Extended Depth Of Field Research Articles

Center-for-Near Extended-Depth-of-Focus Soft Contact Lens for Myopia Control in Children: 1-Year Results of a Randomized Controlled Trial.

IntroductionThis study aimed to assess the safety and efficacy of a novel extended-depth-of-focus (EDOF) soft contact lens for myopia control in children.MethodsA prospective, multicenter, randomized, double-masked, placebo-controlled, contralateral-eye comparison clinical trial was conducted in 72 children (40 male and 32 female) aged 9 to 14 years, with each eye randomly selected to wear either an experimental EDOF contact lens or a single-vision control lens at least 8 h per day, 5 days a week, for 52 weeks. Each contact lens was worn and then replaced daily. Measurements including best-corrected visual acuity, spherical equivalent refractive error (SER), axial length (AXL), and keratometry were performed at weeks 1, 4, and 13, and every 13 weeks thereafter for 52 weeks. The primary outcome measure was the change in SER, measured using cycloplegic auto-refraction. The secondary outcome measure was the change in AXL.ResultsAt week 52, the mean change in SER was significantly lower with the experimental lens (−0.70 ± 0.49 D) than with the control lens (−0.88 ± 0.51 D; P < .001). The mean AXL elongation was significantly lower with the experimental lens (0.34 ± 0.19 mm) than with the control lens (0.38 ± 0.19 mm; P < .001). The EDOF lens reduced AXL and myopia progression by 10.5% and 20.5%, respectively. The change in SER, but no AXL, was significantly associated with EDOF lens wear in adjusted multivariate regression analysis. Reported adverse events did not differ significantly between the two lens types.ConclusionsThe results of this 1-year clinical trial demonstrate that the experimental EDOF soft contact lens slows myopia progression and reduces AXL elongation in children compared with a single-vision contact lens. (This study was retrospectively registered with ClinicalTrials.gov; identifier: NCT04238897; date of registration: January 23, 2020.)

Pheidoleklaman sp. nov.: a new addition from Ivory Coast to the Afrotropical pulchella species group (Hymenoptera, Formicidae, Myrmicinae).

In this study the taxonomy of the Pheidolepulchella species group is updated for the Afrotropical region and the new species P.klaman sp. nov. described. It is integrated into the existing taxonomic system by an updated identification key for the whole group and an update of the known distribution ranges of its members. High quality focus stacking images are provided, with X-ray micro-CT scanned digital 3D representations, of major and minor worker type specimens.

High-resolution 3D shape measurement with extended depth of field using fast chromatic focus stacking.

Close-range 3D sensors based on the structured light principle have a constrained measuring range due to their depth of field (DOF). Focus stacking is a method to extend the DOF. The additional time to change the focus is a drawback in high-speed measurements. In our research, the method of chromatic focus stacking was applied to a high-speed 3D sensor with 180 fps frame rate. The extended DOF was evaluated by the distance-dependent 3D resolution derived from the 3D-MTF of a tilted edge. The conventional DOF of 14 mm was extended to 21 mm by stacking two foci at 455 and 520 nm wavelength. The 3D sensor allowed shape measurements with extended DOF within 44 ms.

Clinical outcomes of a trifocal compared with an extended depth of focus IOL following bilateral cataract surgery

ObjectifComparer les résultats visuels et les résultats décrits par les patients à la suite de l'implantation de 2 types de lentilles intraoculaires (LIO) permettant de corriger la presbytie. MéthodesUn total de 67 patients (134 yeux) ayant fait l'objet d'une chirurgie de la cataracte qui s'accompagnait de l'implantation bilatérale d'une LIO trifocale ou d'une LIO à profondeur de champ étendue ont été évalués 3 mois après l'intervention. Au nombre des paramètres de mesure, citons l'acuité visuelle binoculaire corrigée en fonction de la distance : de près (40 cm), à une distance intermédiaire (60 cm) et de loin (6 m); le questionnaire modifié d'Akman sur la qualité de vie (14 éléments); et l'acuité visuelle de contraste de 10 % de loin et de près, avec et sans éblouissement. RésultatsVoici l'acuité visuelle (AV) binoculaire moyenne en logMAR obtenue avec la lentille PanOptix comparativement à l'AV obtenue avec la lentille Symfony: AV corrigée de près, 0,054 vs 0,228; AV corrigée à une distance intermédiaire, 0,019 vs 0,063; et AV corrigée de loin, –0,016 vs –0,021. Selon le questionnaire sur la qualité de vie, 62 % des patients du groupe PanOptix et 48 % de ceux du groupe Symfony n'ont présenté aucune difficulté ou ont présenté peu de difficulté à réaliser toutes les tâches en lien avec la qualité de vie. Selon un modèle à variables multiples tenant compte de la taille de la pupille et de l'angle kappa (distance « chord mu », yeux droits), les différences se chiffraient à –0,005 (fourchette : de –0,03 à 0,02) et à 0,165 (fourchette : de 0,12 à 0,21), respectivement. De plus, l'acuité visuelle de contraste de 10 % était comparable dans les 2 groupes, et l’éblouissement n'avait pas d'effet. ConclusionsL'AV binoculaire corrigée de près était significativement meilleure dans le groupe PanOptix (p < 0,0001). Ce résultat est demeuré significatif sur le plan statistique même après avoir tenu compte de la taille de la pupille et de la distance « chord mu » (p < 0,001). L'AV à une distance intermédiaire et l'AV de loin était semblable dans les 2 groupes. Les scores de qualité de vie étaient plus élevés dans le groupe PanOptix.

Academy IRIS® Registry Analysis of Incidence of Laser Capsulotomy Due to Posterior Capsule Opacification After Intraocular Lens Implantation.

PurposeAcademy IRIS® (Intelligent Research in Sight) Registry was used to determine the incidence of postoperative neodymium-doped yttrium aluminum garnet laser capsulotomy (Nd:YAG) and time to posterior capsular opacification (PCO) diagnosis based on intraocular lens (IOL) type and brand.MethodsThis retrospective analysis included eyes implanted with 1 of 2 IOL brands, with ≥365 days of follow-up available in the IRIS Registry, and ≥2 visits within 180 days of surgery. Analyses included Nd:YAG incidence due to PCO within 1 year after surgery by IOL type and brand, mean time to PCO diagnosis, and mean time to Nd:YAG.ResultsOf 89,947 eyes after cataract surgery, 24,834 (28%) had PCO diagnosis within 365 days, and 9262 (10%) underwent Nd:YAG; 4.1% of 57,523 eyes with monofocal and 21.2% of 32,424 eyes with diffractive multifocal (MF) or diffractive extended depth of focus (EDOF) IOLs had Nd:YAG. Nd:YAG was 3.2 times more likely in eyes with diffractive MF or diffractive EDOF IOLs versus monofocal. For monofocal IOLs, 3.2% of eyes with AcrySof® and 8.1% of eyes with Tecnis® had Nd:YAG (P<0.0001). For diffractive MF or diffractive EDOF IOLs, 13.0% of eyes with AcrySof and 21.7% of eyes with Tecnis had Nd:YAG (P<0.0001). Nd:YAG risk was 2.4 times higher in eyes with Tecnis versus AcrySof IOLs. Overall, mean time to PCO diagnosis and Nd:YAG was 150.7 and 180.7 days. Mean time to PCO for monofocal versus diffractive MF or diffractive EDOF IOLs was 165.3 versus 139.7 days (P<0.0001). Mean time to Nd:YAG for monofocal versus diffractive MF or diffractive EDOF IOLs was 196.4 versus 175.3 days (P<0.05).ConclusionReal-world data for AcrySof and Tecnis IOLs revealed lower Nd:YAG rates and longer time to PCO diagnosis and Nd:YAG after monofocal versus diffractive multifocal or diffractive EDOF implantation. Nd:YAG rates were significantly lower with AcrySof versus Tecnis IOLs.

Depth of focus extension in optical coherence tomography using ultrahigh chromatic dispersion of zinc selenide.

We report a novel technique to overcome the depth-of-focus limitation in optical coherence tomography (OCT) using chromatic dispersion of zinc selenide lens. OCT is an established method of optical imaging, which found numerous biomedical applications. However, the depth scanning range of high-resolution OCT is limited by its depth of focus. Chromatic dispersion of zinc selenide lens allows to get high lateral resolution along extended depth of focus, because the different spectral components are focused at a different position along axes of light propagation. Test measurements with nanoparticle phantom show 2.8 times extension of the depth of focus compare to the system with a standard achromatic lens. The feasibility of biomedical applications was demonstrated by ex vivo imaging of the pig cornea and chicken fat tissue.

Impact of Intraocular Lens Decentration on the Near Vision Performance of a Wavefront-Correcting Extended Depth of Focus IOL

PURPOSE: To examine the impact of intraocular lens (IOL) decentration on the near vision performance of a wavefront-correcting extended depth of focus (EDOF) IOL. METHODS: Case report. RESULTS: A 77-year-old man presented with poor unaided visual function at near (20/125) and intermediate (20/100) distances after cataract surgery in the right eye with implantation of a wavefront-correcting EDOF IOL. Uncorrected distance visual acuity was 20/25. A 0.4-mm decentration of the central optical component of the IOL was noted and assumed to be the underlying reason for the poor near/intermediate visual function. After reassessing the patient's expectations for spectacle independence for reading, IOL exchange by a multifocal diffractive IOL with capsular tension ring implantation was performed 3 months after surgery. The patient was satisfied, and uncorrected near (20/32) and intermediate (20/32) visual function was restored. CONCLUSIONS: Correct centration of the central 2.2-mm optical part of the wavefront-correcting EDOF IOL seems to play a critical role in achieving satisfactory vision for both intermediate and near distances. The authors suggest the routine implantation of a capsular tension ring together with this lens to minimize the risk for such a complication. [ Journal of Refractive Surgery Case Reports. 2022;2(2):e29–e31.]

Evaluation of a Novel Non-Diffractive Extended Depth of Focus Intraocular Lens – First Results from a Prospective Study

Purpose To evaluate a novel hydrophobic, non-diffractive, extended depth of focus (EDOF) intraocular lens (IOL) design in comparison to two monofocal aspheric lenses. Methods Inclusion criteria for this prospective, monocentric cohort study were opacification of the crystalline lens and patients’ wishes for surgery. In the case of the EDOF IOL, patients asked for a presbyopia correction. All patients received surgery on both eyes. Corrected and uncorrected distance visual acuity (CDVA, UCDVA), uncorrected and distance corrected intermediate visual acuity (UIVA, DCIVA) and defocus curves (all monocular and binocular) were compared three months postoperatively. Results Fifty-six eyes were implanted with an EDOF IOL (LuxSmartTM, Bausch & Lomb GmbH, Berlin, Germany), 50 eyes with a monofocal aspheric IOL: 32 eyes with a clear IOL (Polylens® AS 61, Polytech Domilens, Roßdorf, Germany), 16 eyes with a yellow IOL (iSert® 251, Hoya Surgical Optics GmbH, Frankfurt, Germany). Three months postoperatively, UCDVA was comparable with the EDOF IOL, versus the monofocal IOL (P > 0.9). Binocular DCIVA in the EDOF IOL was significantly higher than in the monofocal IOL (P = 0.001). Monocular DCIVA better than 20/23 Snellen was achieved in 10% with the monofocal IOL and in 68% (P < 0.0001) with the EDOF IOL. Defocus curves showed a depth of focus at 20/23 Snellen of 1.6 vs. 0.83 diopters (D) in the EDOF IOL, vs. the monofocal IOL. No patient reported halos or starbursts in non-standardized questioning. Conclusion This non-diffractive EDOF IOL provided comparably high UCDVA and significantly higher DCIVA than the mono-focal lenses, causing only mild optical phenomena.

Difference in Quality of Vision Outcome among Extended Depth of Focus, Bifocal, and Monofocal Intraocular Lens Implantation.

We aimed to compare the postoperative quality of vision among patients who received extended depth of focus (EDOF), bifocal, and monofocal intraocular lens (IOL) implantation. A retrospective study was conducted, and 87 patients who underwent cataract surgery were enrolled. Patients were categorized into different groups according to IOL design, with 24, 29, and 34 individuals constituting bifocal, EDOF, and monofocal groups. Preoperative and postoperative visual acuity (VA), biometry data, refractive status, contrast sensitivity (CS), higher-order aberrations (HOAs), and a quality of vision questionnaire that consisted of 11 questions were obtained 1 month postoperatively. The Kruskal–Wallis test and Pearson’s chi-square test were applied for statistical analyses. The postoperative CDVA was better in the EDOF group than in the bifocal group (p = 0.043), and the residual cylinder was lower in the EDOF groups than in the other two groups (both p < 0.05). The CS was worse in the EDOF group than in the other two groups (all p < 0.05), while the spherical aberration and trefoil were lower in the EDOF group than in the bifocal group (both p < 0.05). In terms of the quality of vision, the scores were better in the monofocal group than in the EDOF group in seven items (all p < 0.05), and the quality of vision in the bifocal group was better than in the EDOF group in small print reading (p = 0.042). In addition, the incidence of glare was lower in the monofocal group than in the other two groups (p < 0.001), while the spectacle dependence ratio was significantly higher in the monofocal group compared to the other two groups (p < 0.001). In conclusion, the general quality of vision was better in the monofocal group compared to the bifocal and EDOF groups, while the spectacle dependence ratio was significantly higher in the monofocal group than in the other two groups.

Comparison of visual outcomes after two types of mix-and-match implanted trifocal extended-depth-of-focus and trifocal intraocular lenses

To compare visual outcomes between two types of mix-and-match implanted trifocal extended-depth-of-focus (EDoF) and trifocal intraocular lenses (IOLs). A total of 212 eyes of 106 subjects with mix-and-match implanted FineVision Triumf and FineVision HP IOLs (Triumf-HP group) and 212 eyes of 106 subjects with mix-and-match implanted Zeiss AT LARA and AT LISA IOLs (AT LARA-LISA group) were enrolled in this retrospective case-control study. Uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), and binocular distance-corrected defocus curves were measured between 6 and 10weeks after cataract surgery. There was no significant difference in UDVA among the four IOLs. UNVA was the best in eyes with the FineVision HP IOL (0.04 ± 0.06 logMAR), followed by eyes with the AT LISA IOL (0.07 ± 0.07 logMAR), the FineVision Triumf IOL (0.09 ± 0.09 logMAR), and the AT LARA IOL (0.11 ± 0.08 logMAR), respectively. The AT LARA-LISA group had better visual acuity than the Triumf-HP group between - 1.00 D and - 1.50 D of defocus, and the Triumf-HP group had better visual acuity than the AT LARA-LISA group between - 3.00 D and - 4.00 D of defocus. Mix-and-match implantation of trifocal EDoF and trifocal IOLs provided good visual outcomes in far, intermediate, and near distances. The mix-and-match implantation of Triumf-HP IOLs led to better visual outcomes in near vision, while that of the AT LARA-LISA IOLs led to better visual outcomes in intermediate vision.

Clinical Performance of Extended Depth of Focus (EDOF) Intraocular Lenses - A Retrospective Comparative Study of Mini Well Ready and Symfony.

PurposeExtended depth of focus intraocular (EDOF) IOLs form a bridge between single- and multifocal IOL design. This study aimed to compare clinical outcomes obtained after implanting two different optical designs of EDOF IOLs: the Mini Well Ready (SIFI Medtech, Catania, Italy) and Tecnis Symfony (Abbott Laboratories, Illinois, USA).MethodsThe retrospective observational study included 61 patients (122 eyes) who underwent bilateral implantation of the Mini Well Ready IOL (32 patients) or the Tecnis Symfony IOL (29 patients). The following preoperative and postoperative parameters were evaluated: spherical equivalent, anterior astigmatism, pupil size, monocular and binocular uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA), monocular and binocular uncorrected intermediate visual acuity (UIVA) and distance-corrected intermediate visual acuity (DCIVA), monocular and binocular uncorrected near visual acuity (UNVA) and distance-corrected near visual acuity (DCNVA). In the 6 months postoperative period, defocus curve, contrast sensitivity, photopic phenomena, and posterior capsule opacification were assessed.ResultsThe patients receiving the Tecnis Symfony had slightly better monocular and binocular UDVA and CDVA than with the Mini Well Ready IOL, the differences were not statistically significant. Whereas the UIVA, DCIVA, UNVA, DCNVA, UNVA and DCNVA values were higher in the Mini Well Ready group, the differences were not significant. There were no significant between-group differences regarding the defocus curve for the vast majority of tested vergences. Dysphotopsias postoperatively were assessed at 6 months.ConclusionPatients receiving both the Mini Well Ready and Symfony IOLs had excellent visual acuity outcomes and spectacle independence.

In vitro optical performance of multifocal and extended depth-of-focus intraocular lenses in spherical aberration conditions.

To evaluate and compare the optical performances of 4 different types of intraocular lenses (IOLs) in various spherical aberration (SA) conditions. POSTECH, Pohang, South Korea. In vitro laboratory study. A custom optical bench system with adaptive optics was used. A monofocal IOL, a bifocal IOL, a trifocal IOL, and an extended depth-of-focus (EDoF) IOL from Zeiss were evaluated by measuring through-focus modulation transfer function (MTF) as a function of vergence. MTF changes with SA from -0.1 to +0.1 with 0.05 μm step size were analyzed and compared. In aberration-free conditions, the 4 IOLs showed different MTF curves consistent with their designs. In SA conditions, all the IOLs showed MTF value decreases and the decrease rates at the far focus varied from 28% to 38% per 0.1 μm SAs. The trifocal IOL had low MTF values at the intermediate focus in the noise level with ±0.1 μm SAs. All tested IOLs showed MTF decreases with SA in different levels. The trifocal and EDoF IOLs were the most and least sensitive to SA among the evaluated IOLs. The study results might be useful in the selection of IOLs for cataract patients with SA.

Reconfigurable Metalens with Phase-Change Switching between Beam Acceleration and Rotation for 3D Depth Imaging.

Depth imaging is very important for many emerging technologies, such as artificial intelligence, driverless vehicles and facial recognition. However, all these applications demand compact and low-power systems that are beyond the capabilities of most state-of-art depth cameras. Recently, metasurface-based depth imaging that exploits point spread function (PSF) engineering has been demonstrated to be miniaturized and single shot without requiring active illumination or multiple viewpoint exposures. A pair of spatially adjacent metalenses with an extended depth-of-field (EDOF) PSF and a depth-sensitive double-helix PSF (DH-PSF) were used, using the former metalens to reconstruct clear images of each depth and the latter to accurately estimate depth. However, due to these two metalenses being non-coaxial, parallax in capturing scenes is inevitable, which would limit the depth precision and field of view. In this work, a bifunctional reconfigurable metalens for 3D depth imaging was proposed by dynamically switching between EDOF-PSF and DH-PSF. Specifically, a polarization-independent metalens working at 1550 nm with a compact 1 mm2 aperture was realized, which can generate a focused accelerating beam and a focused rotating beam at the phase transition of crystalline and amorphous Ge2Sb2Te5 (GST), respectively. Combined with the deconvolution algorithm, we demonstrated the good capabilities of scene reconstruction and depth imaging using a theoretical simulation and achieved a depth measurement error of only 3.42%.

Comparison of visual results and optical quality of two presbyopia-correcting intraocular lenses: TECNIS symfony versus TECNIS synergy.

This study compared the extended depth of focus (EDOF) intraocular lens (IOL) (ZXR00; Tecnis® Symfony®, Johnson & Johnson Vision, Santa Ana, CA, USA) and a new presbyopia-correcting IOL that combines EDOF and multifocal profiles (ZFR00; Tecnis® Synergy®, Johnson & Johnson Vision, Santa Ana, CA, USA) with the same material. The medical records of patients undergoing cataract surgery with ZXR00 or ZFR00 implantation between March 2021 and July 2021 and with the data available for the 3-month visit were reviewed. The uncorrected near, intermediate, and distance visual acuity (VA), corrected distance VA, defocus curves, refractive errors (RE), optical quality parameters, and patient-reported visual performance parameters were the main outcome measures. Among the twenty-three enrolled patients, twelve patients (21 eyes) received ZXR00 and nine patients (17 eyes) received ZFR00. The mean age of the patients was 59.6 ± 10.6 (range: 49 to 70) and 65.2 ± 8.2 (range: 45 to 82) years in ZXR00 and ZFR00 groups, respectively, without significant difference. There was not a significant difference between the two groups in terms of baseline parameters and postoperative RE. The ZFR00 group showed markedly superior intermediate and near VA (p < 0.001 for all) at 3 months postoperatively. In terms of optical quality, ZXR00 was significantly better than ZFR00 (p < 0.001). Both IOLs had comparable distance VA. ZFR00 IOL was superior for intermediate and near visual acuity, but ZXR00 IOL was better for optical quality. Research with more participants is needed to support this finding.

Optimising curve fitting techniques to look for standardisation of the analysis of defocus curves derived from multifocal intraocular lenses.

IntroductionTo establish the most appropriate curve fitting method to allow accurate comparison of defocus curves derived from intraocular lenses (IOLs).MethodsDefocus curves were plotted in five IOL groups (monofocal, extended depth of focus, refractive bifocal, diffractive bifocal and trifocal). Polynomial curves from 2nd to 11th order and cubic splines were fitted. Goodness of fit (GOF) was assessed using five methods: least squares, coefficient of determination (R 2 adj), Akaike information criteria (AIC), visual inspection and Snedecor and Cochran. Additional defocus steps at −2.25 D and −2.75 D were measured and compared to the calculated visual acuity (VA) values. Area under the defocus curve and range of focus were also compared.ResultsGoodness of fit demonstrated variable results, with more lenient methods such as R 2 adj leading to overfitting and conservative methods such as AIC resulting in underfitting. Furthermore, conservative methods diminished the inflection points resulting in an underestimation of VA. Polynomial of at least 8th order was required for comparison of area methods, but overfitted the EDoF and monofocal groups; the spline curve was consistent for all IOLs and methods.ConclusionsThis study demonstrates the inherent difficulty of selecting a single polynomial function. The R 2 method can be used cautiously along with visual inspection to guard against overfitting. Spline curves are suitable for all IOLs, guarding against the issues of overfitting. Therefore, for analysis of the defocus profile of IOLs, the fitting of a spline curves is advocated and should be used wherever possible.

Prediction accuracy of no-history intraocular lens formulas for a diffractive extended depth-of-focus intraocular lens after myopic corneal refractive surgery.

To compare the accuracy of intraocular lens (IOL) calculation methods for extended depth-of-focus (EDoF) IOLs in eyes with a history of myopic laser-assisted in situ keratomileusis (LASIK)/photorefractive keratectomy (PRK) surgery lacking historical data. Changsha Aier Eye Hospital, Changsha, and Wuhan Aier Eye Hospital, Wuhan, China. Retrospective case series. Patients with axial lengths (ALs) ≥25.0 mm and a history of myopic LASIK/PRK surgery who underwent cataract surgery with implantation of EDoF IOLs were enrolled. A comparison was performed of the accuracy of 10 IOL methods lacking historical data, including Barrett True-K no history (Barrett TKNH), Haigis-L, Shammas, and Potvin-Hill formulas and average, minimum, and maximum IOL power on the ASCRS online postrefractive IOL calculator; Seitz/Speicher/Savini (Triple-S) formula; and Schuster/Schanzlin-Thomas-Purcell (SToP) formulas based on Holladay 1 and SRK/T formulas. IOL power was calculated with the abovementioned methods in 2 groups according to AL (Group 1: 25.0 mm ≤ AL < 28.0 mm and Group 2: AL ≥ 28.0 mm). 64 eyes were included. Excellent outcomes were achieved with the minimum, Barrett TKNH, SToP (SRK/T), and Triple-S formulas in the whole sample and subgroups, which led to similar median absolute error, mean absolute error, and the percentage of eyes with a prediction error within ±0.5 diopters (D). In the whole sample, the Haigis-L and maximum formulas had a significantly higher absolute error than minimum, SToP (SRK/T), and Barrett TKNH formulas. The maximum formula also had a significantly lower percentage of eyes within ±0.5 D than the Barrett TKNH, and SToP (SRK/T) formulas (15.6% vs 50% and 51.5%, all P < .05 with Bonferroni adjustment). Predicting the EDoF IOL power in postmyopic refractive eyes by no-history IOL formulas remains challenging. The Barrett TKNH, Triple-S, minimum, and SToP (SRK/T) formulas achieved the best accuracy when AL ≥ 25.0 mm, while the Barrett TKNH and SToP (SRK/T) formulas were recommended when AL ≥ 28.0 mm.

Visual and patient-reported factors leading to satisfaction after implantation of diffractive extended depth-of-focus and trifocal intraocular lenses.

To evaluate factors that influence postoperative satisfaction in patients with diffractive extended depth-of-focus (EDoF) and multifocal intraocular lenses (mIOLs). Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany. Observational case study. Patients were evaluated after implantation of a diffractive EDoF (Symfony, AT LARA) or trifocal/quadrifocal (AT LISAtri, Panoptix) 3 months postoperatively. A subjective refraction was performed, uncorrected and corrected visual acuities were tested for distance (UDVA, CDVA), intermediate (at 60 cm and 80 cm, UIVA, DCIVA), and near (at 40 cm, UNVA, DCNVA). A test for contrast sensitivity was performed, and the patients filled 2 different questionnaires on daily activities and optical phenomena. Parameters with a potential correlation to the postoperative overall satisfaction were investigated. 94 patients with a mean age of 66 ± 19 years were included. Patients with a better UDVA and UIVA at 60 cm were more likely to choose the same IOL again. The intensity of subjective optical phenomena and the visual quality at different tasks of daily living influenced overall satisfaction. UIVA at 80 cm, UNVA, and corrected visual acuity demonstrated no significant influence on patient satisfaction. The uncorrected visual acuity at specific distances had a direct impact on the subjective visual quality regarding the task performed at those distances. For patients with diffractive EDoF and tri-/quadrifocal IOLs, the UDVA and UIVA at 60 cm seem to be more important than the UNVA and UIVA at 80 cm. Subjective visual quality and optical phenomena influence patient satisfaction, as well.

Extended depth of focus by self-imaging wavefront division with the mirror tunnel.

The mirror tunnel is a component used to extend the depth of focus for compact imaging probes used in endoscopic optical coherence tomography (OCT). A fast and accurate method for mirror tunnel probe simulation, characterization, and optimization is needed, with the aim of reconciling wave- and ray-optics simulation methods and providing a thorough description of the physical operating principle of the mirror tunnel. BeamLab software, employing the beam propagation method, was used to explore the parameter space and quantify lateral resolution and depth of focus extension. The lateral resolution performance was found to depend heavily on the metric chosen, implying that care should be taken in the interpretation of optimization and simulation results. Interpreting the mirror tunnel exit face as an extended object gives an understanding of the probe operation, decoupling it from the focusing optics and potentially helping to reduce the parameter space for future optimization.

Fast extended depth of focus meta-optics for varifocal functionality

Extended depth of focus (EDOF) optics can enable lower complexity optical imaging systems when compared to active focusing solutions. With existing EDOF optics, however, it is difficult to achieve high resolution and high collection efficiency simultaneously. The subwavelength spacing of scatterers in a meta-optic enables the engineering of very steep phase gradients; thus, meta-optics can achieve both a large physical aperture and a high numerical aperture. Here, we demonstrate a fast ( f / 1.75 ) EDOF meta-optic operating at visible wavelengths, with an aperture of 2 mm and focal range from 3.5 mm to 14.5 mm (286 diopters to 69 diopters), which is a 250 × elongation of the depth of focus relative to a standard lens. Depth-independent performance is shown by imaging at a range of finite conjugates, with a minimum spatial resolution of ∼ 9.84 μm (50.8 cycles/mm). We also demonstrate operation of a directly integrated EDOF meta-optic camera module to evaluate imaging at multiple object distances, a functionality which would otherwise require a varifocal lens.

Extended Depth of Focus Versus Monofocal IOLs in Patients With High Myopia: Objective and Subjective Visual Outcomes.

To compare the objective and subjective outcomes between the extended depth of focus (EDOF) Mini Well intraocular lens (IOL) and the aspheric monofocal Mini-4-Ready IOL (both SIFI S.p.A.) in patients with high myopia. In this prospective comparative study, 40 patients with high myopia (axial length ≥ 26 mm) were enrolled: 20 patients were bilaterally implanted with the EDOF Mini Well IOL (EDOF group) and 20 patients were bilaterally implanted with the Mini-4-Ready IOL (monofocal group). Three-month follow-up data included corrected and uncorrected distance visual acuity at 4 m and 80, 67, and 40 cm, defocus curves, subjective and objective contrast sensitivity, objective optical quality (calculated with Optical Quality Analysis System; Visiometrics SL), halometry, and reading performance. Subjective visual quality was evaluated with National Eye Institute Refractive Error Quality of Life Instrument 42 scores. All visual acuities were significantly better in the EDOF group (P ⩽ .04) except monocular and binocular uncorrected and corrected distance visual acuities for distance (P ≥ .50). Defocus curves for myopic and hyperopic values were better in the EDOF group (P ⩽ .05), apart from +0.50 to -0.50 D (P ≥ .16). Contrast sensitivity curves was worse in the EDOF group in the mesopic-with-glare condition (P ⩽ .04). No differences were found in halometric values (P ≥ .15) and OQAS outcomes (P ≥ .47). National Eye Institute Refractive Error Quality of Life Instrument 42 subscale scores were better for expectation, near vision, activity limitations, and dependence on correction in the EDOF group (P ⩽ .04). Intermediate and near visual acuities were better in the EDOF group than in the monofocal group, with a comparable visual quality index between groups. [J Refract Surg. 2022;38(3):158-166.].