Frequency Of Vomiting Research Articles

Preoperative pregabalin to prevent postoperative nausea and vomiting in laparoscopic cholecystectomy

Background. Postoperative laparoscopic cholecystectomy period is often associated with nausea and vomiting, which is stopped by an antiemetics injected intravenously. Meanwhile, it is known that the oral pregabalin before surgery to potentiate the effect of opioids and nonsteroidal anti-inflammatory medications during anesthesia also has an antiemetic effect.The objective was to evaluate the effect of oral pregabalin to reduce the frequency of postoperative nausea and vomiting in laparoscopic cholecystectomy cases.Methods and Materials. Randomized double blind study. One hundred patients of the American Society of Anesthesiology (ASA) class1 were tested and divided into two groups. The first group did not receive any antiemetics preoperatively. The second group received 75 mg of oral pregabalin 30 minutes before anesthesia. We followed up patients postoperatively in the recovery room and general surgical ward for 24 hours, recorded the incidence of nausea and vomiting, prescription of any antiemetics and developing their side effects. We assessed the risk of developing the incidence of postoperative nausea and vomiting by the use of the Koivuranta score.Results. Statistical analysis using SPSS showed a significant reduction of postoperative nausea and vomiting in the second group (pregabalin) compared with the first group.Conclusion. Preoperative 75 mg of oral pregabalin has antiemetic effect on postoperative time. No significant postoperative side effects were noted.

Frequency of typical complications of morphine during its intrathecal and epidural introduction in knee arthroplasty

The objective was to compare the efficacy and safety of morphine in neuraxial blocks during knee arthroplasty.Materials and methods. A retrospective analysis of 60 medical histories of patients who underwent total knee arthroplasty for the period from 2017 to 2019 was performed. All patients were operated under general anesthesia with mechanical ventilation in combination with epidural or spinal analgesia with opiates. Patients of the 1st group (n=20) after catheterization of the epidural space at the level of L1–2 were injected with a morphine solution 1% – 0.3 ml epidurally. Patients of the 2nd group (n=20) were injected with a morphine solution 1% – 0.01 ml intrathecally at the level of L3–4. Patients of the 3rd group (n=20) underwent standard combined anesthesia: general anesthesia with mechanical ventilation and epidural analgesia at the level of L1–2 with a solution of 0.2% ropivacaine in the form of an infusion of 6 ml/hour. All patients received infusion of 0.2% solution of ropivacaine epidurally 6 ml/hour at the level of L1–2 in the postoperative period.The incidence of nausea, vomiting, pruritus, headache and the level of postoperative pain syndrome were assessed on a numerical rating scale 6 hours after the end of the surgery.Results. The level of pain syndrome in patients who received intrathecal and epidural analgesia with morphine was equally low, while in patients who received epidural analgesia with ropivacaine, the level of pain syndrome was statistically significantly higher, which required the additional prescription of non-steroidal anti-inflammatory drugs and/or narcotic analgesics parenterally. The frequency of nausea, vomiting, pruritus and headaches was maximum in the 2nd group, significantly lower in the 1st, while in the 3rd, pruritus did not occur.Conclusion. The use of morphine in neuraxial block in knee arthroplasty has a positive effect on the quality of anesthesia and postoperative pain relief.

The Effect of Giving Wedang Jahe (Ginger Emprit) and Hypnoemesis on the Frequency of Nausea Vomiting in Trimester 1 and 2 Pregnant Women

Emesis gravidarum is a common complaint of nausea and vomiting that occurs in young pregnancies. according to research results the incidence of hyperemesis in the world is between 0.3-3.2% of the total number of pregnancies. Ginger is a rhizome plant which is very popular as a spice and medicinal ingredient. Treatment of nausea and vomiting can also be done through hypnotherapy because hyperemesis gravidarum is caused by the psychological influence of the mother. This study aims to determine the effect of giving ginger drink (Ginger Emprit) and hypnoemesis on the frequency of nausea and vomiting in trimesters 1 and 2 pregnant women in Rw.05 Kp. Cijulang in 2020, for pregnant women who experience nausea and vomiting in Rw 05 Kp. Cijulang started from 05 August - 10 September 2020. The population in this study were all pregnant women Rw. 05 Kp. Cijulang who experienced nausea and vomiting in Trimester 1 and Trimester 2. Sampling Techniques In this study, purposive sampling consisted of 21 pregnant women who experienced nausea and vomiting. The type of data used is primary data, namely data obtained directly from the respondents, the characteristics of the respondents are age, education, gestational age, gravida. This type of research is an experiment with the design of "one shot case study". univariate and bivariate with Wilcoxon statistical test. The results of the univariate study found that 18 pregnant women were affected, there were 3 people who were not affected and none had negative ranks or or the condition became less before and after the ginger wedang was given and 14 had positive ranks or experienced the influence, there were 7 people who experience ties or no influence and no one who experiences negative ranks or or the situation becomes less before and after giving hypnoemesis. While the bivariate results obtained a P value of 0.00 (Pvalue = 0.00 <0.05) it can be seen that there is a relationship between the effect of giving ginger drink and hypnoemesis on nausea and vomiting in pregnant women. It is expected that pregnant women who experience nausea and vomiting can consult with health workers so that they do not become hyperemesis gravidarum.

Ultrasound of Hypertrophic Pylorian Stenosis: About A Case and Literature Review

Hypertrophic pyloric stenosis is an obstruction of the lumen of the pylorus by muscular hypertrophy of the pyloric sphincter, more common in boys. We report the case of a male newborn at 13 weeks of life, born at term with a birth weight estimated at 2900 grams without any particular history. Clinically he had an increased frequency of sputum and postprandial jet vomiting, dehydration and weight loss. Abdominal ultrasound found a lengthening of the pyloric canal measuring 22 mm in length associated with a thickening of the muscularis of the pyloric region measuring 4 mm forming a "pyloric olive" 13 mm in diameter. There was also significant gastric stasis upstream of the hypertrophic stenosis. The examination was carried out at the reference health center of commune III in the district of Bamako. The objective of this work was to provide our experience on the ultrasound semiology of hypertrophic pyloric stenosis with a review of the literature.

Effectiveness of Ginger and Lemon Generation on Nau, Vovoging in Trimester I Pregnant Women

Nausea and vomiting in pregnancy if not treated properly can cause other problems, namely Hyperemesis gravidarum. Hyperemesis gravidarum and other complications of Hyperemesis gravidarum can cause birth defects and abortion. Data from the Ciomas Health Center showed that around 60-90% of pregnant women in the first trimester complain of nausea and vomiting every year. The research method used a quasi-experimental design with one group pre-posttest. The sample in this study was 30 pregnant women in the first trimester. The sampling method in this study was non-probability sampling in the form of accidental sampling. The research instrument used a questionnaire. Bivariate analysis used paired t-test. The average frequency of nausea and vomiting in the first trimester of pregnant women before consuming ginger and lemon was 6 times within 24 hours and after consuming ginger and lemon every day for 2 weeks, the average frequency of nausea and vomiting was 3 times within 24 hours. The results of statistical tests showed that giving ginger and lemon juice was effective in reducing the frequency of nausea and vomiting in the first trimester pregnant women with ap value = 0.000.

The Effect of Nicotine Patch on Reducing Nausea, Vomiting, and Pain Following Laparoscopic Cholecystectomy: A Randomized Clinical Trial.

The effect of nicotine on nausea, vomiting, and postoperative pain has been investigated in studies on animals and humans. This study aimed to evaluate the effect of nicotine patch on decreasing nausea, vomiting, and pain in laparoscopic cholecystectomy. The study sample consisted of 100 non-smoking patients undergoing laparoscopic cholecystectomy under general anesthesia in a triple-blind clinical trial. One hour after the start of surgery, patients were randomly assigned to receive 17.5-mg nicotine or placebo patches. The patches located on the right arm were left for 24 hours. The visual analogue scale (VAS) for pain and N/V score for the severity of nausea and vomiting were measured at intervals of 0, 6, 12, and 24 hours. The results showed there was no statistically significant difference between the groups in terms of pain intensity as well as nausea and vomiting at different time periods after surgery (P>0.05). A total of 36 patients in the nicotine group and 24 patients in the placebo group received meperidine. There was also no statistically significant difference between the two groups in terms of analgesics (P=0.096) and antiemetics (P=0.1). Moreover, the frequency of severe nausea and vomiting during the study in the nicotine group was higher than in the placebo group (4 vs. 1) but this difference was not statistically significant (P>0.05). Receiving a 17.5-mg nicotine patch had a similar effect to receiving placebo in controlling postoperative pain, nausea, and vomiting in non-smokers. Nicotine use had no effect on reducing analgesia.

Management of Adverse Effects of Chemotherapy in Ovarian Cancer through Ayurveda: A Case Report

Cancer is a condition where abnormal cells multiply uncontrollably and can invade nearby tissues. Only 30% of women with ovarian cancer can expect to live for more than 5 years, as 70% of cases are diagnosed at an advanced stage. Ovarian malignancies account for about 15 to 20% of genital malignancies. Surgical intervention and chemotherapy are conventional measures used to treat these conditions. However, due to the specific side effects of chemotherapy, there is a high demand for safer ayurvedic interventions. Hereby, the authors present, a 54-year-old female patient who was diagnosed with ovarian cancer and advised to undergo chemotherapy. After completing six cycles of chemotherapy, administered once every four weeks for six months, the patient experienced complaints of anorexia, nausea, vomiting, epigastric pain, and a burning sensation in the stomach and lower limbs. Despite taking antacids and other suggested medications by the oncologist, the symptoms did not subside. Therefore, the patient sought ayurvedic treatment. Shaman Ayurvedic Chikitsa (Jawahar Mohra Pisti, Keharva Pisti, Swarna Makshik, Mukta Pisti), Shatavari Ghrita, Turmeric Kwath, and Pathya Vihar were prescribed for three consecutive months. After 5-7 days, the patient noticed significant relief in the aforementioned symptoms and felt better. The frequency of vomiting, complaints of anorexia, and burning sensation were also significantly reduced. After three months of ayurvedic treatment, the functions of Apana Vayu, Samana Vayu, and Pachaka Pitta were normalised through appropriate treatment. The selected combination of ayurvedic medicines provided relief due to their Vata-Pitta Shamak, Sheeta guna, and Pittahara properties, which alleviated the burning sensation. In present case report, the aforementioned ayurvedic prescription significantly reduced the adverse effects of chemotherapy and radiotherapy due to its Vata-Pitta Shamak and Pittahara properties.

Дифференциальный диагноз колитов при COVID-19 и бактериальных кишечных инфекциях у детей

Diarrhea with COVID-19 develops in 2–79% of patients. The causes and clinical features of gastrointestinal lesions in patients are different, and the differential diagnosis with acute intestinal infections is difficult. The purpose is to provide a comparative clinical and laboratory characteristics of distal colitis in COVID-19 and classical bacterial diarrhea (salmonellosis, campylobacteriosis). Material and methods. As part of the case-control study, two groups of patients were formed: main group (continuous sample) — 48 children with COVID-19 and negative results of a standard examination for acute respiratory infections pathogens; and control group — 48 children with bacterial colitis. Statistica 8 (USA) and StatTech v 3.1.8. software were used for statistical data analysis. Additionally, multivariate logistic regression and ROC curve analyses were performed. Result and conclusions. Among all children hospitalized with COVID-19 in 2022, 26.2% (48/183) had evidence of distal colon involvement. The most important factors for the differential diagnosis were: the frequency of stool and vomiting, the signs of hemocolitis and dehydration, a concomitant pathology, and the number of red blood cells in the general clinical blood test. The prognostic model developed based on these features has a sensitivity of 93.8% and a specificity of 93.6%. In addition, patients with COVID-19 with a clinical picture of distal colitis were distinguished from bacterial infections by febrile (not pyretic, as in bacterial acute intestinal infections) fever, lymphopenia, and a shorter duration of hospitalization.

Comparison of the Effects of Special Care Enhanced Recovery and Conventional Recovery Methods after Mini Omega Gastric Bypass.

Bariatric surgery is a surgical procedure for patients with extreme obesity. Enhanced Recovery after Surgery (ERAS) is a method that provides special peri- and post-operation care. Here, we aimed to compare the effects of ERAS and standard recovery cares. This is a randomized clinical trial that was performed in 2020-2021 in Isfahan on 108 candidates for mini gastric bypass. Patients were then randomly divided into two equal groups receiving ERAS and standard recovery protocols. Patients were examined and visited after one month regarding the average number of hospitalization days, the average days required to return to normal activity or work, occurrence of pulmonary thromboemboli (PTE) and the rate of readmission. Patients that received ERAS had significantly lower frequencies of nausea and vomiting (P = 0.032). Patients that received ERAS had significantly lower hospitalization duration (P < 0.001) compared to controls. No other significant differences were observed between two groups regarding surgery complication, re-admission rate and occurrence of PTE (P > 0.99 for all). Patients that received ERAS protocol after gastric bypass had significantly lower hospitalization duration and lower incidence of nausea and vomiting. They also had similar post-operative outcomes compared to the standard protocol.

A prospective comparative study of 3 different regimens involving mifepristone and oral/ vaginalmisoprostol combination in medical termination of pregnancy at less than 9 weeks gestation

Background and Objectives: Medical abortion with a combination of mifepristone and a prostaglandin analogue (Misoprostol) is a well-established and adequately studied as an alternative to surgical abortion in early pregnancy for many years now but still no consensus has been reached regarding superiority of one route and dosage. This study is an attempt to compare efficacy in terms of rate of complete abortion, side effects and women’s perceptions of three mifepristone/misoprostol regimens and to study the effect of continued oral misoprostol for one week in medical termination of pregnancies of less than nine weeks gestation. Materials and Methods: Abortion seeking women of less than nine weeks period of gestation were included in this study and were divided into three groups: GROUP I also referred as O+O group, GROUP II the V+O group, and GROUP III referred as V ONLY group. This is an outpatient regimen requiring minimum three visits on day 1, 3 and 15. Initially, tablet mifepristone 200 mg was administered orally in all three groups on day 1. This was followed on day 3 by oral misoprostol 0.8 mg in group I and vaginal 0.8 mg misoprostol in group II & III. It was placebo controlled. Patients were sent home after 4 hour observation period. The oral group and one of the vaginal groups i.e. group I and II continued 0.4 mg of oral misoprostol twice daily for 7 days. Final assessment was done on day 15. Results: All three groups were comparable in terms of rates of complete abortion: Group I 93.06%; II 94.44% and group III 93.06%. Incomplete abortion occurred in 9.72% women in group I, 5.52% in group II and 6.94% women in group III. 73.61 % of women in group I, 76.38% women in group II and 77.76% in group III suffered from lower abdominal pain & cramping. 100% women cited oral route as their preferred route and overall 199 (92%) women were satisfied with treatment, 12(5.6%) were unsure and 5(2.4%) were dissatisfied. For future purposes 100 % women cited medical abortion to be their preferred mode compared to surgical one Conclusion: In light of previous studies establishing superiority of vaginal route over oral, continuation of misoprostol for 7 days possibly improved the efficacy for oral misoprostol group(group I) but it did not seem to further increase the efficacy for vaginal Misoprostol (group II) as all three groups were of comparable efficacy. Additional misoprostol did not shorten the duration of bleeding or induction abortion interval compared to group not continuing additional one week misoprostol. Successful abortion was associated more with lower gestational age,multigravidas and multiparas.Oral group had higher frequency of nausea, vomiting and diarrhea than vaginal administration. Statistically insignificant but still lower number of women were satisfied in the end with the treatment in the oral group compared to vaginal groups despite oral mode being the preferred mode. Additional larger studies are required on initial oral misoprostol administration and its continuation to establish its equivalence to vaginal route.

Impact of timing of midazolam administration on incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery: A randomized, double-blinded, controlled study

ABSTRACT Background A frequently used anxiolytic, midazolam, has recently been recognized for its antiemetic activity during the perioperative period. This study sought to investigate the best time to provide midazolam in order to decrease the frequency of postoperative nausea and vomiting (PONV) without increasing the risk of sedation. Methods A total of 120 women aged 20–60 years who underwent laparoscopic gynecological surgeries were distributed randomly to three groups: group M1 (n = 40) received intravenous 2 mg midazolam 15 min prior anesthesia induction, group M2 (n = 40) received intravenous 2 mg midazolam approximately 30 min prior surgery conclusion, and group C (n = 40) received intravenous normal saline. The frequency of PONV and the rescue antiemetics needs were measured as the primary outcomes during the first 24 hr postoperatively. The secondary outcomes were the severity of nausea, timing of initial emetic attack, time of PACU discharge, patient sedation, and pain scores. Results The frequencies of vomiting and rescue antiemetic use were lower in midazolam groups than controls during early (0–2) and late (0–24) time periods after surgery (P < 0.05), with insignificant difference between M1 and M2 groups. The timing of the first emetic episode was significantly longer in M2 than in C groups (458.3 vs 128.8 minutes) (P < 0.01). Insignificant differences with regard to frequency and severity of nausea, time of PACU discharge, and sedation score were detected among the three groups. Conclusion Midazolam was effective in reducing PONV, whether it was given prior induction of anesthesia or prior end of surgery, without influencing recovery duration or sedation level of the patients.

The effect of warm ginger on the frequency of nausea and vomiting among pregnancy women

Introduction: Nausea and vomiting occur commonly during pregnancy and cause inconvenience among pregnant women. Non-pharmacological therapy with warm ginger was used in this quantitative study to relieve nausea and vomiting in pregnant women. The study aimed to determine the effect of using warm ginger on nausea and vomiting in pregnant women.

0.125% 8ml/h v.s. 0.25% 8ml/h of levobupivacaine in continuous paravertebral block for postoperative analgesia in video-assisted thoracoscopic surgery: a randomized, controlled, double-blind study.

Research has shown that a higher dose of bupivacaine administered in continuous paravertebral block (CPVB) provides a greater analgesic effect after video-assisted thoracoscopic surgery (VATS). In this randomized, controlled, double-blind study, we hypothesized that 0.25% 8ml/h of levobupivacaine administered in CPVB after VATS provides a greater analgesic effect than 0.125% 8ml/h. Fifty patients who underwent unilateral VATS were randomized to receive a postoperative continuous infusion of 0.125% (low group, n = 25) or 0.25% (high group, n = 25) levobupivacaine at 8mL/h for CPVB. The primary outcome was the visual analog scale (VAS) score during coughing on the morning of postoperative day (POD) 1. The secondary outcomes were the VAS scores at rest and during coughing on POD 2, the number of anesthetized dermatomes, the frequency of rescue analgesics, postoperative nausea and vomiting, patient satisfaction, and adverse events and complications. There was no significant difference in the VAS score during coughing on the morning of POD 1 between the low and high groups [median, 37.5 (interquartile range 21-50) vs. 40.0 (interquartile range 21-50), respectively; p = 0.79]. Similarly, there were no significant differences in any secondary outcomes between the two groups. Levobupivacaine at 0.25% 8ml/h in CPVB did not provide better analgesia after VATS over 0.125% 8ml/h. UMIN000037930.

Neutrophil-to-Lymphocyte Ratio as a Predictor of the Need for Surgical Treatment in Children's Intussusception.

Neutrophil-to-lymphocyte ratio (NLR) is an emerging inflammatory marker in abdominal pathologies. Ileocolic intussusception (ICI) involves a progressive intestinal inflammation, and the effectiveness of nonsurgical treatment (enema) might be related to the inflammation degree, although no previous studies have investigated this relationship. Our aim is to identify predictors of the need for surgical treatment in ICI. A single-center, retrospective, case-control study was performed in children with ICI, who were treated with initial nonsurgical management between 2005 and 2019. Patients were divided in two groups: A (effective enema) and B (need for surgery). Admission demographic and clinical and laboratory data were analyzed. Specificity and sensitivity of the different parameters as predictors of the need for surgical treatment were determined by receiver operating characteristic (ROC) curves. A total of 511 patients were included (410: group A; 101: group B), without statistically significant demographic differences. Group B presented significantly higher frequency of vomiting, bloody stools, and longer median time since symptoms onset (24 vs. 8 hours; p < 0.001). Group B presented higher median laboratory inflammatory markers than group A: NLR (6.8 vs. 1.8; p < 0.001), neutrophils (10,148 vs. 7,468; p < 0.001), and C-reactive protein (CRP; 28.2 vs. 4.7; p < 0.001). In ROC curve analysis, NLR had an area under the curve of 0.925, higher than neutrophil count (0.776; p = 0.001), CRP (0.670; p = 0.001), and time since symptoms onset (0.673; p = 0.001). It was estimated a cut-off point of NLR greater than 4.52 (sensitivity: 73.2%; specificity: 94.5%). High NLR values imply a high degree of bowel inflammation and might anticipate the need for surgical treatment in ICI in children. III.

Evaluation of refeeding hypophosphatemia frequency, risk factors, and nutritional status during stem cell transplantation in patients with hematologic malignancy.

Refeeding Hypophosphatemia (RH) occurs with feeding after an extended period of not feeding. Hematological Stem Cell Transplantation (HSCT) is one of the effective methods for hematologic malignancy. Nutritional disorders are frequently observed in hematologic malignancies due to the disease's pathology and the treatment's effect. The study aims to determine the influencing factors by determining the frequency of RH in patients treated with HSCT. The study was conducted prospectively and randomly with 50 patients treated with HSCT for the first time. The study followed patients for 22 days, seven days before, and 14 days after. During the follow-up, data such as Scored Patient-Generated Subjective Global Assessment (PG-SGA), weight changes, nausea, vomiting, diarrhea, mucositis, infection and Graft Versus Host Disease development, need for intensive care, and 12-month mortality were recorded. RH states were evaluated during treatment. RH developed in 78% of patients treated with HSCT. Pre-transplantation PGSGA score, frequency of vomiting, and development of infection were higher in patients with RH (p<0.05). The patients had a mean weight loss of 2.9% after transplantation. Pre-transplantation, 88% of patients were well-nourished (PGSGA 0-3), post-transplantation, 70% of patients were moderately undernourished (PGSGA 4-8), and 30% were severely malnourished (PGSGA ≥ 9). While total protein and albumin decreased after transplantation, CRP increased (p<0.05). According to multivariate logistic regression analysis, infection (95% CI: 1.375-61.379, p=0.022) and pre-transplant PGSGA (95% CI: 1.035-45.454, p=0.046) independently affect RH development. RH was detected at a high rate in patients treated with HSCT. Elevated risk of malnutrition before transplantation, frequency of vomiting, and development of infection were determined as factors affecting RH development.

S1582 Abnormal Glucose Breath Test Does Not Correlate With Patient’s Self-Reported Symptoms and Their Severity

Introduction: Glucose Hydrogen Breath Testing (GBT) is commonly used for diagnosing Small Intestinal Bacterial Overgrowth (SIBO). However, patients present with clinical symptoms (sx) and their predictive value for a positive (pos) GBT remains unclear. AIM: To assess the prevalence of self-reported GI sx profiles in adults with unexplained upper GI symptoms and correlate this with GBT. Methods: We retrospectively analyzed all adult patients presenting to a single medical center from 6/20 –12/21 for GBT. A pos GBT for SIBO was defined by the North American Consensus (≥20 ppm H2 increase over basal within 90 minutes (mins) and/or ≥10 ppm CH4 at any time). Pts completed a GI questionnaire assessing 17 key sxs: regurgitation (RG), chest pain (CP), heartburn (HB), belch (BH), abdominal pain (AP), bloating (BT), gas (GS), nausea (NA), vomit (VT), abdominal cramps (AC), indigestion (ID), distension (DN), fullness (FL), early satiety (ES), diarrhea (DR), constipation (CN), and fatigue (FT). Sxs measured by frequency (None, < 1/week (wk), 1/wk, ≥ 1/wk), intensity (None, Mild, Moderate, Severe), and duration (None, < 10 mins, 10 – 30 mins, ≥ 30 mins). Sub-groups, GERD, Dyspeptic, and IBS were constructed assessing the mean summation scores for Frequency, Intensity, and Duration between negative (neg) and pos GBTs. Univariate analysis and logistic regression analysis was performed. A P-value of < 0.05 was considered statistically significant. Results: We evaluated 184 pts, mean age of 51.7 (18 – 85), 78.3% female, 82.8% Caucasian, and mean BMI of 27.2. No significant differences were seen between GI sx frequency and intensity categories for pts with GBT neg and pos groups. A trend for a higher percentage of pos GBT pts reporting FL (P=0.09) and DR (P=0.07) in sx duration categories of 10 -30 mins (FL: 30.8% vs 27.5%; DR: 31.8% vs 23.4%) and ≥ 30 mins (FL: 51.3% vs 41.3%; DR: 37.2% vs 22.1%) was noted. Regression analysis showed a trend toward a pos GBT for VT frequency of Less than 1/wk: (P = 0.07; OR = 2.99; 95% CI: 0.91, 9.83) and NA intensity of Severe: (P = 0.09; OR = 2.24; 95% CI: 0.86, 5.84). No differences were seen between the GERD, Dyspeptic, and IBS sub-groups (Figure). Conclusion: The pre-test predictability of GI symptoms as it relates to a pos or neg GBT is poor. The yield for a pos GBT varies between 31%-55% and depends on age. In routine practice, when the index of clinical suspicion is high for SIBO, clinicians should consider objective testing with GBT rather than empiric antibiotic treatment.Figure 1.: (Left) Mean Summation Scores for Self-Reported Frequency, Intensity, and Duration Responses to GI Symptoms Relative to the Gastroesophageal Reflux Disease (GERD), Dyspeptic, and irritable bowel syndrome (IBS) Groups. (Right) Prevalence of Positive Glucose Breath Test (GBT) Among Age Cohorts and Glucose Breath Test Measurements

EFEKTIVITAS PEMBERIAN PISANG AMBON (MUSA PARADISIACAL) DENGAN VITAMIN B6 DALAM MENURUNKAN INTENSITAS MUAL MUNTAH PADA IBU HAMIL TM 1 DI KLINIK LINA HINAI KIRI KEC.SECANGGANG

&#x0D; &#x0D; &#x0D; Nausea (nausea) and vomiting (emesis gravidarum) are normal symptoms and are often found in the first trimester of pregnancy. Almost 50-90% of pregnant women experience nausea and vomiting in the first trimester. One of the pharmacological methods that can be used to treat nausea and vomiting in pregnancy is to consume pyridoxine (vitamin B6) and non-pharmacological among them is to consume Ambon banana (Musa paradisiaca) which contains lots of flavonoids and vitamin B6 which is able to overcome nausea and vomiting in pregnancy.The purpose of this study was to determine the effectiveness of giving Ambon bananas and vitamin B6 in reducing the intensity of nausea and vomiting in first trimester pregnant women at the Lina Hinai Kiri Secanggang Clinic.This research method uses Quasi Experimental research with a cross sectional research design. Data analysis was performed with two independent mean difference test. The research design was used with Two Group Only Post Test Design. The sample technique in this study used a purposive sampling technique and as a sample in this study were pregnant women in the 1st trimester who experienced nausea and vomiting and who came to check their pregnancy at the Lina Hinai Kiri Clinic, Secanggang District as many as 30 people.The results showed that the effectiveness of giving Ambon bananas with Vitamin B6 in reducing the intensity of nausea and vomiting in pregnant women. The table above shows that the frequency of nausea and vomiting in the ambon banana group of all respondents is in the effective category. Likewise, in the group giving vitamin B6, all respondents also included in the effective category, namely with a p-value of 0.001 &lt;=0.05 &#x0D; &#x0D; &#x0D;

Evaluation of preoperative duloxetine use for postoperative analgesia following laparoscopic cholecystectomy: A randomized controlled trial.

Background: The pain pattern after laparoscopic cholecystectomy (LC) is complex and distinct from postoperative pain after other laparoscopic procedures, suggesting that procedure-specific optimal analgesic management plans should be proposed. Duloxetine, a non-opioid neuromodulator, has been widely used to manage pain with dual central and peripheral analgesic properties. Aims: To assess the effect of preoperative administration of duloxetine compared to placebo on postoperative pain control in patients undergoing LC. Patients and Methods: This study was a randomized, parallel-group, placebo-controlled, double-blinded study performed on patients undergoing LC. Patients were randomly divided into two groups of 30 each on the day of surgery in the preoperative holding area, using a computer-generated random number to receive 60 mg duloxetine as a single oral dose 2 h before the procedure or placebo. The primary outcome was the difference in the mean of visual analogue scale (VAS) scores between the two studied groups, as measured by the area under the curve (AUC) of the VAS scores. Results: The derived AUC of VAS scores in the duloxetine group (757.89 ± 326.01 mm × h) was significantly lower than that calculated for the control group (1005.1 ± 432.5 mm × h). The mean postoperative VAS scores recorded at 4 and 24 h were statistically different between the study groups (p = 0.041 and 0.003, respectively). As observed in the survival curve analysis, there was no significant difference (p = 0.665) for the time until the patient’s first request for rescue medications in the two groups. The frequency of postoperative nausea and vomiting (PONV) was lower in patients of the duloxetine group than that recorded in those allocated to the control group at 8 and 24-h time intervals (p = 0.734 and 0.572, respectively). Conclusion: Preoperative use of duloxetine reduces postoperative pain significantly compared with placebo. In addition, its use is associated with a reduction in PONV. These preliminary findings suggest that duloxetine could play a role in the acute preoperative period for patients undergoing LC. Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT05115123, identifier NCT05115123],

Comparison of intravenous injection of magnesium sulfate and lidocaine effectiveness on the prevention of laryngospasm and analgesic requirement in tonsillectomy.

The aim of the present study is to compare the effect of intravenous (IV)injectionof magnesium sulfate and lidocaine on the prevention of laryngospasm, and analgesic requirement in tonsillectomy surgeries. In this double-blinded clinical trial, 62 children are randomly selected and categorized into two groups. Two minutes after intubation, group A received 15 mg/kg IV magnesium sulfate, while group B received 1 mg/kg IV 2% lidocaine. Laryngospasm frequency, nausea and vomiting, hemodynamic status (in 15 minutes after extubating), sedation score, analgesic requirement, and duration of recovery were compared between the two groups. Data were analyzed using SPSS software version 21 and with a 95% confidence interval. Both groups had no significant difference based on the age and weight means, as well as sex frequency. 10 patients (32.3%) in the lidocaine group and 3 patients in the magnesium group (9.7%) had stridor, and the difference between the two groups was statistically significant (p = 0.026). Laryngospasm only occurred in a patient of the lidocaine group. The frequency of nausea and vomiting, agitation and analgesic requirement in the lidocaine group were higher than the magnesium group (p= 0.001). However, sedation score and recovery time were higher in the magnesium group (p=0.001). No statistically significant difference was seen between the two groups in terms of hemodynamics. Magnesium sulfate and lidocaine had no difference in the incidence of laryngospasm, but magnesium sulfate was associated with a lower rate of stridor, nausea, vomiting, agitation and analgesic requirement in recovery in comparison to lidocaine.

EFEKTIFITAS PEMBERIAN SEDUHAN JAHE DAN DAUN MINT DALAM MENGURANGI FREKUENSI MUAL MUNTAH PADA IBU HAMIL TRIMESTER PERTAMA

Nausea and vomiting (Morning Sickness) in pregnant women due to increased levels of the hormones Estrogen, Progesterone and Human Chorionic Gonadotropine (HCG) in serum from the placenta. Continuous nausea and vomiting will have an impact on the health conditions of the mother and fetus. Ginger and mint leaves are one way to reduce nausea and vomiting during pregnancy. The purpose of this study was to determine the effectiveness of infusion of ginger and mint leaves in reducing the frequency of nausea and vomiting in pregnant women in the first trimester at Batua Health Center Makassar. This research method is a quasi-experimental research with a pre- and post-test design approach without a control group. This research uses a purposive sampling technique. The statistical test used is Paired Sample t. Test to determine nausea and vomiting before and after the intervention of ginger and mint leaves and T. Independent test to determine nausea and vomiting in the group given ginger and mint leaves. Based on the results using Paired Sample t. The test shows the value of P = 0.000 with a significant level of = 0.05. Therefore, the P value = &lt;0.05, which means that Ho is accepted and Ha is rejected, which means that there is a decrease in the frequency of nausea and vomiting in the administration of boiled ginger and mint leaves. With the Independent T test, it was found that the value of P &lt; then the administration of ginger steeping was very effective in reducing the frequency of nausea and vomitingin First Trimester pregnant women.