You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research & Pathophysiology (MP06)1 Apr 2020MP06-08 DETRUSOR PRESSURES ARE ASSOCIATED WITH COLLAGEN TYPE III EXPRESSION IN THE DETRUSOR OF PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA Carlos Bellucci*, Thiago Hemerly, Vanessa Guimarães, Nayara Viana, Gabriel Camargo, Sabrina Reis, Homero Bruschini, Miguel Srougi, Katia Leite, and Cristiano Gomes Carlos Bellucci*Carlos Bellucci* More articles by this author , Thiago HemerlyThiago Hemerly More articles by this author , Vanessa GuimarãesVanessa Guimarães More articles by this author , Nayara VianaNayara Viana More articles by this author , Gabriel CamargoGabriel Camargo More articles by this author , Sabrina ReisSabrina Reis More articles by this author , Homero BruschiniHomero Bruschini More articles by this author , Miguel SrougiMiguel Srougi More articles by this author , Katia LeiteKatia Leite More articles by this author , and Cristiano GomesCristiano Gomes More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000820.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Studies with patients with benign prostatic hyperplasia (BPH) and animal models of Bladder outlet obstruction (BOO) have shown increased deposition of collagen in the detrusor and increased type III/type I collagen ratio. Collagen deposition in the detrusor has been associated with decreased compliance and detrusor underactivity. The mechanisms involved in the BOO-associated changes in the detrusor extracellular matrix are not well understood. It has been hypothesized that high detrusor pressure promotes increased bladder intramural tension, decreasing blood flow and leading to hypoxia and subsequent fibrosis. We evaluated the gene expression of types I and III collagen (COL I and COL III) in the detrusor of men with BOO due to BPH and its correlation with urodynamic parameters. METHODS: Twenty-eight consecutive patients undergoing open prostatectomy for BPH were evaluated. Urodynamics was performed in all patients preoperatively. A bladder specimen from the dome was obtained during prostatectomy. Nine cadaveric organ donors composed the control group. Detrusor biopsies were prepared for relative gene expression analysis with quantitative real-time polymerase chain reaction of COL I and COL III. Data were expressed as medians and interquartile ranges or absolute values and fractions. Spearman correlation coefficient was used to investigate the association between gene expression and urodynamic parameters, including maximum cystometric capacity (MCC), bladder compliance (BC), maximum flow rate (Qmax), detrusor [email protected] flow rate (PdetQmax), bladder outlet obstruction index (BOOI) and bladder contractile index (BCI). RESULTS: Mean age was 67.0 ± 7.4 years and mean prostate volume was 133.8 ± 43.9 cm3. Mean International Prostatic Symptom Score 23.5 ± 6.2. In comparison with controls, patients with BPH had significant overexpression of COL I and COL III, (Table 1). A positive correlation between COL III expression and PdetQmax, BOOI and BCI was found (Table 2). CONCLUSIONS: Gene expression of collagens I and III is increased in the detrusor of men with BPH. We showed a positive correlation between COL III expression and PdetQmax, BOOI and BCI, which is consistent with the hypothesis that high detrusor pressures decrease blood flow to the bladder leading to fibrosis. Source of Funding: Sao Paulo Research Foundation - FAPESP © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e53-e54 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Carlos Bellucci* More articles by this author Thiago Hemerly More articles by this author Vanessa Guimarães More articles by this author Nayara Viana More articles by this author Gabriel Camargo More articles by this author Sabrina Reis More articles by this author Homero Bruschini More articles by this author Miguel Srougi More articles by this author Katia Leite More articles by this author Cristiano Gomes More articles by this author Expand All Advertisement PDF downloadLoading ...