Percent Fat-free Mass Research Articles

Comparison of the Impact of SGLT2-Inhibitors and Exenatide on Body Fat Composition.

To investigate the effect of SGLT2-iand GLP-1RA as an add-on therapy to metformin on weight loss and body composition, and to compare their effects on glucose and lipid parameters. A descriptive study. Place and Duration of the Study: Goztepe Prof Dr Suleyman Yalcin City Hospital, from January 2016 to May 2021. The study included 50 patients with diabetes on metformin+SGLT2-i(dapagliflozin or empagliflozin, group 1) and 50 patients with diabetes on metformin+GLP-1 receptor agonist (RA, exenatide, group 2). The reduction in weight, BMI, total body, abdominal, leg, and arm fat percentage, and the improvement in body fat-free and muscle mass percentage were significantly higher in Group 2 (p<0.001, p<0.001, p=0.014; p=0.031, p<0.001; p=0.002 and p=0.014, p=0.014, respectively). The decline in abdominal fat mass in the GLP-1 RA group was also significant (p=0.031). There was asignificantdecrease in HbA1c, fasting glucose, and triglyceride levels (p<0.001, p<0.001, and p=0.036) with a significant increase in HDL-C (p=0.015). There was no significant difference between groups for glucose, HbA1c, and lipid parameters (p>0.05). Both SGLT2 inhibitors and exenatide, when added to metformin therapy, were effective in reducing weight and body fat, more by the GLP-agonist. SGLT2-i had no significant impact on decreasing abdominal fat depicting that these agents do not have any benefit in treating visceral adiposity. Type 2 diabetes mellitus, Obesity, GLP-1 receptor, SGLT2 inhibitor, Body fat distribution, Visceral adiposity.

Abstract P619: DNA Methylation at SREBF1 and Long-Term Changes in Body Composition: The POUNDS Lost Trial

Introduction: A previous epigenome-wide association study has causally linked DNA methylation (DNAm) at the SREBF1 gene (cg11024682) with obesity and lipids. However, little is known about whether DNAm at SREBF1 is associated with long-term changes in body adiposity and composition. Hypothesis: We hypothesized that participants with different DNAm at SRBF1 might respond differently to dietary weight-loss interventions on changes in body adiposity and composition. Methods: The current study included 314 individuals with overweight or obese, who participated in POUNDS Lost: a 2-year randomized dietary weight-loss trial. The blood DNAm level was profiled by methylC-capture sequencing at baseline. Regional DNAm at SREBF1 was calculated as the average methylation level over CpGs within ±250 bp of cg11024682. Body composition, including total fat mass (FM), percentage of FM (FM%), total fat-free mass (FFM), percentage of FFM (FFM%), and percentage of trunk fat (TF%) were measured by dual-energy X-ray absorptiometry (DEXA) at baseline, 6 months, and 2 years. Results: Lower regional DNAm at SREBF1 was significantly associated with changes in body composition across 2 years ( Table ). At 6 months, per SD lower regional DNAm at SREBF1 was significantly associated with greater reductions in FM (β [SE] -0.23 [0.07], p=0.002), FM% (-0.30 [0.09], p&lt;0.001), and TF% (-0.44 [0.13], p&lt;0.001), and greater increases in FFM (0.18 [0.08], p=0.028) and FFM% (0.30 [0.09], p&lt;0.001), regardless of dietary intervention groups and independent of concurrent weight loss. Such association remained at 2 years: FM (β [SE] -0.21 [0.10], p=0.045), FM% (-0.32 [0.11], p=0.004), TF% (-0.36 [0.16], p=0.026), FFM (0.22 [0.12], p=0.07) and FFM% (0.32 [0.11], p=0.004). Conclusions: Overweight and obese individuals with a lower regional DNAm at SREBF1 achieved greater improvement in body composition across the 2-year intervention, independent of concurrent weight loss, suggesting DNAm at SREBF1 is predictive of individuals’ response to treatment.

Influence of Body Composition on Cardiorespiratory Fitness and Metabolic Markers in Physically Inactive Individuals with Insulin Resistance: An Observational Study

The aim of this study was to determine body composition influence on cardiorespiratory fitness and metabolic markers in physically inactive individuals with insulin resistance (IR). Nineteen overweight and obese (body mass index [BMI] 25.0–29.9 kg·m−2; ≥ 30.0 kg·m−2, respectively) patients diagnosed with IR (5 men and 14 women; age: 32.74 ± 10.07 years; BMI: 32.5 ± 4.60 kg·m−2). The body composition included BMI, fat mass, and fat-free mass. Cardiorespiratory fitness was measured by maximal oxygen uptake (VO2max). Metabolic markers included maximal fat oxidation, fasting glucose, and insulin. IR was determined by homeostatic model assessment (HOMA-IR). The results of the partial correlations (i.e., body mass, age, and sex) reported that fat-free mass, fat mass, and BMI were significantly correlated with VO2max. Additionally, the multiple linear regression model indicated that fat-free mass and BMI explained the variance of VO2max by 89%. However, no substantial correlations were reported between fat mass or fat-free mass with HOMA-IR, fasting glucose, or insulin. This study concluded that a higher percentage of fat-free mass and lower BMI is positively related to better cardiorespiratory fitness despite the IR status of the participants analyzed.

Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study

BackgroundThe risk of cardiovascular diseases has rapidly increased among middle-aged and elderly. However, little is known about the relationship of body composition changes with the risk of cardiovascular events among this population in China. We explored the associations of 2-year changes in fat percentage (fat%) and fat-free mass percentage (FFM%) with subsequent cardiovascular events in a middle-aged and elderly community-based cohort.MethodsThis study included 1048 participants (456 men [43.51%], aged 50–80 years) without overt cardiovascular disease, who underwent two examinations during 2013–2014 and 2015–2016. All participants were followed up until 2022 for cardiovascular events. A bioelectrical impedance analyzer was used to calculate fat% and FFM% change.ResultsAt baseline, the median body mass index (BMI), fat%, and FFM% were 23.9 (22.1–25.9) kg/m2, 27.2 (20.8–33.6)%, and 72.8 (66.4–79.2)%, respectively. Two-year changes in fat% and FFM% were 0.31 (− 5.53 to 6.87)% and − 0.12 (− 2.36 to 2.06)%. During an average follow-up of 5.5 years, 86 cardiovascular events (8.21%) occurred. Cox regression models showed that hazard ratios (HRs) of every 2% change in fat% and FFM% for cardiovascular events were 1.04 (95% confidence interval [CI] 1.01–1.07) and 0.84 (95% CI 0.74–0.95), respectively. Compared with participants with stable fat% (–2% ≤ ⊿fat% < 2%), those with fat% gain ≥ 2% had an increased risk of cardiovascular events (HR 2.07, 95% CI 1.08–3.97). FFM% loss > 8% was associated with a higher risk of cardiovascular events (HR 3.83, 95% CI 1.29–11.4).ConclusionsIn a middle-aged and elderly community-based Chinese population, fat% gain or FFM% loss was associated with an increased risk of cardiovascular events.

Usual dietary intake, physical activity, weight loss, and body composition after five years of Roux-en-Y gastric bypass.

To estimate usual dietary intake (UDI), physical activity (PA), and their association with weight loss and body composition in patients who underwent Roux-en-Y gastric bypass (RYGB) after five years in the Federal District, Brazil. We assessed anthropometry and body composition using bioimpedance, and dietary intake and PA with three nonconsecutive 24-h recalls. PC-Side was used to estimate UDI. Dietary patterns (DPs) were identified through principal component analysis, and association between UDI and PA with percentage of total weight loss (%TWL) and fat-free mass (FFM) through multinomial logistic regression. Sample (n = 124) presented mean (SD) age of 48.9 (9.4) years, median (IQR) of 9 years (7-10) post RYGB, current BMI = 32.3 kg/m² (28.8-35.7), %TWL = 24.7% (10.9), and FFM = 45.1 kg (41.1-51.9). Mean usual energy intake of 1556 kcal/d, with adequate protein intake, poor fiber intake, and excessive carbohydrate, total fat, and added sugar intake, compared to dietary guidelines. Calcium, vitamins C, D, and E presented the greatest inadequacy (15%, 24%, 32%, and 49% of individuals, respectively, reported usual intake below EAR); 83 participants were considered active/very active, according PA. DP with high energy, protein, total fat, saturated fat, and sodium intake, was negatively associated with %TWL (OR = 0.545, p = 0.037). Protein intake was positively associated with FFM (OR = 1.091, p = 0.004). PA was not associated with %TWL or FFM. Participants demonstrated intake of carbohydrate, fat, fiber, added sugar not in accordance with guidelines. A DP rich in energy, protein, total fat, saturated fat, and sodium appears to decrease TWL. However, protein intake appears to increase FFM.

The association between dietary acid load and body composition in physical education students aged 18–25 years

AimTo find the association between dietary acid load (DAL) and body composition in physical education students.MethodsThis study was carried out on 207 students of both genders aged 18–25 years. DAL was calculated based on potential renal acid load (PRAL) and net endogenous acid production (NEAP) methods. Anthropometric indices were measured. Bioelectric impedance was used to assess body composition and other related items.ResultsThe mean score of NEAP and PRAL was 80.18 ± 31.30 and 33.94 ± 22.11, respectively. The mean weight and fat mass of subjects were 64.05 ± 9.72 kg and 20.28 ± 0.67 kg, respectively. Participants in the highest tertile of PRAL had a higher weight (64.56 ± 1.14 kg) in comparison with participants in the lowest tertile (61.65 ± 1.19 kg) (P = 0.027). After adjusting for confounders, a significant positive association was found between NEAP score and hip circumference (β = 0.206, P = 0.039), body mass index (β = 0.214, P = 0.031), fat mass (β = 0.218, P = 0.001) and body adiposity index (β = 0.182, P = 0.037). Furthermore, a statistically significant negative association was observed between total body water and NEAP score (β = − 0.217, P = 0.001) and the percentage of fat-free mass and NEAP (β = − 0.229, P = 0.001).ConclusionIndividuals with a higher DAL score may have a higher weight, fat mass and hip circumference and a lower fat-free mass. In addition, there might be an association between DAL and obesity.

Изменчивость показателей состава тела детей школьного возраста из семей различного социально-экономического статуса Саратовской области

Numerous publications have noted a general pattern: then higher are the parents’ educational and professional level, and then larger and heavier are their children, which is associated with a higher family income. The purpose of this work is to consider the variability of body composition indicators in schoolchildren 7–17 years old from the Saratov region depending the characteristics of the family’s socio-economic status proposed by us, and to evaluate the impact of the level of material prosperity on the main indicators of the physical development of children and adolescents. Materials and methods. The materials of the comprehensive survey in 2002–2004 children and adolescents 7–17 years old from the cities of the Saratov region, with a total number of 4266 people are used. The average normalized values of total sizes and 17 body composition indicators calculated by different methods were compared in each of 42 groups of boys or girls formed according to 3 gradations by one of 7 socio-economic factors. Results and discussion. There are significant (95%) differences in levels of total body size in children of both sexes, corresponding to the literature data: the higher the indicators of family income, the greater the values of morphological signs, magnitude of differences up to 0.7δ. Boys from large families have the smallest body sizes and very weak development of the fat component. With an increase in the educational and professional levels of mothers, sons have higher total fat-free mass, total water and percentage of fat mass, magnitude of differences 0.4δ–0.7δ. In girls, with an increase in the material income, educational and professional levels of mothers, almost all indicators are growing, except for body density, percentage of fat-free mass and percentage of water, magnitude of differences 0.4δ–0.7δ. Daughters of fathers with secondary professional level have the highest rates of development of the fat-free component (magnitude of differences 0.6δ) and average body size. Conclusions. There is sexual dimorphism in the variability of body composition indicators in school-aged children from families of various socio-economic status. In boys, the relationship between absolute indicators of body composition (reflecting body sizes) and factors of financial income of the family according to the traditional scheme is expressed. In girls – between relative indicators (reflecting the development of fat deposition) and the professional level of parents. In children of parents with high occupational levels, the ratio of fat to muscle component may indicate latent obesity. The method of calculating the body composition does not significantly affect the results of the analysis.

Maternal Nutrition, Body Composition and Gestational Weight Gain on Low Birth Weight and Small for Gestational Age-A Cohort Study in an Indian Urban Slum.

Maternal nutritional status and care during pregnancy are essential for adequate birth weight. In this prospective cohort study (N = 1061) in an urban slum, we investigated the association of maternal anthropometry, body composition, gestational weight gain and dietary intakes with low birthweight (LBW, <2.5 kg). About one-third of the women were short (<150 cm), 35% were underweight (<45 kg), 23% suffered from chronic energy deficiency (CED, BMI < 18.5 kg/m2) and another 30% were overweight/obese. The mean age and BMI were 23 years and 21.7 kg/m2, respectively, and haemoglobin was 10.73 g/dL. The mean birthweight (N = 605) was 2.81 ± 0.5 kg, and the average gestational age was 38 ± 2 weeks. About 15% of infants had LBW, and 48% were small for gestational age (SGA). Maternal body composition was assessed by skinfold thickness (SFT) in all trimesters. In the first trimester (N = 762), we found that mean fat-free mass (FFM), fat mass (FM) and body fat percentage (% BF) were 38.86 kg, 11.43 kg and 21.55%, respectively. Low birthweight was significantly associated with preterm deliveries (p < 0.001) and less fat free mass (p = 0.02) in the third trimester. Among other factors were age (p = 0.017), maternal anthropometry (height: p = 0.031; weight: p = 0.059) and fewer antenatal check-ups (p = 0.037). Small size (SGA) was consistently associated with maternal bodyweight at all trimesters (term I, p = 0.013, term II, p = 0.003 and term III, p < 0.001), fat mass in the third trimester (p < 0.001) and maternal height (p = 0.003).

No Sex Differences In Common Carotid Artery Stiffness Response Following Maximal Oxygen Consumption Test

No Sex Differences in Common Carotid Artery Stiffness Response Following Maximal Oxygen Consumption Test HEYSEL MORALES, MICHAEL DIAZ, ZARIA OPARA, STEVEN HAWKINS, LOUISE KELLY, ALLAN KNOX. PURPOSE: Previous investigations have reported sex differences in the time course of age-related arterial stiffness, with postmenopausal women presenting increased risk of cardiovascular diseases. Using sex as a biological variable has identified differences between males and females in physiological responses to equivalent doses of exercise. The purpose of this study was to determine if sex differences exist in arterial stiffness response to a maximum oxygen consumption (VO2max) exercise test. METHODS: VO2max was measured by indirect calorimetry. Body composition was measured by air displacement plethysmography (BODPOD). Indices of common carotid artery (CCA) stiffness (Peterson’s elastic modulus [Ep], Beta stiffness [B1], distensibility [DIST], and diameter compliance [DC]) were calculated before and within 5 minutes following VO2max. CCA’s were imaged for 1 minute by duplex Doppler ultrasound approximately 2-3cm below bifurcation and stored for offline analysis of velocities and diameters. Brachial blood pressures were captured by automated cuff. RESULTS: Males (n=14) and females (n=15) were matched for age (p=0.549), fat mass (p =0.775), body fat percentage (p=0.08), fat free mass percentage (p=0.087), and VO2max (p=0.349). Males had higher body mass (p < 0.001) and fat free mass (p<0.001). No sex differences were observed before or after exercise for Ep, B1, DIST, and DC (p >0.05 for all). No sex differences were identified for delta changes in any CCA stiffness indices (p >0.05). CONCLUSION: The CCA response to VO2max test is equivalent in males and females who are matched for baseline VO2max, despite males presenting high fat free masses. Previously reported sex differences in response to equivalent exercise dose may not be evident in the CCA stiffness characteristics.

Do Body Composition and Values of Selected Nutritional Status Indices Influence the Glycaemic Index Values of Vegetarian Dishes? A Pilot Study in a Group of Older Women.

An ageing population brings with it the need for public policy to respond to the demands and health needs of this group of people. The ageing process has been shown to be associated with changes in body composition. These mainly concern a decrease in muscle mass and an increase in body fat. Body composition and other indicators of nutritional status are important factors differentiating carbohydrate management. Glycaemic index (GI) values may be affected by differences resulting from individual metabolism. The rate of carbohydrate digestion is also influenced by a number of factors, including the degree to which the product is processed, the structure of the starch, and the presence of protein, fat and dietary fibre. Available studies do not provide information on the glycaemic response following the consumption of specific products by older people with varying BMI and body composition. Therefore, the aim of this study was to evaluate the effect of the body mass index (BMI) values of women aged 50–80 years on the glycaemic response after eating vegetarian meals and the influence of selected indices of nutritional status on their GI values. It has been shown that the areas under the glycaemic curves after the consumption of the tested foods, both traditional and modified, are higher in the group of overweight and obese women. Nevertheless, the GI of meals consumed by those with a BMI ≥ 25.0 kg/m2 is lower than that of foods consumed by women with normal values of this index. In the group of women with BMI 18.5–24.9 kg/m2, on the basis of an analysis of the obtained correlations, it was observed that the GI value of modified products depends on the percentage of body fat (FM%) (p = 0.0363) and the percentage of fat free mass (FFM%) (p = 0.0363), and, in the case of traditional products, also on the percentage of total body water (%) (p = 0.0133). In the group of women with a BMI ≥ 25.0 kg/m2, significant correlations were only found between the GI of modified foods and the waist-to-hip ratio (WHR) (p = 0.0363) and the ratio of waist circumference to height (WHtR) (p = 0.0369) indices. The GI values of food set solely with the participation of young, healthy people should not be the basis for the nutrition planning of all groups of people.

Association between Fat-Free Mass Loss after Diet and Exercise Interventions and Weight Regain in Women with Overweight.

This study aimed to determine if percent fat-free mass loss (% FFML) after diet alone, diet plus aerobic, or diet plus resistance exercise is a predictor of weight regain in women with overweight. One hundred and forty-one premenopausal women with overweight (body mass index, 28 ± 1 kg·m -2 ; age, 35 ± 6 yr) enrolled in a weight loss program to achieve a body mass index <25 kg·m -2 (diet alone, diet plus resistance, or diet plus aerobic exercise) and were followed for 1 yr. Body weight and composition (with dual-energy x-ray absorptiometry) were measured at baseline, after weight loss, and at 1 yr. Participants lost 12.1 ± 2.6 kg of body weight, 11.3 ± 2.5 kg of fat mass, and 0.5 ± 1.6 kg of fat-free mass during the weight loss intervention, followed by weight regain at 1 yr (6.0 ± 4.4 kg, 51.3% ± 37.8%; P < 0.001 for all). % FFML was -3.6 ± 12.4, and a greater % FFML was associated with more weight regain ( r = -0.216, P = 0.01, n = 141), even after adjusting for the intervention group ( β = -0.07; 95% confidence interval, -0.13 to -0.01; P = 0.017). % FFML is a significant predictor of weight regain in premenopausal women with overweight. These results support strategies for conserving fat-free mass during weight loss, such as resistance training. Future research should try to identify the mechanisms, at the level of both appetite and energy expenditure, responsible for this association.

Intermittent fasting two days versus one day per week, matched for total energy intake and expenditure, increases weight loss in overweight/obese men and women

BackgroundIntermittent fasting (IF), consisting of either a one-day (IF1) or two consecutive days (IF2) per week, is commonly used for optimal body weight loss. Our laboratory has previously shown an IF1 diet combined with 6d/week of protein pacing (P; 4–5 meals/day evenly spaced, ~ 30% protein/day) significantly enhances weight loss, body composition, and cardiometabolic health in obese men and women. Whether an IF1-P or IF2-P, matched for weekly energy intake (EI) and expenditure (EE), is superior for weight loss, body composition, and cardiometabolic health is unknown.MethodsThis randomized control study directly compared an IF1-P (n = 10) versus an IF2-P (n = 10) diet on weight loss and body composition, cardiovascular (blood pressure and lipids), hormone, and hunger responses in 20 overweight men and women during a 4-week weight loss period. Participants received weekly dietary counseling and monitoring of compliance from a registered dietitian. All outcome variables were assessed pre (week 0) and post (week 5).ResultsBoth groups significantly reduced body weight, waist circumference, percent body fat, fat mass, hunger, blood pressure, lipids, glucose, and increased percent fat-free mass (p < 0.05). However, IF2-P resulted in significantly greater reductions in body weight (-29%) and waist circumference (-38%) compared to IF1-P (p < 0.05), and showed a strong tendency for greater reductions in fat mass, glucose, and hunger levels (p < 0.10) despite similar weekly total EI (IF1-P, 9058 ± 692 vs. IF2-P, 8389 ± 438 kcals/week; p = 0.90), EE (~ 300 kcals/day; p = 0.79), and hormone responses (p > 0.10).ConclusionsThese findings support short-term IF1-P and IF2-P to optimize weight loss and improve body composition, cardiometabolic health, and hunger management, with IF2-P providing enhanced benefits in overweight women and men.Trial registrationThis trial was registered March 03, 2020 at www.clinicaltrials.gov as NCT04327141.

Effect of Intradialytic Supine Ergometer Exercise on Hemodialysis Patients with Different Nutritional Status.

It is important for hemodialysis patients to exercise while their nutritional status is being monitored. This study aimed to examine the difference in physical exercise function and the effect of exercise intervention in hemodialysis patients who were divided into two groups (high-nutrition and low-nutrition groups) based on the serum albumin levels. A total of 26 outpatients (18 men and 8 women) undergoing hemodialysis (age: 66 ± 10 years) were included in this study. The patients' body composition data (weight, body mass index, percentage of body fat, fat-free mass, and total body water) and physical functions (grip strength, knee extensor strength, open-eyed one-legged standing time, long sitting trunk anteflexion, and 6-minute walking distance [6MWD] test) were measured. The intervention was supine ergometer exercise during hemodialysis, and the patients exercised for 30 minutes during hemodialysis thrice a week. The intervention period was three months. Compared to the high-nutrition group, the low-nutrition group showed a significant decrease in muscle strength. Furthermore, long sitting trunk anteflexion in the high-nutrition group and 6MWD in the low-nutrition group improved significantly after the intervention. The result of this study may indicate that 6MD can be improved by exercise during dialysis, regardless of nutritional status. It is said that low nutritional status has a negative impact on survival rate; thus, considering the impact on survival rate, it is hemodialysis patients with a low nutritional status that should be considered to introduce more active exercise during dialysis.

Pilot study for the development of a screening questionnaire to detect sarcopenic obesity

Caloric restriction-the most prevalent obesity treatment-has a 97% failure rate when spread over 5-7 years. Sarcopenic obesity is thought to be the consequence of chronic dieting and the cause of weight management problems. This pilot study's goal was to develop a screening questionnaire that detects sarcopenic obesity in young and middle-aged female adults. A total of 23 women (ages 19-59) completed a sarcopenic obesity questionnaire and were assessed for total body weight (TBWt), percent fat mass, and percent fat-free mass (%FFM) using the Bod Pod (air plethsmography), and bioelectrical impedance analysis (BIA). Appendicular skeletal mass (ASM) was calculated using BIA. Resting energy expenditure was determined using indirect calorimetry, and the basal metabolic rate (BMR) was calculated using BIA. The screening questionnaire score was negatively correlated with BMR (r2 = 0.885), %FFM (r2 = 0.86), ASM (r2 = 0.79) relative to TBWt and to ASM/BMI (r2 = 0.58). The screening questionnaire had an acceptable sensitivity (83%) and specificity (87%) in detecting sarcopenia measured using ASM/BMI. This pilot intimates that subjects who frequently dieted suffered from a disproportionally lower FFM and BMR relative to the TBWt. The questionnaire can help clinicians recognize the presence of sarcopenic obesity in patients.

Evaluation of Mangalarga Marchador foal development in the first year of life

The purpose of this study was to examine the development pattern of Mangalarga-Marchador foals by determination of muscle development and deposition of adipose tissue associated with the evaluation of blood-based biomarkers. Thus, 72 Mangalarga Marchador foals (ages ranged from 1-12 mo) were randomly selected and divided into 12 age groups (n=6 per group), evaluated monthly. The thickness of the Longissimus dorsi (LD) and rump fat (RF) were determined through an ultrasound performed on each foal’s left side. Such parameters were used to calculate the percentage of body fat (BF), fat mass (FM), and fat-free mass (FFM). Morphometric measurements were taken on the foal’s right side using a tape measure and a hypsometer. Blood samples were collected for determinations of total proteins, albumin, triglycerides, cholesterol, urea, creatinine, and glucose. Morphometric measurements, the thickness of the LD and RF, weight, BF, FM, and FFM showed differences between age groups (P&lt;0.001). Muscle development and fat deposition in subcutaneous tissue were greater between six and 12 months and average weight gain and FFM were proportionally greater between one and six months. We concluded that morphometric measurements increase steadily and linearly during the first 12 months of life, indicating that it is feasible to use the linear regression formula. Moreover, significant differences between age and biochemical biomarkers may be attributed to nutritional and digestive physiology adaptations during these periods.

Examination between the measured and estimated parameters of the participants in the Hungarian Defence Forces Body Composition Program

Introduction: The aim of the research was to analyze the - Introduced in 2015 as a new force protection capability - Hungarian Defence Forces Body Composition Program (HDF BCP) participants’ pattern of the measurement parameters and their relationship to each other, furthermore, to create a measurement protocol that can be used with large number of elements, which allows the estimation of strength and fat-free mass in the following.Methods: The examination was carried out between 2017 and 2020. Within the HDF BCP, the measured and estimated parameters of 283 volunteers between the ages of 18 and 67 years old. A total of 709 measures were made. A Premium Body Impedance Analyzer 500 (BIA) instrument was used for the examinations. In addition, a DYNA 16 strength meter (DYNA) was used which makes it possible to measure the grip strength of both hands at the same time. Statistical calculations are performed with R-Studio program.Results: An increase in the phase angle is accompanied by an increase in the maximum hand grip strength (p &lt; 0.001). The full body strength increases with weight gain regarding both sexes in all age groups tested (p &lt; 0.001). Our linear regression model is suitable for estimating maximum hand grip strength using body weight, fat-free mass, age, and gender values (R2 = 0,74) and to estimate fat-free mass percentage based on body weight, maximum hand grip strength, and gender values (R2 = 0,78).Conclusion: The use of phase angle is an important indicator of a lifestyle change program. In the created linear regression model we will be able to estimate body fraction in significant numbers with high accuracy after measuring minimum parameters.

Sympathomimetic increases resting energy expenditure following bariatric surgery: A randomized controlled clinical trial.

The aim of this study was to test the hypothesis that ephedrine + caffeine (EC) reduces the fall in resting energy expenditure (REE) following bariatric surgery. This 32-week, randomized, double-blinded, placebo-controlled trial included 142 patients who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgery. Participants were randomized to either EC or placebo for 27 weeks, beginning 5 weeks post surgery. The primary end points were change in REE (measured), percentage of predicted REE ([measured REE/Harris-Benedict equation-predicted REE] × 100), and body composition. Secondary outcomes included change in percentage of weight. Adverse events (AEs) were recorded. The reduction in REE was smaller in the EC versus the placebo group, but it was not significant. Percentage of predicted REE was increased in the EC versus the placebo group (difference, mean [SE]: 5.82 [2.29], p = 0.013). Percentage of weight (difference: -3.83 [1.39], p = 0.007) was reduced in the EC versus the placebo group. Percentage of predicted REE was increased and body weight decreased in the EC-treated participants who underwent SG compared with those who underwent SG and were treated with placebo (difference in percentage of predicted REE = 8.06 [2.83], p = 0.006; difference in weight percentage = -4.37 [1.92], p = 0.025). Percentage of fat-free mass was increased in the SG participants treated with EC versus placebo (difference: 1.31 [0.63], p = 0.042). The most common AEs were anxiety, dizziness, insomnia, and tremors. Most AEs were not different from placebo by Week 32. EC enhances weight loss and reduces the fall in REE following bariatric surgery. Adrenergic symptoms mostly resolve over time.

The effects of spasticity on glucose metabolism and soft tissue body composition in patients with spinal cord injury.

Objectives The aim of this study was to assess the effects of spasticity on glucose metabolism and percentage of fat-free mass (FFM%) in patients with spinal cord injury (SCI). Patients and methods A total of 33 patients (22 males, 11 females; mean age: 38.6±12.5 years; range, 20 to 64 years) with SCI defined by the American Spinal Injury Association Impairment Scale Grades A to D were included between September 2014 and May 2018. We assessed spasticity with the Modified Ashworth Scale (MAS) and evaluated spasms with the Penn Spasm Frequency Scale (PSFS). We assessed the glucose metabolism by calculating the Matsuda and HOMA-IR index, and measured FFM% by dual-energy X-ray absorptiometry. Results Fourteen patients had motor complete, and 19 had motor incomplete SCI. The neurological injury levels of the patients were C4-T12. There was a positive correlation between hip adductor muscle MAS and trunk, android, and gynoid FFM% and between hip extensor muscle MAS and android FFM% in patients with motor complete SCI. Hip extensor and knee flexor muscle MAS showed a negative correlation with the HOMA-IR. Hip adductor and extensor muscle MAS, as well as knee flexor and extensor muscle MAS, had a positive correlation with the Matsuda index in these patients. There was a positive correlation between knee extensor muscle MAS and gynoid FFM% and between PSFS and arms, trunk, gynoid, and total FFM% in patients with motor incomplete SCI. There was a negative correlation between hip adductor and extensor muscle MAS, PSFS, and level of fasting glucose in these patients. Conclusion This study supports the notion that spasticity has positive effects on the FFM% and glucose metabolism in patients with motor complete and incomplete SCI.

Stress, Inflammation and Metabolic Biomarkers Are Associated with Body Composition Measures in Lean, Overweight, and Obese Children and Adolescents.

The aim of this study was to examine the associations between multiple indices of stress, inflammation and metabolism vs. body composition parameters in 121 (43 boys, 78 girls) children and adolescents, aged 5–15 y. Subjects were divided into two groups: normal weight (N) (N = 40, BMI z-score = −0.1923 ± 0.6), and overweight/obese (OB) (N = 81, BMI z-score = 2.1947 ± 1.4). All subjects completed the State-Trait Anxiety Inventory for Children (STAIC) and Children’s Depression Inventory, and underwent cortisol measurements in hair, diurnal series of saliva, and morning serum. Circulating concentrations of high sensitivity C-reactive protein (hsCRP) and other inflammation biomarkers were also obtained. Body composition analysis was performed with a clinically validated, advanced bioimpedance apparatus (BIA), while heart rate variability (HRV) was measured as a stress biomarker by photoplethysmography (PPG). The OB group had a higher STAIC-state score, waist-to-hip ratio, skeletal muscle mass, and total and abdominal fat mass, and a lower percent fat-free mass (FFM) and bone density than the N group. HRV did not differ between the groups. In the entire population, percent fat mass correlated strongly with circulating hsCRP (r = 0.397, p = 0.001), ferritin, and other inflammatory biomarkers, as well as with indices of insulin resistance. A strong correlation between serum hsCRP and hair cortisol was also observed (r = 0.777, p < 0.001), suggesting interrelation of chronic stress and inflammation. Thus, body fat accumulation in children and adolescents was associated with an elevation in clinical and laboratory biomarkers of stress, inflammation, and insulin resistance. BIA-ACC and PPG can be utilized as a direct screening tool for assessing overweight- and obesity -related health risks in children and adolescents.

Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.

BackgroundEating disorder (ED) symptoms are prevalent in the general population, but their shared genetic underpinnings with psychiatric, metabolic, and anthropometric traits are not known. Here, we examined if polygenic scores (PGSs) of traits associated with anorexia nervosa are also associated with adolescent ED symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC).MethodsA total of 8654 participants with genotype data and at least one phenotypic measure were included from the ALSPAC study. We associated PGS from 25 traits (16 psychiatric, 4 metabolic, and 5 anthropometric) with eight ED symptoms, including behaviours such as fasting for weight loss and cognitions such as body dissatisfaction.ResultsHigher attention deficit hyperactivity disorder PGS and lower educational attainment PGS were associated with fasting for weight loss. Higher insomnia PGS was associated with increased body dissatisfaction. We found no evidence of an association between metabolic trait PGS and any ED symptom. Fat‐free mass, fat mass, and body fat percentage PGSs, were positively associated with binge eating, excessive exercise, fasting for weight loss, body dissatisfaction, and weight and shape concern.ConclusionsED symptoms are genetically associated with psychiatric and anthropometric, but not with metabolic traits. Our findings provide insights for future genetic research investigating on why some individuals with ED symptoms progress to develop threshold EDs while others do not.