Exclusion Barriers Research Articles

Performance Standards and Acceptable Test Conditions for Preventive Termiticide and Insecticide Treatments, Termite Baiting Systems, and Physical Barriers for New Structures or Buildings under Construction (Pre-Construction; During Construction; Post-Construction)

Florida Administrative Code (FAC) 5E-2.0311, “Performance Standards and Acceptable Test Conditions for Preventive Termite Treatments for New Construction,” approved in 2003, currently remains without change as originally written. This Code requires broad revision to include updating existing and new termite management methods and technologies, describing acceptable testing protocols that objectively evaluate termite management product efficacy, and clearly and accurately define product performance standards required for approval and use in Florida, USA. This manuscript provides modification and expansion of the existing Code, first in outline form, then followed by a proposed complete revision including detailed explanations for each outline heading and sub-heading. Efficacy requirements, acceptable test conditions, and performance standards requirements are described for termite management products, materials, and non-chemical physical exclusion barriers. We also include testing protocols for field plot and structure efficacy tests. Minimum performance standards also are described for field plots and structure tests to include: (1) termiticide applications to soil, (2) termite baiting systems, (3) pesticides applied directly to wood and building components, (4) pesticide combination mixtures, and (5) new application technologies, products, and methodologies. Although this manuscript addresses revision of a specific Florida Administrative Code, it also is appropriate for consideration by the United States Environmental Protection Agency (USEPA) as well as regulatory entities in other states responsible for pesticide regulation and consumer protection services when writing or revising their code requirements for termite management.

Comparative In Vivo Analysis of the Integration Behavior and Immune Response of Collagen-Based Dental Barrier Membranes for Guided Bone Regeneration (GBR).

Collagen-based resorbable barrier membranes have been increasingly utilized for Guided Bone Regeneration (GBR), as an alternative to non-resorbable synthetic membranes that require a second surgical intervention for removal. One of the most important characteristics of a resorbable barrier membrane is its mechanical integrity that is required for space maintenance and its tissue integration that plays a crucial role in wound healing and bone augmentation. This study compares a commercially available porcine-derived sugar-crosslinked collagen membrane with two non-crosslinked collagen barrier membranes. The material analysis provides an insight into the influence of manufacturing on the microstructure. In vivo subcutaneous implantation model provides further information on the host tissue reaction of the barrier membranes, as well as their tissue integration patterns that involve cellular infiltration, vascularization, and degradation. The obtained histochemical and immunohistochemical results over three time points (10, 30, and 60 days) showed that the tissue response to the sugar crosslinked collagen membrane involves inflammatory macrophages in a comparable manner to the macrophages observed in the surrounding tissue of the control collagen-based membranes, which were proven as biocompatible. The tissue reactions to the barrier membranes were additionally compared to wounds from a sham operation. Results suggest wound healing properties of all the investigated barrier membranes. However, the sugar-crosslinked membrane lacked in cellular infiltration and transmembraneous vascularization, providing an exclusive barrier function in GBR. Moreover, this membrane maintained a similar swelling ratio over examined timepoints, which suggests a very slow degradation pattern and supports its barrier function. Based on the study results, which showed biocompatibility of the sugar crosslinked membrane and its stability up to 60 days post-implantation, it can be concluded that this membrane may be suitable for application in GBR as a biomaterial with exclusive barrier functionality, similar to non-resorbable options.

Ethical and Social Challenges in Research with Children Exposed to Forced labour, Exploitation, and Trafficking

This article explores the ethical and social challenges in research with children exposed to forced labour, exploitation, and trafficking. It examines whether the participation of children in evidence generation has the potential to affect them and how the researcher avoids potential discomfort. This requires investigating the multiple issues and contexts that affect the children. Essentially, conducting a child-centred evidence generation is ethically reasonable based on how such investigation is carried out and on how a child is affected by the research activities. The process of recruiting participants, avoiding potential harm, ensuring privacy, anonymity and confidentiality corresponds to the best possible regulation, in full respect of the interests of children. What is pursued is a child-centred evidence generation, capable of responding in an acceptable way, from an ethical point of view to the question about the methodology of the research itself. In addition, child-centred research enhances the sharing of perspectives and insights, which break down the barriers of exclusion. Against this background, this article contributes to the identification, interpretation, and clarification of ethical and social questions that arise in relation to child-centred evidence generation. Similarly, it furthers awareness on the significance of ethical reflection and in making informed decisions and choices to mitigate against potential harm to participants during and after the research.

The Double-Edged Sword of Health and Safety: COVID-19 and the Policing and Exclusion of Migrant Asian Massage Workers in North America

Migrant Asian massage workers in North America first experienced the impacts of COVID-19 in the final weeks of January 2020, when business dropped drastically due to widespread xenophobic fears that the virus was concentrated in Chinese diasporic communities. The sustained economic devastation, which began at least 8 weeks prior to the first social distancing and shelter in place orders issued in the U.S. and Canada, has been further complicated by a history of aggressive policing of migrant massage workers in the wake of the war against human trafficking. Migrant Asian massage businesses are increasingly policed as locales of potential illicit sex work and human trafficking, as police and anti-trafficking initiatives target migrant Asian massage workers despite the fact that most do not provide sexual services. The scapegoating of migrant Asian massage workers and criminalization of sex work have led to devastating systemic and interpersonal violence, including numerous deportations, arrests, and deaths, most notably the recent murder of eight people at three Atlanta-based spas. The policing of sex workers has historically been mobilized along fears of sexually transmitted disease and infection, and more recently, within the past two decades, around a moral panic against sex trafficking. New racial anxieties around the coronavirus as an Asian disease have been mobilized by the state to further cement the justification of policing Asian migrant workers along the axes of health, migration, and sexual labor. These justifications also solidify discriminatory social welfare regimes that exclude Asian migrant massage workers from accessing services on the basis of the informality and illegality of their work mixed with their precarious citizenship status. This paper draws from ethnographic participant observation and survey data collected by two sex worker organizations that work primarily with massage workers in Toronto and New York City to examine the double-edged sword of policing during the pandemic in the name of anti-trafficking coupled with exclusionary policies regarding emergency relief and social welfare, and its effects on migrant Asian massage workers in North America. Although not all migrant Asian massage workers, including those surveyed in this paper, provide sexual services, they are conflated, targeted, and treated as such by the state and therefore face similar barriers of criminalization, discrimination, and exclusion. This paper recognizes that most migrant Asian massage workers do not identify as sex workers and does not intend to label them as such or reproduce the scapegoating rhetoric used by law enforcement. Rather, it seeks to analyze how exclusionary attitudes and policies towards sex workers are transferred onto migrant Asian massage workers as well whether or not they provide sexual services.

Evaluating Exclusion Barriers for Treefrogs in Agricultural Landscapes

ABSTRACTAgricultural co‐management aims to promote environmental sustainability while maintaining food‐safety standards. Amphibians, especially treefrogs, are known to enter fields of fresh produce intended for human consumption, which raises concerns for food safety and quality. We evaluated the effects of modifications to reduce the scalability of exclusion barriers on the fence‐crossing behavior of Pacific treefrogs (Hyliola regilla) from lettuce fields in the Salinas Valley of California during January to May 2019. From small‐scale field experiments, we found that fences modified with a horizontal lip at the top prevented all treefrogs from successfully crossing over. Fences incorporating sandpaper were also effective at deterring treefrog crossings compared to fences made of fiberglass square mesh (window screen) and polypropylene fabric (silt fence). The fence design that inhibited the most treefrog crossings—aluminum flashing with a horizontal lip—was a modification to commercially available material that is feasible to install at large scales, is durable over long periods of time, and can help to exclude additional nuisance wildlife, such as small mammals and lizards. Our findings provide quantitative evidence on the efficacy of an exclusion barrier constructed with off‐the‐shelf material that can be easily modified to improve the co‐management of amphibians and agriculture. © 2021 The Authors. Wildlife Society Bulletin published by Wiley Periodicals LLC on behalf of The Wildlife Society.

Challenges and LIS Responses to Digital Literacy in Crisis

As a result of the COVID-19 pandemic beginning in the Spring of 2020, vulnerable Canadians were left behind by digital exclusion, which was exacerbated by an increased reliance on digital technologies. In this article, I seek to provide an overview of the links between digital inclusion, social justice, and the values of the LIS profession. Because of the COVID-19 pandemic crisis, another crisis of digital exclusion has revealed the ways in which digital citizenship and socio-economic exclusion are fundamentally intertwined. In response, many LIS professionals have overcome extensive closures and reductions in resources to find innovative solutions to this crisis of inequality. This article will provide just a few examples of these responses from LIS organizations. Indeed, even among overwhelming barriers, LIS professionals have not lost sight of community values and commitment to social justice in challenging times. In unprecedented times, LIS professionals have found innovation to address ongoing social and economic barriers of digital exclusion.

The Use of Barriers to Limit the Spread of Aquatic Invasive Animal Species: A Global Review

Aquatic invasive species (AIS) are one of the principal threats to freshwater biodiversity. Exclusion barriers are increasingly being used as a management strategy to control the spread of AIS. However, exclusion barriers can also impact native organisms and their effectiveness is likely to be context dependent. We conducted a quantitative literature review to evaluate the use of barriers to control animal AIS in freshwater ecosystems worldwide. The quantitative aspect of the review was supplemented by case studies that describe some of the challenges, successes, and opportunities for the use of the use of AIS exclusion barriers globally. Barriers have been used since the 1950s to control the spread of AIS, but effort has been increasing since 2005 (80% of studies) and an increasingly diverse range of AIS taxa are now targeted in a wide range of habitat types. The global use of AIS barriers has been concentrated in North America (74% of studies), Australasia (11%), and Europe (10%). Physical barriers (e.g., weirs, exclusion screens, and velocity barriers) have been most widely used (47%), followed by electric (27%) and chemical barriers (12%). Fish were the most targeted taxa (86%), followed by crustaceans (10%), molluscs (3%) and amphibians (1%). Most studies have been moderately successful in limiting the passage of AIS, with 86% of the barriers tested deterring >70% of individuals. However, only 25% of studies evaluated barrier impacts on native species, and development of selective passage is still in its infancy. Most studies have been too short (47% < 1 year, 87% < 5 years) to detect ecological impacts or have failed to use robust before-after-control-impact (BACI) study designs (only 5%). Hence, more effective monitoring is required to assess the long-term effectiveness of exclusion barriers as an AIS management tool. Our global case studies highlight the pressing need for AIS control in many ecoregions, and exclusion barriers have the potential to become an effective tool in some situations. However, the design and operation of exclusion barriers must be refined to deliver selective passage of native fauna, and exclusion barriers should only be used sparingly as part of a wider integrated management strategy.

The role of physical culture and sport activities in migrant integration

The relevance of the research topic consists in solving the scientific and practical problem of integrating migrants into the host community. The purpose of the research is to identify the role of physical culture and sports in the social integration of migrants. The methodology of the research is presented by the theories of assimilation of migrants with the local population; multiculturalism as the idea of the existence of a multinational state; transnationalism implemented in the conditions of globalization, informatization and digitalization of the society. The research methods used are content analysis of documents; analysis of statistical data, secondary analysis of sociological data, comparative analysis. The novelty of the research issue lies in the critical understanding of the advantages and limitations of physical training and sports as tools for integrating migrants into host communities in foreign countries. The results of the research have been defined: the role of physical training and sports activities in the process of migrants' integration based on the domestic and foreign research; the main approaches to the implementation of migration policy measures in world practice (assimilation, multiculturalism and transnationalism) as well as the assessment of its success, by using the Migrant Integration Index. The study allows us to draw a conclusion about the dual nature of the integration potential of physical culture and sports in the implementation of migration policy: on the one hand, it is a way of revealing socio-cultural capital, searching for additional opportunities for self-realization in a new socio-cultural environment, overcoming social isolation, eliminating barriers of social exclusion; on the other hand, it is a deterrent effect of migrants' age, gender, ethnicity, religion, level of education, attitude to various sports and physical activity in the countries of entry and exit on the integration process.

Psychosocial Barriers of Public Transport Use and Social Exclusion among Older Adults: Empirical Evidence from Lahore, Pakistan.

Transport planning and public health have been intertwined historically. The health impact of public transport services, such as social exclusion, is a widely discussed research topic. Social exclusion is a paramount concern for older adults’ health in the wake of emerging global challenges. However, there remains a significant research gap on how psychosocial barriers faced by older adults in using public transport services influence the social exclusion behavior. The present research provides empirical evidence and shows the impact of certain psychosocial barriers of public transportation on older adults’ social exclusion. A total of 243 Pakistani older adults (aged 60–89 years old) voluntarily participated in this cross-sectional study. The participants provided self-reports on their psychosocial barriers (including perceived norms, attitude, personal ability, habits, neighborhood social constraints, and intention) and the corresponding social exclusion. Partial Least Square Structural Equation Modeling (PLS-SEM) was utilized for the data analysis. The structural path model supported the significant associations between psychosocial barriers and social exclusion. Except for perceived descriptive norms, all other psychosocial barriers predicted older adults’ social exclusion. The research portrays the significance of the psychosocial factors to examine social exclusion and offers practical implications for urban and transport planners. The concerned policymakers can use the research findings to develop age-sensitive, socially sustainable, and healthy cities.

Das leis inclusivas às práticas sociais no âmbito de uma sociedade para todos

O presente artigo busca apresentar alguns fatores que subsidiam a construção de uma sociedade para todos, em que haja menos desigualdade social e que as pessoas com deficiências possam exercer seu papel de cidadão, passando de uma vida segregada a uma vida ativa, social, participativa. A Lei Brasileira de Inclusão ou Estatuto da Pessoa com Deficiência de 2016 deu aparato legal e constitucional a tais visões, fazendo com que a luta por ações sociais inclusivas sejam uma luta ideológica, de ações atitudinais. A inclusão de todos deve transpor as barreiras da exclusão. Essa luta existe e persiste para que as pessoas com deficiências, as que sofrem preconceitos de ordem racista, religiosa, sexual, linguística, cultural ou social possam ter as mesmas oportunidades de desenvolvimento e de prática social daqueles que não sofrem tais situações.

Versatile Yolk–Shell Encapsulation: Catalytic, Photothermal, and Sensing Demonstration

Here, a novel, versatile synthetic strategy to fabricate a yolk-shell structured material that can encapsulate virtually any functional noble metal or metal oxide nanocatalysts of any morphology in a free suspension fashion is reported. This strategy also enables encapsulation of more than one type of nanoparticle inside a single shell, including paramagnetic iron oxide used for magnetic separation. The mesoporous organosilica shell provides efficient mass transfer of small target molecules, while serving as a size exclusion barrier for larger interfering molecules. Major structural and functional advantages of this material design are demonstrated by performing three proof-of-concept applications. First, effective encapsulation of plasmonic gold nanospheres for localized photothermal heating and heat-driven reaction inside the shell is shown. Second, hydrogenation catalysis is demonstrated under spatial confinement driven by palladium nanocubes. Finally, the surface-enhanced Raman spectroscopic detection of model pollutant by gold nanorods is presented for highly sensitive environmental sensing with size exclusion.

Education Concept by KH Morality. Munir Ahmad and Implementation in Modern Cottage Muhammadiyah Paciran Lamongan

Insight Education must be free from bondage and narrow, primordial, and exclusive barriers of thought. Education should be based on morality. This research is conducted at The Modern Cottage Paciran Muhammadiyah Lamongan with the problem formulation: (1) How is the concept of moral education According to KH. Ahmad Munir? (2) How is the implementation of moral education According to KH. Munir Ahmad at Muhammadiyah Paciran Modern Cottage ?. In the data collection the author uses observation documentation and interview methods. While the data to the analysis uses descriptive analysis of data from interviews with eight informants. From the results of the study can be Obtained the description that, the thoughts of KH. Munir Ahmad rejected the dichotomy of science. Islamic education is education that leads to the liberation of students and democratic, it means that it Gives freedom to ask questions, be critical and debatable. The curriculum form has the dimensions of integrated curriculum mattered, with the basic principle that is capable of giving birth to a building of an ummatic curriculum. The significance of the moral education curriculum and the learning methodology in Pondok Modem Muhammadiyah Paciran is quite significant, its implementation is based on interviews from 8 informants items, namely two students and six religious teachers and religious teachers

Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow.

Nanoparticle‐based therapeutic formulations are being increasingly explored for the treatment of various ailments. Despite numerous advances, the success of nanoparticle‐based technologies in treating brain diseases has been limited. Translational hurdles of nanoparticle therapies are attributed primarily to their limited ability to cross the blood–brain barrier (BBB), which is one of the body's most exclusive barriers. Several efforts have been focused on developing affinity‐based agents and using them to increase nanoparticle accumulation at the brain endothelium. Very little is known about the role of fundamental physical parameters of nanoparticles such as size, shape, and flexibility in determining their interactions with and penetration across the BBB. Using a three‐dimensional human BBB microfluidic model (μHuB), we investigate the impact of these physical parameters on nanoparticle penetration across the BBB. To gain insights into the dependence of transport on nanoparticle properties, two separate parameters were measured: the number of nanoparticles that fully cross the BBB and the number that remain associated with the endothelium. Association of nanoparticles with the brain endothelium was substantially impacted by their physical characteristics. Hard particles associate more with the endothelium compared to soft particles, as do small particles compared to large particles, and spherical particles compared to rod‐shaped particles. Transport across the BBB also exhibited a dependence on nanoparticle properties. A nonmonotonic dependence on size was observed, where 200 nm particles exhibited higher BBB transport compared to 100 and 500 nm spheres. Rod‐shaped particles exhibited higher BBB transport when normalized by endothelial association and soft particles exhibited comparable transport to hard particles when normalized by endothelial association. Tuning nanoparticles' physical parameters could potentially enhance their ability to cross the BBB for therapeutic applications.

Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections.

There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass. We compared the ability of adeno-associated virus (AAV), adenovirus (Ad), and lentiviral (LV) vectors to deliver genes to renal cells. When vectors were delivered by the intravenous (IV) route in mice, weak luciferase activity was observed in the kidney with substantially more in the liver. When gene delivery was observed in the kidney, expression was primarily in the glomerulus. To avoid these limitations, vectors were injected directly into the kidney by retrograde ureteral (RU) and subcapsular (SC) injections in mice. Small AAV vectors transduced the kidney, but also leaked from the organ and mediated higher levels of transduction in off-target tissues. Comparison of AAV2, 6.2, 8, and rh10 vectors by direct kidney injection demonstrated highest delivery by AAV6.2 and 8. Larger Ad and LV vectors transduced kidney cells and mediated less off-target tissue transduction. These data demonstrate the utility of direct kidney injections to circumvent the kidney size exclusion barrier. They also identify the effects of vector size on on-target and off-target transduction. This lays the foundation for the use of different vector platforms for gene therapy of diverse kidney diseases.

ECHO CHAMBERS DI DUNIA MAYA: TANTANGAN BARU KOMUNIKASI ANTAR UMAT BERAGAMA

This article tries to see a phenomenon called Echo Chambers through the perspective of Stella Ting-Toomey’s Intercultural Communication Theory. This study shows that the development of social media was also followed by the shadow of Echo Chambers. The tendency to isolate oneself and associate with those who understand one another will create separate spaces between one religion and another. As a result, communication which is an effort to eliminate the polarization of the differences between "Us" and "The Others" is precisely the way to form an exclusivism in cyberspace. Among the efforts to anticipate the emergence of a gap is to create melting-pot spaces in the real world. Counter narrative also needs to be built to open these exclusive barriers. Muslim scholars sought to introduce the importance of communication in achieving the harmony in community. Some Ulama have also explained the role and function of communication in achieving the goals of the ummah, as well as trying to provide an Islamic perspective regarding communication behavior. More important, is to create a person who is a wise, open user of social media and uses epoche in looking at the world outside.

Power, Subsidiarity, and the Economy of Exclusion

AbstractAccording to Pope Francis, an “economy of exclusion” is an economy with barriers that prevent individuals and groups from participating in the economy and society to their full potential. Power is a key determinant for both exclusion and inclusion. All economies are based on power relations and an “economy of exclusion” is an abuse of power. This contribution looks at what economic power is and how it can build barriers of exclusion or pathways to inclusion. We use income inequality as a measure of exclusion, giving a general history of power and inequality to demonstrate the role of power. Lastly, we look at the concept of subsidiarity in Catholic social thought as a principle to guide the use of power in the economy.

Exclusive factors and regional barriers to protecting the national identity of ukrainians in the globalization of hybridization

Exclusive factors and regional barriers to protecting the national identity of ukrainians in the globalization of hybridization

Fish community responses to invasive fish removal and installation of an exclusion barrier at Lake Ohinewai, Waikato

ABSTRACTIntroduced common carp (Cyprinus carpio) are a recognised threat to New Zealand’s freshwater ecosystems. In 2011, an invasive fish removal programme was undertaken in 16.8 ha Lake Ohinewai, a Waikato riverine lake. Active fish removal using netting and boat electrofishing was supported by installation of a one-way exclusion barrier on the outflow to Lake Ohinewai. The barrier was designed to allow fish passage downstream out of the lake, while preventing adult carp from moving upstream. The estimated carp population was reduced from 8,548 fish (5,863–12,937, 95% confidence limits) in 2011–454 fish (251–889, 95% CL) in 2014. However, by 2016 the carp population had recovered to 2,063 fish (1,070–4,328, 95% CL) with increased abundance in invasive brown bullhead catfish (Ameiurus nebulosus) also observed. This research demonstrates that carp populations can be reduced to low abundances in the short to medium term, but continued removal will be required for on-going control.

Ideological foundations of exclusive development of the National State of Ukraine

Сurrent article, probably for the first time, analyzes the model of state-building, where the nation is considered to be conscious of its national idea of the future development. It argues that based on this Idea, the stratagems for building a nation-state of indigenous people with all the proper attributes are being developed. The title nation living in this state has an exclusive (exceptional) natural, cultural, religious and historical right to self-determination and protection. The paper notes that in a process of elimination of imperial assimilation barriers, these stratagems perform three fundamental and at the same time interrelated functions of spiritual revival: consolidation of the nation, its identification and integration into a civilized world. Everything impeding the realization of these core functions for national progress is stressed to be a remnant of the hostile neighbourhood of the past, which contemporaries must not keep for the future generation to attain a better future. In this context, an integrated approach to the National Idea is proposed as a set of integral stratagems of national progress, which made it possible to highlight the corresponding priorities of building a national state in each block of stratagems. For example, in the unity bloc - to return the peace and integrity of the country; in the defense of “ukrainianness” – not only to adopt, but also actually implement the law on the Ukrainian language, speed up de-communization, strengthen security in particularly in the national information space. As for the “dignity” bloc, one should not only “not embrace”, but also adhere to the vector of civilizational development, achieve admission to NATO, the EU, achieve high socio-economic living standards of people of developed countries, indicators of their well-being and recreation, protect their health; and at the same time - develop their own strength and resources. The achievement of the planned indicators before Ukraine admittance to NATO and EU, which constitute its homework, affects not only the named blocks of stratagems, but also the structure of global and regional factors, exclusive barriers that still lie in the field of Ukrainian studies of virgin land. In the paper the conclusion is made that in the conditions of an aggressive external environment and continued imperial support of the “fifth columns” in Ukraine - this poses a great danger to state sovereignty, national identity and European-NATO integration. Moreover, further disregard for them is deadly as a continuation of any war and imperial assimilation. In the circumstances of the hybrid war of Russia against Ukraine, it is vital for a person individually, existentially for a nation as a social community of people and globally dangerous for the development of the cultural diversity of humanity as a whole. Comprehensive account of these, triple-connected processes, is of great importance for developing an effective road map for the ultimate exit of Kyiv from the orbit of Moscow’s imperial claims, enhancing the self-exclusive subjectivity of Ukraine, and accelerating its accession to the number of free countries of the world.

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Prostate cancer is characterized by T-cell exclusion, which is consistent with their poor responses to immunotherapy. In addition, T-cells restricted to the adjacent stroma and benign areas are characterized by anergic and immunosuppressive phenotypes. In order for immunotherapies to produce robust anti-tumor responses in prostate cancer, this exclusion barrier and immunosuppressive microenvironment must first be overcome. We have previously identified mesenchymal stem cells (MSCs) in primary and metastatic human prostate cancer tissue. An Opal Multiplex immunofluorescence assay based on CD73, CD90, and CD105 staining was used to identify triple-labeled MSCs in human prostate cancer tissue. T-cell suppression assays and flow cytometry were used to demonstrate the immunosuppressive potential of primary MSCs expanded from human bone marrow and prostate cancer tissue from independent donors. Endogenous MSCs were confirmed to be present at sites of human prostate cancer. These prostate cancer-infiltrating MSCs suppress T-cell proliferation in a dose-dependent manner similar to their bone marrow-derived counterparts. Also similar to bone marrow-derived MSCs, prostate cancer-infiltrating MSCs upregulate expression of PD-L1 and PD-L2 on their cell surface in the presence of IFNγ and TNFα. Prostate cancer-infiltrating MSCs suppress T-cell proliferation similar to canonical bone marrow-derived MSCs, which have well-documented immunosuppressive properties with numerous effects on both innate and adaptive immune system function. Thus, we hypothesize that selective depletion of MSCs infiltrating sites of prostate cancer should restore immunologic recognition and elimination of malignant cells via broad re-activation of cytotoxic pro-inflammatory pathways.