Network function virtualization (NFV) is a concept aimed at achieving telecom grade cloud ecosystem for new‐generation networks focusing on capital and operational expenditure (CAPEX and OPEX) savings. This study introduces empirical throughput prediction model for the virtual network function (VNF) and network function virtualization infrastructure (NFVI) architectures based on Linux kernel. The model arises from the methodology for performance evaluation and modeling based on execution area (EA) distribution by CPU core pinning. EA is defined as a software execution unit that can run isolated on a compute resource (CPU core). EAs are derived from the elements and packet processing principles in NFVIs and VNFs based on Linux kernel. Performing measurements and observing linearity of the measured results open the possibility to apply model calibration technique to achieve general VNF and NFVI architecture model with performance prediction and environment setup optimization. The modeling parameters are derived from the cumulative packet processing cost obtained by measurements for collocated EAs on the CPU core hosting the bottleneck EA. The VNF and NFVI architecture model with performance prediction is successfully validated against the measurement results obtained in emulated environment and used to predict optimal system configurations and maximal throughput results for different CPUs.