Fatigue tests under high static pre-stress loads can provide meaningful results to better understand the time-dependent failure characteristics of rock and rock-like materials. However, fatigue tests under high static pre-stress loads are rarely reported in previous literature. In this study, the rock specimens were loaded with a high static pre-stress representing 70% and 80% of the uniaxial compressive strength (UCS), and cyclic fatigue loads with a low amplitude (i.e., 5%, 7.5% and 10% of the UCS) were applied. The results demonstrate that the fatigue life decreased as the static pre-stress level or amplitude of fatigue loads increased for different rock types. The high static pre-stress affected the fatigue life greatly when the static pre-stress was larger than the damage stress of rocks in uniaxial compression tests. The accumulative fatigue damage exhibited three stages during the fatigue failure process, i.e., crack initiation, uniform velocity, and acceleration, and the fatigue modulus showed an “S-type” change trend. The lateral and volumetric strains had a much higher sensitivity to the cyclic loading and could be used to predict fatigue failure characteristics. It was observed that volumetric strain $$\varepsilon _{{\text{v}}}$$ = 0 is a threshold for microcracks coalescence and is an important value for estimating the fatigue life.
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