Frequent Component Research Articles

Sinemurian biostratigraphy of the Tannscharten section near Reichraming (Lower Jurassic, Schneeberg Syncline, Northern Calcareous Alps)

Abstract Lower Jurassic ammonites were collected from deep-water limestones of the Tannscharten section, southwest of Reichraming (Northern Calcareous Alps, Upper Austria). The outcrop provides a rich Upper Sinemurian (Lower Jurassic) ammonite fauna of the Allgäu Formation. The area is situated in the westernmost part of the Schneeberg Syncline in the north of the Reichraming Nappe (High Bajuvaric Unit). The ammonite fauna consists of seven different genera, each apparently represented by 1-2 species. Echioceratids are the most frequent components (Echioceras, Leptechioceras, Paltechioceras), followed by the phylloceratids (Juraphyllites, Partschiceras) and oxynoticeratids (Gleviceras, Paroxynoticeras). Juraphyllites libertus, Partschiceras striatocostatum, Gleviceras paniceum, Echioceras quenstedti, Echioceras raricostatoides, Paltechioceras boehmi, Leptechioceras meigeni, Leptechioceras macdonnelli and Paltechioceras oosteri are new for the Schneeberg Syncline and allow for the first time a detailed biostratigraphy of the Echioceras raricostatum zone. The assemblage is correlated with other faunae from Austria, Germany, United Kingdom, France, Switzerland and Romania. The cephalopod fauna consists of a mix of elements from the Northwest European Province and the Mediterranean Province. The detailed biostratigraphy based on ammonites is presented here.

Pathogenesis of ANCA-Associated Pulmonary Vasculitis.

Antineutrophil cytoplasmic antibodies (ANCAs) are autoantibodies specific for antigens located in the cytoplasmic granules of neutrophils and lysosomes of monocytes. ANCAs are associated with a spectrum of necrotizing vasculitis that includes granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. Pulmonary vasculitis and related extravascular inflammation and fibrosis are frequent components of ANCA vasculitis. In this review, we detail the factors that have been associated with the origin of the ANCA autoimmune response and summarize the most relevant clinical observations, in vitro evidence, and animal studies strongly indicating the pathogenic potential of ANCA. In addition, we describe the putative sequence of pathogenic mechanisms driven by ANCA-induced activation of neutrophils that result in small vessel necrotizing vasculitis and extravascular granulomatous necrotizing inflammation.

Serum uric acid predicts incident metabolic syndrome in the elderly in an analysis of the Brisighella Heart Study

Several epidemiological studies report a positive correlation between hyperuricemia and metabolic syndrome (MetS) in adults, which hyperuricemic subjects seem to more easily develop. We aimed to verify if serum uric acid (SUA) concentrations were positively associated with MetS prevalence and middle-term (4-year) incidence in older overall healthy subjects. We also purposed to identify which SUA cut-off values could be functional in MetS diagnosis in addition to the traditionally used parameters. For this reason, we selected from the historical cohort of the Brisighella Heart Study 923 older healthy subjects repeatedly visited during the 2008 and 2012 population surveys. In our sample, MetS was more frequent for higher SUA concentrations rather than the population’s mean in both men [OR = 2.12, 95%C.I.(1.55, 2.90)] and women [OR = 2.69,95%C.I.(1.91, 3.78)]. ROC analysis showed SUA was predictive of MetS in the whole population [AUC = 0.647, 95%C.I.(0.609, 0.686), P = 0.000001] and in both sex subgroups [men: AUC = 0.592, 95%C.I.(0.529, 654); P = 0.004; women: AUC = 0.758, 95%C.I.(0.711, 0.806), P < 0.000001], even there were sex-related differences in the best cut-off values (5.5 mg/dL for men; 4.2 mg/dL for women). Prospectively, SUA appeared predictive of middle-term (4-year) MetS incidence in the whole population (AUC = 0.604, 95%C.I.[0.518, 0.690], P = 0.029, best cut-off value = 4.7 mg/dL) and in the female group (AUC = 0,641, 95%C.I.[0.519, 0.762], P = 0.039, best cut-off value = 3.9 mg/dL) though not in the male one (P > 0.05). In conclusion, in our cohort, SUA is a frequent component of MetS, other than a middle-term predictor of newly diagnosed MetS in older women.

New Data on Endohelminth Communities of Barbel Barbus Barbus from the Bulgarian Part of the River Danube.

SummarySpecies diversity and composition of the parasite communities of barbel (Barbus barbus) at the infracommunity and component community levels were studied in the Lower Danube River, Bulgaria. During the two-year investigations, five parasite species have been found in 92 host fish: Bathybothrium rectangulum (Cestoda), Acanthocephalus anguillae and Pomphorhynchus laevis (Acanthocephala) and larval stages of Contracaecum sp. and Raphidascaris acus (Nematoda). Bathybothrium rectangulum and R. acus found in barbel represented new host records in Bulgaria. Parasite communities of barbel were species-poor and highly unbalanced. Pomphorhynchus laevis represented the dominant (core) species (prevalence 98.9 %), the second most frequent component parasite was Contracaecum sp. (P = 14.1 %) and remaining three species occurred only accidentally in barbels. Differences in species richness, prevalence, intensity of infection and ecological indices between individual seasons (spring, summer, autumn) were statistically signifi cant, but considerably affected by unequal species structure of communities with highly prevailing P. laevis. Low parasite species diversity of barbel and low values of most ecological indices, when compared with previous studies in this area (or other Bulgarian parts of the River Danube) might indicate that environmental conditions are impaired and thus, not favourable for the development of barbel parasites (primarily to their intermediate host survival) in the Lower Danube River of Bulgaria.

Testicular germ cell tumors: revisiting a series in light of the new WHO classification and AJCC staging systems, focusing on challenges for pathologists

Testicular germ cell tumors (TGCTs) are strikingly heterogeneous, reflecting a complex tumor model, posing serious challenges for pathologists. Accurate classification and staging, according to most recent systems, is fundamental. We aimed to revise a series of consecutively diagnosed TGCTs (2005-2016) in light of the new World Health Organization (WHO) classification and American Joint Committee on Cancer (AJCC) staging systems, discussing dilemmas imposed to pathologists. All 164 patients' clinical files/histological slides were reviewed. Follow-up was last updated on November 2017. Statistical analysis was performed with SPSS (v24). P < 0.05 was considered significant. Non-seminomatous tumors (NSTs) showed more frequently cysts, necrosis, hemorrhage, lymphovascular invasion (LVI) and higher stage than seminomas (SEs) (P < .001, P = .015, P < .001, P = .001, P = .007). Embryonal carcinoma (EC), yolk sac tumor (YST) and teratoma (TE) were the most frequent components in mixed tumors (82.5%, 82.5% and 80.7%). SEs with "atypical features" showed more LVI, higher mitotic count and more extensive necrosis (P = .030, P < .001, P = .016). LVI and >50%EC component, but not rete testis invasion, were associated with higher stage (P < .001, P = .009). Regarding SEs, there was an association between tumor size and both stage (P = .004) and LVI (P < .001). Only four patients disclosed altered stage group when AJCC 8th Edition was employed. Disease recurrence/progression occurred in 5.4% of cases. In two cases, tumor components in metastasectomy specimens were not present in the primary TGCT. Overall survival at 5 years was 98.6%. TGCTs are challenging neoplasms, and pathologists and clinicians alike must be aware of recent updates in classification and staging for adequately tailoring treatment strategies.

A Anamnese Fonoaudiológica segundo os preceitos da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF)

Objetivo: identificar, por meio da anamnese fonoaudiológica, quais as categorias e componentes mais frequentes relacionados à funcionalidade segundo os princípios da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF), em quadros de Transtornos de Linguagem e Fala. Métodos: pesquisa retrospectiva de acervo parcial de registros de entrevista fonoaudiológica de clínica-escola, correspondente a 1000 casos avaliados entre os anos de 2004 a 2013; após cálculo estatístico, constituiu-se uma amostra por conveniência de 110 protocolos. Analisaram-se os registros da anamnese de acordo com as 362 categorias do nível dois da CIF e considerou-se na seleção um corte, arbitrário, nas 30 primeiras categorias mais frequentes de cada domínio e entre todas elas, para o agrupamento. Para o tratamento estatístico adotou-se o Teorema do Limite Central e a Leis dos Grandes Números para o cálculo pré-amostral e o teste não-paramétrico Igualdade de Duas Proporções, na análise da frequência. Resultados: as categorias mais frequentes foram: b176 (funções mentais para a sequência de movimentos complexos), d310 (comunicar e receber mensagens orais), d330 (falar) e e410 (atitudes individuais de membros da família próxima). Os componentes mais frequentes foram função do corpo e atividades/participação, os menos frequentes, os fatores ambientais e estrutura do corpo. As queixas “aprendizagem e fala” e “dificuldades de aprendizagem” foram as que apresentaram mais categorias nos componentes. Conclusão: foi possível a identificação de categorias e componentes da CIF, relacionados à funcionalidade, recorrentes em relatos da anamnese fonoaudiológica. Deste modo, esse resultado amplia o olhar e o cuidado do fonoaudiólogo com a saúde do indivíduo.

Dynamic correction for forefoot varus in stage II-A adult flatfoot: Technique tip

Posterior tibial tendon dysfunction (PTTD) is a progressive disorder and a common cause of adult acquired flatfoot deformity, and forefoot varus is a frequent component in advanced cases. The author proposes peroneus brevis-to-longus transfer as an additional step to correct the forefoot varus component of stage II-A posterior tibial tendon dysfunction. We have performed this dynamic correction of forefoot varus in 12 patients at our institution, and observed promising clinical and radiographic improvement. It is a soft tissue procedure that avoids additional incisions and represents a favorable alternative to more demanding techniques, such as osteotomy or arthrodesis.

Kidney Stone Composition in Third-World Areas: What Kashgar Tells Us?

To analyze urinary stone compositions in patients from Kashgar, China. We analyzed the components of urinary stones in 732 consecutive patients with urolithiasis admitted to the First and Second People's Hospital of Kashgar Prefecture, Xinjiang, from July 2014 to November 2016. The patients were divided into two groups by ages: group A, 0 to 18 years and group B, >18 years old. The distributions of various stone compositions were analyzed and correlated with the gender and age. The mean age of group A was 3.90 ± 4.09 years and that of group B was 39.88 ± 16.40 years. The overall gender ratio (male:female) was 2.27:1. Ammonium acid urate (AAU) stone was the most frequent stone, male 35.83% and female 33.48%. Female patients were significantly more common than male patients in calcium apatite stone (p = 0.004). Of all 732 cases, patients younger than 18 years were more than patients older than 18 years (58.47% vs 41.53%). The majority of the patients (77.87%) had the stone located in the upper urinary tract. Two peak ages for both genders were noted in 1 to 3 years and 19 to 40 years group of the patients. In group of 1 to 3 years patients, male were more than female (37.60% vs 24.55%, p = 0.001), whereas in the group of 10 to 18 years patients, female were more than male (10.71% vs 4.13%). AAU was the predominant stone component in group <1 year (70. 5%, p < 0.01, as compared with other groups.). Uric acid stone was more prevalent in group >60 years (66.8%, p < 0.01) than in other groups. Patients in 1 to 3 years were in the peak age group of AAU stones in both the upper and lower urinary tract. Most of the patients with urolithiasis diagnosed and treated in Kashgar are <18 years old, especially younger than 3 years old. The most frequent stone component in this area was AAU. More than 50% patients <18 years old had AAU stone. The mechanisms that could trigger the high prevalence of AAU stone in patients <18 years old are worth further investigation.

Blunt Chest Trauma: A Radiologic Approach and Review

Blunt chest trauma, a frequent component of trauma admissions, is the second leading cause of death in motor-vehicle accidents. Additionally, it may be associated with significant morbidity in those who survive. Radiography, ultrasonography, and computed tomography (CT) have a widespread role in evaluating blunt chest trauma, importantly aiding in the diagnosis and management of injury. Herein, we discuss the most common salient injuries, imaging protocol considerations and imaging findings associated with acute blunt chest trauma.

Effective therapies for the treatment of complex posttraumatic stress disorder: A qualitative systematic review

Background. Current literature shows that posttraumatic stress disorder and complex posttraumatic stress disorder symptoms differ. Although the psychological treatments available for posttraumatic disorder are well established, little is known about the effectiveness of those aimed at the treatment of complex posttraumatic stress. Objective. To evaluate the efficacy of psychological treatments for complex posttraumatic stress disorder. Method. A systematic qualitative search was conducted according to PRISMA guidelines, searching four psychological and health electronic databases: Medline, Pilots, PsycINFO, and Pubmed. Three reviewers independently selected the studies in two phases: preselection (criteria for complex posttraumatic stress disorder, replicable psychological treatment, and treatment effect) and selection (additional criteria: type of study, participants, and treatment). Results. Of the 615 studies reviewed, 25 were preselected, eight of which met the inclusion and methodological quality criteria. Five studies explored adult populations (with one exception, all were randomized clinical trials) and three child populations (clinical studies with pre- post-treatment design, with and without control group). Most studies with adult populations included psychoeducation, cognitive restructuration, and exposure therapy. The studies with child samples included EMDR and mindfulness as the most frequent treatment components. Discussion and conclusion. The evidence was insufficient to determine the most effective treatment. More research on this issue is required.

СТРУКТУРНО-СЕМАНТИЧЕСКАЯ КЛАССИФИКАЦИЯ СЛОЖНЫХ СУЩЕСТВИТЕЛЬНЫХ АВИАЦИОННОГО АНГЛИЙСКОГО ЯЗЫКА

The article considers compound nouns of aviation English. The author examines the structure of compound nouns, provides the examples of different models of compound nouns, identifies the most productive model and within this model differentiates the most frequent components. Semantic relations between the components of compound nouns are determined. Lexico-semantic groups of nouns in the structure of a compound word are identified. The originality of the study lies in the fact that in spite of a great number of linguistic papers devoted to stem-composition and compound words, compound nouns of aviation English for the first time become an object of the research.

HISTOPATHOLOGICAL CHARACTERISTICS OF PLEOMORPHIC ADENOMA; A RETROSPECTIVE ANALYSIS OF 120 CASES

Background: The salivary gland pleomorphic adenoma (PA) is a benign epithelial neoplasm, histologically characterized by a great diversity of morphological aspects. It is the most common neoplasm of salivary gland origin. Objective: Studying the histopathological characteristics of PA with special attention to the various morphological features of the epithelial cells and stromal components of this neoplasm. Methods: Hematoxylin and Eosin (H&amp;E) stained tissue sections of 120 cases of PA were reviewed. The tumors were classified according to their histological subtypes as described by Seifert et al. The epithelial components were analyzed considering the type of cells and the morphological pattern. The stromal components were analyzed according to the presence of myxoid, hyaline, chondroid or calcified tissue. Results: This study revealed that most of the tumors were located in the parotid gland (44%). Myxoid or stroma-rich was the most frequent histological subtype (43%). Plasmacytoid cells were the most commonly seen epithelial component (100%), followed by cuboidal cells in (80%) of the cases. Trabecular pattern was the predominant epithelial morphological pattern (90 %), and the myxoid component was the most frequent stromal component (80%). Conclusion: PA of the salivary glands demonstrates a wide variety of cells, stromal components, and morphological characteristics. Since it is the most frequent salivary gland neoplasm that can resemble other salivary gland tumors, the knowledge about these variations is essential for a correct diagnosis. Keywords: Histopathology, pleomorphic adenoma, salivary gland neoplasms Citation: Sarkis SA, Al-Drobie BF, MajeedGH, Al-Marzooq TJM.Histopathological characteristics of pleomorphic adenoma; a retrospective analysis of 120 cases. Iraqi JMS. 2018; Vol. 16(1): 84-91. doi: 10.22578/IJMS.16.1.12

Show and Tell: Video Modeling and Instruction Without Feedback Improves Performance but Is Not Sufficient for Retention of a Complex Voice Motor Skill

Modeling and instruction are frequent components of both traditional and technology-assisted voice therapy. This study investigated the value of video modeling and instruction in the early acquisition and short-term retention of a complex voice task without external feedback. Thirty participants were randomized to two conditions and trained to produce a vocal siren over 40 trials. One group received a model and verbal instructions, the other group received a model only. Sirens were analyzed for phonation time, vocal intensity, cepstral peak prominence, peak-to-peak time, and root-mean-square error at five time points. The model and instruction group showed significant improvement on more outcome measures than the model-only group. There was an interaction effect for vocal intensity, which showed that instructions facilitated greater improvement when they were first introduced. However, neither group reproduced the model's siren performance across all parameters or retained the skill 1 day later. Providing verbal instruction with a model appears more beneficial than providing a model only in the prepractice phase of acquiring a complex voice skill. Improved performance was observed; however, the higher level of performance was not retained after 40 trials in both conditions. Other prepractice variables may need to be considered. Findings have implications for traditional and technology-assisted voice therapy.

Detailed pathologic analysis on the co-occurrence of non-seminomatous germ cell tumor subtypes in matched orchiectomy and retroperitoneal lymph node dissections.

The frequency of co-occurrence between germ cell tumor (GCT) components in non-seminomatous germ cell tumor (NSGCT) orchiectomy specimens and their correlation with histologic findings in subsequent retroperitoneal lymph node dissection (RPLND) specimens have not been well characterized. The objective of the study was to report the first detailed clinicopathologic analysis of NSGCT orchiectomy and RPLND samples to determine the likelihood and agreement of the co-occurrence of GCT components. A total of 118 consecutive patients with NSGCT treated between 1988 and 2012 who underwent both orchiectomy and RPLND at a single academic tertiary care center were analyzed. Statistical analysis of co-occurrence likelihood and agreement of GCT components was performed, both within and between orchiectomy and RPLND specimens. Embryonal carcinoma was the most frequent component present in orchiectomy specimens, and there were multiple significant associations between orchiectomy GCT components; seminoma occurred less frequently with embryonal carcinoma (OR 0.29 [95% confidence interval (CI) 0.11-0.75]; p<0.01), and teratoma more frequently occurred with choriocarcinoma (OR 9.64 [95% CI 1.22-76.12]; p=0.01). Presence of teratoma in the orchiectomy specimen predicted for a fourfold increase in distant metastasis on multivariate analysis (HR 4.92 [1.14-18.9]; p=0.02). The only significant association of co-occurrence in the RPLND specimen was between embryonal carcinoma and teratoma (OR 0.01 [95% CI 0-0.07]; p<0.001), where it was significantly less likely for them to occur together. Our findings are limited by their retrospective nature. The co-occurrence of GCT components within orchiectomy specimens does not appear to be a completely random process. However, there is less agreement and more randomness between the occurrence of the GCT components in matched orchiectomy and RPLND samples. In this report, we look at the co-occurrence of different GCT components within matched orchiectomy and RPLND pathology specimens and show that co-occurrence is not a completely random process.

Connection between jets, winds and accretion in T Tauri stars

Mass loss from jets and winds is a key ingredient in the evolution of accretion discs in young stars. While slow winds have been recently extensively studied in T Tauri stars, little investigation has been devoted on the occurrence of high velocity jets and on how the two mass-loss phenomena are connected with each other, and with the disc mass accretion rates. In this framework, we have analysed the [O i]6300 Å line in a sample of 131 young stars with discs in the Lupus, Chamaeleon and σ Orionis star forming regions. The stars were observed with the X-shooter spectrograph at the Very Large Telescope and have mass accretion rates spanning from 10-12 to 10-7M⊙ yr-1. The line profile was deconvolved into a low velocity component (LVC, | Vr | &lt; 40 km s-1) and a high velocity component (HVC, | Vr | &gt; 40 km s-1), originating from slow winds and high velocity jets, respectively. The LVC is by far the most frequent component, with a detection rate of 77%, while only 30% of sources have a HVC. The fraction of HVC detections slightly increases (i.e. 39%) in the sub-sample of stronger accretors (i.e. with log (Lacc/L⊙) &gt;−3). The [O i]6300 Å luminosity of both the LVC and HVC, when detected, correlates with stellar and accretion parameters of the central sources (i.e. L∗, M∗, Lacc, Ṁacc), with similar slopes for the two components. The line luminosity correlates better (i.e. has a lower dispersion) with the accretion luminosity than with the stellar luminosity or stellar mass. We suggest that accretion is the main drivers for the line excitation and that MHD disc-winds are at the origin of both components. In the sub-sample of Lupus sources observed with ALMA a relationship is found between the HVC peak velocity and the outer disc inclination angle, as expected if the HVC traces jets ejected perpendicularly to the disc plane. Mass ejection rates (Ṁjet) measured from the detected HVC [O i]6300 Å line luminosity span from ~10-13 to ~10-7M⊙ yr-1. The corresponding Ṁjet/Ṁacc ratio ranges from ~0.01 to ~0.5, with an average value of 0.07. However, considering the upper limits on the HVC, we infer a Ṁjet/Ṁacc ratio &lt; 0.03 in more than 40% of sources. We argue that most of these sources might lack the physical conditions needed for an efficient magneto-centrifugal acceleration in the star-disc interaction region. Systematic observations of populations of younger stars, that is, class 0/I, are needed to explore how the frequency and role of jets evolve during the pre-main sequence phase. This will be possible in the near future thanks to space facilities such as the James Webb space telescope (JWST).

Transfusion support in preterm neonates &lt;1500 g and/or &lt;32 weeks in a tertiary care center: A descriptive study

BACKGROUND:Lack of recent studies focusing on indications, pattern, and benefits of transfusions in low birth weight (B.Wt) and low gestational age (GA) preterm neonates prompted us to undertake this study.AIM:To estimate the transfusion requirements and outcomes in preterm neonates <1500 g and/or <32 weeks.SETTINGS AND DESIGN:This is a cross-sectional study conducted over a period of 2 years in a tertiary care center.MATERIALS AND METHODS:This study was conducted with 101 preterm neonates <1500 g and/or <32 weeks who received blood transfusions in the Neonatal Intensive Care Unit. Restrictive pattern of transfusion was followed. Demographic details and antenatal, neonatal, laboratory, and transfusion parameters were collected.STATISTICAL ANALYSIS USED:Statistical analyses were performed using SPSS 16.RESULTS:The study participants received 311 transfusions. Transfusion requirements decreased with increasing GA and B.Wt. Majority of blood transfusions occurred during the first 2 weeks of life. Packed red blood cells (PRBCs) were the most frequent blood components transfused. Ninety-six percent of the study population had an uneventful transfusion. Mean hemoglobin improvement after PRBC transfusions was 2.3 ± 2.1 g/dl. Improvement in apnea occurred in 76% PRBC transfusions. Infants with sepsis, patent ductus arteriosus, bronchopulmonary dysplasia, disseminated intravascular coagulation, and dyselectrolytemia received more number of transfusions.CONCLUSION:This study would serve as an audit for neonatal blood transfusion therapy. Close adherence to neonatal transfusion policy and restrictive transfusion guidelines helps reduce inappropriate use of blood products and adverse transfusion reactions.

Comparison of the prevalence of metabolic syndrome in patients with schizophrenia and bipolar disorder: a cross-sectional study from Black Sea region

Objective: Previous research has suggested that metabolic syndrome is more prevalent among patients with schizophrenia and bipolar disorder. Given the scarcity of comparative research on these disorders, this study aims to compare the prevalence of metabolic syndrome in two diagnostic groups and to identify sociodemographic or clinical factors related to metabolic syndrome. Methods: A total of 235 patients diagnosed with schizophrenia (n=160) and bipolar disorder (n=75) and were being followed up by a metabolic monitoring program in a specialized outpatient clinic and using antipsychotic therapy for at least eight weeks have participated in this cross-sectional study. Patients were diagnosed with metabolic syndrome according to National Cholesterol Education Program Adult Treatment Panel-III (NCEP ATP-III) criteria. Sociodemographic and clinical data including metabolic records were collected retrospectively by reviewing the patients’ medical records. Results: The overall prevalence of meta-bolic syndrome was 32.3% and waist circumference was the most frequent individual component with a prevalence of 60%. There were no differences in the prevalence of metabolic syndrome between schizophrenia and bipolar patients. Age, body mass index (BMI), and use of certain types of atypical antipsychotics were found related to metabolic syndrome. Conclusion: The prevalence of metabolic syndrome and its components among patients with severe mental illness is alarming irrespective of their diagnoses. Thus, metabolic screening is crucial especially for high-risk groups.

Prevalence of metabolic syndrome in young patients with ST-elevation myocardial infarction

Background: Atherosclerotic cardiovascular disease influences young patients as well as the elderly. A large proportion of patients with coronary artery disease (CAD) have metabolic syndrome (MS), although the frequency and association of its different components are not clear. To the best of our knowledge, there is no any study about the prevalence of MS among young patients with ST-elevation myocardial infarction (STEMI). We sought to determine the prevalence of MS in patients below 46 years of age who presented with STEMI and underwent primary percutaneous coronary intervention. Methods: In the present prospective study, 141 consecutive patients with STEMI <46 years of age admitted to intensive coronary care unit. STEMI was defined according to the ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. All patients were grouped presence of MS. In the second step, the components of MS were analyzed, excluding patients with diabetes mellitus (DM). Results: The total prevalence of MS was 46.8% (n = 66). In MS group, the most frequent component of MS was low high-density lipoprotein (HDL) levels (84.8%), followed by elevated triglycerides (TGs) (78.1%). A total of 121 patients did not have DM and 51 (42.1%) of these patients presented with MS. Conclusions: The prevalence of MS in young patients with STEMI is high. Low HDL cholesterol (HDLc) concentrations and high TG levels are cardiovascular risk factors, regardless of low-density lipoprotein cholesterol levels and they are found too often in our study. These results highlight the need to implement preventative strategies for reducing overall cardiovascular risk in young patients as well as elderly.

NAT2 GENE POLYMORPHISM AS A PREDICTOR OF FAILURE FOR SURGICAL TREATMENT OF PELVIC ORGAN PROLAPSE: RESULTS OF A PROSPECTIVE COHORT CLINICAL STUDY

Background: Pelvic organ prolapse (POP) is the most frequent disease component in the structure of gynecological pathology (from 28 to 38.9%) and its incidence is increasing. Most of the research studies were initiated to develop various kinds of operative treatment for common prolapse cases (POP-Q III−IV); however, a large number of surgical interventions associated with a high percentage of complications and a high rate of relapses confirm the difficulty for problem-solving. In this regard, there is a need to expand ideas about the pathogenesis of the disease and develop approaches to the prediction of recurrence surgical treatment, choosing the correct and timely treatment strategy. Currently, great importance is given to the study of genetic control of connective tissue metabolism. The evidence demonstrated that polymorphism of NAT2 gene results in genetically determined disorders of connective tissue catabolism which increases the possibility of disease development approximately in 2 times. Point mutations in NAT2 lead to the so-called slow-acetylation which determines the predominance of the decay rate of collagen over its synthesis.Aim: Analyze the significance of NAT2 polymorphism as a predictor for failure of surgical treatment of pelvic organ prolapse.Materials and methods: The prospective cohort clinical trial enrolled 140 women of the reproductive age (from 28 to 42 y.o.) with symptomatic prolapse (POP-Q Stage II−III) who were examined and received treatment in the period from 2008 to 2014. All patients underwent surgical treatment of POP. The treatment included colpoperineorrhaphy with levatorplasty. In 12.9% of patients who had stress urinary incontinence — in combination with a loop urethropexies transobturatory access (Transobturator Vaginal Tape, TVT-O). Long-term results of treatment effectiveness were assessed in 3−5 years. Results: The findings revealed that the incidence rate of point mutations of NAT2 gene was 2-fold higher in patients with POP included in the ineffective treatment group (61.8%) if compared to the rate registered in the effective treatment group (30.6%).Conclusions: The obtained data indicate that the presence of point mutations in NAT2 gene is a poor prognostic factor for general types of genital prolapse and a predictor for failure of surgical treatment.

From the glass through the nose and the mouth

Motion verbs are often used to predicate entities such as roads, paths and the like as in “The road snakes tothe port of Shakespeare Baybefore climbing over the last hillto Picton” or “La carreteraserpenteaunos 30 kilómetros entre las montañas de la cordillera Nipe”. The verbs foreground thepathconfiguration and dynamic rendering of things that cannot move – a phenomenon known asfictive motion(Langacker 1987;Talmy 1996). However, motion verbs are also frequent components in specialized contexts such as wine discourse, where they communicate different sensory experience of wines as in “Exotic, exuding red berry aromas and flavors thatsneak upon you rather than hit you over the head”, “Bright and focused, offering delicious flavors thatglidesmoothlythroughthe silky finish”, or “En boca tiene una magnifica entrada, aunque en el pasosobresalenrasgos vegetales y seprecipitahacia un final en el que predominan notas tostadas y amargas”. Using two corpora of tasting notes written in English and in Spanish, I examine the motion expressions used to communicate the sensory experiences of the wines and explore the motivations for their use in descriptions of wines’ aromas, flavours and mouthfeel. Three questions are at the heart of this study. They are (i) what types of scenarios are described through motion expressions, (ii) what sensory perceptions do they describe, and (iii) what may the differences between English and Spanish be?