Experimental Granulation Research Articles

Age factor in the formation and metabolism of experimental granulation tissue.

Age factor in the formation and metabolism of experimental granulation tissue.

Reflection of collagen synthesis in experimental granulation tissue on plasma protein-bound hydroxyproline.

During the accumulation of collagen in sponge-induced granulomas in rats, the plasma protein-bound hydroxyproline (hyproprotein) increased about two-fold. A rise in plasma non-protein hydroxyproline was also evident. These hydroxyproline fractions returned to the original levels during the involution phase of granuloma. Little change was found in the urinary excretion of hydroxyproline during the experimental period.

Effect of thyroid hormones, somatotrophin, insulin and corticosteroids on synthesis of collagen in granulation tissue both in vivo and in vitro.

ABSTRACT The effect of hormonal factors on the collagen synthesis in experimental granulation tissue of rats was studied (1) in vivo by assessing the development of the tensile strength and (2) in vitro by measuring the capacity of collagen synthesis from 14C-proline by incubated granuloma slices. The hormonal agents were either administered in vivo or added to the incubation media. When hormones were given in vivo, only cortisol affected the tensile strength of the granuloma markedly, but when the capacity of collagen synthesis was assessed, it was found that somatotrophin slightly increased and thyroxine decreased the synthesis. The effect of glucocorticoids, if any, was to increase the conversion of labelled proline into hydroxyproline. In those experiments in which the hormonal factors were added to the incubation media, thyroxine and particularly insulin, increased the incorporation of 14C-proline into collagen. Somatotrophin decreased the incorporation of proline in these experiments, presumably by artifact reactions.

EFFECT OF LATHYRISM ON NUCLEIC ACIDS AND SUBCELLULAR PARTICLES OF THE EXPERIMENTAL GRANULATION TISSUE.

EFFECT OF LATHYRISM ON NUCLEIC ACIDS AND SUBCELLULAR PARTICLES OF THE EXPERIMENTAL GRANULATION TISSUE.

Effect of an anabolic steriod on the tensile strength of granulation tissue in various nutritional states.

ABSTRACT The administration of an anabolic steroid (17α-methyl-17β-hydroxy-androsta-1,4-dien-3-one) to rats improved the tensile strength of experimental granulation tissue and of healing skin wounds on the 12th postoperational day. This, however, only occurred in undernourished animals which showed a retarded development of connective tissue. This difference is also reflected in the collagen content of the granulation tissue. The treatment caused a slight increase in the tensile strength in all the feeding groups on the second postoperational day.