Family History Of Psoriasis Research Articles

Clinical differences between early- and late-onset psoriasis in Thai patients.

There is a paucity of data regarding clinical differences between early-onset psoriasis (EOP) and late-onset psoriasis (LOP) in Asian populations. This study aimed to investigate clinical differences between EOP (onset at the age of <40 years) and LOP (onset at the age of ≥40 years) in Thai patients. From 2002 until 2008, staff and residents in the Department of Dermatology, Siriraj Hospital, were asked to complete a questionnaire detailing the age of onset, family history of psoriasis, comorbid diseases, clinical features, nail and joint involvement, and severity of psoriasis in all psoriasis patients. Data were analyzed using descriptive statistics and chi-squared tests. A total of 1017 patients were enrolled. Of these, 663 (65.2%) patients had EOP and 354 (34.8%) had LOP. The mean ± standard deviation age of onset was 24.8 ± 8.7 years in the EOP group and 51.6 ± 9.6 years in the LOP group. The two most common comorbid diseases were hypertension and diabetes mellitus in both groups. Patients with EOP had a significantly higher likelihood of both a family history of disease and guttate psoriasis. Palmoplantar psoriasis was more commonly found in LOP patients. Nail and joint involvement and disease severity were not associated significantly with age of onset. The present study supports the hypothesis that there are clinical differences between EOP and LOP in Asian populations.

Clinical and immunogenetic characterization in psoriatic arthritis patients

In psoriatic arthritis (PsA), genetic factors play a substantial role in disease susceptibility as well as in its expression. This study aims to determine the distribution of class I and class II HLA antigens in PsA patients and secondly to analyze the influence of genetic factors in the clinical expression of the disease. Consecutive PsA patients (CASPAR criteria) with less than 1 year of disease duration were included. Sociodemographic and clinical data were recorded. Blood samples were obtained, DNA was extracted by polymerase chain reaction (PCR), and class I (A, B, and C) and class II (DR) HLA antigens were determined by oligotyping. A control group of 100 nonrelated healthy controls from the general population served as control. p values were corrected (pc) according to the number of alleles tested. A total of 73 patients were included, 37 were females (50.7 %) with a median disease duration of 72 months (interquartile range (IQR) 24-149). Thirty-three patients (45.2 %) had a family history of psoriasis. When analyzing all the class I and class II HLA antigens, a significantly higher frequency of B38 (odds ratio (OR) 2.95, p = 0.03) and Cw6 (OR 2.78, p = 0.009) was found in PsA patients compared to the control group. On the contrary, the HLA-A11 (OR 0.14, p = 0.04) and B7 (OR 0.31, p = 0.03) were significantly more frequent among healthy controls. Furthermore, B18 was significantly more frequent in patients with early arthritis onset (less than 40 years): seven patients (22.6 %) with early onset compared to two patients (4.8 %) with late onset (p = 0.03). No association between HLA-B27 and spondylitis or HLA-DR4 with polyarticular involvement was observed. The HLA-B38 and Cw6 alleles are associated with a greater PsA susceptibility in Argentine population.

AB0736 Strategy for the Early Detection and Referral of Patients with Suspected Spondyloarthritis

ObjectivesTo design a strategy for early detection and referral of patients with suspected spondyloarthritis (SpA) by primary care physicians (PCP).MethodsWe used a modified RAND/UCLA methodology and systematic review (SR). A...

SAT0395 Scalp Psoriasis as A Surrogate Marker for Psoriatic Arthritis Severity and Treatment Response

BackgroundPatients with psoriasis (PsO) are at an increased risk of developing psoriatic arthritis (PsA).1 It has been observed that scalp PsO is indicative of more severe PsO, and increased PsO...

A case-control study and analyze the epidemiological importance risk of family history of psoriasis

Letter to the Editor DOI: 10.7241/ourd.20141.24 A CASE-CONTROL STUDY OF EPIDEMIOLOGICAL IMPORTANCE RISK OF FAMILY HISTORY OF PSORIASIS Anca Chiriac 1 , Caius Solovan 2 , Anca E Chiriac 3 , Liliana Foia 4 , Piotr Brzezinski 5 Dermato-Physiology Department, Apollonia University Iasi, Strada Muzicii nr 2, Iasi-700399, Romania Department of Dermatology, University of Medicine V Babes, Timisoara, Romania Medical student, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania Department of Biochemistry, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania. Department of Dermatology, 6th Military Support Unit, os. Lendowo 1N, 76270 Ust- ka, Poland Source of Support: Nil Competing Interests: None Corresponding author: Ass. Prof. Anca Chirac Our Dermatol Online. 2014; 5(1): 90-91 ancachiriac@yahoo.com Date of submission: 14.09.2013 / acceptance: 28.10.2013 Cite this article: Anca Chiriac, Caius Solovan, Anca E Chiriac, Liliana Foia, Piotr Brzezinski. A case-control study of epidemiological importance risk of family history of psoriasis. Our Dermatol Online. 2014; 5(1):90-91. Sir between 2004-2011, in an Out-patient Clinic in North-Eastern part of Romania.The sex ratio of psoriasis was 1.18:1 (male patients 54.13%, female patients 45.87%), median age at the diagnosis was 29.34±15.24SD; family history of psoriasis (by declaration) was 29.53% (Tabl. I). We have conducted a case-control study to analyze the epidemiological importance risk of family history of psoriasis. The retrospective study was done on 1236 patients diagnosed with psoriasis on clinical and histopathological grounds, Family history Nr. cases Absent Present First degree Children Parents Second degree Grand parents Grand children Brothers/sisters Third degree Grand-grand parents Uncle/aunt Fourth degree Cousins Total Table I. Results of the study. 90 © Our Dermatol Online 1.2014 www.odermatol.com

Genotype-phenotype correlations in a prospective cohort study of paediatric plaque psoriasis: lack of correlation between HLA-C*06 and family history of psoriasis.

This study aims to investigate associations between observed clinical parameters and known genetic risk factors of psoriasis in a well-defined prospective cohort of paediatric patients with plaque psoriasis (n = 151). Significant associations were found for paediatric-onset psoriasis with ERAP1 (p = 0.002), IL23R (p = 0.01), LCE3C_LCE3B-del (p = 0.00049) and HLA-C*06 (p = 3.15 × 10(-30)). Psoriasis severity was associated with the single nucleotide polymorphisms tagging IFIH1 and ERAP1 (p < 0.05). An onset before 10 years of age was associated with IL12B (p = 0.02). Nail psoriasis was more often seen in HLA-C*06-negative patients (p = 0.008). Remarkably, family history is clearly not associated with HLA-C*06 in this specific group. The large proportion of patients with a positive family history in HLA-C*06 negative patients (and the lack of correlation between the two) indicates that other genes, either alone or interaction between two or more genes, may have significant effects on heritability.

Study of lipid profile for psoriatic patients in AL-Anbar governorate.

Psoriasis is a chronic inflammatory skin condition which affects approximately 1-3% of the world's population (1). It appears as red plaques covered with silvery scale that flakes away from the skin.Psoriatic plaques are often found on the elbows, scalp and knees but can also affect other parts of the body such as the face, feet and mucous membranes.Psoriasis is not contagious, nor is it caused by an allergy. However, the tendency to develop the condition can be genetically transmitted. Psoriasis causes itching in 60% to 70% of cases (2). However, the exact etiology of psoriasis is unknown. Abnormalities in lipid metabolism have been proposed because the abnormalities in lipids lead to abnormalities in skin formation which is made from lipids. To evaluate the serum lipids profile in psoriatic patients of Al-Anbar governorate and to compare the results with other external studies. The study group included 60 patients with psoriasis, and 30 healthy volunteers. Blood lipid profile was determined using commercial kits from reliable French and Spain companies. All patients had psoriasis involving less than 30% of body surface. Their ages ranged from 10 to 60 years with a mean of 32 years. Family history of psoriasis was positive in a percentage of (20%) of the patients. The mean levels of serum lipids (total cholesterol, triglyceride, low density lipoprotein, and very low density lipoprotein) in patients with psoriasis were found to be significantly higher than those of healthy individuals. The mean levels of high density lipoprotein were not significant. This study strengthens the relationship between the lipids intake, formation, and metabolism with the pathogenesis of psoriasis. Therefore it is concluded that psoriatic patients should be evaluated for hyperlipidemia and obstructive vascular diseases. Administrating lipid-lowering medicines for patients particularly cases with severe disease may be beneficial prognosis.

Clinical study on psoriasis patients for past 30 years (1982–2012) in Seoul National University Hospital Psoriasis Clinic

Psoriasis is a chronic relapsing disorder which shows variable clinical features. The long-term clinical study with many patients is important to elucidate the epidemiologic characteristics and clinical features of psoriasis. The purpose of this study was to analyze the epidemiologic characteristics and clinical features of psoriasis in Korean patients. Epidemiologic and clinic data and assessments for severity of extent and activity of psoriasis were collected from the medical records of 5084 patients, who had been newly diagnosed with psoriasis in the Psoriasis Clinic of Seoul National University Hospital between 1982 and 2012. The sex ratio of the psoriasis patients was 1.2:1 (male 54.6%, female 45.4%). The peak age of onset in males was 20s, while it was the teenage years in females. A total of 63.5% of patients developed psoriasis before 30years of age. Family history of psoriasis was observed in 26.0% of patients. Moderate to severe extent of involvement were more frequently observed in male patients and patients under 30years of onset age than in females and patients 30years or over of onset age, respectively. Moderate to severe disease activity were also more frequently presented in male patients, but not in patients under 30years of onset age. The most common morphological type was nummular (56.7%), followed by large plaque (28.5%) and guttate (8.5%). Nail involvement accompanied in 26.4% of patients. We demonstrated the epidemiologic and clinical characteristics of psoriasis in Korean patients.

SAT0526 ICG-Enhanced Fluorescence Optical Imaging (FOI) Detects Typical Inflammatory Changes in Subjects with Arthralgia and Psoriasis

BackgroundEarly diagnosis of psoriatic arthritis (PsA) is a major challenge. ICG-enhanced fluorescence optical imaging (FOI) is a novel technology that enables detection of inflammation in the hands with high sensitivity...

AB0926 The relationship between disease activity indices in patients with psoriatic arthritis

BackgroundPsoriatic arthritis (PA) is a chronic inflamatory joint diseasewhich combines skin disease (psoriasis) with various joint manifestations (spondylitis, peripheral arthritis, dactilytis and enthesitis) (1). Some authors said that 11% of...

AB0371 In RA patients with very strongly positive serology there is a striking discordance in presentation between those with very strongly positive ACPA levels associated with negative or low-positive rf levels and those with very strongly positive RF levels

BackgroundRA has been viewed for many years as a heterogeneous collection of rheumatic diseases. Previously rheumatoid factor (RF) positive and negative patients were regarded as distinct clinical subtypes. Additionally, within...

Clinical and epidemiological comparison of patients affected by palmoplantar plaque psoriasis and palmoplantar pustulosis: a case series study

In 2007 the International Psoriasis Council proposed that palmoplantar pustulosis (PPP) should be considered a separate condition from psoriasis, despite the presence of certain phenotypes common in both diseases. To describe and compare demographic and clinical characteristics among patients with PPP and palmoplantar plaque psoriasis. This was a retrospective case series study from 2005 to 2010. The following data were obtained: age, sex, family history, smoking habits, nail involvement, joint involvement, disease duration, lesion morphology (plaque or pustular), histological diagnosis, comorbidities, and Physician's Global Assessment (PGA) score for extrapalmoplantar lesions. The sample size calculation indicated that 80 patients, 40 patients for each group (palmoplantar plaque psoriasis and PPP) were needed to see clinically relevant differences between groups. Ninety patients were selected, 51 with palmoplantar plaque psoriasis and 39 with PPP. No statistically significant differences were registered between patients affected by PPP and palmoplantar plaque psoriasis as regards age at onset of the disease (48 vs. 44 years; P=0·4), disease duration (6 vs. 10 years; P=0·1), family history of psoriasis (28% vs. 33%; P=0·7), concomitant arthritis (26% vs. 25%; P=1·0), or smoking habits (54% vs. 41%; P=0·2). We observed a female predominance (P=0·01) and a lesser frequency of nail involvement (P=0·03) in patients affected by PPP. Our data suggest a close relationship between PPP and psoriasis. The existing data concerning epidemiology, clinical presentation, genetics, histopathology and pathogenesis do not permit a clear distinction between these two entities, which seem to coincide in many aspects. PPP appears to have a marked predilection among female smokers.

AB0572 Additional risk for cardiovascular comorbidities in patients with psoriatic arthropathy

BackgroundCardiovascular(CV) comorbidities are an important issue of inflammatory arthritis (1.2), given that mortality increases with the severity form of the disease(3). CV risk factors and metabolic factors were present more...

SAT0282 Presentation Patterns in a Cohort of Patients with Psoriatic Arthritis

BackgroundArthritis is estimated to precede skin psoriasis in approximately 15% of psoriatic arthritis patients (PsA) (1). However this data is based on studies published prior to the development of the...

Asymptomatic crusted lesions

A 92-year-old man was admitted to our hospital because of a 4-month history of an asymptomatic rash with widespread crusting. Five months earlier, the patient had been diagnosed with chronic lymphocytic leukemia and began anticoagulant therapy for chronic atrial fibrillation. The physical examination revealed large, malodorous, crusted plaques located on the chest, limbs, and stomach and sparing the face and back (Fig 1). The patient denied pruritus, although he often manipulated and scratched the crusted lesions. The patient had no previous or family history of psoriasis or other skin diseases. He had lived alone for many years and had not traveled abroad. The patient denied any other drug intake. 1.What is the most likely diagnosis? A.Drug eruption B.Psoriasis C.Pemphigus foliaceus D.Crusted scabies E.Darier disease 2.What is the most appropriate management? A.Topical 1% permethrin B.Topical 10% lindane (lotion) C.Topical 5% permethrin D.Topical corticosteroids E.Cyclosporine 3.What measures should be taken to control the infestation and avoid transmission to others? A.Only treat the patient B.Treat the patient and family members C.Treat the patient, family members, and any other individuals who are in close contact with the patient, and even pets, such as cats or dogs D.Treat the patient, family members, and any other individuals who are in close contact with the patient E.Only treat the patient and isolation for 1 month

Undifferentiated seronegative spondyloarthritis with inflammatory bowel disease and a family history of psoriasis. Sicca syndrome

Background: Seronegative spondyloarthritis is characterized by the presence of subcutaneous nodules, asymmetrical peripheral arthritis, sacroileitis with or without spondylitis, and rheumatoid-factor negativity. Other common clinical manifestations include oral ulcers, conjunctivitis, and cutaneous lesions such as psoriasis. Familial aggregation has also been described. According to the 1986 classification, corresponding clinical entities include ankylosing spondylitis, psoriatic arthritis, Reiter’s syndrome, arthritis associated with inflammatory bowel disease (IBD), and undifferentiated spondyloarthritis. The disease is also frequently associated with the HLA B27 antigen. From the clinical point of view, there are often incomplete forms of spondyloarthritis, such as reactive arthritis triggered by asymptomatic infections, psoriatic arthritis without psoriasis itself, initial phases of specific forms of spondyloarthritis or the phase of ankylosing spondylitis characterized by sacroiliac lesions, and all forms that remain undifferentiated for long periods of time. Moreover, there are close relations between arthropathy and IBDs, such as Crohn’s disease, ulcerative colitis, and Whipple’s syndrome. Recently, microscopic inflammatory bowel lesions and psoriatic arthritis have been described. Case report: A 30-year-old man (HLA B27-negative) who had been vaccinated against TBC and HBV presented with a 6-year history of recurrent episodes of predominantly left-sided sciatica. The pain was worse at night and during rest. He was suffering from bilateral sacroileitis without spondylitis. Three to five times a day, usually after eating, he passed watery feces containing mucous and small amounts of bright red blood. Colonoscopy revealed pancolitis with histological evidence of chronic inflammation interspersed with areas of acute inflammation, edema, hyperemia, and glandular distortion. One year later, the clinical manifestations and histological findings were essentially unchanged: glandular distortions, chronic and acute inflammation of the lamina propria and crypt microabscesses. There were no granulomas and no evidence of uveitis. The inflammatory index was positive; FR, ENA, ANA titers were negative. He began therapy with adalimumab (loading dose 80 mg followed by 40 mg every 15 days) and mesalazine (2.4 g per os), and the clinical manifestations of the disease improved significantly.

Psoriasis and Psoriatic Arthritis in Peruvian Aborigines: A Report from the GRAPPA 2011 Annual Meeting

To determine the presence of psoriasis and psoriatic arthritis (PsA) in aboriginal people living in the Andean Mountains of Peru. Consecutive patients with psoriasis and PsA attending an arthritis clinic in Juliaca, Puno, Peru, located 3824 m above sea level were examined. The CASPAR (ClASsification of Psoriatic ARthritis) criteria were used for classification of PsA. Diagnosis of psoriasis was confirmed by a dermatologist. Seventeen patients [11 (65%) men and 6 (35%) women] fulfilled classification criteria for PsA; one patient was of European ancestry and is not included in this report. Of the 16 aboriginal patients in this report, 5 were natives of Quechua ancestry and one was native Aymara. At the time of their first clinic visit, no native patient with PsA had a family history of psoriasis or PsA, and all patients exhibited an established disease of long duration and severity. Methotrexate was the drug of choice for all patients; 2 patients are currently receiving biological therapy. Contrary to what has been reported in the literature, both psoriasis and PsA are present in aboriginal people from the Andean Mountains of Peru. More studies are needed to further define the phenotype of these disorders, as well as the pathogenetic role of genetic and environmental factors.

Evaluation of coronary heart disease risks in patients with psoriasis

Objective To estimate the 10-year risk of coronary heart disease in patients with psoriasis,and to determine whether the risk profile is affected by disease duration,family history and clinical types of psoriasis.Methods Data were pooled from 322 inpatients with psoriasis and 297 inpatients with other skin diseases (151 cases of acute urticaria,33 drug eruption,113 herpes zoster) from December 2008 to December 2010 in the Department of Dermatology,West China Hospital of Sichuan University.Risks of coronary heart disease were estimated by using the Framingham risk score algorithm.Wilcoxon rank test,Kruskal-Wallis test and chi-square tests were used to evaluate the differences in risks and risk factors between the patients with psoriasis and controls.Results As far as the Framingham 10-year risk score was concerned,the difference was statistically significant between the patients with psoriasis and the control population (6％ vs.4％,Z =4.342,P =0.000),as well as between patients with different clinical types of psoriasis (6％ for psoriasis vulgaris vs.4％ for pustular psoriasis vs.7％ for psoriasis arthropathica vs.7％ for erythroderma psoriaticum,H =8.484,P ＜ 0.05),but was insignificant between patients with familial and sporadic psoriasis (6％ vs.6％,Z =0.406,P ＞ 0.05 ).No correlation was observed between the Framingham 10-year risk and psoriasis duration (P ＞ 0.05 ).Conclusions Increased risks of coronary heart disease exist in patients with psoriasis compared with those with acute urticaria,drug eruption or hepers zoster,and in patients with psoriasis arthropathica or erythroderma psoriaticum compared with those with pustular psoriasis.The Framingham 10-year risk of coronary heart disease is uncorrelated with disease duration and unaffected by family history of psoriasis. Key words: Psoriasis; Coronary disease; Risk assessment

Psoriasis and phenotype of patients with early inflammatory back pain

BackgroundPsoriasis is an important clinical feature in spondyloarthritis. However, the influence of psoriasis on the clinical, functional and imaging features of patients with inflammatory back pain (IBP) related to spondyloarthritis...

Study of Genetic Polymorphisms in the Tumor Necrosis Factor α Promoter Region in Spanish Patients With Psoriasis

BackgroundSeveral studies have reported an association between tumor necrosis factor α (TNF-α) polymorphisms and inflammatory diseases such as psoriasis vulgaris and psoriatic arthritis, although the results vary according to the population studied. No studies have been performed in the Spanish population. ObjectiveTo analyze the polymorphisms of the promoter region of the TNF-α gene in patients with moderate to severe psorasis and to identify potential differences in genotype compared to a group of healthy volunteers. Material and methodsEighty-nine patients with moderate to severe psoriasis and 76 healthy controls with no personal or family history of psoriasis were selected. Polymorphisms of the TNF-α promoter region of both groups were genotyped. ResultsWe observed a higher prevalence of the genotype with both wild-type alleles at positions -238 (GG genotype, 86.5% vs 70.4%, respectively) and -1031 (TT genotype, 80.2% vs 45.8%, respectively) in patients compared to the healthy control group. The differences at positions -308 and -857 were not significant. ConclusionThere are differences in polymorphisms at positions -238 and -1031 in patients with moderate to severe psoriasis compared to healthy volunteers. This observation provides further support for the importance of the part that TNF-α plays in the pathophysiology of this disease.