Flare Area Research Articles

Decreased Axon Flare Reaction to Electrical Stimulation in Patients With Chronic Demyelinating Inflammatory Polyneuropathy.

In chronic inflammatory demyelinating polyradiculopathy (CIDP), the impairment of unmyelinated nerve fibers appears unexpected. The measurement of the electrically induced axon flare reflex is a clinical test to assess the peripheral C-nociceptor function. In this study, we compared the flare area in patients suffering from CIDP with healthy subjects. We examined 18 patients fulfilling the criteria for CIDP (11 men, mean age 51.8 years, SD 15.1) and 18 age-matched adult healthy volunteers (control group) (11 men, mean age 51.9 years, SD 15.8). The flare responses were elicited by transcutaneous electrical stimulation and recorded by laser Doppler imaging. There was a significant reduction of electrically induced maximum flare area in the foot dorsum of patients with CIDP (t-value 2.08, P = 0.04) which proved to be length-dependent measured by a numerical index comparing the results with the forearm and thigh. The repeatedmeasures ANOVA revealed statistically significant smaller flare areas in all body regions for the CIDP group (P < 0.001). The axon flare reaction to electrical stimulation was decreased in patients with chronic demyelinating inflammatory polyneuropathy. The evaluation of the axon flare response can be proposed as a noninvasive objective functional test to detect an impaired C-fiber function in CIDP patients with the advantages of simplicity of the procedure, time economy, and objectivity.

Concentrations of some heavy metals in underground water samples from a Nigerian crude oil producing community.

Pollution due to oil exploration activities in the Niger Delta region of Nigeria and government under-investments in potable water infrastructure has led to the dependence of the population on personal boreholes. Yet, there are little quality or surveillance reports on such waters. The concentrations of heavy metals in underground water samples from an oil producing area, Umuebulu, in the Niger Delta were therefore investigated. Water samples were collected from three test points, each approximately 300m from (1) wellhead area (WHA), (2) flare area (FA) and (3) effluent discharge area (EDA), and one control point located 10km away from any oil-related activity. The concentrations of lead, arsenic and cadmium were determined in the samples using atomic absorption spectrophotometry. All three heavy metals were present in the test, and control water samples at concentrations significantly (P<0.05) exceeding the maximum contaminant levels recommended by the World Health Organization. The total hazard index of the water samples showed that their consumption constituted significant health risks in the order EDA>FA>WHA>Control. Appropriate water treatment and surveillance is warranted and therefore recommended for underground water resources of the studied community.

Atmospheric Corrosion of Corrugated Iron Roofing Sheet in Oil Producing Locations in Southeastern Nigeria

The study evaluated the atmospheric corrosion of corrugated iron roofing sheets in rural, urban, and marine environments using rain water harvested from roofs of various ages. Corrosion study was based on the weathering processes leading to high levels of sulphate, chloride and nitrate in rainwater in the three areas. Results showed that roofs below one year and 2 years in age were more susceptible to rusting than roofs above 15 years. The mean corrosion rates were higher in marine (Ibeno) ranging between 0.16 × 103 μm/yr and 2.94 × 103 μm/yr followed by rural (Okobo) 0.08 × 103 - 1.88 × 103 μm/yr, and the least was urban (Uyo) 0.031 × 103 μm/yr - 0.79 × 103 μm/yr. Sulphates, nitrates and chlorides were high in the marine environment, which also coincided with the area of gas flare by Mobil Oil exploration activities. Increase in temperature and acid rain formations in this area led to increased acid rainstorm. This could manifest in the erosion of beach and wetland, inundates low-lying areas (Ibeno, Ibaka (James town), Oron, Utan brama, Utan-Effiong and Mbe-Ndoro) flooding and loss of coastal land and mangrove forests. Above all, gas flaring affects atmospheric water quality in which soil, crops, fruits, streams, and rivers are affected.

The Energetics of White-light Flares Observed by SDO/HMI and RHESSI

White-light (WL) flares have been observed and studied for more than a century since their first discovery. However, some fundamental physics behind the brilliant emission remains highly controversial. One of the important facts in addressing the flare energetics is the spatio-temporal correlation between the WL emission and the hard X-ray (HXR) radiation, presumably suggesting that energetic electrons are the energy sources. In this study, we present a statistical analysis of 25 strong flares (≥M5) observed simultaneously by the Helioseismic and Magnetic Imager (HMI), on board the Solar Dynamics Observatory (SDO), and the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI). Among these events, WL emission was detected by SDO/HMI in 13 flares, associated with HXR emission. To quantitatively describe the strength of WL emission, equivalent area (EA) is defined as the integrated contrast enhancement over the entire flaring area. Our results show that the EA is inversely proportional to the HXR power-law index, indicating that stronger WL emission tends to be associated with a larger population of high energy electrons. However, no obvious correlation is found between WL emission and flux of non-thermal electrons at 50 keV. For the other group of 13 flares without detectable WL emission, the HXR spectra are softer (larger power-law index) than those flares with WL emission, especially for the X-class flares in this group.

TRPV1 antagonist JNJ-39439335 (mavatrep) demonstrates proof of pharmacology in healthy men: a first-in-human, double-blind, placebo-controlled, randomized, sequential group study.

This double-blind, randomized, placebo-controlled, sequential group, phase 1 study was designed to assess in healthy men, the safety, tolerability, pharmacokinetics, and translational pharmacodynamics of JNJ-39439335 (mavatrep), a transient receptor potential vanilloid subtype 1 antagonist; it was preceded by a translational preclinical study which assessed the ability of JNJ-39439335 to block capsaicin-induced flare in rats, providing predictive pharmacokinetic and pharmacodynamic data that informed the subsequent phase 1 clinical study. The clinical study consisted of 2 parts: part 1 assessed pharmacokinetics and pharmacodynamics, including heat pain detection threshold and heat pain tolerance, of JNJ-39439335, and part 2 assessed pharmacodynamic effect of JNJ-39439335 on capsaicin-induced flare and sensory testing on naïve and UVB-sensitized skin in humans. Plasma concentrations of JNJ-39439335 peaked at approximately 2 to 4 hours postdose, then declined multiexponentially, with a prolonged terminal phase (half-life: 30-86 hours). Renal clearance of JNJ-39439335 was negligible. JNJ-39439335 treatment resulted in clear, consistent dose-related increases in heat pain detection threshold, heat pain tolerance, and heat pain latency. JNJ-39439335 reduced the capsaicin-induced flare area and flare intensity, with complete blocking observed in the 50-mg dose group at 144 hours postdose. This was consistent with the capsaicin flare results observed with JNJ-39439335 in rats. The most common adverse events observed in the clinical study were related to increases in body temperature after JNJ-39439335 treatment; these were predominately mild to moderate in severity with no evidence of exposure dependence up to 225 mg. JNJ-39439335 was well tolerated at single doses up to 225 mg, recommending its suitability for further clinical development.

New Observations of Balmer Continuum Flux in Solar Flares

Increase in the Balmer continuum radiation during solar flares was predicted by various authors, but has never been firmly confirmed observationally using ground-based slit spectrographs. Here we describe a new post-focal instrument, the image selector, with which the Balmer continuum flux can be measured from the whole flare area, in analogy to successful detections of flaring dMe stars. The system was developed and put into operation at the horizontal solar telescope HSFA2 of the Ondřejov Observatory. We measure the total flux by a fast spectrometer from a limited but well-defined region on the solar disk. Using a system of diaphragms, the disturbing contribution of a bright solar disk can be eliminated as much as possible. Light curves of the measured flux in the spectral range 350 – 440 nm are processed, together with the $\mathrm{H}\upalpha$ images of the flaring area delimited by the appropriate diaphragm. The spectral flux data are flat-fielded, calibrated, and processed to be compared with model predictions. Our analysis of the data proves that the described device is sufficiently sensitive to detect variations in the Balmer continuum during solar flares. Assuming that the Balmer-continuum kernels have at least a similar size as those visible in $\mathrm{H}\upalpha$ , we find the flux increase in the Balmer continuum to reach 230 – 550 % of the quiet continuum during the observed X-class flare. We also found temporal changes in the Balmer continuum flux starting well before the onset of the flare in $\mathrm{H}\upalpha$ .

Parameters of superflares on G-Type stars observed with the Kepler space telescope

We continued the analysis of 279 G-type stars with superflares (energies in the range of 1033–1036 erg). We calculated the SFL parameter (part of the stellar surface which emits in the flare). The SFL estimates were derived from the relation connecting this value with the amplitude of the flare and its radiation on the assumption of the blackbody character of the emission at times close to its maximum. Most SFL values are in the range of 0–0.1, with values of 0.2–0.4 for some strong flares. Dependence of SFL on effective temperature for stars with superflares is similar to that found earlier for the spottedness parameter S. The SFL distribution reaches its maximum in the temperature range of about 5100–5250 K and decreases with the effective temperature increase. We suggested an assumption on the presence of bimodal distribution in the “SFL–rotation period” relation with a gap for objects with rotation periods P of about 10 days. For stars with P less than 10 days, the given data can indicate a decrease in flare areas with the P increase. Our analysis showed that significant changes both in flare energy and in flare areas can be achieved with small changes in spottedness S for one and the same star.

Comparative evaluation of H1 receptor blocking activity and safety of newer H1antagonist mizolastine with loratadine and placebo: a randomized double blind three way crossover study

Background: Histamine is a naturally occurring body constituent synthesized from L-histidine by histidine decarboxylase enzyme that is expressed throughout the body including central nervous system neurons, gastric mucosa, mast cells and basophils. The objective of this study was to compare the pharmacological activity and safety of 10 mg mizolastine, 10 mg loratadine and placebo in healthy human volunteers. Methods: After randomly allocating the 3 drugs, a battery of psychometric tests was done. Histamine prick test for wheal and flare reaction, VAS for sedation and itch followed by salivary flow test were done. Vitals were recorded. The subjects were randomized to receive either of the treatment in a cross-over manner with washout period of 7 days. The wheal and flare areas were recorded before and after 1,2,4,8, and 24 hours. Results: Mean inhibition on histamine induced wheal and flare response with mizolastine was highly significant as compared to placebo from 1 hour onwards (p<0.001) with maximum inhibition of 98.1±1.8% at 4 hours and of 85.1±24.8percent at 8 hours, for wheal and flare, respectively. The mean inhibition on histamine induced response with loratadine was significant from 2 hours (p<0.05) for wheal area and 1 hour onwards up to 24 hours (P<0.01) for flare area with the maximum inhibition of 56.2±31.6 percent and 60.1±14.2percent at 8hours, respectively. Mean inhibition on histamine induced itch with mizolastine was also significant from 4 hours onwards and persisted up to 24 hours (p<0.05) with maximum inhibition of 58.6±54.2% at 8 hours for the itch response, unlike loratidine. There was no significant change in mean effect on sedation assessed on a VAS of 0-100 mm. There was no significant change in psychomotor functions, salivary flow or vital parameters. All were well tolerated. Conclusions: Mizolastine has good antihistaminic activity than loratadine. Neither drug causes any psychomotor impairment or has anti-cholinergic action.

Oblique Bernstein Mode Generation Near the Upper-hybrid Frequency in Solar Pre-flare Plasmas

We study analytically the generation process of the first harmonics of the pure electron weakly oblique Bernstein modes. This mode can appear as a result of the rise and development of a corresponding instability in a solar active region. We assume that this wave mode is modified by the influence of pair Coulomb collisions and a weak large-scale sub-Dreicer electric field in the pre-flare chromosphere near the footpoints of a flare loop. To describe the pre-flare plasma we used the model of the solar atmosphere developed by Fontenla, Avrett, and Loeser (Astrophys. J. 406, 319, 1993). We show that the generated first harmonic is close to the upper-hybrid frequency. This generation process begins at the very low threshold values of the sub-Dreicer electric field and well before the beginning of the preheating phase of a flare. We investigate the necessary conditions for the existence of non-damped first harmonics of oblique Bernstein waves with small amplitudes in the flare area.

ANOMALOUS RELATIVE AR/CA CORONAL ABUNDANCES OBSERVED BY THE HINODE /EUV IMAGING SPECTROMETER NEAR SUNSPOTS

In determining the element abundance of argon (a high first ionization potential; FIP element) relative to calcium (a low FIP element) in flares, unexpectedly high intensities of two Ar xiv lines (194.40, 187.96 Å) relative to a Ca xiv line (193.87 Å) intensity were found in small (a few arcseconds) regions near sunspots in flare spectra recorded by the Extreme-ultraviolet Imaging Spectrometer on the Hinode spacecraft. In the most extreme case the Ar xiv line intensity relative to the Ca xiv intensity was 7 times the value expected from the photospheric abundance ratio, which is about 30 times the abundance of argon relative to calcium in active regions, i.e., the measured Ar/Ca abundance ratio is about 10 instead of 0.37 as in active regions. The Ar xiv and Ca xiv lines are formed near 3.4 MK and have very similar contribution functions. This is the first observation of the inverse FIP effect in the Sun. Other regions show increases of 2–3 over photospheric abundances, or just photospheric abundances. This phenomenon appears to occur rarely and only over small areas of flares away from the regions containing multi-million degree plasma, but more work is needed to quantify the occurrences and theirmore » locations. In the bright hot regions of flares the Ar/Ca abundance ratio is coronal, i.e., the same as in active regions. In this Letter we show three examples of the inverse FIP effect.« less

A randomized, double-blind, crossover study to evaluate the depth response relationship of intradermal capsaicin-induced pain and hyperalgesia in healthy adult volunteers.

The purpose of this study was to evaluate pain and hyperalgesia in response to different depths of intradermal (ID) capsaicin injections in healthy volunteers. Double-blind, cross-over study. Clinical Research Laboratory. Fifteen healthy male subjects received ID capsaicin injections into the volar aspect of each forearm at depths of 1 mm, 3 mm, 5 mm, and 7 mm. After injection, spontaneous pain, elicited pain, flare response, heat thresholds, and area of hyperalgesia were measured at various time points. Spontaneous pain, elicited pain (pinprick, stroking, and hot pain), hyperalgesia area, and allodynia area. No significant difference was found between any depths in spontaneous pain, elicited pain (pinprick, stroking, hot pain), hyperalgesia area, or allodynia area. A significant difference was found in the change in heat threshold between 5 mm and 1 mm, 7 mm and 1 mm, 5 mm and 3 mm, 7 mm and 3 mm depths. A significant difference was found in flare area between 5 mm and 3 mm depths. A significant difference was found in systolic blood pressure area under the curve (AUC) between 7 mm and 1 mm depths, and for both systolic and diastolic pressures for 5 mm and 1 mm depths, and 5 mm and 3 mm depths. A significant difference was found in pulse AUC between 5 mm and 1 mm depths and 5 mm and 3 mm depths. Injection of capsaicin at different depths in the skin had different effects on heart rate and blood pressure but no effect on pain. These results may have implications on the pharmacology and analgesic predictive value of the model of ID capsaicin.

Slamming Strength Assessment Analysis of Large Container Ship

The analysis of slamming effect has been mainly discussed about the local strength assessment and the global longitudinal strength assessment under slamming loads. The former is to forecast the local design pressure and access the local structural strength. To achieve the strength assessment of local structure of the ship bow, the slamming design pressure results of bow bottom and bow flare areas have been selected, so as to show the calculation results of relative velocity extreme values and design slamming pressure. And then according to the slamming loads and strength assessment, the direct strength assessments have been used to check key areas. The latter is to forecast the global vertical design moment and access the global longitudinal strength through three dimension finite model.

Axon-reflex based nerve fiber function assessment in the detection of autonomic neuropathy

Axon-reflex-based tests of peripheral small nerve fiber function including techniques to quantify vasomotor and sudomotor responses following acetylcholine iontophoresis are used in the assessment of autonomic neuropathy. However, the established axon-reflex-based techniques, laser Doppler flowmetry (LDF) to assess vasomotor function and quantitative sudomotor axon-reflex test (QSART) to measure sudomotor function, are limited by technically demanding settings as well as interindividual variability and are therefore restricted to specialized clinical centers. New axon-reflex tests are characterized by quantification of axon responses with both temporal and spatial resolution and include "laser Doppler imaging (LDI) axon-reflex flare area test" to assess vasomotor function, the quantitative direct and indirect test of sudomotor function (QDIRT) to quantify sudomotor function, as well as the quantitative pilomotor axon-reflex test (QPART), a technique to measure pilomotor nerve fiber function using adrenergic cutaneous stimulation through phenylephrine iontophoresis. The effectiveness of new axon-reflex tests in the assessment of neuropathy is currently being investigated in clinical studies.

A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers.

BackgroundTransient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel widely expressed in skin tissues, and peripheral sensory nerve fibres. Activation of TRPV1 releases neuropeptides; the resulting neurogenic inflammation is believed to contribute to the development of pruritus. A TRPV1 antagonist has the potential to perform as an anti-pruritic agent. SB705498 is a TRPV1 antagonist that has demonstrated in vitro activity against cloned TRPV1 human receptors and when orally administered has demonstrated pharmacodynamic activity in animal models and clinical studies.ObjectivesTo select a topical dose of SB705498 using the TRPV1 agonist capsaicin; to confirm engagement of the TRPV1 antagonistic action of SB705498 and assess whether the dose selected has an effect on itch induced by two challenge agents.MethodsA clinical study was conducted in 16 healthy volunteers to assess the effects of 3 doses of SB705498 on skin flare induced by capsaicin. Subjects with a robust capsaicin response were chosen to determine if the selected topical formulation of SB705498 had an effect on challenge agent induced itch.ResultsFollowing capsaicin challenge the greatest average reduction in area of flare was seen for the 3% formulation. This dose was selected for further investigation. Itch intensity induced by two challenge agents (cowhage and histamine) was assessed on the Computerised Visual Analogue Scale. The difference in average itch intensity (Weighted Mean Over 15 Mins) between the 3% dose of SB705498 and placebo for the cowhage challenge was −0.64, whilst the histamine challenge showed on average a −4.65 point change.ConclusionsThe 3% topical formulation of SB705498 cream was clinically well tolerated and had target specific pharmacodynamic activity. However there were no clinically significant differences on pruritus induced by either challenge agent in comparison to placebo. SB705498 is unlikely to be of symptomatic benefit for histaminergic or non-histaminergic induced itch.Trial RegistrationClinicalTrials.gov NCT01673529

An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch.

This study tested a modified experimental model of heat-induced hyperalgesia, which improves the efficacy to induce primary and secondary hyperalgesia and the efficacy-to-safety ratio reducing the risk of tissue damage seen in other heat pain models. Quantitative sensory testing was done in eighteen healthy volunteers before and after repetitive heat pain stimuli (60 stimuli of 48°C for 6 s) to assess the impact of repetitive heat on somatosensory function in conditioned skin (primary hyperalgesia area) and in adjacent skin (secondary hyperalgesia area) as compared to an unconditioned mirror image control site. Additionally, areas of flare and secondary hyperalgesia were mapped, and time course of hyperalgesia determined. After repetitive heat pain conditioning we found significant primary hyperalgesia to heat, and primary and secondary hyperalgesia to pinprick and to light touch (dynamic mechanical allodynia). Acetaminophen (800 mg) reduced pain to heat or pinpricks only marginally by 11% and 8%, respectively (n.s.), and had no effect on heat hyperalgesia. In contrast, the areas of flare (−31%) and in particular of secondary hyperalgesia (−59%) as well as the magnitude of hyperalgesia (−59%) were significantly reduced (all p<0.001). Thus, repetitive heat pain induces significant peripheral sensitization (primary hyperalgesia to heat) and central sensitization (punctate hyperalgesia and dynamic mechanical allodynia). These findings are relevant to further studies using this model of experimental heat pain as it combines pronounced peripheral and central sensitization, which makes a convenient model for combined pharmacological testing of analgesia and anti-hyperalgesia mechanisms related to thermal and mechanical input.

Physical conditions in the chromosphere of a two-strand solar flare with ejection

Chromosphere layers of solar flares were investigated according to the observed profiles of the Hα line. A two-strand flare was observed on September 4, 1990. Spectra were obtained with the ATsU-26 solar horizontal telescope at Terskol Peak Observatory (3100 m). Spectra photometry is performed for two bright nodes of one strand of the flare. Some profiles are superposed to the ejection. The observed profiles are characterized by high emissions in the wings of the Hα line (up to 10–12 A) under relatively low intensity in the center of Hα (r = 0.35–0.6). To explain such profile behavior we calculated flare models with two or three components. Separate components of the model correspond to unresolved details in the flare area and therefore the averaged profile is calculated. Emission in the far wings is explained by model components with deep heating of chromosphere layers. These occupy 5–12% of the total area. Noticeable emission asymmetry is explained by ray velocities of up to 70 km/s and more. The models are determined by agreement of the observed and calculated profiles. We processed several photometric profiles for seven observations. The temperature in the models with deep heating in the lower cromosphere is increased by 1000–2500 K with respect to the model with an undisturbed chromosphere VAL-C. The second feature of the observed profiles is their high asymmetry and shift with respect to the undisturbed profiles. This can be explained by the opposite motion of the material. We revealed that for the most of the profiles the line-of-sight velocities were directed to the observer in the upper chromosphere (10–100 km/s) and from the observer in the lower chromosphere (5–20 km/s).

Statistical relationship between the succeeding solar flares detected by the RHESSI satellite

The Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) has observed more than 80,000 solar energetic events since its launch on February $12^{\rm th}$, 2002. Using this large sample of observed flares, we studied the spatio-temporal relationship between succeeding flares. Our results show that the statistical relationship between the temporal and spatial differences of succeeding flares can be described as a power law of the form $R(t)\sim t^p$ with $p=0.327\pm 0.007$. We discuss the possible interpretations of this result as a characteristic function of a supposed underlying physics. Different scenarios are considered to explain this relation, including the case where the connectivity between succeeding events is realised through a shock wave in the post Sedov-Taylor phase or where the spatial and temporal relationship between flares is supposed to be provided by an expanding flare area in the sub-diffusive regime. Furthermore, we cannot exclude the possibility that the physical process behind the statistical relationship is the reordering of the magnetic field by the flare or it is due to some unknown processes.

Bilateral Hypersensitivity to Capsaicin, Thermal, and Mechanical Stimuli in Unilateral Complex Regional Pain Syndrome

Complex regional pain syndrome is multifactorial. Exaggerated inflammatory responses to limb injury may be involved. The authors hypothesized that capsaicin-induced pain and neurogenic inflammation (skin perfusion and flare area) are increased in patients with complex regional pain syndrome compared with that in controls. Twenty patients with unilateral upper-limb complex regional pain syndrome and 20 age-, sex-, and body mass index-matched controls participated. Topical capsaicin 5% was applied to the back of both hands for 30 min, and pain intensity was assessed on a visual analogue scale. A laser Doppler perfusion imager scanner estimated capsaicin-induced skin perfusion and flare area. Autonomic and small-fiber function was assessed by sensory testing, quantitative sudomotor axon reflex test, and vasoconstrictor responses. The authors found bilateral hypersensitivity to capsaicin (P ≤ 0.02), skin fold (P = 0.001), joint pressure (P < 0.0001), cold (P ≤ 0.01), and heat pain (P ≤ 0.04) in patients compared with that in controls and thermal and mechanical hyperalgesia in the complex regional pain syndrome-affected hand compared with that in the unaffected hand (P ≤ 0.001). The patients had normal capsaicin-induced flare areas, thermal detection thresholds, quantitative sudomotor axon reflex test, and vasoconstrictor responses. The main finding is bilaterally increased capsaicin-induced pain in patients compared with controls. The flare response to capsaicin was normal, suggesting that the increased pain response was not due to increased neurogenic inflammation. The bilateral hypersensitivity to painful chemical, thermal, and mechanical stimuli not confined to the innervation area of a peripheral nerve or root cannot be explained by a regional change and may partly be due to central sensitization.

CHARACTERIZING A DRAMATIC Δ V ∼ –9 FLARE ON AN ULTRACOOL DWARF FOUND BY THE ASAS-SN SURVEY

We analyze a $\Delta V\sim-9$ magnitude flare on the newly identified M8 dwarf SDSS J022116.84+194020.4 (hereafter SDSSJ0221) detected as part of the All-Sky Automated Survey for Supernovae (ASAS-SN). Using infrared and optical spectra, we confirm that SDSSJ0221 is a relatively nearby (d$\sim$76 pc) M8 dwarf with strong quiescent H$\alpha$ emission. Based on kinematics and the absence of features consistent with low-gravity (young) ultracool dwarfs, we place a lower limit of 200 Myr on the age of SDSSJ0221. When modeled with a simple, classical flare light-curve, this flare is consistent with a total $U$-band flare energy $E_U\sim$ 10$^{34}$ erg, confirming that the most dramatic flares are not limited to warmer, more massive stars. Scaled to include a rough estimate of the emission line contribution to the $V$ band, we estimate a blackbody filling factor of $\sim$$10-30\%$ during the flare peak and $\sim$$0.5-1.6\%$ during the flare decay phase. These filling factors correspond to flare areas that are an order of magnitude larger than those measured for most mid-M dwarf flares.

Reduced skin reactivity to vasoconstrictor and vasodilator substances in atopic eczema

Atopic eczema is a common chronic inflammatory disease with itchy skin and altered skin reactions to acetylcholine and nicotinic acid compared to healthy non-atopic individuals. The aim of this study was to evaluate skin reactivity to 11 vasoactive substances and peptides by skin prick and intradermal tests in 20 patients with atopic eczema and 20 healthy controls. Skin reactions, blanching, wheal and flare areas were measured by planimetry, 15 minutes after provocation. Patients with atopic eczema had significantly smaller reactions at certain concentrations of the vasodilators acetylcholine, bradykinin, calcitonin gene-related peptide, substance P and vasoactive intestinal peptide for flare, and of substance P and vasoactive intestinal peptide for wheals, in intradermal testing and/or in skin prick testing. Testing of the vasoconstrictors angiotensin-II, arginine-vasopressin, endothelin-1 and noradrenaline in atopic eczema resulted in significantly smaller reactions at certain concentrations for blanching in intradermal testing and/or skin prick testing. Significantly smaller reactions were seen with arginine-vasopressin for wheals and with arginine-vasopressin and noradrenaline for flares in intradermal testing and/or skin prick testing at certain concentrations. Significantly larger wheals were seen with angiotensin-II and endothelin-1 in intradermal testing and/or skin prick testing at certain concentrations. No significant differences were found for prostaglandin E2. These results demonstrate not only a reduced responsiveness to vasodilators but also to vasoconstrictor substances and peptides in patients with atopic eczema, which may be considered a general feature of atopic eczema skin.