Frequency Of Bipolar Disorder Research Articles

A Comparative Analysis of the Frequency of Bipolar Spectrum Disorder in Patients with and Without Psoriasis

Background: Psoriasis is a chronic disease that significantly negatively affects a patient’s quality of life. Based on etiopathological characteristics, there is strong evidence of susceptibility to psychological disorders, such as depression and bipolar disorder, in patients suffering from psoriasis. Objectives: We investigated the frequency of bipolar spectrum disorders in psoriasis patients compared to healthy controls in a selected population in Iran. Methods: This case-control study was conducted on two sample groups, with and without psoriasis (50 people in each group). The statistical population included all individuals referred to Shohadaye Tajrish and Taleghani Hospitals of Shahid Beheshti University of Medical Sciences, selected using the available method and assigned to two groups in 2023. The participants were examined for the presence of bipolar spectrum disorders using the Mood Disorder Questionnaire (MDQ) and the Bipolar Spectrum Diagnostic Scale (BSDS). Results: According to the MDQ questionnaire, the frequency rates of bipolar disorder in the patients and controls were 20% and 40%, respectively, with no significant difference between the groups (P = 0.108). Based on the BSDS, the frequency of bipolar disorder in the two groups, with and without psoriasis, was estimated to be 25% and 32.1%, respectively, with no significant difference (P = 0.226). The rate of major depressive disorders was also 22% and 26%, with no significant difference (P = 0.640). Conclusions: Among Iranian patients with psoriasis, the presence of the disease may not be associated with an increased risk of bipolar spectrum disorders.

The relationship between emotional appetite and bipolar features in obese and non-obese individuals

Objectives: It is known that many different positive and negative emotions can affect appetite and also, individuals who have bipolar features often have emotional fluctuations. In this study, it was aimed to investigate the relationship between emotional appetite and bipolar features in obese individuals. Methods: One hundred and ninety obese individuals who applied for bariatric surgery and 136 non-obese individuals were evaluated with Emotional Appetite Questionnaire (EMAQ), Beck- Depression Inventory (BDI), Beck-Anxiety Inventory (BAI) and The Temperament Evaluation of Memphis, Pisa, Paris and San-Diego Auto-questionnaire (TEMPS-A) in the study. Results: In obese individuals who applied for bariatric surgery, the frequency of bipolar disorder was found to be 2% and binge eating disorder (BED) frequency was 51.2%. It was found that scores of appetite in negative emotions were higher in obese individuals with BED compared to obese individuals and it was higher in obese individuals compared to normal weight individuals. Cyclothymic features explained 27.2%, 25.8% and 15.7% of scores of appetite in negative situations of obese individuals with BED, obese individuals without BED and normal weight individuals, respectively. Conclusions: As a result of this study, it can be concluded that scores of appetite in negative situations may be affected by cyclothymic features in obese individuals with BED, in obese and normal weight individuals. Depression and anxiety symptoms are effective factors in explaining scores of appetite in negative situations of obese individuals with BED, obese and normal weight individuals.

The prevalence of bipolar mood disorders in the medically ill patients hospitalized in general hospitals

Introduction Bipolar mood disorders are the eighth cause of disability in the world. Several studies have shown the prevalence of bipolar disorders in patients with medical diseases is higher than healthy controls. Aims This study aimed to investigate the prevalence of bipolar disorders in the medically ill patients hospitalized in general hospitals. Methods In this cross-sectional study, 706 patients (342 men, 49%) admitted to different wards of three general hospitals randomly enrolled to the study. Demographic questionnaire, MDQ (Mood Disorder Questionnaire) and BSDS (Bipolar spectrum Diagnostic Scale) were used. The criteria for inclusion were informed consent and cooperation for the study, lack of cognitive and mental disorders and being literate. Results In 84 (12.1%) and 145 (20.8%) patients, respectively BSDS and MDQ questionnaire results were positive. In 75% of patients, the results of both tests were negative, while in 9.7% of hospitalized patients, the results of both tests were positive. The frequency of bipolar mood disorders was not significantly different between male and female, but the frequency of bipolar disorders was significantly higher in singles, smokers, alcohol abusers, younger age and lower education level. The highest rate of bipolar disorders was reported in the orthopaedic ward. Conclusion The prevalence of bipolar mood disorders in hospitalized medically ill patients is significant, due to the impact of the disorder on the lifestyle, compliance and the prognosis, identification and treatment of bipolar mood disorders is important in these patients.

Major depression and bipolar disorders in CADASIL: a study using the DSM-IV semi-structured interview

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral microangiopathy characterized by migraine, cerebrovascular events, and cognitive impairment. Although recognized as a cardinal feature of the disease, psychiatric disturbances have rarely been the object of focused studies. We performed a structured evaluation of mood disorders in CADASIL. Twenty-three patients with CADASIL (five men and 18 women) were assessed by psychiatrists using the Structured Clinical Interview for the DSM-IV, clinician version. For the quantitative assessment of current mood disorder symptoms, the Hamilton Rating Scale for Depression (HRSD) and the Young Mania Rating Scale (YMRS) were used. A lifetime depressive episode was recorded in 17/23 (73.9%) patients with CADASIL. Six (26.1%) patients with CADASIL reported a current depressive episode. A diagnosis of manic lifetime episode was made in 6 (26.1%) patients with CADASIL. The HRSD mean score in patients with current depression was 9.1 ± SD 8.1. The YMRS mean score was 14.2 ± SD 4.1 for manic CADASIL. This study confirms that mood disorders are frequent in CADASIL. The use of a structured psychiatric interview outlines a frequency of depression higher than that previously reported but also reveals a considerable frequency of bipolar disorders. If confirmed in larger series, these data suggest that a greater attention should be paid to the psychiatric aspects in CADASIL.

Detecting Differences in Diagnostic Assessment of Bipolar Disorder

During the past 25 years, semistructured diagnostic interviews have been the standard for diagnostic evaluations in research relying on reliable and valid psychiatric assessment and diagnosis. However, the use of semistructured interviews still requires interpretation of the diagnostic criteria and does not preclude the application of different diagnostic thresholds. The goal of this report from the Rhode Island Methods to Improve Diagnostic Assessment and Services project is to illustrate how a self-report scale can be used to detect systematic differences in the application of diagnostic criteria for bipolar disorder and to demonstrate the wide variation in how broadly different groups tend to diagnose bipolar disorder. We compared the frequency of bipolar diagnoses in 4 studies that examined the performance of mood disorders questionnaire (MDQ) with the Structured Clinical Interview for DSM-IV (SCID). We also compared the prevalence rate of MDQ cases and the ratio of SCID diagnoses with MDQ cases. The frequency of bipolar disorder in the 4 studies ranged from 10.9% to 76.2%-a 7-fold difference in prevalence rates. The frequency of MDQ-positive cases ranged from 17.8% to 31.2%, less than a 2-fold difference in prevalence rates. Thus, there was much less variability in MDQ rates than diagnosis rates. Moreover, the rank order of the prevalence of MDQ cases differed from the rank order of the prevalence of SCID diagnoses. The SCID/MDQ ratio significantly differed between the studies. These findings demonstrate how systematic differences in diagnostic practice might be detected using a self-administered scale such as the MDQ. The results also underscore that wide variation exists in the bias toward diagnosing bipolar disorder, even after controlling for differences in prevalence among samples.

Association of Bipolar and Substance Use Disorders in Parents of Adolescents With Bipolar Disorder

We have previously shown that juvenile bipolar disorder (BPD) is a risk for substance use disorders (SUD). Here we examine the expression of both disorders in families of youth with BPD to evaluate the familial risk mechanism. We studied 108 adolescent BPD probands with 187 parents (34 with SUD and 58 parents) and 96 control probands with 177 parents with structured interviews. We compared the prevalence of BPD and SUD with Cox proportional hazards models with time to onset of BPD or SUD as the dependent variable and proband diagnosis (Control, BPD, or BPD+SUD) as the independent variable. The parents of the proband youth with BPD (without SUD) and BPD+SUD were more likely to develop BPD than the parents of control subjects [omnibus test chi2=10.18, p=.006]; we found no differences between the two bipolar groups. Parents of proband youth with BPD and with BPD+SUD were more likely than relatives of control subjects to develop SUD [omnibus test chi2=14.69, p<.001]; however, we found no differences between the parents of the two proband bipolar groups. Within the parents of proband youth with BPD+SUD, we found higher risk of SUD in parents with BPD than in those without BPD [chi2=8.39, p=.004], although the frequency of BPD was low in this group of parents. Bipolar disorder and SUD are prevalent in the first-degree relatives of adolescents with BPD. Adults with BPD were more likely to manifest SUD with preliminary evidence of BPD and SUD cosegregation.