While moving toward Baby Friendly Hospital designation, we evaluated our practices and discovered that the practice of admitting stable newborns who were exposed to their mothers’ chorioamnionitis was not supported by evidence. To improve quality, satisfaction, and fiscal responsibility we recognized that this practice required a synergistic problem solving approach. To develop, implement, and evaluate a process that provides increased surveillance and minimizes mother–infant separation by initiating sepsis screening and antibiotic therapy in the newborn nursery rather than in the NICU. The tradition of admitting newborns who were exposed to chorioamnionitis to the NICU was neither family-centered nor fiscally efficient. Furthermore, it interfered with bonding, affected breastfeeding, and overused NICU resources. Our interprofessional clinical leadership team recognized the need to align with Baby Friendly and family-centered care practices. The team developed admission criteria, guidelines, tools, and communication strategies for chorio admissions to the newborn nursery. If stable at birth, skin-to-skin continued until the newborn was transferred to the newborn nursery for sepsis screening and antibiotic administration. Using the plan-do-study-act (PDSA) methodology, the process was tested, evaluated, revised, and fully implemented. Since implementation, more than 160 NICU admissions have been avoided, and quality metrics have been met. A transition process that provides family-centered, evidence-based, and cost-effective care for at-risk newborns has far-reaching benefits. At a magnet hospital with an emphasis on evidence-based research and best practice, nurses and their leadership have a responsibility to examine current practices and initiate those that are evidence-based and patient centric.