Alzheimer's disease (AD) risk-related biomarkers may be quantitatively modeled for independent or interactive effects on preclinical trajectories of cognitive change. Biomarkers may alter cognitive trajectories (a) independently as risk-reducing or risk-increasing and (b) interactively as risk-intensifying or protection-enhancing. Both modifiable (e.g., vascular health) and non-modifiable (e.g., genetic) biomarkers may exert effects differentially according to important selection classifications (e.g., sex, cognitive status). We examine a series of dynamic AD biomarker interactions (i.e., insulin degrading enzyme [IDE], pulse pressure [PP]) that predict non-demented cognitive performance and longitudinal change differentially for three cognitive status groups. The participants from the Victoria Longitudinal Study (n=623; 53–95 years, M=70.6) were objectively classified in three cognitive status groups: Cognitively Exceptional (CE, n=79), Cognitively Normal (CN, n=394), and Cognitively Impaired (CI, n=150). All participants contributed executive function (EF) performance (6 tests, one latent variable) on up to three waves across 9 years. Latent growth modeling (Mplus) was used for statistical evaluation. First, for the full sample, overall 40-year EF decrements were moderated by PP. Specifically, higher PP (worse vascular health) was associated with worse EF performance and steeper decline; establishing a benchmark dynamic biomarker fan effect. Second, further moderation by IDE showed a dynamic fan effect similar to the benchmark, although homozygote carriers of the risk-increasing allele (AA) had lower performance and steeper decline. Third, markedly differential biomarker interaction effects were observed for each cognitive status group. For the CE group, the dynamic fan effect was evident but at elevated levels and sustained slopes for all IDE x PP combinations. For the CN group, the pattern mirrored that of the overall benchmark with the AA genotype exhibiting steeper decline at all levels of PP. For the CI group, the dynamic fan effect exhibited lower performance, as well as consolidated and steeper decline. The beneficial effects of better vascular health are evident in genetically low risk and cognitively intact adults. However, once cognitive impairment is established vascular health plays an apparent but not significant role in aging decline. Dementia biomarkers from different modalities interact in distinct patterns across non-demented exceptional, normal, and impaired aging groups.