Flexible tactile sensors (FTS), which have been extensively used in force sensing devices, are gaining tremendous attentions in various application fields, such as robots, electronic skin (E-Skin), human-machine interaction (HMI), and many other rapidly developing frontier technologies. However, fabricating FTS achieving both high sensitivity and broad sensing range remains a great challenge. Moreover, the integration of FTS with flexible circuit boards has long been a hot topic due to its potential applications in flexible hybrid electronics (FHEs). Here, we report a novel flexible tactile sensor with ultrahigh sensitivity and wide sensing range and its application in a self-cleaning and fully integrated wearable tactile sensing system for real-time analysis. Benefiting from the conductive sensing materials composed of fine inverted pyramid arrays and double-covered sensing layers, the sensor exhibits a superior sensitivity of 451.292 kPa−1, a wide working range up to 250 kPa, and a fast response time of 31 ms, as well as long-term durability. Furthermore, the sensor system can accurately monitor the grasped force in real-time and easily be fixed on a flexible clamping jaw or human hands. Our design concept and experimental approach, either for the flexible sensor or the whole system, potentially push further the wearable electronics toward practical applications.