The shock compression response of Ti+2B (1:2 Ti:B stoichiometric ratio) reactive powder mixtures at ~50% theoretical material density (TMD) is investigated for shock pressures up to 5 GPa to investigate the possible shock-induced chemical reactivity of this highly exothermic mixture. The shock adiabat is produced from instrumented parallel-plate gas-gun impact experiments on encapsulated powders using poly-vinylidene fluoride (PVDF) stress gauges to measure the input and propagated stresses and wave speed in the powder. The shock compression regime is probed from crush-up to full density and onward to assess the potential onset of a shock-induced chemical reaction event in the powder mixture. A series of two-dimensional continuum meso-scale simulations on validated simulated microstructures are performed to predict the shock compression response and identify the meso-scale mechanics that are essential for reaction. The suitability of the synthetic microstructural representations is evaluated by comparing the experimental and predicted pressure traces.