Background and Aim: In patients with pancreaticobiliary maljunction (PBM), pancreatic juice frequently refluxes into the bile duct. This results in a high risk of biliary carcinoma. No consensus has been reached on whether preventive resection of the extrahepatic bile duct is necessary in PBM cases without dilatation of the extrahepatic duct. The aim of this study is to examine the biliary complications of patients with PBM in relation to the degree of extrahepatic bile duct dilatation and thus to determine appropriate management. Patients and Methods: We have treated 98 patients (21 males and 77 females, average = 48.0) with PBM. The PBM cases could be divided into 5 groups according to the maximum diameter of the extrahepatic bile duct:≤10, 11-15, 16-20, 21-30, ≥31mm. The clinicopathological findings of biliary carcinomas associated with PBM were examined and compared with 232 cases of gallbladder carcinoma and 159 cases of bile duct carcinoma that were not associated with PBM. Results: Gallbladder carcinoma occurred in 36 of 65 patients (55%) with PBM whose maximum diameter of the extrahepatic bile duct was ≤30 mm, but no gall bladder carcinoma occurred in patients with PBM whose maximum diameter of the extrahepatic bile duct was ≥31 mm. Bile duct carcinoma occurred in 6 of 52 patients (12%) with PBM whose maximum diameter of the extrahepatic bile duct was ≥21 mm, but no bile duct carcinoma occurred in patient with PBM whose maximum diameter of extrahepatic bile duct was ≤20 mm. The age at diagnosis of the patients with gall bladder (58.9 ± 8.8 vs. 69.4 ± 8.7 years old, p < 0.01) or bile duct carcinoma (54.8 ± 14.3 vs. 68.8 ± 9.1 years old, p < 0.01) associated with PBM was significantly younger than those without PBM. Gallstones were rarely detected in patients with gallbladder carcinoma associated with PBM (8% vs. 62%, p < 0.01). There were no significant differences between cases of gallbladder carcinoma associated with and without PBM in the location and histology, incidence of multiple biliary carcinoma. Multiple biliary carcinomas frequently occurred in the patients with bile duct carcinoma associated with PBM (50% vs. 4%, p < 0.01). Conclusion: PBM with an extrahepatic bile duct diameter ≤30 mm is associated with a high risk of gallbladder carcinoma. Furthermore, PBM with an extrahepatic bile duct diameter ≥21 mm is associated with a high risk of bile duct carcinoma. The treatment of choices for PBM with biliary dilatation is excision of extrahepatic bile duct and gallbladder with Roux-en-Y reconstruction of the biliary tree. However, given the present study, only cholecystectomy should be recommended as prophylactic treatment for patients with PBM without biliary dilatation.
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