Extrapleural Locations Research Articles

Solitary fibrous tumor occurring in the colon as submucosal mesenchymal lesion: report of two cases and review of the literature.

Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm most often arising from the pleura and rarely in extra-pleural locations, including the gastrointestinal tract. We describe two cases of a SFT presenting as submucosal colonic lesion and review the literature on this lesion. One submucosal lesion was localized in the cecum and was 10mm in size. The second lesion presented as a 17mm submucosal rectal lesion. Both lesions presented as well-circumscribed submucosal lesions arranged in short fascicles, blending with abundant collagenous stroma. In both cases, the spindle cells were positive for CD34, STAT6 and CD99, and molecular studies showed NAB2:STAT6 fusion supporting the diagnosis of SFT. Both patients are alive and well 10 and 5years post-excision, respectively. In conclusion, SFT can occur in the colon as a submucosal lesion and should be included in the differential diagnosis of colonic mesenchymal lesions.

Identifying the uncommon solitary fibrous tumour in a rare location - A case report.

Introduction and importanceThe authors describe a case work up of an unusual natal cleft soft tissue tumour which eventually was concluded as solitary fibrous tumour. Solitary fibrous tumour is an uncommon fibroblastic tumour which commonly presents in pleural region and very rarely in extrapleural location such as natal cleft. Accurate identification of this tumour, considering the indeterminate nature of the tumour irrespective of the location, avoided misdiagnosis and played a vital role in follow up management of the patient.Case presentation43 year old female patient presented with a painless lump in the natal cleft region for a short duration of 7 months with no other significant medical or surgical or family or psychosocial history. She was not on any regular medications.Clinical discussionDue to unusual location of the tumour broad range of differential diagnosis including benign and malignant entities were discussed based on histological findings and immunophenotyping. Mammary type myofibroblastoma, glomus tumour, clear cell renal cell carcinoma and clear cell sarcoma of soft tissue were few to note. STAT6 immunohistochemical stain played a crucial role in unravelling this case. Due to gradual increase in size of the lump complete surgical excision was performed with no local recurrence of the tumour.ConclusionIt is important to recognise this rare mesenchymal tumour with intermediate malignant potential occurring at uncommon natal cleft region for which complete surgical enucleation is curative.

Liver metastases of a malignant solitary fibrous tumor: the important role of immunohistochemistry in this rare entity.

Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin that normally appears in the pleura; however, it has been described in other extrapleural locations. This tumor is rarely malignant and only a few cases of metastatic SFT have been described.

TUMEUR FIBREUSE SOLITAIRE RETROPERITONEALE : A PROPOS D’UNE OBSERVATION AU CENTRE HOSPITALIER UNIVERSITAIRE HUBERT KOUTOUKOU MAGA DE COTONOU (BENIN)

Solitary fibrous tumors (SFT) usually develop in the pleura. Several extrapleural locations of these tumors have been recently reported. Here we report the case of a large retroperitoneal SFT. This was a 62-year-old patient admitted with a painful left flank mass that had progressed for 6 months with no other associated signs. She presented a good general condition and an arching of the left flank which corresponded to a firm, regular and sensitive mass, not adherent to the superficial plane, little mobile in relation to the deep plane and measuring 10 cm. This mass was solid and echogenic with significant vascularization on ultrasound, and was intensely enhanced with perilesional neovascularization on CT. Under general anesthesia, surgical exploration, by a midline laparotomy associated secondarily with a left transverse one, revealed a retroperitoneal mass of the left flank and the iliac fossa of about 10 cm long axis without extension to neighboring organs rendering its resection complete. The operative consequences were simple. Pathological examination of the resection piece concluded that a retroperitoneal TFS was completely excised. On immunohistochemistry, tumor cells strongly expressed CD34. They were also positive to CD99 and bcl2. With a follow-up of 2 years, there is no sign of recurrence but long-term follow-up is still necessary. Retroperitoneal SFT is rare. Diagnosis was confirmed by immunohistochemistry after complete tumor removal. Long-term follow-up is still necessary. Key words: Solitary fibrous tumor, retroperitoneum, Surgery, immunohistochemistry, Prognosis

Intra-Abdominal Malignant Solitary Fibrous Tumor with Peritoneal Dissemination: A Case Report

Solitary fibrous tumor (SFT) is a rare mesenchymal tumor primarily found in the pleura, with occasional presentations in extra-pleural locations. SFTs are typically diagnosed based on compressive symptoms due to their large size. Most SFTs are benign with a low recurrence rate, with an overall good prognosis with an overall 5-year survival of over 90%. Approximately 12-22% of SFTs are malignant and are associated with a higher recurrence rate of up to 78%. Given the low incidence and sparse case series literature, no adjuvant therapies have demonstrated a survival benefit. We present the first case of abdominal malignant SFTs with peritoneal dissemination, describing the presentation, histopathology, treatment planning and surveillance.

Solitary Fibrous Tumor Low Rectum Simulating Cancer

Introduction: The solitary fibrous tumor is a benign mesenchymal tumor of rare extra-pleural location. We report a case of solitary fibrous tumor observed in the lower rectum simulating cancer. The objective was to discuss the diagnostic and therapeutic management of the solitary fibrous in Madagascar. Observation: This is a sixty-five-year-old man, seen in consultation for dyskinesia, with no family history of neoplasia. The digital rectal examination revealed a large, non-budding, firm mass at the level of the right posterolateral surface with a lower pole located 2 cm from the anal margin, the remains of the physical examination are normal. Abdominal computed tomography showed a mass measuring 8 × 7 × 5.5 cm at the expense of the rectal wall of regular tissue density, without a mesenteric node or secondary localization. the biopsy had not found any malignant cells. This result is due to insufficiently deep biopsy samples of the mass, which led us to perform a complete surgical excision by coloprotectomy. The operative follow-up to which was simple. Immunohistochemical study of the surgical specimen confirmed the diagnosis with a positive CD 34 marker. The outcome was favourable without metastasis or recurrence after a six-month follow-up. Conclusion: The rectal localization of the solitary fibrous tumor is exceptional. The diagnosis is histological confirmed by the immunohistochemical study with a positive CD 34 marker.

Solitary Fibrous Tumor in Pelvis Extended to Transverse Mesocolon and Peritoneum

Solitary fibrous tumor (SFT) is a rare, spindle-cell neoplasm, which is classified as mesenchymal neoplasm emanating from ubiquitous dendritic interstitial cells. SFTs are benign tumor with a low rate of malignancy developed in intrathoracic areas and its growth is rarely observed in extrapleural locations. Based on to the rarity of malignant SFT, there is no certain treatment to the inoperable malignant. This case study is a report of a man with SFT of the pelvis, transverse mesocolon, and peritoneum. So far, more than 58 patients with SFT of the pelvic have been reported in the literature, out of which 26% of them were malignant either clinically or histologically. The female/male ratio was equal within the age range of 27–83 years. The size of reported tumors were ranged 1–33 cm. Malignancy were reported in 26% of cases.

OP - SOLITARY FIBROUS TUMOR IN THE FLOOR OF THE MOUTH IN A PATIENT PREVIOUSLY AFFECTED BY A PLEOMORPHIC ADENOMA

A solitary fibrous tumor (SFT) is a benign neoplasm derived from pluripotential mesenchymal cells. Although described as a pleural tumor, SFTs affecting extrapleural locations have been reported, but involvement of the oral cavity is rare. A 37-year-old woman was referred for evaluation of a painful swelling in the mouth. Her medical history revealed surgical removal of a pleomorphic adenoma on the left submandibular gland 12 years earlier. Intraoral examination showed a firm, tender to palpation, submucosal swelling on the left side of the floor of the mouth. The provisional diagnosis was a recurrent pleomorphic adenoma and an incisional biopsy was performed. Histological examination showed a storiform spindle cell proliferation arranged in cellularized areas interspersed by a dense fibrous tissue with fewer cellularized areas. The neoplastic spindle cells were immunopositive for CD34, bcl-2, and CD99, leading to the diagnosis of SFT. The patient was submitted to a conservative surgical removal of the lesion and analysis of the surgical specimen confirmed the SFT. The patient remains in clinical follow-up for one year with no signs of local recurrence. An SFT is a rare benign mesenchymal tumor that should be considered in the differential diagnosis of oral submucosal swellings.

Giant Extrapleural Solitary Fibrous Tumor of the Thigh.

Giant Extrapleural Solitary Fibrous Tumor of the Thigh.

Pediatric Renal Solitary Fibrous Tumor

Solitary fibrous tumors (SFTs) are unusual spindle cell neoplasms initially described in the pleura but have since been discovered in many extrapleural locations. SFT of the kidney is extremely rare, the majority occurring in middle-aged adults. To date, only two pediatric cases of renal SFT have been reported. We report a case of large SFT in the kidney of a 3-year-old boy that was clinically and radiologically thought to be a nephroblastoma. This case is the first pediatric renal SFT to be reported with detailed histopathologic and cytogenetic analyses. SFT should be included in the differential diagnosis of pediatric renal tumors.

Solitary fibrous tumour of the pancreas: a case report

The solitary fibrous tumour is an uncommon neoplasm of mesenchymal origin. It occasionally develops in extra pleural locations, and is very infrequent in the pancreas. A 40-year-old woman had an unsuspected solitary fibrous tumour detected by chance in the body of the pancreas. Detection of the mass occurred with imaging studies. CT and MRI images showed the well-circumscribed benign lesion, with 3 cm on its greatest diameter. Treatment consisted of partial pancreatectomy, and her postoperative recovery was uneventful.

Suboccipital Malignant Solitary Fibrous Tumor: Report of a Case

Solitary fibrous tumors (SFTs) are rare soft-tissue sarcomas usually arising in the pleura of the thoracic cavity. Thirty percent of SFTs present in extrapleural locations, and infrequently in the head and neck region. While the majority of SFTs are benign, aggressive variants have been described. We report a case of a patient with a malignant SFT arising in the suboccipital soft tissues of the neck. We elucidate the diagnostic and therapeutic challenges in managing this tumor in this unusual location.

Solitary Fibrous Tumor of the Suboccipital Area

Solitary Fibrous Tumors (SFTs) are uncommon spindle-cell neoplasms usually arising in the pleura of the thoracic cavity. Thirty percent of SFTs are found frequently in the extrapleural locations, but infrequently in the head and neck region, and very rarly in the suboccipital area. The treatment of choice for SFTs is a complete surgical excision of the tumor. Recurrent SFTs are more often associated with incomplete excision. In this article, we present a by surgical excision case of an 87-year-old woman, who was treated for SFT arising in the suboccipital area by surgical excision with no recurrence after 6 months. � Korean J Otorhinolaryngol-Head Neck Surg 2012;55:599-602 Key WordsZZHead and neck neoplasms ㆍSolitary fibrous tumor.

Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review

Solitary fibrous tumour (SFT) is a rare soft tissue tumour of uncertain histogenesis and unpredictable biological behaviour, which was first described in the pleura and subsequently in many extra-pleural locations. Fat-forming SFT is a sub-type of SFT and only a handful of cases have been reported in the literature. We present the clinical, radiological and histological features of a case of intraspinal fat-forming SFT, along with a literature review. This is the first known report of a fat-forming SFT in the spine.

Solitary Fibrous Tumor Originating in the Pelvis: A Case Report

A 52 year old male presented with changes in bowel movements, and a mass was detected on digital rectal exam. Both CT and MRI revealed a large pelvic and gluteal mass filling the pelvic cavity displacing the adjacent pelvic structures. After surgical removal, pathology revealed solitary fibrous tumor; a rare neoplasm uncommonly discovered in the thorax, and even less commonly in extrapleural locations. We discuss in this article imaging findings and histological features of extrapleural solitary fibrous tumor.

Histologically Malignant Solitary Fibrous Tumour of the Anterior Thoracic Wall: A Case Report and Review of the Literature

Solitary fibrous tumour (SFT) is a rare oncological entity that most often arises in the pleura. Over the past 10 years, the tumour has been described at numerous extrapleural locations. We present the case of a 42-year-old female Caucasian patient with an extrapleural SFT located at the anterior thoracic wall for 22 years, with atypical histological characteristics and clinical features of malignancy. Management consisted of a wide surgical resection, plastic reconstruction, and postoperative radiotherapy. Although extrapleural SFT usually behaves as a benign soft tissue tumour, it can also present with a more aggressive local behavior, including locoregional recurrence or metastasis. In that case, a multidisciplinary approach is required for accurate diagnosis and proper management.

Orbital Solitary Fibrous Tumor: A Case Report and Review of the Literature

Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm typically arising in the pleura and involving the orbit as its most common extra-pleural location. We herein describe a well documented case of orbital SFT arising in a 62-year-old woman presenting with progressive swelling of the right upper eyelid and proptosis. The tumor had a benign clinical course, with radical surgical excision followed by regression of the clinical symptoms. We review the clinical, histopathological, and immunohistochemical features of the orbital SFT described so far, with particular emphasis on differential diagnosis with other spindle cell orbital neoplasms.

Cutaneous Solitary Fibrous Tumor: A Report of 2 Cases and Review of the Literature

Solitary fibrous tumor is an uncommon mesenchymal neoplasm that can arise in both pleural and extrapleural locations. Composed of spindled cells intimately admixed with collagen bundles arranged in a "patternless pattern," this heterogeneous tumor can mimic a variety of benign and malignant mesenchymal neoplasms. We present the histological and immunohistochemical findings of two primary cutaneous solitary fibrous tumors, discuss the differential diagnosis, and review the literature. Although solitary fibrous tumors in cutaneous and subcutaneous regions are extremely rare, it should be considered in the differential diagnosis of primary spindle cell neoplasms of the skin.

Solitary fibrous tumor nosa, zatok sitowych i przedniego dołu czaszki

Summary Solitary fibrous is rare mesenchymal neoplasm that usually arises in the pleura or less commonly is related to other serosal surfaces. There were reported SFTs in some extrapleural locations. There locations cause diagnostic difficulties. Ethmoid sinuses, nasal cavity and anterior fossa are rare site for SFTs. Authors report a case of SFT of the nasal cavity, paranasal sinuses and anterior fossa in 33 year-old woman to show the difficulty and importance of recognition. Diagnostic procedures and medical treatment are presented. This report pays attention that SFT should be taken into consideration during diagnostic process of spindle-cell lesions of the nasal cavity and paranasal sinuses in order to avoid some confusions.

Extrapleural Intrathoracic Implantation of Permanent Pacemaker in the Pediatric Age Group

Permanent pacemaker implantation in pediatric patients poses challenges in finding a suitable pocket for generator implantation. We present our experience with 6 patients in whom the pacemaker was placed in an extrapleural intrathoracic location. We find that an extrapleural intrathoracic pocket is a useful site for generator placement in the neonatal and pediatric age group. It is safe, reproducible, and both the lead and generator can be placed through a single incision. We briefly discuss the advantages and disadvantages of other techniques that require a single incision for both lead and generator placement.