One of the significant challenges during wellbore drilling is accurately predicting frictional pressure losses in symmetrical drill pipes. In this work, a Bayesian regularized neural network (BRANN) and multivariate adaptive regression splines (MARS) are employed to develop accurate and interpretable models for predicting frictional pressure losses during drilling. Utilizing data of frictional pressure loss collected through experimentation, the models are created. The model inputs include mud flow rate, mud density, pipe diameter (inside and outside diameters), and viscometer dial readings, while pressure loss is the output. Statistical comparisons between the model predictions and the actual values demonstrate the models’ ability to reasonably forecast frictional pressure losses in wells. The performance of the models, as measured by error metrics, is as follows: BRANN (0.999, 0.076, 16.76, and 11.67) and MARS (0.998, 0.0989, 21.32, and 16.499) with respect to the coefficient of determination, average absolute percentage error, root mean square error, and mean absolute error, respectively. Additionally, a parametric importance study reveals that, among the input variables, internal and external pipe diameters are the top predictors, with a relevancy factor of −0.784 for each, followed by the mud flow rate, with a relevancy factor of 0.553. The trend analysis further confirms the physical validity of the proposed models. The explicit nature of the models, together with their physical validation through trend analysis and interpretability via a sensitivity analysis, adds to the novelty of this study. The precise and robust estimations provided by the models make them valuable virtual tools for the development of drilling hydraulics simulators for frictional pressure loss estimations in the field.
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