Fluid Distribution Research Articles

Population Pharmacokinetic Model of Intravenous Immunoglobulin in Patients Treated for Various Immune System Disorders

Intravenous immunoglobulin (IVIG) is used to treat various immune system disorders, but the factors influencing its disposition are not well understood. This study aimed to estimate the population pharmacokinetic parameters of IVIG and to investigate the effect of genetic polymorphism of the FCGRT gene encoding the neonatal Fc receptor (FcRn) and clinical variability on the pharmacokinetic properties of IVIG in patients with immune system disorders. Patients were recruited from 4 hospitals in Malaysia. Clinical data were recorded, and blood samples were taken for pharmacokinetic and genetic studies. Population pharmacokinetic parameters were estimated by nonlinear mixed-effects modeling in Monolix. Age, weight, baseline immunoglobulin G concentration, ethnicity, sex, genotype, disease type, and comorbidity were investigated as potential covariates. Models were evaluated using the difference in objective function value, goodness-of-fit plots, visual predictive checks, and bootstrap analysis. A total of 292 blood samples were analyzed from 79 patients. The IVIG concentrations were best described by a 2-compartment model with linear elimination. Weight was found to be an important covariate for volume of distribution in the central compartment (Vc), volume of distribution in the peripheral compartment (Vp), and clearance in the central compartment, whereas disease type was found to be an important covariate for Vp. Goodness-of-fit plots indicated that the model fit the data adequately. Genetic polymorphism of the FCGRT gene encoding the neonatal Fc receptor did not affect the pharmacokinetic properties of IVIG. This study supports the use of dosage based on weight as per current practice. The study findings highlight that Vp is significantly influenced by the type of disease being treated with IVIG. This relationship suggests that different disease types, particularly inflammatory and autoimmune conditions, may alter tissue permeability and fluid distribution due to varying degrees of inflammation. Increased inflammation can lead to enhanced permeability and retention of IVIG in peripheral tissues, reflecting higher Vp values.

Review on spontaneous imbibition mechanisms in gas-water systems: Impacts on unconventional gas production and CO2 geo-sequestration

Spontaneous imbibition, a fundamental process in porous media, involves the displacement of a non-wetting phase by a wetting phase driven by capillary pressure. It plays a key role in various applications, particularly in unconventional gas production and greenhouse gas geo-sequestration. Despite extensive research in this area, conflicting results and explanations persist regarding imbibition phenomena, particularly in gas-water systems. This paper aims to address this gap by providing a comprehensive review of basic concepts, mechanical analyses, pore-filling patterns, front evolutions, and influencing factors associated with spontaneous imbibition. Mechanical factors including capillary force, viscous force, gravitational force, hydrostatic force, inertial force, capillary back force, and dead end force, play crucial roles in water imbibition with different boundary types. The pore-filling pattern significantly affects microscopic fluid distribution and front evolution during the imbibition process. To resolve conflicting findings, we systematically analyze the influencing factors of spontaneous imbibition within gas-water systems, encompassing rock properties, fluid characteristics, rock-fluid interactions, and reservoir properties. Furthermore, we present an in-depth discussion on the imbibition and trapping mechanisms relevant to unconventional gas production and CO2 geo-sequestration, providing insights into force analyses and influencing factors. Gas production strategies and favorable conditions for CO2 capillary trapping are proposed. Finally, we outline existing knowledge gaps and suggest potential directions for future research. This review thus provides useful insights and suggestions for advancing our understanding of spontaneous imbibition within gas-water systems and optimizing unconventional gas production and CO2 geo-sequestration practices.

Improving fluid identification in well logging using Continuous Wavelet Transform and Vision Transformers: An innovative approach

Well logging fluid prediction is one of the key steps in assessing oil and gas reserves. By analyzing downhole logging data, different types of fluids contained in underground rocks, such as crude oil, natural gas, and water, can be determined. This information is crucial for assessing the abundance and recoverable reserves of oil and gas resources and helps guide oil and gas exploration and development work. We have introduced a novel model called CWT (Continuous Wavelet Transform)-ViT (Vision Transformer). CWT can simultaneously provide frequency information at different scales, enabling the model to analyze downhole logging data more comprehensively and accurately at different scales. Underground rock structures often exhibit features at multiple scales, and CWT can effectively capture these features, aiding in better differentiation of different types of fluids. The ViT model utilizes the Transformer architecture, allowing for global attention over input sequences without being limited by sequence length. This enables the model to comprehensively understand the overall information of downhole logging data and extract richer features. For complex geological structures and fluid distributions in geological exploration, the global attention mechanism helps the model better grasp the overall situation, thereby improving the accuracy of fluid prediction. When we used the CWT-ViT method for well logging fluid prediction, we achieved a high accuracy rate of 97.50% in the first dataset, which further improved to 97.77% in the second dataset. These results demonstrate the significant robustness and efficiency of the CWT-ViT method in lithology prediction using well logging data. We also conducted blind well experiments, and our CWT-ViT model outperformed other models, achieving a blind well prediction accuracy of 97.36%. Therefore, the experiments indicate that the key to improving accuracy in well logging fluid prediction with CWT lies in its multiscale analysis capability, effectively capturing different fluid characteristic frequencies. Additionally, CWT enhances signal features and removes noise, increasing the precision of fluid identification. Finally, the integration with ViT further optimizes fluid prediction performance, making it outstanding in complex geological environments. The advantages of ViT in fluid prediction include its excellent sequence modeling capability, effective handling of long-distance dependencies, and enhanced ability to capture fluid characteristics in complex well logging data.

Performance and energy consumption study of a dual-evaporator loop heat pipe for chip-level cooling

The dual-evaporator loop heat pipe (DeLHP) exhibits more applications than a single-evaporator loop heat pipe in a chip-level cooling field. However, increasing the evaporators leads to a complex pipeline structure. This study focuses on developing and investigating a new parallel structure for the DeLHP. Experimental research was conducted to analyze the startup characteristics of DeLHP under single-load and dual-load conditions, and its operational characteristics under various variable power conditions. Numerical simulation was employed to analyze the fluid distribution and flow characteristics. The results indicate that heating the evaporator near the vapor pipeline achieves faster startup and more stable temperatures under a single load. Under dual loads, DeLHP exhibits a faster startup compared to a single load. When the thermal load near the vapor pipeline is greater than the load on the evaporator near the liquid pipeline, DeLHP starts faster and maintains a lower stable temperature. Under a maximum total load of 300 W, the heating surface temperature stabilizes below 80 ℃. The numerical simulation results indicate that when evaporator 1 near the liquid pipeline is individually heated, the temperatures, vapor fractions, and fluid velocities of the two evaporators are more balanced. The power usage effectiveness reaches a minimum value of 1.09 at 150 W. These research findings provide reliable and substantive support for the performance optimization of DeLHPs in practical applications.

Study on the Percolation Law of Tight Gas in the Western Sulige Area based on the Lattice Boltzmann method

Abstract To address the problem of unable to determine the percolation law of tight sandstone gas reservoirs under laboratory conditions, especially when there are no water production measurements and no obvious edge and bottom water. In this study, takes the Western Sulige area as the research object, and based on the geological characteristics of the Western Sulige area and the lattice Boltzmann method, establishes a LB mechanism model for tight gsa in the Western Sulige area, identify Identify fluid distribution and percolation rules in the pore throat structure of Western Sulige area The results show that There are four types of bound water in the pore throats of the western Sulige area, including trapped water, bind pore water, dead pore water, and liquid film.. The remaining gas in the production process is mainly distributed in the pore throat structure, including bind pore gas, fine throat pore gas, and water seal gas. In the early stage of gas-water production, formation water mainly in the form of liquid film reduces the cross-section of natural gas flow. Subsequently, formation water mainly in the form of liquid droplets clogs the throat, thereby reducing the gas percolation capacity. Due to the capillary suction effect, liquid–solid viscous forces, and pore–throat structures, the reservoirs of Western Sulige Area is prone to water lock damage, resulting in reduced production and even production suspension of gas wells. Therefore hydraulic fracturing is a necessary measure for the development of tight gas, but the increase in the intensity of fracturing operations has increased the width of fractures and strengthened the water lock phenomenon, further worsening the percolation capacity of the matrix.

Role of decoupling process on the configurations of compact stars induced by Thomas-Fermi dark matter with null complexity in f(T) gravity

Our goal in this work is to find an anisotropic solution for a self-bound compact object composed of dark matter with a null complexity factor in f(T)-gravity theory. We use a well-known gravitational decoupling via complete geometric deformation (CGD) technique to examine the role of decoupling parameters on the configuration of compact objects. Initially, we derive the null complexity condition for f(T)-gravity decoupled system which leads to a relation between gravitational potentials. Next, we apply the CGD approach to split the decoupled system into two subsystems. The initial system refers to a pure f(T) gravity system consisting of an isotropic fluid distribution, where the isotropy criterion is equivalent to the condition in Einstein's gravity. The solution of the first system is solved through the Vlasenk-Pronin space-time metrics while the second system associated with the deformation function is solved by the density constraints method by mimicking a new source with Thomas-Fermi dark matter density profile that generates the anisotropy in the decoupled system. The physical validity of the anisotropic solution is checked by the graphical analysis of the pressure, density, energy, and stability conditions. We have also shown the effect of torsion and decoupling parameters on the configuration of anisotropic compact objects. The energy exchange (ΔE) of fluid distribution is also discussed. We found that ΔE is positive throughout the stellar configuration, which implies that energy is effectively transmitted to the surrounding environment.

Comprehensive discussion of Krori–Barua Bardeen compact stars on modified f(R) theories of gravity with scalar potential

The objective of this paper is to deal with physical features of charged anisotropic compact objects in the framework of [Formula: see text] modified theory of gravity. To accomplish the desired objective, we consider a spherically symmetric spacetime with charged anisotropic fluid distribution. In addition, we utilize the Krori–Barua metric, i.e. [Formula: see text] and [Formula: see text] for exploring the field equations. Moreover, we compare the interior boundary to the bardeen model as an exterior geometry to calculate the unknown constrains. Further, to check the existence of bardeen stellar structure, we discuss the behavior of physical properties such as energy density, pressure components, anisotropy, equation of state parameters, stability analysis, energy bounds, equilibrium condition, adiabatic index, compactness factor and surface redshift. Conclusively, all the obtained results show that the system under consideration is physically stable, free from singularity and viable.

A new perspective on gravitational collapse: a comprehensive analysis using Θ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\Theta $$\\end{document} parametrization

In this article, we have studied some new facets of gravitational collapse, beyond conventional notions of black holes, and naked singularities. The present work is focused on the unresolved problems of theoretical physics concerning the final fate of the gravitational collapse of any massive star. By generalizing the foundational work of Oppenheimer and Snyder (Phys Rev 56:455, 1939), we have considered the homogeneous gravitational collapsing system filled with perfect fluid distributions (devoid of dust fluid) within the framework of GR theory. The article investigates a homogeneous gravitational collapsing system using a parametrization scheme for the expansion-scalar (Θ)\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$(\\Theta )$$\\end{document} and determining the exact solution of field equations. Further, by employing the known Darmois–Israel boundary condition, we have discussed the solution in more detail, and the model’s physical and geometrical quantities are obtained in terms of stellar mass (M), making it crucial for astrophysical applications. To assess the astrophysical viability of our model, we consider a massive star-β\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\beta $$\\end{document}Canis Majoris and throughout this study we have presented a detailed numerical and graphical analysis of our model. The analysis of singularities in the models is conducted through the examination of the apparent horizon. Our findings demonstrate that the star continues to collapse indefinitely in co-moving time, ultimately leading to a space-time singularity-this represents a case of continuous gravitational collapse. We propose that this scenario describes an “Eternal Collapsing Object,” which may be treated as a “mathematical black hole without any finite equilibrium state.” Our presented models undergo rigorous physical tests to ensure their regularity, causality, and stability, and to satisfy the necessary energy conditions.

Role of Rastall gravity in constructing new spherically symmetric stellar solutions

This paper formulates new stellar solutions corresponding to a static spherical spacetime through the minimal gravitational decoupling in the context of Rastall theory. For this, we initially adopt a seed source to be the isotropic and then add a new gravitating matter source whose impact is controlled by the decoupling parameter. The addition of the later source enhances the degrees of freedom in the corresponding equations of motion. To reduce them, we apply the geometric transformation only to a radial metric potential that divides the field equations into two sets, each of them govern the impact of only one source. Afterwards, we take into account the Schwarzschild solution to make the metric potentials known. Moreover, different constraints on the components of newly added source are employed to develop some suitable solutions of the second system. We construct three different solutions to the total fluid distribution and check their graphical behavior for certain parametric values. Finally, we conclude all our resulting models to be agree with the energy conditions in this extended theory.

Shear-induced fluid localization, episodic fluid release and porosity wave in deformable low-permeability rock salt

Understanding fluid distribution and migration in deformable low-permeability rock salt is critical for geologic disposal of nuclear waste. Field observations indicate that fluids in a salt formation are likely compartmentalized into relatively isolated patches and fluid release from such a formation is generally episodic. The underlying mechanism for these phenomena remains poorly understood. In this paper, a hydrological-mechanical model is formulated for fluid percolation in a rock salt formation under a deviatoric stress. Using a linear stability analysis, we show that a porosity wave (a train of alternating high and low porosity pockets) can emerge from positive feedbacks among intergranular wetting, grain boundary weakening and shear-induced material dilatancy. Fluid localization or episodic release can be viewed as a stationary or propagating porosity wave respectively. Fluid pockets transported via a porosity wave remain relatively isolated with minimal mixing between neighboring pockets. We further show that the velocity of fluid flow can be significantly enhanced by the emergence of a porosity wave. The concept and the related model presented in this paper provide a unified consistent explanation for the key features observed in fluid flow in rock salt. The similar process is expected to occur in other deformable low-permeability media such as shale and partially molten rocks under a deviatoric stress. Thus, the result presented here has an important implication to hydrocarbon expulsion from shale source rocks, radioactive waste isolation in a tight rock repository, and caprock integrity of a subsurface gas (CO2, H2 or CH4) storage system. It may also help develop a new engineering approach to fluid injection into or extraction from unconventional reservoirs.

Minimal Einstein-Aether theory

We show that there is a phenomenologically and theoretically consistent limit of the generic Einstein-Aether theory in which the Einstein-Aether field equations reduce to Einstein field equations with a perfect fluid distribution sourced by the aether field. This limit is obtained by taking three of the coupling constants of the theory to be zero but keeping the expansion coupling constant to be nonzero. We then consider the further reduction of this limited version of Einstein-Aether theory by taking the expansion of the aether field to be constant (possibly zero), and thereby we introduce the Minimal Einstein-Aether theory that supports the Einstein metrics as solutions with a reduced cosmological constant. The square of the expansion of the unit-timelike aether field shifts the bare cosmological constant and thus provides, via local Lorentz symmetry breaking inherent in the Einstein-Aether theories, a novel mechanism for reconciling the observed, small cosmological constant (or dark energy) with the large theoretical prediction coming from quantum field theories. The crucial point here is that minimal Einstein-Aether theory does not modify the well-tested aspects of General Relativity such as solar system tests and black hole physics including gravitational waves.

Myxedema in Both Hyperthyroidism and Hypothyroidism: A Hormetic Response?

Myxedema is a potentially life-threatening condition typically observed in severe hypothyroidism. However, localized or diffuse myxedema is also observed in hyperthyroidism. The exact cause and mechanism of this paradoxical situation is not clear. We report here the analysis of body fluid distribution by bioelectrical impedance analysis (BIA) in 103 thyroid patients, subdivided according to their functional status. All BIA parameters measured in subclinical thyroid dysfunctions did not significantly differ from those observed in euthyroid controls. On the contrary, they were clearly altered in the two extreme, opposite conditions of thyroid dysfunctions, namely overt hyperthyroidism and severe hypothyroidism, indicating the occurrence of a typical hormetic condition. Surprisingly, differences in BIA parameters related to fluid body composition were even more evident in hyperthyroidism than in hypothyroidism. A hormetic response to thyroid hormone (TH)s was previously reported to explain the paradoxical, biphasic, time- and dose-dependent effects on other conditions. Our results indicate that myxedema, observed in both hypothyroid and hyperthyroid conditions, represents another example of a hormetic-type response to THs. BIA offers no additional valuable information in evaluating fluid body composition in subclinical thyroid dysfunctions, but it represents a valuable method to analyze and monitor body fluid composition and distribution in overt and severe thyroid dysfunctions.

Long-Term Comparison of Nanosilica and Polyacrylamide/Polyethyleneimine Gels as Water Shutoff Agents in Permeable Matrix

Summary The oil and gas industry faces numerous challenges, among which the management of excessive water production is a significant concern. Nanosilica gel is a newly developed silicate gel for water shutoff applications. No investigation has been conducted to evaluate the gel’s performance over an extended period. The objective of this study is to evaluate the long-term performance of nanosilica gel in a permeable matrix over 6 months while also comparing this performance with polyacrylamide/polyethyleneimine (PAM/PEI) gel. Coreflooding experiments were conducted to evaluate the performance of the nanosilica gel of 75/25 wt% (nanosilica/activator) and PAM/PEI gel (9/1 wt%) on carbonate core samples at 200°F. The experiment involved initial permeability assessment, gel placement, and endurance tests up to 1,000 psi. Additional measurements of computed tomography (CT) scan and nuclear magnetic resonance (NMR) were implemented: CT scans visualized density changes, and NMR measured fluid distribution in the pore system. Then, samples were aged at 167°F for 6 months, with endurance tests (up to 1,000 psi) conducted in the first, third, and sixth months to assess gel-plugging efficiency. The results demonstrated nanosilica gel’s remarkable plugging efficiency, achieving a reduction in permeability from 144.85 md to 0.001 md initially and sustaining differential pressures up to 1,000 psi with minimal leakoff rates. After 6 months, nanosilica gel maintained plugging efficiency above 99.98%, while PAM/PEI gel efficiency reduced to 99.85%. The nanosilica gel achieved slightly better long-term plugging performance than PAM/PEI gel with a maximum leakoff rate of 0.25 cm3/min in 6 months (2.165 cm3/min for PAM/PEI gel). CT scan analysis confirmed effective gel placement within the pore systems, and minimal degradation occurred over time with less significant impact on the efficiency of nanosilica gel compared with PAM/PEI gel.

Electrical conductivity model for reactive porous media under partially saturated conditions with hysteresis effects

The electrical conductivity of a porous medium is strongly controlled by the structure of the medium at the microscale as the pore configuration governs the distribution of the conductive fluid. The pore structure thus plays a key role since different geometries translate in variations of the fluid distribution, causing different behaviors measurable at the macroscale. In this study, we present a new physically-based analytical model derived under the assumption that the pore structure can be represented by a bundle of tortuous capillary tubes with periodic variations of their radius and a fractal distribution of pore sizes. By upscaling the microscale properties of the porous medium, we obtain expressions to estimate the total and relative electrical conductivity. The proposed pore geometry allows us to include the hysteresis phenomenon in the electrical conductivity estimates. The variations on these estimates caused by pore structure changes due to reactive processes are accounted by assuming a uniform dissolution of the pores. Under this hypothesis, we describe the evolution of the electrical conductivity during reactive processes. The expressions of the proposed model have been tested with published data from different soil textures, showing a satisfactory agreement with the experimental data. Hysteretic behavior and mineral dissolution are also successfully addressed. By including hysteresis and mineral dissolution/precipitation in the estimates of the electrical conductivity, this new analytical model presents an improvement as it relates those macroscopic physical phenomena to its origins at the microscale. This opens up exciting possibilities for studies involving electrical conductivity measurements to monitor water movement, and hysteretic and reactive processes in porous media.

Study on the hydraulic conveyance characteristics of suspended coarse particles within pipelines

The Flow Regime Transition Device transforms the gelled crude oil mass into gelled crude oil particles for hydraulic conveying. The gelled crude oil particles may reaggregate into gelled crude oil mass at the later stage of hydraulic conveying. Therefore, understanding the patterns of hydraulic suspension conveying gelled crude oil particles is vital for safely gathering and efficiently conveying crude oil. This paper employs the CFD-DEM coupling technique to conduct a numerical study on the hydraulic conveying characteristics of gelled crude oil particles. The accuracy of the model and the solution method is verified by comparing them with the experimental data of particle concentration distribution, and single particle rise behavior, and particle transport flow of gelled crude oil. The size range of gelled crude oil particles spans from 0.0001 m to 0.003 m. We operate the transportation within a velocity range of 0.5 to 4 m/s and a concentration range of 0.022 to 0.0537. Simulation results indicate two flow regimes in the hydraulic conveying of gelled crude oil particles: an upper-moving bed flow and a heterogeneous suspension flow. With increased conveying velocity, the upper moving bed flow gradually transitions to a heterogeneous suspension flow. Beneath the upper moving bed flow, some scattered particles exist, likely resulting from the action of turbulent diffusion. Changes in conveying concentration and particle size have a minor impact on the velocity distribution of particles and fluid but a more significant effect on the particle distribution across the pipe cross-section. Also, when conveying particles of different sizes, most smaller particles travel along the pipe wall.

Laboratory measurements of water saturation effects on the acoustic velocity and attenuation of sand packs in the 1–20 kHz frequency range

AbstractWe present novel experimental measurements of acoustic velocity and attenuation in unconsolidated sand with water saturation within the sonic (well‐log analogue) frequency range of 1–20 kHz. The measurements were conducted on jacketed sand packs with 0.5‐m length and 0.069‐m diameter using a bespoke acoustic pulse tube (a water‐filled, stainless steel, thick‐walled tube) under 10 MPa of hydrostatic confining pressure and 0.1 MPa of atmospheric pore pressure. We assess the fluid distribution effect on our measurements through an effective medium rock physics model, using uniform and patchy saturation approaches. Our velocity and attenuation (Q−1) are accurate to ±2.4% and ±5.8%, respectively, based on comparisons with a theoretical transmission coefficient model. Velocity decreases with increasing water saturation up to ∼75% and then increases up to the maximum saturation. The velocity profiles across all four samples show similar values with small differences observed around 70%–90% water saturation, then converging again at maximum saturation. In contrast, the attenuation increases at low saturation, followed by a slight decrease towards maximum saturation. Velocity increases with frequency across all samples, which contrasts with the complex frequency‐dependent pattern of attenuation. These results provide valuable insights into understanding elastic wave measurements over a broad frequency spectrum, particularly in the sonic range.

Pore Structure and Fluid Distribution of Lower Cretaceous Jiufotang and Shahai Shales in the Ludong Sag, Northeast China

Pore Structure and Fluid Distribution of Lower Cretaceous Jiufotang and Shahai Shales in the Ludong Sag, Northeast China

Quantification of immiscible displacement in a rough-walled fracture through direct visualization

Subsurface substance migration in the fractured rock aquifer is mainly controlled by fractures, and immiscible fluid-fluid displacement in fractures is important to many geophysical processes and engineering activities. Using a fracture-visualization system, we present the qualitative and quantitative assessment of fracture geometry associated with fluid movement and distribution in the rough fracture. Based on fracture geometry and statistical analysis, we first conducted a quantitative study of fracture surface roughness and aperture distribution. Then, fractal dimensions of displacement front and residual oil distribution were determined by image processing procedures. Influenced by wettability and micro-scale roughness, at the end of the displacement, residual oil saturation of molded sample is lower (6.45%–25.74%), and displacement pattern is more uniform, indicating that displacement effect is better. Due to smaller differences in residual oil saturation (9.08%) under different injection directions, the impact of wettability on the displacement process is greater than that of anisotropic roughness. Additionally, the fractal dimension of the displacement front increased under low injection rates initially but decreased when the rate was increased later. Overall, visualized temporal monitoring of experimental images enabled us to provide a preliminary assessment of the impact of anisotropic roughness and the material constituting the fracture wall on invading fluid saturation and the fractal dimension of the displacement front under various injection rates.

Numerical simulation to influence of fluid distribution on acoustic attenuation coefficient in gas water two-phase fractured media

Abstract The equivalent fluid model simplifies the actual distribution state of fluid, and the relationship between rock elastic properties and pore fluid parameters established by the equivalent fluid model usually deviates greatly from the experimental results. A random discrete fracture model is established, and the gas-water two-phase distribution in fracture pores is described in detail. Based on the acoustic wave theory, the finite difference numerical simulation of the acoustic wave field of the rock sample model is carried out. The variation law of acoustic attenuation coefficient with saturation under the different pore fluid distribution modes is analyzed. It is of great significance to the prediction of rock pore structure and the identification of reservoir fluid.

Fluid distribution during surgery in the flat recumbent, Trendelenburg, and the reverse Trendelenburg body positions.

The distribution and elimination of infused crystalloid fluid is known to be affected by general anesthesia, but it is unclear whether changes differ depending on whether the patient is operated in the flat recumbent position, the Trendelenburg ("legs up") position, or the reverse Trendelenburg ("head up") position. Retrospective data on hemodilution and urine output obtained during and after infusion of 1-2 L of Ringer's solution over 30-60 min were collected from 61 patients undergoing surgery under general anesthesia and 106 volunteers matched with respect to the infusion volume and infusion time. Parameters describing fluid distribution in the anesthetized and awake subjects were compared by population volume kinetic analysis. General anesthesia decreased the rate constant for urine output by 79% (flat recumbent), 91% (legs up) and 91% (head up), suggesting that laparoscopic surgery per se intensified the already strong anesthesia-induced fluid retention. General anesthesia also decreased the rate constant governing the return of the distributed fluid to the plasma by 32%, 15%, and 70%, respectively. These results agree with laboratory data showing a depressive effect of anesthetic drugs on lymphatic pumping, and further suggest that the "legs up" position facilitates lymphatic flow, whereas the "head up" position slows this flow. Both Trendelenburg positions increased swelling of the "third fluid space". General anesthesia caused retention of infused fluid with preferential distribution to the extravascular space. Both Trendelenburg positions had a modifying influence on the kinetic adaptations that agreed with the gravitational forces inflicted by tilting to body.