Men have distinct facial anatomy and facial patterns. Autologous fat grafting techniques can be tailored to maintain masculine features.Interest in male facial rejuvenation has grown in recent decades. Autologous fat grafting is favored for its natural, durable results and regenerative benefits.Men have angular facial structures with prominent brows, wider jaws, and thinner fat layers. Aging leads to forehead rhytids, midface hollowing, nasal lengthening, jawline blunting, and a more rectangular profile due to bone loss and skin laxity.Thorough preoperative evaluation and facial analysis are important for successful planning and outcomes.There are various commercially available tools for fat harvesting and processing. The Tulip cannula and PureGraft systems are described in this article. Microfat (1,000-1,500 microns) is preferred in facial grafting for its balance of volume restoration and low nodularity risk. The brow, infraorbital region, midface, jawline, and chin can be targeted to restore a youthful, masculine contour.Research on male-specific outcomes, including hormonal and weight effects on graft longevity and patient-reported outcomes, is limited and is an area ripe for future investigation.As interest in male aesthetics increases, tailoring facial rejuvenation techniques to their anatomy and aging is essential for successful outcomes.

A patient's ethnicity and culture need to be considered prior to male facial rejuvenation. Here, we describe the most important factors across ethnicities that affect the analysis, treatment, and postoperative considerations of commonly performed procedures.There are some traits commonly associated with certain ethnicities that differ from each other. These span skeletal structure, skin characteristics, predisposition to poor scarring, periorbital and nasal anatomy, and hair qualities.As they pertain to the described differences in traits, certain variations exist within procedures to accommodate non-Caucasian patients. This is to make results more natural, fitting to a patient's ethnicity and goals, and to account for differences in postoperative healing.An integral part of every patient encounter is to listen to the patient's perspective and goals prior to developing a treatment plan. Their facial analysis should subsequently be performed in the context of their ethnicity. The management of non-Caucasian facial rejuvenation patients should not be taught as a variation of the norm but rather as unique considerations to modify known surgical techniques for each individual ethnicity and culture. Training needs to emphasize and popularize these differences.

This article presents a comprehensive, anatomically precise approach to deep plane facelift surgery in male patients, a demographic with increasing interest in facial rejuvenation but historically underserved by techniques optimized for female anatomy. While foundational facelift principles are shared between genders, the male patient presents unique structural, vascular, and aesthetic demands that necessitate specific modifications to technique, planning, and execution.Key anatomical distinctions in the male face, including denser subcutaneous tissue, increased vascularity, prominent subplatysmal structures, and horizontally oriented submuscular aponeurotic system (SMAS)-platysma continuity, require surgical planning that respects and preserves masculine facial definition. The submental region is often complicated by hypertrophic digastric musculature and submandibular gland visibility, necessitating targeted management to optimize the cervicomental angle.This article outlines a male-specific technique emphasizing extended deep plane dissection, ligamentous release, SMAS repositioning with minimal subcutaneous dissection, and submental access. Deep plane neck procedures, including conservative subplatysmal fat reduction, digastric contouring, partial submandibular gland reduction, and corset platysmaplasty, supplement the facial portion of the procedure.When performed with anatomical precision and gender-specific adaptation, preservation-based techniques with extended deep plane facelift surgery yield consistent, natural, and structurally restorative outcomes in male patients.

Introduction: The importance of having healthy skin drives the demand for herbal and safe products that led to the development of a novel Ayurvedic facial kit by using Yashtimadhu Taila (Liquorice oil) and Modified Shastika Shali Pinda Sweda (Navara rice bolus sudation) for facial skin rejuvenation. Aim: To introduce a novel, natural procedure in Ayurvedic cosmetology and standardise the formulation of a facial kit. Materials and Methods: This was an in-vitro, experimental, laboratory-based formulation study. The formulation was prepared at Dr. DY Patil University- School of Ayurveda, Nerul, Navi Mumbai, India and all analytical evaluations were carried out at Adhrsya Lifesciences, a certified laboratory. For this invitro study, a facial kit was developed in sequential stages as part of an experimental, laboratory-based formulation study. Yashtimadhu (Glycyrrhiza glabra, Liquorice) and Amalaki (Emblica officinalis, Indian Gooseberry) were authenticated and subjected to phytochemical analysis. Yashtimadhu Taila was prepared and standardised as per classical Ayurvedic reference. A modified Shastika Shali Pinda Pottali (Navara rice bolus bag) incorporating Yashtimadhu was prepared, standardised and subjected to nutritional analysis. Finally, the kit was assembled, consisting of Yashtimadhu Taila, the prepared bolus for massage and Mukha Lepa (face pack) derived from the paste of opened bolus bags. Results: Nutritional analysis of Shastika Shali Pinda (bolus) revealed the presence of Antioxidant, Antibacterial properties along with essential nutrients such as Vitamin-A, B, D and E, minerals like calcium, phosphorus, magnesium, as well as protein, carbohydrate, Polyunsaturated Fatty Acids (PUFA) and Monounsaturated Fatty Acids (MUFA). Standardisation confirmed that Yashtimadhu Taila and Shastika Shali Pinda met the required quality parameters, demonstrating compliance with safety and quality parameters. Conclusion: The tests on Yashtimadhu Taila (oil) and Shastika Shali Pinda (bolus) confirm that they are safe for use and possess properties beneficial for improving skin health.

While facelift literature has largely focused on female patients, recent research highlights unique anatomical and psychosocial considerations in male facial rejuvenation. The short scar neck lift is explored to present the indications, technique, and outcomes as an alternative to the deep plane facelift in selected male patients.The short scar neck lift employs limited periauricular incisions to address submental fullness, platysmal banding, and mild-to-moderate cervical skin laxity. Ideal candidates demonstrate localized cervical and mandibular aging without significant midface descent. The procedure may be combined with submental liposuction, platysmaplasty, and energy-based devices to enhance skin contraction.In appropriately selected patients, the short scar neck lift achieves meaningful improvement in cervicomental angle definition with reduced operative time, morbidity, and recovery compared with deep plane facelifts. The short scar neck lift is a versatile, lower-morbidity alternative for male patients with localized cervical aging. Its targeted approach, adaptability, and favorable recovery profile make it a valuable addition to the male facial rejuvenation surgical algorithm.

Perceived age is an objective surrogate for facial rejuvenation, but comparative evidence across facelift techniques using human and AI raters is limited.This trial assessed whether facelift techniques differ in rejuvenation effect and whether AI estimates align with human evaluations.Randomized clinical trial.A total of 30 women (45-65 years) underwent rhytidectomy by deep plane, high SMAS, or plication (n = 10 each). Standardized photographs were rated by 200 laypersons (9,000 evaluations) and three AI models (180 evaluations). Primary outcome was change in perceived age (Δ age); secondary analyses included technique comparison, AI accuracy, rater bias, and human-AI correlation.All techniques significantly reduced perceived age, with no statistical difference between groups. Amazon Rekognition and HowOldDoYouLook were more accurate. Human-AI correlation was moderate (r = 0.41, p = 0.020). Raters under 30 underestimated age (p < 0.001).Human and AI evaluations showed no technique differences, with AI estimates resembling human assessments.

Blepharoplasty is among the fastest-growing aesthetic procedures in male patients, reflecting shifting cultural norms and increasing demand for facial rejuvenation that preserves masculine features. This review outlines the anatomical and aging patterns specific to the male periorbital region and discusses contemporary surgical techniques tailored to this population.The gender-specific anatomical differences in the periorbital region influence both surgical planning and outcomes are highlighted.Aging in men involves distinct patterns that must be addressed to preserve masculine facial identity.Surgical strategies emphasize conservative tissue excision, preservation of eyelid fullness, and avoidance of feminizing features.Men are predisposed to complications like lower lid malposition, visible scarring, and wound dehiscence due to anatomical factors and skin characteristics. Overcorrection may lead to feminization, necessitating a conservative surgical philosophy and meticulous technique.A deep understanding of sex-specific anatomy and aging, coupled with meticulous surgical technique, is essential for achieving natural, harmonious outcomes that align with the male aesthetic ideal.

In recent years, the advancements of minimally invasive, energy-based facial treatments have been followed by an increase in male patient's demand. This article presents a review of current energy-based devices for male facial rejuvenation, aiming to inform clinicians on evidence-based treatment options.A search of the scientific literature in the PubMed database from inception to June 2025 was conducted. Articles were included if they discussed energy-based options for male facial rejuvenation. Out of 70 articles screened, 23 met the inclusion criteria. In included articles, 18 energy-based options used for male facial rejuvenation were reported.This review provides an overview of the wide array of energy-based devices available for male facial rejuvenation. The literature suggests that these technologies can be effectively and safely used to tighten skin, improve contouring while reducing adiposity, enhance skin quality and tone, and manage cosmetic vascular lesions.

Male Facial Rejuvenation.

Energy-based devices are widely used for facial rejuvenation; as a result, an increasing proportion of patients presenting for facelift or necklift surgery have a history of prior treatment with ultrasound- or radiofrequency-based technologies. While the efficacy and safety of these devices are well-established, their cumulative effects on facial soft tissues critical to deep-layer facelift surgery remain under-recognized. This article examines three commonly used energy-based facial tightening modalities - microfocused ultrasound, high-frequency parallel beam ultrasound, and fractional radiofrequency microneedling - from the perspective of the facelift surgeon. Device-specific mechanisms of action and tissue-level effects are reviewed, followed by discussion of their potential operative implications and the senior author's experience-informed strategies for managing these patients. Recognition of these effects is essential for patient counseling, operative planning, and preservation of long-lasting surgical outcomes.

Exosomes have gained increasing attention in aesthetic medicine for their regenerative properties and role in skin and hair rejuvenation. By stimulating collagen production, delivering growth factors, and supporting follicle regeneration, they offer a novel, noninvasive approach to facial rejuvenation and hair growth. A systematic review and meta-analysis were conducted to evaluate the clinical efficacy of exosome therapies in aesthetic indications. A comprehensive search of Medline, Embase, Cochrane, Trip Database, and ClinicalTrials.gov was performed on February 2, 2025. Eligible studies included human trials reporting outcomes on wrinkles, pigmentation, elasticity, skin texture, erythema, overall aesthetic improvement, hair density, or hair thickness. Thirty-nine studies were included: 26 focused on skin outcomes and 13 on hair outcomes. Meta-analyses were performed using random-effects models where percent improvement and standard error were available. Facial wrinkle reduction averaged 20.2% (95% CI, 15.3%-25.2%; P < .001). Additional skin-related outcomes improved by 14.7% to 23.4%, including pigmentation, elasticity, texture, erythema, and overall appearance. Hair density and thickness improved by 23.6% (95% CI, 18.1%-29.0%) and 18.0% (95% CI, 11.1%-24.9%), respectively. Nine ongoing clinical trials were identified across the United States, Iran, and China. Risk of bias in randomized controlled trials was assessed using the Cochrane risk of bias (ROB2) tool. Although heterogeneity and nonstandardized protocols limit generalizability, findings indicate consistent, meaningful improvements in both skin and hair outcomes. These results support further investigation of exosome therapies as a regenerative modality in aesthetic medicine. Level of Evidence: 3 (Therapeutic).

Mesenchymal stem cell (MSC)-derived exosomes are emerging as cell-free bioregenerative platforms in aesthetic dermatology. Umbilical cord (UC-MSC) and adipose-derived (AD-MSC) exosomes are among the most studied sources, yet existing data derive from heterogeneous models that preclude direct comparison. No standardized head-to-head evaluation in a human skin aging model has been conducted. The aim of the study is to compare the regenerative and antiaging effects of UC-MSC and AD-MSC exosomes using a physiologically relevant ex vivo human skin aging model. MSCs were isolated and characterized per International Society for Cellular Therapy criteria. Exosomes were purified through differential ultracentrifugation and analyzed by nanoparticle tracking and flow cytometry. Cytokine cargo was profiled using multiplex assays. Human dermal fibroblasts and ex vivo skin explants were used to assess proliferation, senescence-associated β-gal activity, melanogenesis, senescence-associated secretory phenotype (SASP) suppression (interleukin-6, matrix metalloproteinase-9), and extracellular matrix (ECM) biosynthesis. Topical retinoic acid and resveratrol served as reference controls. Both exosome types increased fibroblast proliferation and reduced senescence. AD-MSC exosomes showed higher vascular endothelial growth factor (VEGF) content, driving angiogenesis and greater collagen and hyaluronic acid production. UC-MSC exosomes, enriched in transforming growth factor-beta and platelet-derived growth factor-BB (PDGF-BB), demonstrated stronger immunomodulatory activity and more pronounced SASP reduction in ultraviolet-damaged skin. Both reduced melanogenesis without altering melanocyte viability. UC-MSC and AD-MSC exosomes exhibit distinct yet complementary regenerative profiles. AD-MSC exosomes favor dermal ECM remodeling and hydration, whereas UC-MSC exosomes exert potent anti-inflammatory and photo-protective effects. These findings support their potential for personalized regenerative dermatology and combinatory exosome-based facial rejuvenation strategies.

Freestyle facelift: a versatile approach for personalized facial rejuvenation

Non-ablative radiofrequency (RF) treatments have emerged as a popular modality for skin tightening, offering effective results with minimal downtime. This case series evaluates the clinical outcomes of a novel high-frequency (6.78 MHz) hybrid RF system that combines monopolar and bipolar energy with active cooling, in five patients with Fitzpatrick skin Types III and IV. Treatments targeted facial zones, including the midface, lower face and perioral regions. All patients tolerated the treatment well, reporting low pain scores (VAS 2–3/10), with no pigmentary changes, scarring or other adverse events. Objective wrinkle reduction was observed in three patients, ranging from 16.6% to 45.1%. Active contact cooling maintained epidermal temperatures below 42°C, reducing pain and preventing thermal injury. All patients reported good-to-excellent satisfaction with the outcomes. These findings are consistent with the literature supporting the safety and efficacy of RF in darker skin types and emphasise the protective role of active cooling in minimising thermal injury. This case series demonstrates the safety, effectiveness and comfort of hybrid RF with integrated active cooling for non-invasive facial rejuvenation in patients with skin of colour.

LaserLift is a minimally invasive laser procedure that involves a revolutionary technology for contouring the lower face and neck. This procedure uses a 1440-nm Nd:YAG laser designed for small areas, thereby providing a less invasive option than surgical facelift procedures. From 2014 to 2024, 256 patients between the ages of 20 and 67 were treated with a laser device: the Precision Tx™ laser system. Each patient's history was recorded, and general or local anesthesia was administered using Klein's solution. The laser settings were customized to target fat and tighten skin in specific areas. Additional treatment methods could be used. Treatment efficacy was assessed for each patient using the Global Aesthetic Improvement Scale (GAIS) and a modified seven-category photographic classification evaluated by the treating surgeon. Among the 256 patients, 142 completed follow-up evaluations ranging from six months to ten years (mean ~63 months). A 22.67% improvement in face and neck classification scores was observed. Significant enhancement in skin firmness and collagen production was noted across all age groups.Younger patients responded particularly well, but positive outcomes were seen in older individuals as well.Patient satisfaction was very high, with a mean GAIS score of 1.32, and 95.45% of patients reported high satisfaction. The Precision Tx™ laser treatment significantly improves skin tightening, collagen production, and facial contouring. Precision Tx™ laser treatment is less invasive than traditional facelifts, with high patient satisfaction and a shorter recovery time. The results of this study support the use of Precision Tx™ as a new regenerative surgery for face and neck rejuvenation. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Introduction: The ageing process begins at birth and becomes apparent as the years go by. Wrinkles and hyperpigmentation or photoaging {due to exposure to Ultraviolet (UV) radiation} are signs of ageing facial skin. Nowadays, facial ageing is a big issue, with attention being paid especially to premature ageing, facial laxity, and roughness. Therefore, the safest alternative to achieve a healthier and more radiant face is to apply herbal cosmetics. Need of the study: Modern cosmetic formulations are costly as well as may cause various side effects. There are some Ayurvedic rasayanas and cosmetic formulations with potential effects on ageing, which have not yet been studied on face rejuvenation. Out of which Amalaki has antioxidant properties mentioned in the Charaka Samhita. Manjishtadi taila is mainly indicated in Vali palita (wrinkles), Twak vaivarnya, depicted in Chakradatta samhita. So, using Manjishtadi serum as a modified form can give better results in face rejuvenation. Also, no study has been done on Amalaki vati and Manjishtadi serum in terms of face rejuvenation. Hence, the present study will mitigate the empirical knowledge gap. Aim: To evaluate the comparative efficacy of Amalaki vati and Manjishtadi serum versus tablet limcee and retinol serum in terms of face rejuvenation. Materials and Methods: The present randomised open labelled standard control superiority clinical trial will be held at Kayachikitsa Outpatient Department (OPD), Inpatient Department (IPD) of MGACH and RC Salod (H) Wardha, Maharashtra, India and Speciality Camps from March 2025 to February 2026. Two groups will be taken, with 31 patients in each. In group A (control group), participants will be given one tablet of Limcee (500 mg) once daily, along with the nightly application of retinol serum. In group B (trial group), participants will be given one tablet of Amalaki Vati (500 mg) once daily, combined with the nightly application of Manjishtadi serum. Assessment parameters i.e., wrinkle severity scale and hyperpigmentation severity scale, will be compared before and after treatment in each group by performing paired and unpaired t-tests. A p-value of &lt;0.05 will be considered significant.

To evaluate the effectiveness of high-frequency microneedling (HFM) using a layering technique versus conventional HFM for facial rejuvenation, with the Fitzpatrick Wrinkle and Laxity Classification Scale (FWCS) score at 3 months post-treatment as the primary endpoint. A prospective non-randomized controlled study was conducted on 30 patients undergoing facial rejuvenation at Changzhou TCM Hospital (January-December 2024), who were divided into two groups (n = 15 each). The conventional group received standard HFM, while the layered group received HFM with needle length, power, and pulse width adjusted for superficial, middle, and deep skin layers. The primary endpoint was the Fitzpatrick Wrinkle and Laxity Classification Scale (FWCS) score at 3 months post-treatment. Secondary endpoints included FWCS scores at 1 and 2 months, VISIA-derived skin texture/pore scores, Global Aesthetic Improvement Scale (GAIS) scores, Cutometer skin rebound rate, and patient satisfaction. Assessments were performed pre-treatment and at 1, 2, and 3 months post-treatment. Statistical analyses were conducted using SPSS 22.0, with linear mixed-effects models for repeated measures, ordinal methods for GAIS, and Fisher's exact test for satisfaction. Pre-treatment FWCS scores showed no significant difference (p > 0.05). At 1 month, the layering group showed a significantly greater FWCS score reduction (2.53 vs. 1.34, p < 0.05). FWCS scores remained significantly lower in the layering group at 2 and 3 months (p < 0.05). Skin texture improvement was significantly better maintained in the layering group at 2 and 3 months (p < 0.05). Pore improvement was significantly better in the layering group only at 3 months (p < 0.05). GAIS scores indicated significantly superior rejuvenation effects in the layering group (p < 0.001). Patient satisfaction was significantly higher in the layering group (93.33% vs. 60.00%, p < 0.05). No serious adverse reactions occurred; transient redness and mild discomfort resolved quickly in both groups. The HFM layering technique demonstrates superior efficacy over conventional HFM for facial rejuvenation, with more significant and sustained improvements in wrinkles, skin texture, pores, and elasticity, as well as higher patient satisfaction. Both techniques are safe, though the layered approach is associated with slightly longer downtime.

There is increasing patient demand for improved skin quality and the desire to achieve rejuvenated skin and improve self-confidence. The objective of this 12-week study was to assess changes in skin quality and subject satisfaction after using a novel anti-aging 10-peptide serum (Pep Up Collagen Boost Face & Neck Serum; Colorescience Inc., Carlsbad, CA). Healthy adult subjects seeking facial and neck skin rejuvenation (N = 48) were divided into two groups. Group A included subjects not currently using prescription, medical grade, advanced, or physician-dispensed skincare products and Group B included subjects who currently were using such products. Subjects in both groups applied the anti-aging peptide serum twice daily as part of their daily skincare routine for 12 weeks and were evaluated after 4, 8, and 12 weeks of treatment. Improvements in Global Skin condition and other parameters associated with skin quality were assessed by three investigators. By Week 12, 89.6% of subjects showed clinical improvement (p < 0.01), with most (52%) achieving moderate-to-marked global improvement. Both groups had median global scores of 3.0, with similar mean scores (Group A, 2.6; Group B, 2.8). Subjects in both groups indicated improvements in global scores (Group A, 91.7%; Group B, 87.5%) and most subjects in both groups demonstrated marked improvements from baseline (54.2% and 50.0%). The product was well-tolerated and subject satisfaction was high. The twice-daily application of a novel anti-aging 10-peptide serum restores several markers of facial and neck skin quality that were incremental to basic skincare routines and professional skincare regimens.

Absorbable barbed sutures have been widely used for minimally invasive facial rejuvenation. However, clinical lifting performance varies due to differences in suture geometry, which remain insufficiently quantified. The study aims to evaluate the effects of barb rotation angle, barb orientation, and pulling speed on the lifting performance and efficiency of the barbed sutures. The goal is to identify the optimized geometric design for facial lifting applications. The barbs were fabricated with four rotation angles (30°, 45°, 90°, and 180°) and four orientations (Forward, Reverse, Forward-Reverse, and Reverse-Forward). The fabricated sutures were tested at 10, 50, and 100 mm/min. Maximum lifting and holding displacements and lifting efficiency were quantified. Statistical analysis was conducted using one-way ANOVA with Tukey's post hoc test (p < 0.05). Higher pulling speed increased maximum lift but reduced efficiency due to slippage. The maximum lift was at 100 mm/min (2.03 ± 0.08 mm), whereas the highest lifting efficiency was at 10 mm/min (42.7%). For the barb rotation angles, the 90° configuration showed the highest lifting efficiency (35.5%) and superior anchor stability (p < 0.05). Regarding the barb orientation, the Forward orientation produced the largest lift (1.72 ± 0.18 mm), while the Forward-Reverse orientation achieved the highest efficiency (35.5%). The optimized Forward-Reverse 90° configuration exhibited improved holding capacity and reduced slippage compared to a commercial barbed suture. Barb geometry critically affects the lifting performance of the suture. The Forward-Reverse 90° configuration shows the optimal lifting efficiency and stability, offering clinically relevant guidance for designing next-generation facial lifting sutures.

Introduction Hyaluronic acid (HA) fillers are widely utilized in aesthetic medicine for facial rejuvenation, including in the periocular region. Although generally considered safe, severe inflammatory responses can occur. This report describes a case of a 42-year-old woman who developed a significant periocular reaction following HA microinjections, clinically resembling necrotizing fasciitis. Case Presentation The patient, with no significant medical or ophthalmic history, presented to the emergency department with acute periocular swelling, redness, and inability to open her right eye three hours after HA microinjections. Clinical examination revealed marked periorbital edema, chemosis, and restricted ocular motility in the right eye. The severity of the presentation initially suggested necrotizing fasciitis. A CT scan indicated preseptal cellulitis without post-septal involvement. Treatment with intravenous antibiotics, systemic corticosteroids, antihistamines, and topical therapies led to significant improvement. Conclusion This case highlights the need to recognize severe inflammatory reactions following periocular HA injections, which may mimic life-threatening conditions. Timely intervention and systematic evaluation are essential for achieving favorable outcomes.