ABSTRACTOxidative damage to cellular constituents is one of the major mechanisms of alcoholic liver injury, and administration of antioxidants ameliorates alcoholic liver disease. The present study investigated the influence of (-) epigallocatechin gallate (EGCG), a major polyphenol component of green tea, on oxidant–antioxidant balance, protein, and lipid damage in liver of rats fed ethanol. Chronic ethanol administration (6 g/kg/day × 60 days) caused liver damage that was manifested by excessive formation of lipid peroxidation end products such as thiobarbituric acid-reactive substances (TBARS), lipid hydroperoxides (LHP), and conjugated dienes (CD) accompanied by a reduction in enzymic and non-enzymic antioxidant levels. Further, ethanol caused a rise in protein carbonyl formation and loss of protein thiol groups. Ethanol-fed rats exhibited increased staining for the presence of 4-hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), and 2,4-dinitrophenol (DNP) protein adducts in liver. The detrimental effects of ethanol were alleviated upon simultaneous treatment with EGCG (100 mg/kg/day) for the last 30 days of alcohol feeding. These findings show that EGCG ameliorates protein and lipid damage induced by the hepatotoxin, ethanol.