The emergence of Industry 4.0 (I4.0) is reshaping industries worldwide, driven by rapid technological progress and the need for open innovation. This study focuses on understanding the interdependencies of driving factors of I4.0 maturity in developing countries using Fuzzy Multi-Criteria Decision Analysis (MCDA) methods. By analyzing Indonesia, Pakistan, and Venezuela, the research aims to foster open innovation and address the unique challenges these nations face in adopting I4.0 technologies. I4.0 maturity models are essential for evaluating current maturity levels and identifying areas for improvement. However, the complexity and interdependence of various factors—ranging from data science and technology to policy, governance, and open innovation dynamics, such as social open innovation and the role of SMEs—complicate this process. This study employs Fuzzy TOPSIS and Fuzzy DEMATEL to identify the critical factors influencing I4.0 maturity and analyze their interdependencies and prioritization. The results indicate that 'Data and Information' and 'Willingness to Change' are crucial across all countries, while strategic differences between large enterprises and SMEs highlight the need for tailored approaches. This research highlights the importance of continuous IT investment, digital leadership, collaborative ecosystems, and agile strategies in fostering open innovation and driving I4.0 adoption. This research contributes to the theoretical and practical understanding of I4.0 maturity, offering valuable insights for practitioners and academics to explore the dynamic interactions of I4.0 factors and their impact on operational efficiency.