Felipe De Brigard's book “Memory and Remembering”, part of the series "Elements of the Philosophy of Mind", describes the study of memory as a philosophical and cognitive phenomenon. The book examines both the classical ideas of Descartes and Locke, as well as the more modern approaches of Husserl, Merleau-Ponty, and Heidegger, which offer different perspectives on the problem of memory.

Beyond task-based connectivity in fMRI: Reply to comments on "Connectivity analyses for task-based fMRI" by Shenyang Huang, Felipe De Brigard, Roberto Cabeza, Simon W. Davis.

Founded in Chile in 2012, the now Paris-based practice Plan Común has become one of the most interesting practices working in the field of housing today. For years Plan Común has channeled its efforts into finding commissions and opportunities within an increasingly hostile market for truly affordable housing. In 2023, the practice completed the Maison Commune, a multi-unit residential building characterized by an abundance of collective spaces, located next to the Parisian Cemetery of Pantin. Our interview with Plan Común members Kim Courrèges and Felipe De Ferrari focuses on the details of the Maison Commune’s financial scheme. Devised as a “prototype,” this self-commissioned project was an opportunity for Plan Común to conceive a project without traditional intermediaries. By bypassing developers, the architects were able to redirect those costs to build less private and more collective areas—“non-profitable” square meters—that would otherwise not find space in a balance sheet. By adapting a system of financing used in real estate, Plan Común found the margins to make something meaningful.

En este trabajo damos a conocer una pintura de la Virgen María realizada por Francisco Pacheco que se hallaba en 1620 entre las posesiones de Felipe de Cuadros Caro, primo de Rodrigo Caro. Esta obra no se ha conservado o no ha sido identificada todavía. Se aportan asimismo otras noticias sobre el entramado de relaciones entre los principales personajes que aparecen en el documento analizado.

AVALIAÇÃO DO DESEMPENHO DE MÉTODOS DE ESTIMATIVA DA EVAPOTRANSPIRAÇÃO POTENCIAL DE REFERÊNCIA PARA O MUNICÍPIO DE BENJAMIN CONSTANT, AMAZONAS (*) ARISTÓTELES DE JESUS TEIXEIRA FILHO1 E AMÓS FELIPE DE FARIA BATISTA BRAGA2 (*) Trabalho retirado do Projeto “Evapotranspiração Potencial no Amazonas”, Iniciação Científica “PIB-A/0008/2022”, Universidade Federal do Amazonas, agosto de 2022/2023. 1 Professor Associado do Instituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas, Campus Itacoatiara, Av. Nossa Senhora do Rosário, 3863 - Bairro Tiradentes, Itacoatiara, Amazonas, Brasil, aristoteles@ufam.edu.br 2 Estudante do Curso de Agronomia do Instituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas, Campus Itacoatiara, Av. Nossa Senhora do Rosário, 3863 - Bairro Tiradentes, Itacoatiara, Amazonas, Brasil, fariafelipe964@gmail.com 1 RESUMO A disponibilidade de água para uma cultura pode ser melhor definida pelo intervalo em que o clima permitirá à planta manter uma razão de transpiração igual à razão de absorção de água pelas raízes. Assim, objetivou-se avaliar o desempenho dos métodos indiretos de estimativa da evapotranspiração de referência de Blaney-Criddle, Camargo, Hargreaves-Samani, Jensen-Haise, Thornthwaite, Makkink, FAO 24 da Radiação e Blaney-Criddle-Frevert em comparação com o método padrão de Penman-Monteith. Os dados meteorológicos utilizados foram obtidos na estação meteorológica convencional de Benjamin Constant do Instituto Nacional de Meteorologia, compreendendo dados mensais da normal provisória de 10 anos. Os indicadores estatísticos utilizados foram: coeficiente de correlação, coeficiente de determinação, índice de exatidão e o coeficiente de segurança ou desempenho. Os métodos ajustados ao método padrão de Penman-Monteith com desempenho “ótimo” foram Makkink, FAO 24 da Radiação, Jensen-Haise, Hargreaves-Samani, Blaney-Criddle-Frevert e Blaney-Criddle, recomendados para o município de Benjamin Constant, AM. O modelo de Camargo apresentou desempenho “sofrível”, podendo ser recomendado após ajustes locais. Enquanto o modelo de Thornthwaite apresentou desempenho “mau”, não podendo ser recomendado em razão da baixa exatidão e precisão em relação ao método padrão. Palavras-chave: Penman-Monteith, planejamento agrícola, tomada de decisão. TEIXEIRA FILHO, A. de J.; BRAGA, A. F. DE F. B. PERFORMANCE EVALUATION OF REFERENCE POTENTIAL EVAPOTRANSPIRATION ESTIMATION METHODS FOR THE CITY OF BENJAMIN CONSTANT, AMAZONAS 2 ABSTRACT Water availability for a crop can be best defined by the range in which the climate allows the plant to maintain a transpiration rate equal to the rate of water absorption by the roots. Thus, the objective was to evaluate the performance of the indirect reference evapotranspiration estimation methods of Blaney-Criddle, Camargo, Hargreaves-Samani, Jensen-Haise, Thornthwaite, Makkink, FAO 24 of Radiation, and Blaney-Criddle-Frevert in comparison with the standard Penman‒Monteith method. The meteorological data used were obtained from the Benjamin Constant conventional meteorological station of the National Institute of Meteorology, comprising monthly data from the 10-year provisional normal. The statistical indicators used were the correlation coefficient, determination coefficient, accuracy index, and safety or performance coefficient. The methods adjusted to the Penman‒Monteith standard method with “optimal” performance were Makkink, FAO 54 of the Radiation, Jensen‒Haise, Hargreaves‒Samani, Blaney‒Criddle‒Frevert and Blaney‒Criddle, recommended for the municipality of Benjamin Constant, AM. The Camargo model presented “sufferable” performance and can be recommended after local adjustments. The Thornthwaite model presented “poor” performance and cannot be recommended because of its low accuracy and precision compared with those of the standard method. Keywords: Penman-Monteith, agricultural planning, decision making.

Abstract Over the past two decades, only incremental progresses have been made in the therapeutic management of colorectal cancer (CRC). This is in part attributed to the fact that the Wnt pathway, the oncogenic pathway that initiates the transformation of CRC and sustains tumor maintenance, has been largely undruggable. While most efforts targeting Wnt signaling have revolved around interfering with Wnt target genes that regulate cell growth, we turned our attention to a subset of genes encoding for negative regulators of the pathway. Of particular interest are the cell-surface E3 ubiquitin ligases, ring finger protein 43 (RNF43) and ZNRF3, two known negative regulators of Wnt signaling that promote the turnover of Wnt receptors Frizzled/low-density lipoprotein receptor-related proteins (FZD/LRPs) via ubiquitination-mediated degradation. Given their exposed extracellular domains (ECDs), we set out to explore whether this intrinsic cellular degradative machinery could be repurposed for an antibody-based targeted protein degradation platform. More specifically, we have devised a technology that exploits the elevated expression of ZNRF3 and RNF43 in colon cancer by generating bispecific antibodies that can tether these E3 ubiquitin ligases to a variety of cell surface receptors to promote tumor receptor degradation. Most notably, these antibody degraders are highly active in vivo and can degrade receptors in a tumor specific manner while sparing normal tissues. This platform, that we have been dubbed Proteolysis Targeting Antibodies (PROTABs) describes a strategy for the rapid development of potent, bioavailable and tissue-selective degraders of cell-surface proteins. Citation Format: Felipe de Sousa e Melo. Exploiting the oncogenic state of colorectal cancer for therapeutic development. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6134.

Movement Disorders Clinical PracticeAccepted Articles CLINICAL VIGNETTES BACLOFEN-RESPONSIVE TASK-SPECIFIC DYSTONIA: VIDEO CASE REPORT Antonio Marcos da Silva Catharino, Corresponding Author Antonio Marcos da Silva Catharino catharino.antonio@gmail.com Department of Neurology of Hospital Geral de Nova Iguaçu, PhD student in Neurology at the Federal University of the State of Rio de Janeiro - UNIRIO, Adjunct Professor of Medicine at Iguaçu University - UNIG / Nova Iguaçu, RJ, Brazil Correspondence to: Details Antônio Marcos da Silva Catharino, Rua Gavião Peixoto 70, Room 811, CEP 24.2230- 100, Icaraí, Niterói-RJ, Brazil; Phone: +55 (21) 36203220, E-mail: catharino.antonio@gmail.comSearch for more papers by this authorAna Paula Santos de Assis, Ana Paula Santos de Assis Medical student at Iguaçu University. Iguaçu University - UNIG / RJ, Nova Iguaçu, RJ, BrazilSearch for more papers by this authorFelipe de Castro Felício, Felipe de Castro Felício Medical student at Iguaçu University. Iguaçu University - UNIG / RJ, Nova Iguaçu, RJ, BrazilSearch for more papers by this authorDaniel Antunes Pereira, Daniel Antunes Pereira Medical student at Iguaçu University. Iguaçu University - UNIG / RJ, Nova Iguaçu, RJ, BrazilSearch for more papers by this authorGilberto Canedo Martins Jr, Gilberto Canedo Martins Jr Professor of Neurology - Universidade Iguaçu- UNIG-RJ, Nova Iguaçu - RJ; Physician of the Neurology Service of Nova Iguaçu General Hospital, Nova Iguaçu, RJ, BrazilSearch for more papers by this author Antonio Marcos da Silva Catharino, Corresponding Author Antonio Marcos da Silva Catharino catharino.antonio@gmail.com Department of Neurology of Hospital Geral de Nova Iguaçu, PhD student in Neurology at the Federal University of the State of Rio de Janeiro - UNIRIO, Adjunct Professor of Medicine at Iguaçu University - UNIG / Nova Iguaçu, RJ, Brazil Correspondence to: Details Antônio Marcos da Silva Catharino, Rua Gavião Peixoto 70, Room 811, CEP 24.2230- 100, Icaraí, Niterói-RJ, Brazil; Phone: +55 (21) 36203220, E-mail: catharino.antonio@gmail.comSearch for more papers by this authorAna Paula Santos de Assis, Ana Paula Santos de Assis Medical student at Iguaçu University. Iguaçu University - UNIG / RJ, Nova Iguaçu, RJ, BrazilSearch for more papers by this authorFelipe de Castro Felício, Felipe de Castro Felício Medical student at Iguaçu University. Iguaçu University - UNIG / RJ, Nova Iguaçu, RJ, BrazilSearch for more papers by this authorDaniel Antunes Pereira, Daniel Antunes Pereira Medical student at Iguaçu University. Iguaçu University - UNIG / RJ, Nova Iguaçu, RJ, BrazilSearch for more papers by this authorGilberto Canedo Martins Jr, Gilberto Canedo Martins Jr Professor of Neurology - Universidade Iguaçu- UNIG-RJ, Nova Iguaçu - RJ; Physician of the Neurology Service of Nova Iguaçu General Hospital, Nova Iguaçu, RJ, BrazilSearch for more papers by this author First published: 25 January 2023 https://doi.org/10.1002/mdc3.13669 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/mdc3.13669. AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Accepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset version of record will appear in the future. RelatedInformation

ABSTRACT This paper analyses documents on health and disease among Chamorro people during and after 333 years (1565–1898) of the Spanish claim to and occupation of Guam. Here, a complex neurodegenerative disease—known locally as lytico-bodig and medically as amyotrophic lateral sclerosis and Parkinsonism-dementia complex (ALS/PDC)—reached hyperendemic proportions in the mid-twentieth century but then declined and is now disappearing. A tau-dominated polyproteinopathy, clinical phenotypes included amyotrophic lateral sclerosis (ALS or lytico), atypical parkinsonism with dementia (P-D or bodig), and dementia alone. A plausible etiology for lytico-bodig is consumption of flour derived from the incompletely detoxified seed of Cycas micronesica (fadang in Chamorro; Federico in Spanish), a poisonous gymnosperm that survives climatic extremes that can affect the island. Traditional methods for safe consumption appear to have been lost over the course of time since governors Francisco de Villalobos (1796–1862) and Felipe de la Corte (1855–1866) proposed banning consumption in view of its acute toxic effects. A death certificate issued in 1823 might suggest ALS/PDC in people dying with disability or impedidos, and premature aging and a short life was linked to food use of fadang in the mid-1850s (Guam Vital Statistics Report, 1823). During the Japanese occupation of Guam (1941–1944), Chamorro people took refuge in the jungle for months, where they relied on insufficiently processed fadang as a staple food. After World War II, traditional foods and medicines were subsequently replaced as islanders rapidly acculturated to North American life.

Um cineasta nascido em Madrid em 1916, mas que ainda jovem se viu envolvido nas disputas políticas entre apoiantes do regime de Franco e os seus opositores. Trabalhou na França sob ocupação nazi e depois de um processo judicial nos tribunais espanhóis, instalou-se em Portugal. Aí desenvolveu uma grande produção cinematográfica, realizando dezenas de filmes, muitos deles também filmados nas colónias portuguesas em África, especialmente em Angola e Moçambique. No final da sua vida estabeleceu-se no sul de França, perto de Cannes, onde veio a falecer. Palavras-Chave: Felipe de Solms; Cinema de Propaganda; Cinema colonial português; Portugal; África.

Abstract Extensive biological and clinical evidence supports the notion many CRC tumors are addicted to EGFR/KRAS/MAPK signaling. For example, mutations in KRAS, BRAF and other MAPK pathway components confer intrinsic or acquired resistance to anti-EGFR therapy. However, a significant proportion of acquired resistance cases have remained unexplained. ARID1A mutations are found in approximately 11% of CRC tumors, but a connection between ARID1A mutations and EGFR/MAPK signaling activation in CRC has not been previously suspected. By leveraging the genomic biomarker data collected from 333 patients at baseline and at progression who participated in the CALGB/SWOG 80405 trial, we found that mutations in ARID1A, a key component of SWI/SNF complex, were enriched in the cell free DNA of 6/16 of the patients whose tumors had become resistant to anti-EGFR therapy with ARID1A mutations detected at either timepoint (adj. p = 0.03, OR = 0.09, two-tailed fisher's exact test). In contrast, there was no evidence of enriched ARID1A mutations in patients treated with bevacizumab. To investigate the potential role of a broader ARID1A deficiency phenotype in resistance to cetuximab therapy, we developed an ARID1A mutant-like signature from TCGA that captures the transcriptional profile characteristic of ARID1A mutants. Using this signature to stratify CALGB patients based on gene expression data collected on tissue at diagnosis, we also found patients with an ARID1A mutant-like gene expression profile had worst outcome in patients treated with cetuximab than bevacizumab with adjustment for established clinical variables for both OS [p = 0.0002, hazard ratio (HR) 6.2, 95% confidence interval (CI) 2.4-16], and PFS [p = 0.0008, HR 4.7 (1.9 -12)], suggesting that ARID1A mutations may be also a mechanism of intrinsic resistance to anti-EGFR therapies. Gene expression analysis demonstrated that ARID1A deficiency leads to re-activation of an EGFR-like signature, suggesting reactivation of this pathway as a possible mechanism of resistance. Furthermore, CRISPR knockout of ARID1A in the cetuximab-sensitive CRC cell line NCI-H508 conferred elevated MAPK signaling relative to parental line and resistance to cetuximab in culture. Consistent with these findings, we also observed strong mutual exclusivity between ARID1A mutations and mutations in the EGFR/MAPK signaling pathway in more than 40,000 lung and colorectal cancer patients profiled in the FoundationCore® database. Strikingly, in lung cancers where EGFR mutations structural variants (SV) are more prevalent, EGFR SV was the top mutually exclusive alteration with ARID1A mutations in lung cancers. Of 5980 lung cancer patients with ARID1A and/or EGFR SVs, only 100 patients (1.7%) had both SVs. Taken together, our data suggest that ARID1A loss-of-function mutations may promote resistance to cetuximab by driving an EGFR-like transcription program in the absence of ligand-dependent activation of EGFR. Our results suggest that ARID1A defects could be potentially used as an exclusion biomarker for cetuximab treatment decisions, and they provide a rationale for exploring therapeutic MAPK inhibition in ARID1A mutant CRC patients. Citation Format: Radia Marie Johnson, Xueping Qu, Joshua Thomas, Yvonne Kschonsak, Ling-Yuh Huw, Fang-Shu Ou, Ethan Sokol, Nnamdi Ihuegbu, Oliver Zill, Omar Kabbarah, Anneleen Daemen, Richard Bourgon, Alan Venook, Federico Innocenti, Heinz-Josef Lenz, Felipe de Sousa e Melo, Carlos Bais. ARID1A mutations induce an EGFR-like gene expression signature and confer intrinsic and acquired resistance to cetuximab treatment in first line metastatic CRC [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr LB-063.

Con motivo del Tercer Centenario del nacimiento del escultor Felipe de Espinabete (1719-1799), uno de los más conspicuos maestros del Rococó castellano, el presente artículo quiere dar a conocer una serie de nuevas atribuciones que aumentarán sensiblemente su catálogo productivo.

A avicultura sustentável vem ganhando cada vez mais expressividade no mercado. Esse aumento na procura pelo modo de criação de aves semicaipiras se deve a valorização de produtos que são gerados levando em consideração os cuidados com o meio ambiente e com o bem-estar humano e animal. Objetivou-se por meio deste trabalho de extensão promover e acompanhar a produção de aves semicaipiras, que se encontra em fase de transição, de um sistema tradicional para uma criação em sistema orgânico, na Comunidade Quilombola Dezidério Felipe de Oliveira, localizada na Picadinha, município de Dourados, MS. O desenvolvimento desta atividade teve como base os princípios de sustentabilidade e a preocupação em valorizar o trabalho da comunidade, mantendo seu modo de vida tradicional. As práticas foram desenvolvidas no período de novembro de 2017 a setembro de 2018, com o acompanhamento de dois ciclos de produção. As aves foram criadas com milho, ração concentrada e hortaliças produzidas em sistema orgânico. A prática de manejo sustentável de aves reuniu os saberes científicos adquiridos pelos docentes e discentes da UFGD e as experiências acumuladas dos Quilombolas com o sistema de produção animal. Os resultados mostraram um aumento na renda, com venda de 72% das aves adquiridas no primeiro ciclo, e uma melhora no modo de criação das aves do segundo ciclo que proporcionou maior ganho de peso nos frangos de corte. Além disso, com o fortalecimento e desenvolvimento sustentável da produção de aves na comunidade Quilombola, constatou-se uma melhoria na qualidade alimentar das famílias envolvidas no projeto.

Felipe de Jesus Legarreta-Castillo, <i>The Figure of Adam in Romans 5 and 1 Corinthians 15: The New Creation and Its Ethical and Social Reconfiguration</i>

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 194097, “Real-Time MPD Optimization in Challenging Scenarios,” by Guilherme Siqueira Vanni, SPE, André Alonso Fernandes, Gleber Tacio Teixeira, Antonio Carlos Vieira Martins Lage, André Leibsohn Martins, SPE, and Felipe de Souza Terra, Petrobras, and Marcelo de Souza Cruz, Fabio Rodrigues G. da Silva, and Cristiano édio Dannenhauer, Engineering Simulation and Scientific Software, prepared for the 2019 SPE/IADC International Drilling Conference and Exhibition, The Hague, 5–7 March. The paper has not been peer reviewed. This work focuses on the development of specific methodologies to support managed-pressure-drilling (MPD) operations implemented on real-time diagnostic software. The developed methodology proposes as output ideal operating parameters, such as choke pressure, pump-flow rate, or adjustments related to drilling-fluid properties. The methodology considers the best approach to meet the restrictions imposed by the operational window. The real-time optimization procedures proposed are a further step to ensure reliability of MPD operations in challenging scenarios. Real-Time MPD Optimization Specific modules were developed from a drilling-problem diagnostic software to provide real-time support for MPD operations. The primary advance represented by these modules is the consolidation, in a computational tool, of MPD best practices. The tool, which uses real-time drilling data as input, will propose and enable immediate action in the event of anomalous situations or ones not predicted in project planning. Dynamic Pore-Pressure Test (DPPT) and Dynamic Formation Integrity (DFIT) Procedures. These procedures allow a more-accurate estimate of values for pore and fracture pressures, respectively. These procedures are suited particularly for drilling in narrow operating window scenario, because they allow correction of geological-profile data obtained previously with current field geopressure. Thus, the probability of gain and loss events becomes smaller in an MPD operation when compared with a conventional drilling scenario. During these tests, in each pressure step performed in the choke, the software calculates the volume balance related to the compression or decompression of the fluid in the well. The software calculates the volume that decreased from the active tank (DFIT) or increased in the active tank (DPPT). The software also calculates the volume balance related to the compression (DFIT) or decompression (DPPT) of the fluid in the well. These calculations determine whether these volume variations, both real and expected, follow the same magnitude. The difference between them is the criterion used to stop both procedures (DPPT and DFIT). In Petrobras’ drilling operations, this proposed limit normally is set to 2 bbl. This preset threshold is a minimum acceptable value to consider that a gain or loss is occurring. If this difference surpasses the limit value, the module triggers a message warning the rig crew. After these procedures, the simulator updates the operating window, using real downhole data [effective circulating density (ECD)] in a conservative way. The logic adopted for updating is to use the largest value between the DPPT and the value of the pore gradient present on the project. For the fracture gradient, inverse logic is adopted; the lowest value between the DFIT and the fracture gradient obtained on the project is used. Fig. 1 illustrates the pore-gradient update.

A theory of cognitive systems individuation is presented and defended. The approach has some affinity with Leonard Talmy’s Overlapping Systems Model of Cognitive Organization, and the paper’s first section explores aspects of Talmy’s view that are shared by the view developed herein. According to the view on offer – the conditional probability of co-contribution account (cpc) – a cognitive system is a collection of mechanisms that contribute, in overlapping subsets, to a wide variety of forms of intelligent behavior. Central to this approach is the idea of an integrated system. A formal characterization of integration is laid out in the form of a conditional-probability based measure of the clustering of causal contributors to the production of intelligent behavior. I relate the view to the debate over extended and embodied cognition and respond to objections that have been raised in print by Andy Clark, Colin Klein, and Felipe de Brigard.

Abstract The weather diary of Felipe de Zúñiga y Ontiveros was recorded in Mexico City from 1775 to 1786. It is the earliest meteorological observational record of Mexico. The diary provides daily meteorological information for rain frequency, temperature, frost, hail, thunderstorms, and wind, with higher resolution than any other contemporary documentation or natural proxy from this region. The seasonal distributions of rainy days, temperature, hail, and thunderstorms correspond well with those from the Tacubaya Observatory in Mexico City (1886–2016). Two drought periods (1780/81 and 1785/86) and one wet period (1782/83) were identified. The drought spanning from 1785 to 1786 is known in the literature as “the hunger year” because it represented the most severe famine during the colonial period (1521–1821). This paper analyzes—for the first time—this event at a daily scale. Similar to the reported droughts of 1909/10 and 2010/11, 1785/86 was a very dry period. But the dry conditions of 1785 were followed by intense frosts that started in late August and continued through September and October. This combination led to the destruction of crops and subsequent famine. The duration of the frost does not have analogs during the instrumental period, probably because of the intense warming and land changes registered over the last years in the region.

This substantial edition of Los amotinados de Flandes is an expansion of Fernández’s dissertation and the work is evident in the extensive introduction that clocks in at an impressive one hundred seventy-five pages. In it, the editor makes a deep dive into the historical and textual history that frames the play as well as providing extensive notes on every aspect of the play. The text of the play itself is formatted well and is clear and easy to follow, although the tiny font can be an eyestrain.From the first page of this edition, Pérez Fernández works to establish this lesser known play as part of a larger group of plays dealing with the prolonged war in the Low Countries. She notes that it is part of almost three dozen such plays (13) and that such works served the propaganda purposes of the Spanish empire because theater had a wider audience than many other means of diffusion, noting “la justificación de la hegemonía del Imperio de los Austrias son las arterias por las fluyen las comedias flamencas” (17).Following this introduction the reader is provided with a summary of the work. In this play, Isabela, a woman of Flanders, is in love with the Spanish captain Don Diego de Silva, who in turn loves Lucrecía de Parma. Diego is simultaneously dealing with his tercio that is in rebellion (amotinado) due to months’ worth of back pay owed the soldiers. When he and his superior, the count of Fuentes, learn of an imminent attack, they convince the rebels to rejoin them and due to the capture of a Flemish spy are able to reverse the intended Flemish trap and win the day. The play ends with the death of the Flemish captain, the marriage of Isabela to Diego, and the arrival of the Archduke Albert of Austria, ruler of the Spanish Netherlands.The following sections deal with the limited historical criticism of the work and the actual historical events that form the base of the play’s action. It is here that I think that the efforts of Pérez Fernández really shine. She connects the play to four historical events: “el motín de Tilemón, suceso que da nombre a la obra; la campaña del conde de Fuentes; la batalla en la que muere Felipe de Nasai, líder flamenco; y, por último, la recepción y entrada del archiduque Alberto” (30). This allows her to situate the action of the play on October 4, 1595. She continues to link Vélez to specific sources as she builds a chain of texts leading from the actual events to the play text: “Parece que Vélez conocía estas fuentes pues, las causes, condiciones, desarrollo, reclamaciones y disposiciones de los amotinados reproducen ciertos aspectos que incluyen las crónicas” (35). Backed by this evidence she argues, successfully in my view, that the work should be considered a historical play.The fifth section brings in further analysis set in a historical context. Throughout this section, Pérez Fernández connects historical reality with her analysis of the play. I particularly appreciate her analysis as to why Vélez set the play in 1595. Her argument, that by the 1630s the scarcity of Spanish military victories forced authors to mine the past for appropriate material, serves as the core for her interpretation of the text. As she notes: “El pasado glorioso de las grandes campañas quedaba ya muy lejos, al igual que las empresas de Spínola o de Gonzalo de Córdoba. Ahora la falta de recursos y los numerosos conflictos en los que estaba inmerso el Imperio auguraban una estrepitosa crisis y su inminente ocaso” (55). This clear decline of Spanish power is reflected in the play’s need to present former Spanish victories as part of the natural order and, as she later argues, the symbolic connection between the Spanish leadership, the tercio amotinado, and the love plot serves to reinforce a vision of a Spain willing to sacrifice and whose noble character guarantees eventual victory despite seemingly impassable obstacles. This leads her to the conclusion that a primary purpose of the play was to “publicar y defender la continuación de la ofensiva flamenco, cuyo principal promotor era el Conde-Duque, patron de Luis Vélez” (68). This link to the very real desires of the playwright’s sponsor who had significant control over Vélez’s place at court further supports Pérez Fernández’s argument and neatly connects a number of threads in the play, providing us with a convincing interpretation of the text.My greatest “complaint” about this edition is that the material provided in section 5.7 Personajes, is too in depth. This section spends more than thirty pages providing background on the various characters, both historical and fictional. I place the word “complaint” in quotations because the problem is not one of quality or value, but rather one of priorities. The introduction to the play is quite long and the font used in this edition is tiny. The edition, as a whole, could be arguably improved by cutting much of this section in favor of larger text and a tighter introduction. This would have improved readability without sacrificing core elements of the initial study.Sections six and seven move to the technical aspects of the work. This includes discussion of the structure of the play, its use of space, aparts, versification, etc. There is also a discussion of the date of composition of the play with 1632 set as the most likely year based on a number of factors including historical events, internal evidence, and verse structure. The final section is an in-depth discussion of the text, its variants, and all available early editions. The introduction ends with a description of the criteria used for the edition and an extensive bibliography.The text of the play itself is well organized and easy to read, but the notes are somewhat oddly configured. There is a set of footnotes at the bottom of the page and a separate set of endnotes. The footnotes are primarily concerned with variants with an occasional reference to the preliminary study. The endnotes, marked in the text with “°,” provide context, vocabulary, and similar historical information. The endnotes are very extensive, filling thirty pages for a play that only occupies a total of ninety pages, including footnotes. Although the content is valuable, the placement makes it more difficult to use. I think it would have been better to flip the foot- and endnotes so that readers could easily read the explicative comments and look up variants if desired.Overall, the text is a valuable addition to comedia scholarship. The historical background is painstakingly researched and the bibliography is quite helpful for those looking to further their knowledge of the political dynamics of the period. I also appreciate the analysis. It is painstaking in its research and its conclusions are well supported. In conclusion, this edition is a satisfying work whose depth and detail will especially appeal to academics who wish to do a deep dive into one or more of the topics addressed.

En primer lugar quiero agradecer a las autoridades de la Sociedad Argentina de Diabetes y al Comité Editor de la Revista, el interés por invitarme a compartir con mis colegas la experiencia de mi vida profesional.Mi perfil corresponde al de una médica pediatra con la subespecialidad en Nutrición y Diabetes. En 1961 cursé Pediatría como última materia de la carrera de Medicina en Casa Cuna. En ese lapso, me di cuenta que la Pediatría sería mi especialidad, por lo cual al finalizar la cursada decidí quedarme en la cátedra del Prof. Felipe de Elizalde. Por eso, luego de obtener mi título y durante 10 años, me desenvolví como médica en la sala tercera de Pediatría General.

This academic article is based on the results obtained from doctoral research defended in May of 2016 , with the title: "Government advertising in the construction of cultures of peace: the case of the Mexican Federal Government (2006-2012) in the framework of the war on drugs", which highlights the potential of government advertising for the promotion of values, behaviors and actions that build collective well-being. The research analyzes qualitatively 127 T.V. spots issued by different Departments of the Mexican Republic during the six-year presidential term of Felipe de Jesús Calderón Hinojosa, to unveil that the Mexican government, instead of using its advertising efforts to contribute to the pacification of the country, used this communicative tool to legitimize its strategy of facing drug trafficking through an armed approach. Throughout the messages presented in the T.V. spots, a clearly differentiated story between "good" and "bad" people is described, using the threat of drugs as the axis of its persuasive strategy and transmitting a culture of fear that generates more concerns and insecurities than the values needed to counteract violence. At the same time, the promotion of cultures of peace in the story offered by the Mexican Federal Government is minimal and circumstantial, from what it can be affirmed that it does not offer keys to understand and transform the conflict, but a narrative that reinforces the war on drugs and legitimizes it.

Abstract Stratification of Colorectal Cancer (CRC) into actionable molecular subtypes has tremendous clinical value. Recently, a consolidated classifier identified four molecularly distinct CRC subtypes (CMS1-4) that were associated with unique biology and clinical outcomes based on global transcriptional analysis of frozen tissues. Here, we developed and applied a novel CRC panel that is ideally suited for transcriptional classification of archival clinical samples. Findings from in silico analysis demonstrated that the 800 genes on our panel could accurately classify CRC samples from external public datasets into the correct CMS subtypes. We applied our panel in the analysis of a novel cohort of 312 formalin-fixed paraffin-embedded (FFPE) tissues from 205 patients, and were able to detect all 4 CMS subtypes in primary CRCs and in metastases. When we examined the CMS subtypes of primary tumors and matched metastases from 50 patients we found 70% of cases to be concordant, as were key biologies, such as WNT/MYC pathway activation in CMS2 and EMT features in tumors of the CMS4 subtypes. This was confirmed by in situ hybridization (ISH) using the markers ASCL2 for CMS2 and SPARC for CMS4, respectively. Discordance in the CMS subtypes between primary tumors and matched metastases were observed in 30% of cases and may reflect tumor heterogeneity. Our findings suggest that our CRC-focused panel many have clinical utility for CMS classification of FFPE samples, and point to potential risks of using CMS subtypes of primary tumors to inform clinical decision-making at the metastatic stage in a subset of patients. Citation Format: Ling-Yuh Huw, Robert Piskol, Felipe de Sosa e Melo, Doris Kim, Xueping Qu, Hartmut Koeppen, Mark Lackner, Garret Hampton, Omar Kabbarah, Rachel Tam. A custom gene expression panel for consensus molecular subtype classification of archival primary and metastatic colorectal cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2708. doi:10.1158/1538-7445.AM2017-2708