The elastic behaviour and the pressure ( P) induced structural evolution of Na 6Cs 2Ga 6Ge 6O 24 · Ge(OH) 6, a synthetic compound isotypic with cancrinite (CAN topology), have been investigated up to 5.01(5) GPa by means of in situ X-ray synchrotron powder diffraction with a diamond anvil cell and using a nominally penetrating hydrous P-transmitting medium (methanol:ethanol:water = 16:3:1). No evidence of phase-transition was observed within the P-range investigated. The P– V data were fitted with a Murnaghan equation-of-state (M-EoS). The elastic parameters obtained, using the data weighted by the uncertainties in P– V, are: V 0 = 757.16(7) Å 3, K T0 = 36(2) GPa [ K T0 = 1/ β = − V 0(∂ P/∂ V) P=0 , where β is the volume compressibility coefficient] and K′ = (∂ K T0/∂ P) = 9(1). The elastic behaviour along the a and c axis was described with a “linearised” M-EoS. The refined parameters of the linearised M-EoS are: a 0 = 13.0314(4) Å, K T0( a) = 40(2) [ β j = −1/(3 K T0( j)) = (1/ l 0 j )(∂ l j /∂ P), where β j is the axial compressibility coefficient] and K′( a) = 11(1) for the a-axis; c 0 = 5.1485(4) Å, K T0( c) = 31(1) GPa and K′( c) = 7.4(8) for the c-axis. The elastic anisotropy of Na 6Cs 2Ga 6Ge 6O 24 · Ge(OH) 6 is only marginal, being K T0( a): K T0( c) = 1.29:1. The configuration of the extra-framework content is basically maintained at high-pressure, without any major changes. The Ge(OH) 6-polyhedron is strongly compressed in response to the applied pressure, but there is no evidence of further deformation. On the other hand the Na(O 3OH 3)-polyhedron and the large Cs-polyhedron appear to be compressed in a way to lessen the deformation with increasing pressures. Despite the use of a hydrous P-transmitting fluid for the H P-experiment and the large “free-diameters” of the channels in CAN framework, no evidence of superhydration effect was observed within the P-range investigated.