites. Despite the small number of samples, 72 of these sites showed an adjusted p value of < 0.000001, suggesting a low probability of statistical errors. Among the 72 sites, 70 exhibited a hypermethylation pattern in soft tissue sarcoma, with only two sites showing a hypomethylation pattern. Thirty of 34 soft tissue sarcomas were distinguished from normal samples using hierarchical cluster analysis. There was a different methylation pattern between leiomyosarcoma and liposarcoma at 7445 sites. Using the data, hierarchical clustering analysis showed that liposarcoma was distinguished from leiomyosarcoma. When we used the same approach and included other subtypes with three or more samples, only leiomyosarcoma and myxofibrosarcoma were separated from the other subtypes, while liposarcoma and alveolar soft-part sarcoma were mixed with the others. When comparing DNA methylation profiles between low-grade (Grade 1) and high-grade (Grades 2 and 3) soft tissue sarcomas, a difference in methylation pattern was observed at 144 cytosine-phosphate-guanine sites. Among these, 132 cytosine-phosphate-guanine sites exhibited hypermethylation in the high-grade group compared with the low-grade group. Hierarchical clustering analysis showed a division into two groups, with most high-grade sarcomas (28 of 31) separated from the low-grade group and few (3 out of 31) clustered together with the low-grade group. However, three high-grade soft tissue sarcomas were grouped with the Grade 1 cluster, and all of these sarcomas were Grade 2. When comparing Grades 1 and 2 to Grade 3, Grade 3 tumors were separated from Grades 1 and 2. We observed a different DNA methylation pattern between soft tissue sarcomas and normal tissues. Liposarcoma was distinguished from leiomyosarcoma using methylation profiling. High-grade soft tissue sarcoma samples showed a hypermethylation pattern compared with low-grade ones. Our findings indicate the need for research using methylation profiling to better understand the diverse biological characteristics of soft tissue sarcoma. Such research should include studies with sufficient samples and a variety of subtypes, as well as analyses of the expression and function of related genes. Additionally, efforts to link this research with clinical data related to treatment and prognosis are necessary. Level III, diagnostic study.

Gender mismatch and bias in people‐centric operations: Evidence from a randomized field experiment

AbstractResearch at the interface of operations management (OM) and gender bias has mostly focused on operational outcomes such as hiring decisions on behalf of the employer (or firm). Largely overlooked is how the design of operational processes exacerbates (or diminishes) the amount of gender bias exhibited on behalf of the customer in a people‐centric operations environment. In this study, we conduct a randomized field experiment with a partner firm to assess gender mismatch and bias in client‐consultant exchanges. The experimental design enables us to examine gender bias within dyadic exchanges when there are gender matches (female client‐female consultant or male client‐male consultant) or gender mismatches (female client‐male consultant or male client‐female consultant). We find that reporting the consultant's gender significantly increases the client's likelihood of leaving more and higher reviews, increases the clickthrough rate on recommended products, and that the effect is stronger for females than for male consultants. We also provide support for the heterogenous effects of client experience depending on the gender (mis)match in client‐consultant exchanges, including whether the prior effects hold when there is gender masking or manipulation (e.g., reported female consultant when actually male). Our findings offer important theoretical contributions and practical implications for OM scholars and managers.

The effect of asymmetric grammatical gender systems on second language processing: Evidence from ERPs

Aims and objectives: This study examined the effect of the first language (L1) grammatical gender (GG) system on the second language (L2) gender agreement processing, particularly when L1 and L2 are asymmetric in their number of gender values such as in Spanish and German languages. Methodology: Behavioral and brain responses (ERPs) were registered while German native-speakers (16) and Spanish-German bilinguals (24) read sentences for comprehension. We manipulated gender agreement between the determiner and the noun: Der/*die Ring, “themasc/*thefem ringmasc.” The nouns were either of similar or opposite gender across languages or unique in L2 (neuter gender). Data and analysis: Behavioral responses measured participants’ ability to discriminate grammatical from ungrammatical sentences. For ERPs, N400 and P600 components were analyzed by means of a linear mixed-effect model. Findings/conclusion: Behavioral data showed that German native-speakers discriminated gender agreement violations better than Spanish-German bilinguals, irrespective of lexical gender overlap across languages. Native speakers showed a P600 effect to gender agreement violations, whereas bilinguals showed an N400-like effect to gender mismatches that involved same-gender nouns across languages and neuter gender nouns. Interestingly, opposite gender nouns between L1 and L2 that agreed in gender with the determiner were processed as incorrect for the bilinguals. These results suggest transfer effects from L2 learners’ L1 GG system that facilitate L2 gender agreement processing for similar and neuter gender nouns or hinder it for opposite gender nouns across languages. Originality: This study used ERPs to demonstrate how asymmetries in terms of the number of lexical gender categories between L1 and L2 GG systems can affect L2 learners’ ability to process L2 gender agreement in a native-like manner. Significance/implications: These findings elucidate the challenges L2 learners face when learning a three-gender value system in L2, including a great number of gender incongruences between L1 and L2 nouns and a new neuter gender category.

The Representation of Gender and Inflectional Class in Italian: A Reply to Kučerová 2018

Kučerová (2018) puts forward a novel theory of the morphology and interpretation of nominal gender in Italian. Here, we take issue with this theory from both empirical and theoretical standpoints. We first show that several generalizations presented as empirical support for it are incorrect. We then point out three fundamental theoretical challenges. First, the proposed three-way classification of nouns does not represent the full range of facts, because it does not take into account plural morphology or the interdependencies of class and gender features. Second, the account of gender mismatch in terms of “semicon-servativity” fails to capture the Italian data, once the full paradigm is considered. Finally, the use of phase theory to model contextual valuation of gender faces an insurmountable lookahead problem.

His or Her? Errors in Possessive Determiners Made by L2-English Native Spanish Speakers

Native Spanish speakers commonly confuse third person singular possessive determiners when making gender agreements, which is considered an error-prone grammatical feature because there are syntactic differences in their use between English and Spanish. This study conducted an elicited production task to explore whether proficiency in English affects the correct use of his/her by Spanish speakers in speech production, whether participants make more errors depending on the gender match or mismatch between the possessor and the possessum in the noun phrase, and whether there are differences in the number of errors made due to the gender of the possessor. The results showed that sentences with a gender mismatch condition had higher error rates and that advanced L2 speakers made fewer mistakes than less proficient ones. However, proficiency did not mitigate the number of errors in sentences which required the use of the feminine possessive determiner, which is in line with the theory of the default masculine gender in Spanish. The study provides valuable insights into the challenges faced by native Spanish speakers when producing possessive gender agreements in English and highlights the need for more targeted instruction to address these issues in the teaching of English as a foreign language.

Pretransplant erythroferrone levels are predictive of 1-year all-cause mortality or acute rejection after heart transplantation

Abstract Background/Introduction Heart transplantation (HTx) remains the treatment of choice for selected advanced heart failure (HF) patients. Iron deficiency is a significant factor in the prognosis of HF, and iron metabolism may play a role after HTx since pretransplant hemoglobin levels predict posttransplant 1-year all-cause mortality. In addition, iron deficiency (ID) is known to impact antigen-specific immune response. Purpose The aim of this study was to quantify the impact of pretransplant iron metabolism components on the primary composite outcome 1-year all-cause mortality (ACM) or 1-year acute cellular rejection. Methods This prospective Swiss national cohort study included consecutive patients with HTx between 2008 to 2017. Iron metabolism was assessed measuring plasma iron, ferritin, erythroferrone (ERFE), hepcidin and interleukin-6 immediately before transplant surgery. Endomyocardial biopsies were procured in accordance with the common national posttransplant surveillance protocol. Acute cellular rejection was defined as histological 2R or 3R rejection according to the ISHLT nomenclature 2004 in the diagnosis of heart rejection. Results A total of 276 HTx recipients were included, median age was 52 [IQR 41;59] years, 24.6% (n=68) were females. HTx recipients with incident combined endpoint (n=118, 42.8%) were not significantly different from controls for demographic or transplant operation parameters, donor/recipient gender or HLA mismatch, ferritin, hepcidin (0.5 [IQR 0.5-1.5] vs. 0.5 [IQR 0.5-1.2]; p=0.382) µg/L), interleukin-6, and most biological parameters associated with posttransplant risk. However, participants with incident combined endpoint had lower haemoglobin levels (125 [IQR 102-134] vs. 128 [IQR 114-141 ] g/L; p=0.004), lower Na+ levels (137.5 [IQR 135-139 ] vs. 138 [IQR 136-140] mmol/L; p=0.017), and higher ERFE levels (1.40 [IQR 0.84-1.84 ] vs. 1.19 ng/mL [IQR 0.91-2.92]; p=0.013) compared to those without the endpoint (n=158, 57.2%). The incidence of the combined endpoint was higher in patients presenting with ERFE levels above the third quartile (&amp;gt;2.25 ng/mL; p=0.003). Multivariable analysis using stepwise backward elimination (table) showed that ERFE levels &amp;gt;2.25 ng/mL predicted the incidence of the combined endpoint with an OR of 2.17 (95% CI: 1.19-3.94) (p=0.011). Conclusion The study demonstrates that increased pretransplant ERFE levels are independently associated with 1-year posttransplant all-cause mortality and 1-year acute cellular rejection. This association is in line with results from chronic kidney disease indicating association of ERFE levels with cardiovascular outcome and studies showing iron-induced immune cell activation. In fact, ERFE reduces hepcidin expression as shown in the present and other studies. Thereby, intestinal iron uptake increases resulting in immune cell activation which may explain the higher incidence of heart rejection observed in the present study.FigureTable

The impact of recipient and donor gender-match and mismatch on the post-liver transplant outcomes of patients with primary biliary cholangitis.

In this study, we evaluate the effects of donor gender on post-liver transplant (LT) prognosis. We specifically consider patients with primary biliary cholangitis (PBC). The 2005 to 2019 UNOS transplant registry was used to select patients with PBC. The study cohort was stratified by donor gender. All-cause mortality and graft failure hazards were compared using iterative Cox regression analysis. Subanalyses were performed to evaluate gender mismatch on post-LT prognosis. There were 1885 patients with PBC. Of these cases, 965 entries had male donors and 920 had female donors. Median follow-up was 4.82 (25-75% IQR 1.83-8.93) years. Having a male donor was associated with higher all-cause mortality (aHR 1.28 95%CI 1.03-1.58) and graft failure (aHR 1.70 95%CI 1.02-2.82). Corresponding incidence rates were also relatively increased. In the sub-analysis of female recipients (n=1581), those with gender-mismatch (male donors, n=769) were associated with higher all-cause mortality (aHR 1.41 95%CI 1.11-1.78) but not graft failure. In the male recipient subanalysis (n=304), no associations were found between gender-mismatch (female donors, n=108) and all-cause mortality or graft failure. This study shows that recipients who have male donors experienced higher rates of all-cause mortality following LT. This finding was consistent in the female recipient-male donor mismatch cohort.

Not all grammar errors are equally noticed: error detection of naturally occurring errors and implications for eye-tracking models of everyday texts.

Grammar errors are a natural part of everyday written communication. They are not a uniform group, but vary from morphological errors to ungrammatical word order and involve different types of word classes. In this study, we examine whether some types of naturally occurring errors attract more attention than others during reading, measured by detection rates. Data from 211 Danish high school students were included in the analysis. They each read texts containing different types of errors: syntactic errors (verb-third word order), morphological agreement errors (verb conjugations; gender mismatches in NPs) and orthographic errors. Participants were asked to underline all errors they detected while reading for comprehension. We examined whether there was a link between the type of errors that participants did not detect, the type of errors which they produce themselves (as measured in a subsequent grammar quiz), and the type of errors that are typical of high school students in general (based on error rates in a corpus). If an error is infrequent in production, it may cause a larger surprisal effect and be more attended to. For the three subtypes of grammar errors (V3 word order, verb errors, NP errors), corpus error rates predicted detection rates for most conditions. Yet, frequency was not the only possible explanation, as phonological similarity to the correct form is entangled with error frequency. Explicit grammatical awareness also played a role. The more correct answers participants had in the grammar tasks in the quiz, the more errors they detected. Finally, we found that the more annoyed with language errors participants reported to be, the more errors they detected. Our study did not measure eye movements, but the differences in error detection patterns point to shortcomings of existing eye-tracking models. Understanding the factors that govern attention and reaction to everyday grammar errors is crucial to developing robust eye-tracking processing models which can accommodate non-standard variation. Based on our results, we give our recommendations for current and future processing models.

#2515 GENDER DIFFERENCES IN KIDNEY TRANSPLANTATION: A 10-YEAR RETROSPECTIVE STUDY

Abstract Background and Aims Chronic kidney disease represents a world-wide health problem, affecting approximately 195 million women around the world. Risk of development of chronic kidney disease is greater in women in comparison to men. Method We retrospectively analysed cohort of 1457 patients after kidney transplantation from all transplant centres in Slovakia over period of ten years from 2010 – 2020. Parameters taken into account were cause of end-stage renal disease (ESRD), outcome of transplantation in a context of differences between the genders. Results Out of 1,457 patients, 557 (517 primary transplantation) were women, 900 (831) men. Primary causes leading to end-stage renal disease (ESRD) in female recipients where we observed a statistically significant difference between genders were tubulointerstitial nephritis (32.1% in females vs. 22.3% in males, p&amp;lt;0.0001), autosomal dominant polycystic kidney disease (17.6% vs. 11.6%, p = 0.0013), and systemic lupus erythematosus (2.3% vs. 0.2%, P = .0001). In male recipients native kidneys were more frequently affected by glomerulonephritis (38% vs. 25.7%, p&amp;lt;0.0001), nephropathy as a complication of type 2 diabetes mellitus (7.8% vs. 4.1%, p&amp;lt;0.0001), and IgA nephropathy (2.9% vs. 1.1%, P = .0232). There were no statistically significant gender differences in other causes of ESRD. However, there was no significant difference in time spent on dialysis between female and male recipients (39.4 ± 39 months vs. 35.8 ± 33.2 months, p&amp;gt;0.05), female recipients waited for a kidney transplant significantly longer (32.9 ± 27.4 months vs. 39.4 ± 31.5 months, p&amp;lt;0.0001). Overall death-censored graft survival rates in our cohort in female and male recipients were after 12 months 91.2% vs. 93.1%, p=NS, 5 years 80.7% vs. 82.6%, p=NS, and 10 years 60% vs. 66.7%, p=NS (Fig. 1). After 12 months, 5 and 10 years, the overall patient survival rates among female vs. male recipients were 96.8% vs. 97.1%, p=NS; 89.9% vs. 88.9%, p=NS; and 72.9% vs. 76%, p=NS (Fig. 2), respectively. Conclusion Despite comparable patient and graft survival rates in male and female recipients in our study, there are other studies showing that gender, as well as gender mismatch significantly influence outcomes of transplantation.

Prognostic factors for lung transplant recipients focusing on age and gender: the Japanese lung transplantation report 2022

PurposeTo clarify the impact of donor and recipient characteristics on the survival of recipients before and after lung transplantation in the Japanese population.MethodsPatients’ data were collected for retrospective analysis from all authorized lung transplant centers in Japan. We included 1963 patients listed for lung transplantation by the end of December 2021, comprised of 658 deceased-donor and 270 living-donor lung transplants.ResultsPrimary disease had a significant impact on the mortality of patients waiting for transplantation. The indications for transplant significantly affected the post-transplant survival rate of deceased-donor lung transplant recipients. The recipient’s age also significantly affected the post-transplant survival rate of the deceased-donor and living-donor lung transplant recipients. The recipients of grafts transplanted from donors aged 61 years or older showed a worse post-transplant survival rate (≧60 years old). The survival rate for the combination of a female donor to a male recipient among the deceased-donor lung transplant recipients was the worst among the four combinations.ConclusionThe donor and recipient characteristics significantly impacted the survival of recipients after lung transplantation. The underlying mechanism of the negative impact of the gender mismatch of female donor to male recipient on post-transplant survival needs to be investigated further.

Gender mismatch and bias in people‐centric operations: Evidence from a randomized field experiment

AbstractWhile considerable progress has been made in understanding gender mismatch and bias in the physical workplace, there is a limited understanding of how these biases manifest in online platforms where gender masking and manipulation can easily occur. In this study, we collaborate with an online product and service firm in Asia and propose a field experiment design to examine how gender bias influences people‐centric operations in online platforms. By assigning different gender combinations of clients and consultants, we examine how the effect of gender bias differs depending on the gender match or mismatch of the entities in the information exchange process. Using 7 months of data, we provide preliminary evidence of gender biases of different client‐consultant gender pairings. Theoretical and practical implications are discussed.

"Incidence and significance of donor-specific antibodies in haploidentical stem cell transplantation".

PGF is a devastating complication after allogeneic transplant. We retrospectively analyzed our haploidentical transplant registry to report the incidence and impact of DSA and anti-HLA on engraftment. 107 patients were identified. Median recipient-age of 22, median donor-age of 31. Sixty-two patients had AML (58%), 29 had ALL (27%), 16 (15%) had other malignancies. Sixty-one recipients (57%) had positive anti-HLA, 56 of them had the DSA results available, of these 17 patients had DSAs (15% of the total number of patients, or 28% of patients who have anti-HLA antibodies). The median cumulative MFI was 2062. Sixty-three percent of the DSA were against class-II HLA antigens. The OS, CIR, aGvHD, and cGvHD did not differ between patients with and without anti-HLA antibodies, nor between patients with and without DSA. The gender of the recipient and donor, as well as the gender mismatch between recipient and donor, were statistically associated with the incidence of anti-HLA antibodies. Three patients only developed GF (2.8%), one was primary (0.9%) and the other two secondary GF (1.9%). None of the GF cases was in patients with anti-HLA antibodies or DSA. The presence of anti-HLA or DSAs did not affect the outcomes including the incidence of PGF.

Genetic Validation of Psoriasis Phenotyping in UK Biobank Supports the Utility of Self-Reported Data and Composite Definitions for Large Genetic and Epidemiological Studies

Genetic Validation of Psoriasis Phenotyping in UK Biobank Supports the Utility of Self-Reported Data and Composite Definitions for Large Genetic and Epidemiological Studies

Grammars for placeholders: The dynamic turn

In verbal communication, when a speaker encounters a word-formulation problem (e.g. memory lapse), she may resort to several linguistic strategies, including the use of a placeholder (PH). A PH is a dummy item with which a speaker fills in the syntactic slot of a target form that she is unable or unwilling to produce. There is a growing body of work investigating PHs in a variety of languages, but the bulk of extant studies provide a descriptive and/or functional analysis and little attention has been paid to formal modelling. In the present article, we offer a wide range of PH examples in Japanese, French, and German, including new data on gender mismatches, and develop a formal account in Dynamic Syntax. We propose a general mechanism to process a PH time-linearly and show how it is implemented in the grammars of several languages. In this analysis, a PH-involving string is parsed incrementally, and a conceptual structure is built up progressively, during which a PH introduces a meta-variable, to be updated based on the parse of a target form on an unfixed node or a LINKed node. The account is further extended to various PH-involving dialogic phenomena in talk-in-interaction.

Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality

Background: De novo post-transplant diabetes mellitus (PTDM) is a frequent complication among renal transplant recipients; it confers a high risk for graft failure and patient mortality. This single-centre study aimed to determine the incidence and risk factors of PTDM and its effects on graft outcome and mortality. Methods: In a single-centre longitudinal cohort analysis of 383 non-diabetic renal transplant follow-up recipients, outcomes were analysed through a detailed chart review. We hypothesized that different donor and recipient characters such as age, gender, and HLA mismatch would affect PTDM development in renal transplant recipients. PTDM is defined on basis of fasting plasma sugar (≥7 mmol/L or ≥126 mg/dL), random plasma sugar (≥11.1 mmol/L or ≥200 mg/dL), and glycated haemoglobin (HBA1C: >6.5% or 48 mmol/mol). We assessed PTDM incidence, risk factors, and its effect on patient mortality and graft outcome using Cox regression. Results: The mean age at the time of transplantation was 35.70 (±14.27) years, and 50.91% were male. PTDM incidence in the study period was 23.30%. Independent risk factors include older age at the time of transplantation, cyclosporine immunosuppression, cytomegalovirus, and hepatitis C virus infection. PTDM is not associated with graft dysfunction, whereas it significantly carries high mortality. Conclusion: PTDM is common among renal transplant recipients. Older age at the time of transplantation, cyclosporine immunosuppression, cytomegalovirus, and hepatitis C virus are risk factors. PTDM carries high mortality but is not associated with graft failure.

Donor gender effect on graft function in adult Egyptian patients undergoing living donor liver transplantation: A single centre study

ABSTRACT Background The aim of this study was to evaluate the role of donor-to-recipient gender match in the setting of living donor liver transplant as a potential predictor of graft and recipient survivals. Methods In this retrospective, single-center study, the data of 342 adult primary liver transplants were analyzed. The donor and recipient’s characters, intraoperative data, and postoperative outcomes were recorded. Results The donor-recipient gender matched patients had significantly better graft survival outcomes than the gender mismatched ones. The 2-year graft survival probability was 95.7% in the matched group compared to 89.1% in the mismatched one (p = 0.026). A female donor-male recipient combination (87.3%) showed worse 2-years graft survival than a male-to-male transplant (94.8%), while it gave better graft survival than male to female (61.3%). The estimated relative risk of graft rejection was 5.91 times significantly higher in a male–female combination than in a male-to-male one (Hazard ratio = 5.91, 95% CI = 1.34–26.11). Conclusion This study suggests that donor-recipient gender mismatch is associated with poor liver graft survival outcomes, with higher risk of graft rejection in male-female transplants than in male-to-male ones. Though, further larger studies including multiple datasets are needed, with adjustments for various graft, donor, and recipient factors to reach solid evidence.