Shoreline changes are important indicators of natural and manmade impacts on inland waters and particularly lakes. Man-induced changes in Lake Sevan water level during the 20th century affected not only the ecological status of the Sevan water but also near-shore areas. This article considers a long-term study of changes in Lake Sevan shoreline that occurred between 1973 and 2015. The Normalized Difference Water Index (NDWI) was applied to delineate the Sevan shoreline changes according to periods of lake water fluctuation from multi-temporal Landsat images and Historical changes in shorelines were analyzed with help of the Digital Shoreline Analysis System (DSAS) toolbox. Data obtained from the analysis have indicated that changes in the lake shoreline that occurred in different periods are similar to those in the lake water balance. Areas with the greatest shoreline changes have comparatively flat relief, so in the result of the lake water level raise vast forested areas were submerged. This study shows that application of multi-temporal spatial imagery and GIS methods can provide valuable information on time-and-space changes in the Sevan shoreline. Such information is important for monitoring Lake Sevan shoreline and nearshore changes.