This study investigates the behaviour of the hot gas temperature and associated smoke numerically in case of fire inside a medical centre. Fire Dynamics Simulator (FDS), provided by NIST, has been used to run the simulations for all proposed cases. Different solutions are suggested to reduce the severity of the hot gas temperature and smoke thickness, in case of fire inside the building. Among all investigated solutions, natural ventilation can do the best job. A mechanical fan is also an option, but not as good as a natural vent found at the top of the building. Natural ventilation can offer cheap and clean solutions to improve the safety level and environmental conditions inside the building, which offers an appropriate evacuation process for firefighters and civilians inside the building.