Effects of population density stress on fecal microbiota and metabolites of Qinghai-Tibet Plateau root voles (Microtus oeconomus)—A field experiment

Linking faecal microbiota changes to clinical and prognostic features in dogs with mast cell tumours through 16S rRNA gene sequencing.

We report a 16S rRNA gene amplicon sequencing dataset describing gut and fecal microbiota of the electric eel Electrophorus varii, a freshwater electrogenic fish lacking baseline microbiome references. Fecal and gut samples (n = 3 per group) from an individual eel were analyzed to characterize genus-level taxonomic composition and alpha diversity. The gut samples were strongly predominated by Cetobacterium, whereas the fecal samples contained more heterogeneous community structures. Principal component analysis (PCA) based on Hellinger-transformed relative abundances was applied to primarily separate gut and fecal microbiota samples along the first principal component (PC1) axis (92.8 %). Shannon alpha diversity was significantly higher in fecal microbiota compared with gut microbiota. Although the present dataset is based on triplicate samples from a single individual, expanded studies incorporating multiple electrogenic species and species-level comparisons will be necessary to determine whether electric discharge environments are associated with significant shifts in freshwater fish gut microbiome structure.

Early ecological changes in intestinal microbiota with the long-acting GLP-2 analog apraglutide in short bowel syndrome.

Enterolactone mitigates atherosclerosis by facilitating resolution of ferroptosis-associated intimal inflammation via the Keap1/Nrf2/GPX4 pathway.

A novel low-protein diet feeding strategy with reduced amylose/amylopectin ratio: effects on growth performance, gut health, and behaviour in nursery pigs.

From association to intervention: Semantic trajectories and knowledge frontiers in epilepsy-gut microbiota research revealed by bibliometrics and NLP.

Kudzu root-derived carbon dots modulate gut microbiota and metabolites for pan-organ targeted macrophage polarization in synergistic diabetes therapy.

High-molecular weight hyaluronic acid protects against colitis by remodeling microbiota and restoring barrier function.

The gut-tumor metabolic axis: A comprehensive exploration of bidirectional crosstalk in cancer immunotherapy.

Faecal microbiota transplant (FMT) is an effective therapy for recurrent Clostridioides difficile infection (CDI); its use is increasingly being investigated for other indications. Although regional surveys and national registries have provided insight into local practices, a comprehensive global overview of FMT access, implementation and governance is lacking. A survey regarding key aspects related to FMT use was disseminated electronically to members of the World Gastroenterology Organization, European FMT Network and International Society of Infectious Diseases. Responses were analysed both descriptively and using appropriate statistical methods. A total of 80 responses were obtained from 55 countries. FMT was available in significantly more Tier 1/2 than Tier 3/4 nations (24/28 vs 8/27; P < 0.001). In countries lacking access to FMT, reasons included: lack of expertise/infrastructure; financial constraints; regulatory uncertainty; and perceived lack of clinical need. Most countries using FMT employed both upper and lower gastrointestinal administration routes; 18/32 (56%) used capsulised FMT. Almost all countries with access to FMT used it to treat CDI, albeit with different thresholds for the number of CDI episodes prior to use. There were many non-CDI indications for FMT in current use. Payment for stool donation was reported by 10 countries. This is the first global overview of FMT availability and governance, highlighting substantial international inequities and considerable heterogeneity in regulation, clinical use, donor screening and cost. Standardization of practice and targeted support for lower-income countries is needed to ensure equitable access and to promote safe, high-quality delivery as FMT and microbiome-based therapeutics continue to evolve.

A polysaccharide from Pueraria lobata ameliorates hepatic fibrosis via gut microbiota-dependent suppression of ferroptosis.

Hyperuricemia is a common metabolic disorder associated with gout, renal dysfunction, and cardiovascular complications. Although Astragalus membranaceus has long been used in traditional medicine, the influence of gut microbiota biotransformation on its potential urate-lowering activity remains unclear. In this study, ethanol and water extracts of Astragalus membranaceus were subjected to invitro fecal microbiota biotransformation, and their xanthine oxidase (XO) inhibitory activities before and after biotransformation were compared. The transformed ethanol extract was further fractionated by solvent partitioning, and the resulting fractions were characterized by UPLC-MS/MS. The results showed that biotransformation altered the XO inhibitory activity of both extracts, with a more evident increase in the ethanol extract than in the water extract. Among the solvent fractions, the ethyl acetate fraction exhibited the strongest inhibitory activity. Chemical profiling tentatively characterized 62 compounds and revealed marked compositional changes after biotransformation, particularly a reduction in glycosidic constituents together with enrichment of corresponding aglycone-related compounds. These findings suggest that gut microbiota biotransformation may be an important factor influencing the potential urate-lowering activity of Astragalus membranaceus and provide a basis for further identification of its bioactive constituents.

A fructan-type polysaccharide from Lycium ruthenicum attenuates liver fibrosis via microbiota-dependent ferroptosis inhibition.

Targeting astrocytic Nrf2 by Trilobatin alleviates lipopolysaccharide-induced depressive-like behaviors and cognitive impairment in mice: Mechanistic insights into gut microbiota and metabolites modulation.

Reducing cadmium bioavailability in soil with micronutrient sulfates: Insights from duodenal transporter expression and intestinal microbiota in a mouse model.

Gut microbiota in pathogenesis and therapeutic potentials in rheumatoid arthritis.

Strontium chelate with Achyranthes bidentata polysaccharide as a carrier promotes bone regeneration through mediating the gut-liver-bone axis in TD chickens.

Lianweng formula alleviates colonic inflammation through gut microbiota-mediated inactivation of the PTGS2/AKR1C3/ALOX5 pathway and subsequent suppression of arachidonic acid metabolism.

Tryptophan-kynurenine metabolism: A link between the gut microbiota dysbiosis and cognitive impairment.