ABSTRACT Frictional dermatitis is a cutaneous change resulting from prolonged friction on the Atopic dermatitis skin. Over the last 6 months, we came across 20 atopic dermatitis patients with acanthosis nigricans, periorbital perioral pigmentation, maturational hyperpigmentation, pigmented transverse nasal band, and/or cutaneous amyloidosis lesion. Treatment given for atopic dermatitis (oral steroid, tofacitinib, and cytotoxic drugs improved atopic dermatitis and frictional dermatitis change (acanthosis nigricans, periorbital and/or perioral pigmentation, maturational hyperpigmentation, pigmented transverse nasal band, and cutaneous amyloidosis lesion). However, both atopic dermatitis and frictional dermatitic change recurred within 2–4 weeks of discontinuing the therapy for atopic dermatitis. Based on the site of occurrence (body fold and possible friction on the body), and response atopic dermatitis treatment these changes were hypothesized to be possibly due to the result of 1) trauma on the atopic skin developed frictional dermatitic change due to flexion, extension, and friction. This is reported to bring awareness among the physicians that the changes like acanthosis nigricans, periorbital perioral pigmentation, maturational hyperpigmentation, pigmented transverse nasal band, cutaneous amyloidosis may the atopic dermatitis developed following friction induced by frictional dermatitis induced by itch, friction, or body fold movement (flection and extension), in atopic dermatitis patients.
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