Evidence-based Lifestyle Intervention Research Articles

Lifestyle medicine program for patients with breast cancer at Kaiser Permanente Oakland.

359 Background: Patients with breast cancer can benefit from comprehensive care strategies beyond conventional treatments. At Kaiser Permanente East Bay (KPEB), 350-400 patients are diagnosed with breast cancer annually, many seeking lifestyle changes to improve their prognosis. The KPEB Lifestyle Medicine Program aims to improve recovery and overall well-being through evidence-based lifestyle interventions. Methods: The KPEB Lifestyle Medicine Program is founded on evidence-based interventions focusing on nutrition, physical activity, stress management, sleep, substance use, and social support. Led by a multidisciplinary team, the program ran from September 29 to November 17, 2022, featuring 8 weekly 1-1.5 hour virtual classes. The program enrolled 18 patients under 60 years of age with stage I-III breast cancer who completed active treatment. Topics covered in the program included nutritional counseling, exercise regimens, stress reduction techniques, sleep guidance, support for managing substance use, and fostering social connections. Additional topics included sexual health, anti-hormonal medication side effects, menopause, and mindfulness. Restorative yoga and cooking classes were also offered and participants formed personal groups for connection outside class. Patients had virtual one-on-one appointments with a physician before, midway, immediately after, and six months post-program, followed annually by the survivorship clinic. Blood work (HbA1c, cholesterol) was conducted before and six months after program completion. Results: Of the n=18 participants, 1 participant dropped out before the first class, and 1 participant attended only 1 class. On average, attendance was 90%, with 90% of participants extremely satisfied with the program and 80% reporting increased confidence in applying course learnings. The class on sexual health and managing side effects of anti-hormonal medications and menopause was the most well-received. Patients were metabolically healthy at program entry and exit, with significant LDL improvement (average LDL: entry = 100, exit = 83). Average HbA1c remained stable (entry = 5.52, exit = 5.57). Conclusions: The KPEB Lifestyle Medicine Program was well-attended, effectively addressed the needs of breast cancer patients, and enhanced overall health. Further research will explore longer-term benefits and broader application in oncology care.

Proceedings of the 2022 "Lifestyle Intervention for Epilepsy (LIFE)" symposium hosted by Cleveland Clinic.

Lifestyle interventions are strategies used to self-manage medical conditions, such as epilepsy, and often complement traditional pharmacologic and surgical therapies. The need for integrating evidence-based lifestyle interventions into mainstream medicine for the treatment of epilepsy is evident given that despite the availability of a multitude of treatments with medications and surgical techniques, a significant proportion of patients have refractory seizures, and even those who are seizure-free report significant adverse effects with current treatments. Although the evidence base for complementary medicine is less robust than it is for traditional forms of medicine, the evidence to date suggests that several forms of complementary medicine including yoga, mindfulness meditation, cognitive behavioral therapy, diet and nutrition, exercise and memory rehabilitation, and music therapy may have important roles as adjuncts in the treatment armamentarium for epilepsy. These topics were discussed by a diverse group of medical providers and scientists at the "Lifestyle Intervention for Epilepsy (LIFE)" symposium hosted by Cleveland Clinic. PLAIN LANGUAGE SUMMARY: There are many people with epilepsy who continue to have seizures even though they are being treated with medication or brain surgery. Even after seizures stop, some may experience medication side effects. There is research to suggest that certain lifestyle changes, such as yoga, mindfulness, exercise, music therapy, and adjustments to diet, could help people with epilepsy, when used along with routine treatment. Experts discussed the latest research at the "Lifestyle Intervention for Epilepsy (LIFE)" symposium hosted by Cleveland Clinic.

Tackling Cravings in Medical Weight Management: An Update on Pathophysiology and an Integrated Approach to Treatment

Background/Objectives: Food cravings involve a strong drive to consume palatable foods irrespective of nutritional status. Importantly, cravings contribute substantially to the obesity epidemic. Managing hunger alone is insufficient for weight management as this relates only to homeostatic eating and does not address the complex aetiology of hedonic eating and its crucial role in food cravings. Medical weight management clinics and anti-obesity medication trials do not routinely identify and address food cravings. Methods: We conducted a narrative review of the literature consisting of 115 peer-reviewed articles (original articles and reviews). We included articles focused on food craving pathophysiology, assessment, and management strategies providing contrasts against the current medical model of weight management seen in obesity pharmacotherapy trials as well as the current standard of practise. Results: We outline the neurohormonal and psychological drivers of cravings, which lead to a spectrum of eating behaviours, from comfort food eating to binge eating disorders. We provide an overview of ways of identification and measurement options, including their strengths and weaknesses, and an overview of management strategies and their cravings control efficacy, spanning lifestyle modifications like nutrition and sleep, psychological therapies (i.e., cognitive behavioural therapy [CBT], acceptance-based therapies such as mindfulness) and, last but not least, medications that not only are approved for weight reduction but reduce cravings. Finally, based on these findings, we provide a proposed integrated and iterative model that is able to evolve and adapt to the individual over time in tackling cravings for long-term weight loss maintenance. Conclusions: The findings emphasise the importance of cravings management and provide a synthesis on how cravings can be identified in a medical weight management setting, which can be practically implemented in an integrated iterative model spanning anti-obesity medications that have craving control data to evidence-based lifestyle and psychological interventions.

264 - Weight loss and remission of pre-diabetes with an evidence-based lifestyle intervention

264 - Weight loss and remission of pre-diabetes with an evidence-based lifestyle intervention

Adapting the National Diabetes Prevention Program: Learning from Lifestyle Coach strategies and adjustments during the COVID-19 pandemic in the United States

BackgroundThe National Diabetes Prevention Program (National DPP) is an evidence-based lifestyle intervention successfully disseminated across the United States. Some adaptations have been made to address real-world needs, including during the COVID-19 pandemic. This study aims to qualitatively describe adaptations Lifestyle Coaches made in response to the pandemic. MethodsBetween May and June 2021, Lifestyle Coaches (n = 300) from organizations across the United States answered open-ended survey questions about adjustments implemented during the pandemic. Survey responses were descriptively coded and codes were grouped into categories. ResultsNearly all coaches transitioned the format of their class from in-person to remote delivery (93.0 %; n = 279). Other commonly-reported strategies included adjusting contact with participants (48.0 %; n = 144), increasing support for participants (36.7 %; n = 110), and tailoring materials (28.3 %; n = 85). ConclusionsMaintaining these adaptations may address barriers to engagement in the National DPP and improve access to the program. Increased support for emotional symptoms and ensuring a patient-centered approach to care are particularly promising strategies.

Enactment, Evaluation, and Expansion of a Healthy Living Club in an Out of School Setting: A Community-Academic Partnership.

Interventions in community settings, where children spend substantial out of school time, may enhance access to evidence-based lifestyle interventions. The Boys and Girls Club of Lawrence (BGCL) and New Balance Foundation Obesity Prevention Center at Boston Children's Hospital partnered to revise, enact, and evaluate BGCL's existing Healthy Living Club and then flexibly expand the program to increase access. The BGCL is within walking distance of three public housing communities and easily accessible to members, of whom 90% identify as Hispanic. The interventions comprised nutrition sessions and either fitness activity sessions (N+FA Cycle 1, n = 63, 26 hours; N+FA Cycle 2, n = 94, 27 hours) or academic basketball practices (N+AB Cycle 2, n = 99, 72-80 hours), leveraging time already in the schedule where fitness could be intentionally promoted by coaches. Among children aged 8-15 years, mean [95% confidence interval (CI)] changes (beginning to end) in percentage above the BMI median were significant [N+FA Cycle 1: -2.4 (-4.1, -0.8); N+FA Cycle 2: -4.3 (-5.4, -3.1); N+AB Cycle 2: -5.5 (-6.9, -4.1)]. Lifestyle interventions, implemented with flexibility in existing programs, had beneficial impact, indicating potential of community-academic partnerships.

Real-world impacts from a decade of Quality Enhancement Research Initiative-partnered projects to translate the Diabetes Prevention Program in the Veterans Health Administration.

To describe the impacts of four Veterans Health Administration (VA) Quality Enhancement Research Initiative (QUERI) projects implementing an evidence-based lifestyle intervention known as the Diabetes Prevention Program (DPP). 2012-2024 VA administrative and survey data. This is a summary of findings and impacts from four effectiveness-implementation projects focused on in-person and/or online DPP across VA sites. Patient demographics, participation data, and key findings and impacts were summarized across reports from the VA Diabetes-Mellitus Quality Enhancement Research Initiative (QUERI-DM) Diabetes Prevention Program (VA DPP) Trial, QUERI-DM Online DPP Trial, the Enhancing Mental and Physical Health of Women through Engagement and Retention (EMPOWER) QUERI DPP Project, and EMPOWER 2.0 QUERI Program. Between 2012 and 2024, four VA QUERI studies enrolled 963 Veterans in DPP across 16 VA sites. All participants had overweight/obesity with one additional risk factor for type 2 diabetes (i.e., prediabetes, elevated risk score, or history of gestational diabetes) and 56% (N = 536) were women. In addition to enhancing the reach of and engagement in diabetes prevention services among Veterans, these projects resulted in three key impacts as follows: (1) informing the national redesign of VA MOVE! including recommendations to increase the number of MOVE! sessions and revise guidelines across 150+ VA sites, (2) enhancing the national evidence base to support online DPP delivery options with citations in national care guidelines outside VA, and (3) demonstrating the importance of gender-tailoring of preventive care services by and for women Veterans to enhance engagement in preventive services. Over the past decade, the evolution of VA QUERI DPP projects increased the reach of and engagement in diabetes prevention services among Veterans, including women Veterans who have been harder to engage in lifestyle change programs in VA, and resulted in three key impacts informing type 2 diabetes and obesity prevention efforts within and outside of VA.

Implementing an evidence-based behavioral weight-loss program in community mental health centers: A randomized pilot study.

Obesity is a leading cause of preventable death among individuals with serious mental illness (SMI). A prior randomized controlled trial demonstrated the efficacy of a lifestyle style intervention tailored to this population; however, such interventions need to be adapted and tested for real-world settings. This study evaluated implementation interventions to support community mental health program staff to deliver an evidence-based lifestyle intervention to clients with obesity and SMI. In this cluster-randomized pilot trial, the standard arm combined multimodal training with organizational strategy meetings and the enhanced arm included all standard strategies plus performance coaching. Staff-coaches delivered a 6-month group-based lifestyle intervention to clients with SMI. Primary outcomes were changes in staff knowledge, self-efficacy, and fidelity scores for lifestyle intervention delivery. Linear mixed-effects modeling was used to analyze outcomes, addressing within-site clustering and within-participant longitudinal correlation of outcomes. Three sites were in the standard arm (7 staff-coaches); 5 sites in the enhanced arm (11 staff-coaches). All sites delivered all 26 modules of the lifestyle intervention. Staff-coaches highly rated the training strategy's acceptability, feasibility and appropriateness. Overall, mean knowledge score significantly increased pre-post by 5.5 (95% CI: 3.9, 7.1) and self-efficacy was unchanged; neither significantly differed between arms. Fidelity ratings remained stable over time and did not differ between arms. Clients with SMI achieved a mean 6-month weight loss of 3.8 kg (95% CI: 1.6, 6.1). Mental health staff delivering a lifestyle intervention was feasible using multicomponent implementation interventions, and preliminary results show weight reduction among clients with SMI. The addition of performance coaching did not significantly change outcomes. Future studies are needed to definitively determine the effect on client health outcomes.

Culinary Medicine: Needs and Strategies for Incorporating Nutrition into Medical Education in the United States.

In the past decade, medical education has increasingly incorporated evidence-based lifestyle interventions as primary strategies for preventing and managing noncommunicable diseases. This shift embraces the growing recognition of the significant impact of lifestyle on health outcomes, driving diseases including obesity, diabetes, heart disease, and cancer. Now deemed "food is medicine" (FIM), diet-related interventions witnessed integration into healthcare systems and recognition in the United States' White House Conference on Hunger, Nutrition, and Health in 2023. As FIM gains traction, investigating optimal strategies for team-based education becomes essential. Healthcare teams need the necessary knowledge and tools to effectively administer FIM services and collaborate across disciplines, ultimately enhancing disease prevention, chronic disease management, health quality, value, and overall wellness. Culinary medicine (CM), a vital component of FIM, bridges nutrition education, pragmatic culinary skills, and conventional strategies to improve chronic disease management. CM involves experiential learning, imparts practical skills, and encourages behavior change by addressing food-related determinants of health and promoting equitable access. Teaching kitchens serve as physical or virtual learning spaces and as a didactic and experiential method (skills lab), playing a crucial role by integrating culinary, lifestyle, integrative, and conventional medicine. A growing number of medical schools in the United States and globally offer CM education via diverse methods including interest groups, electives, and specialty tracks, encompassing didactic sessions, hands-on kitchen education, and virtual teaching methods. Given the rising demand for CM programs, this article aims to describe, map, and compare existing CM education types in medical education. It provides actionable recommendations for medical schools to establish and expand CM programs by fostering service-learning partnerships, clinical innovation, and interdisciplinary research. As FIM gains prominence, cultivating a robust foundation of educational strategies is vital to ensure seamless integration into both medical education and collaborative medical practice.

Conducting Photovoice With Binational Cancer Survivors to Identify Health Behavior Change Intervention Preferences

Abstract: Background: Culturally adapted behavior interventions are needed to support lifestyle behavior change for survivors of cancer. Objectives: To identify programming preferences of Mexicanorigin female survivors of breast cancer living on the U.S./Mexico border. Methods: We conducted a nine-week photovoice project with survivors of breast cancer in Nogales, Sonora/Arizona exploring viewpoints on food and dietary habits, wellness activities, and preferences for healthy lifestyle intervention programming. Photovoice, a participatory qualitative research technique, provided participants with research skills to document and share their lived experience through photographs. Weekly sessions began with photograph presentations and concluded with group discussion of common themes. Data were analyzed following a thematic content analysis using session notes and written narratives compiled during discussion sessions. Results: Survivors ( n = 6) worked collaboratively with facilitators to identify themes related to diet and physical activity behavior. Connection between food and culture and the importance of enjoying meals with others was emphasized. Primary activity interests included leisure-time recreation that relieved anxiety related to their cancer diagnosis rather than regimented exercise routines. Participants noted the importance of giving and receiving social support and emphasized altruism to support positive mood and self-efficacy during survivorship. Networking and knowledge sharing were considered valuable. Conclusions: Our findings highlight the importance of collaborative research such as photovoice to gain insights for adaptation of evidence-based lifestyle interventions for Mexican-origin survivors of cancer. Key adaptation considerations include culturally relevant dietary preferences and patterns, physical activities with a strong mind-body component, and opportunities for social engagement and experience sharing.

30,000 Feet Overview of Lifestyle Medicine

Chronic diseases account for the highest morbidity and mortality among adults and, increasingly, adolescents and young adults in the United States. This imposes great economic stress on the healthcare system. Chronic diseases can largely be attributed to several key harmful lifestyle behaviors, including poor diet, low physical activity, substance abuse, and stress, to mention just a few. Recent research demonstrates that sustained healthy lifestyle behaviors can not only prevent and treat but may even reverse many of these chronic diseases. The American College of Lifestyle Medicine (ACLM) defines Lifestyle Medicine (LM) as "the use of evidence-based lifestyle therapeutic intervention—including a whole-food, plant-predominant eating pattern, regular physical activity, restorative sleep, stress management, avoidance of risky substances, and positive social connection—as a primary modality, delivered by clinicians trained and certified in this specialty, to prevent, treat, and often reverse chronic disease.” ACLM has worked to establish and update LM core competencies over the last decade. Many training programs have adopted evidence-based LM didactic and clinical training across various health professions students to ensure trainees meet these competencies. We aim to provide a brief overview of LM, discuss the six pillars of LM: nutrition, physical activity, avoidance of risky substances, restorative sleep, stress reduction, and positive social connection, and discuss their significance in wellness from the patient’s and the physician’s perspectives.

Abstract P377: The Restore Health Equity Research Network: An American Heart Association-Funded Initiative to Prevent Hypertension in Black Communities

Introduction: The RESTORE Network is an American Heart Association-funded health equity research network that is testing the implementation of evidence-based interventions for hypertension prevention in community settings. The goals are to: (1) Work with Black communities to mitigate the negative impact of social determinants of health on blood pressure (BP) in Black adults; (2) Develop and test strategies for implementing evidence-based lifestyle interventions in Black communities; (3) Disseminate findings to policy makers, payors and stakeholders to promote adoption of effective hypertension prevention strategies in Black communities; and (4) Train early-career scientists in health equity and hypertension research. Methods: RESTORE Network investigators across eight institutions are conducting five hybrid implementation-effectiveness trials to test scalable, sustainable, and potentially cost-effective implementation strategies to mitigate adverse social determinants of health that contribute to the high prevalence of hypertension in Black communities. The implementation strategies include the use of: 1) trained community health workers (Alabama, Baltimore, Detroit); 2) community-based organizations as portals of food access and patient navigation (New York City, Alabama, Boston, Detroit); 3) patient activation via home BP monitoring (Baltimore); and 4) digital technologies (Baltimore, Detroit). The social determinants of health targeted are: poor access to care, low health literacy, food insecurity, barriers to physical activity, neighborhood deprivation, under-insurance, and inadequate linkage to medical and social services. The five projects are based on the National Institute on Minority Health and Health Disparities (NIMHD) Research Framework, and evaluation of each implementation strategy is guided by the RE-AIM (Reach, Effectiveness, Adoption, Implementation and Maintenance) implementation research framework. The projects are supported by five highly-integrated cores (BP Measurement, Statistical, Intervention, Community Engagement, Training). RESTORE will advance the career of early stage investigators in hypertension, health equity, implementation science and community-engaged research; trainees will work on network projects, develop their own projects, complete rotations across network sites, and attend lectures and workshops. Synergy across projects will facilitate economic and scale-up analyses to inform policy makers on the strategies being tested. Discussion: The RESTORE Network will advance health equity in the U.S. by identifying community-driven, sustainable and effective implementation strategies to deliver lifestyle interventions that prevent hypertension in Black adults. The strong infrastructure of the network will support new collaborations and ancillary studies that are aligned with our mission.

Adaptation and study protocol of the evidence-based Make Better Choices (MBC2) multiple diet and activity change intervention for a rural Appalachian population

BackgroundRural Appalachian residents experience among the highest prevalence of chronic disease, premature mortality, and decreased life expectancy in the nation. Addressing these growing inequities while avoiding duplicating existing programming necessitates the development of appropriate adaptations of evidence-based lifestyle interventions. Yet few published articles explicate how to accomplish such contextual and cultural adaptation.MethodsIn this paper, we describe the process of adapting the Make Better Choices 2 (MBC2) mHealth diet and activity randomized trial and the revised protocol for intervention implementation in rural Appalachia. Deploying the NIH’s Cultural Framework on Health and Aaron’s Adaptation framework, the iterative adaptation process included convening focus groups (N = 4, 38 participants), conducting key informant interviews (N = 16), verifying findings with our Community Advisory Board (N = 9), and deploying usability surveys (N = 8), wireframing (N = 8), and pilot testing (N = 9. This intense process resulted in a comprehensive revision of recruitment, retention, assessment, and intervention components. For the main trial, 350 participants will be randomized to receive either the multicomponent MBC2 diet and activity intervention or an active control condition (stress and sleep management). The main outcome is a composite score of four behavioral outcomes: two outcomes related to diet (increased fruits and vegetables and decreased saturated fat intake) and two related to activity (increased moderate vigorous physical activity [MVPA] and decreased time spent on sedentary activities). Secondary outcomes include change in biomarkers, including blood pressure, lipids, A1C, waist circumference, and BMI.DiscussionAdaptation and implementation of evidence-based interventions is necessary to ensure efficacious contextually and culturally appropriate health services and programs, particularly for underserved and vulnerable populations. This article describes the development process of an adapted, community-embedded health intervention and the final protocol created to improve health behavior and, ultimately, advance health equity.Trial registrationClinicalTrials.gov Identifier NCT04309461. The trial was registered on 6/3/2020.

A comparative review of nutrition education intervention duration and impact on reduction of prediabetes or Type 2 diabetes mellitus among adults aged 45 years or older.

Prediabetes and Type 2 diabetes mellitus (T2DM) is increasingly prevalent and both conditions have a variety of comorbidities. There are many programs aimed at the reduction or prevention of prediabetes and/or T2DM. However, only a few studies have evaluated the effect of intervention duration and evidence-based frameworks on specific populations at risk for prediabetes or T2DM. This review evaluated evidence-based lifestyle intervention programs to determine whether the duration of programming relates to the efficacy of evidence-based lifestyle change interventions. The aim was to assess relevant outcomes of these interventions in prediabetic or T2DM individuals aged 45 and older. The PRISMA framework was followed. Searches systematically screened and evaluated 2654 articles. Thirteen articles met the inclusion/exclusion criteria. Databases searched included: PubMed; SCOPUS; ProQuest; Biomed Central; SpringerLink; ScienceDirect; EBSCOHost; JSTOR; Taylor & Francis; Wiley Online; BioOne; CINAHL; SAGE Journal; and Google Scholar (2009-2022). Identifying the most effective timeframe for lifestyle intervention programming to reduce the risks associated with prediabetes/T2DM can help providers develop appropriate educational initiatives for patients at risk for pre-diabetes and/or T2DM. After screening, there were 13 studies which met the review criteria. All of the studies included in this comparative review used evidence-based interventions. Evidence-based lifestyle intervention programs that are ≥12 months produced significant and consistent results in mediating outcomes related to prediabetes/T2DM than <12-month programs in adults aged 45 years and older.

Evaluating environmental and inhibitory control strategies to improve outcomes in a widely available weight loss program

BackgroundAlthough many people try to lose weight, a large proportion of individuals do not achieve clinically significant weight loss. Nonresponse and relapse rates in lifestyle interventions are largely explained by challenges in avoiding or resisting temptation in the context of omnipresent food access. Innovative enhancement strategies are needed to help individuals manage temptation in evidence-based lifestyle interventions. MethodsThis prospective, four-parallel-arm, randomized controlled trial tests the efficacy of two weight management enhancement strategies on weight and dietary outcomes among individuals with overweight or obesity: (1) an environmental control strategy combining modification of the home food environment and grocery delivery (AVOID) and (2) an impulse control strategy involving daily, gamified inhibitory control training (RESIST). Women and men (n = 500) with overweight or obesity (Body Mass Index between 25 and 40.0 kg/m2) will be enrolled in a 12-month commercial weight-loss program (WW, formerly Weight Watchers©) and randomly assigned to one of four conditions: (1) WW alone, (2) WW + AVOID, (3) WW + RESIST, or (4) WW + AVOID + RESIST. Anthropometric, dietary, cognitive, and household food environment assessments will be conducted in English or Spanish at enrollment and at 6- and 12-month follow-up. DiscussionThis research addresses the pragmatic question of how to best optimize behavior change: Should we modify the choice environment, strengthen individuals' self-regulation, or both, to maximize behavior change? This work can inform the development of enhancement strategies to promote adherence to lifestyle recommendations and other impulse control challenges.

Association of dietary risks, behavioural and lifestyle factors, and the magnitude of disability burden among Australian cancer patients: An observational epidemiology study

BackgroundCancer patients are confronted with a variety of other health-related issues, including physical disability, poor quality of life, and psychological challenges. This study aims to quantify the association of dietary, behavioural and lifestyle risk factors and comorbidities on the magnitude and distribution of disability burden among cancer patients in Australia. MethodsThis study comprised a sample of 2283 cancer patients drawn from the latest nationwide Australian National Health Survey conducted in 2017–18. Negative binomial regression models were used to estimate the incidence rate ratio (IRR) of the number of disabilities and its associations. ResultsForty-five percent of cancer patients experienced at least one disability. The magnitude of disability was significantly associated with sugar-sweetened drink consumption ≥ 3 days per week (IRR= 1.12, 95% CI: 1.02–1.26), a lack of physical activity (IRR = 1.69, 1.38–2.07), frequent or regular alcohol consumption (IRR = 1.95, 1.84–2.08), poor health status (IRR = 1.99, 1.78–2.24) and the presence of five or more chronic comorbid conditions (IRR = 3.59, 2.90–4.46). Cancer patients who consumed vegetables at least two or more times per day had a 10% lower risk of disability burden (IRR = 0.90, 0.82–0.99). ConclusionsThis study shows the association of diet, behavioural, and lifestyle risk factors on the degree of disability burden among cancer patients, highlighting the need for bold and effective policies. The findings will inform the implementation of evidence-based lifestyle interventions and offer a foundation for evaluating their influence on cancer survivors’ health.

Survey of CDC-recognized community pharmacies providing the National Diabetes Prevention Program and impact of the COVID-19 pandemic on program delivery

BackgroundThe Centers for Disease Control and Prevention (CDC) established the National Diabetes Prevention Program (NDPP) to prevent type 2 diabetes using an evidence-based lifestyle intervention program provided by community- and health care–based organizations, including community pharmacies. ObjectivesThis study aimed to characterize CDC-recognized community pharmacies offering NDPP and determine the impact of the coronavirus disease 2019 (COVID-19) pandemic on program delivery. MethodsA list of CDC-recognized community pharmacies offering NDPP was obtained from the CDC Registry of Recognized Programs on September 19, 2020. A 23-question cross-sectional survey was created to obtain information about program inception, delivery, recruitment, enrollment, program evaluation, reimbursement, and the impact of the COVID-19 pandemic. Each pharmacy was contacted via telephone using a standardized script and invited to complete the survey over the phone or online. A follow-up e-mail was then sent approximately 2 weeks later to pharmacies that had not responded. ResultsA total of 73 community pharmacies were identified in the CDC registry. Of the 64 eligible community pharmacies, 42% (n = 27) completed the survey. Most community pharmacies offering NDPP were in the Southeastern (41%) and Midwestern (22%) regions of the United States. A majority were independent pharmacies (78%) and had “pending” CDC recognition status (74%). Program delivery primarily occurred in the pharmacy (48%) or in a hybrid model (26%). Most programs were not submitting reimbursement claims (74%) and did not charge participants (82%). Nearly two-thirds of pharmacies (63%) strongly agreed that COVID-19 had significantly affected their programs, yet most (67%) continued to offer NDPP during the pandemic. ConclusionTo our knowledge, this is the first characterization of CDC-recognized community pharmacies providing NDPP. Best practices for implementing NDPP at community pharmacies warrant further exploration and models to ensure long-term sustainability. COVID-19 affected most community pharmacies providing NDPP, but the majority continued to offer NDPP during the pandemic.

Health Promotion Among Mexican-Origin Survivors of Breast Cancer and Caregivers Living in the United States-Mexico Border Region: Qualitative Analysis From the Vida Plena Study.

BackgroundHispanic survivors of cancer experience increased cancer burden. Lifestyle behaviors, including diet and physical activity, may reduce the cancer burden. There is limited knowledge about the posttreatment lifestyle experiences of Hispanic survivors of cancer living on the United States–Mexico border.ObjectiveThis study aims to support the development of a stakeholder-informed, culturally relevant, evidence-based lifestyle intervention for Mexican-origin Hispanic survivors of cancer living in a border community to improve their dietary quality and physical activity.MethodsSemistructured interviews with 12 Mexican-origin Hispanic survivors of breast cancer and 7 caregivers were conducted through internet-based teleconferencing. The interviews explored the impact of cancer on lifestyle and treatment-related symptoms, perception of lifestyle as an influence on health after cancer, and intervention content and delivery preferences. Interviews were analyzed using a deductive thematic approach grounded in the Quality of Cancer Survivorship Care Framework.ResultsKey survivor themes included perception of Mexican diet as unhealthy, need for reliable diet-related information, perceived benefits of physical activity after cancer treatment, family support for healthy lifestyles (physical and emotional), presence of cancer-related symptoms interfering with lifestyle, and financial barriers to living a healthy lifestyle. Among caregivers, key themes included effects of the cancer caregiving experience on caregivers’ lifestyle and cancer-preventive behaviors and gratification in providing support to the survivors.ConclusionsThe interviews revealed key considerations to the adaptation, development, and implementation of a theory-informed, evidence-based, culturally relevant lifestyle program to support lifestyle behavior change among Mexican-origin Hispanic survivors of cancer living in border communities. Our qualitative findings highlight specific strategies that can be implemented in health promotion programming aimed at encouraging cancer protective behaviors to reduce the burden of cancer and comorbidities in Mexican-origin survivors of cancer living in border communities.

Abstract PO-033: Qualitative analysis of the lifestyle programming preferences of Mexican-origin breast cancer survivors and cancer caregivers living on the U.S./Mexico border

Abstract Introduction: Hispanics face unique challenges after cancer treatment, including less cancer survivorship knowledge, lower quality of life, higher comorbid conditions, and socioeconomic disadvantages. Using a community-based participatory approach, we engaged in a qualitative exploration of lifestyle-related behaviors and behavior modifiers of Mexican-origin breast cancer survivors and their caregivers living in a border community to inform the development and implementation of an evidence-based lifestyle intervention to reduce cancer burden and metabolic co-morbidities. Methods: The study was conducted through a community-academic partnership (La Vida Plena) between the University of Arizona and Mariposa Community Health Center located on the Arizona/Mexico border. Eligibility criteria for cancer survivors included 1) self-identification as Hispanic and 2) cancer diagnosis in the previous 15 years. For cancer caregivers, eligibility criteria included 1) self-identification as a caregiver for an individual with cancer. Participants completed a questionnaire querying diet and physical activity behaviors pre- and post-cancer diagnosis. Semi-structured interviews included ten open-ended questions related to the impact of cancer on lifestyle, perceptions of lifestyle and health after cancer, and intervention content/delivery. Interviews were transcribed and analyzed using a deductive thematic approach grounded by the Cancer Survivorship Care Quality Framework. Results: A total of 23 participants were recruited with 19 (n=12 cancer survivors, n=7 caregivers) completing the study. Mean age was 55.6 ± 12.5 years and 41.1 ± 15.3 years for cancer survivors and caregivers, respectively. All survivors experience at least one comorbid condition with 58% experiencing 4 or more comorbid conditions. Key themes identified among cancer survivors included: 1) family as an influence on lifestyle behaviors; 2) perception of the Mexican diet as unhealthy; 3) financial barriers for a healthy lifestyle; 4) the role and challenges of physical activity after cancer treatment; 5) impact of physical effects of treatment on lifestyle behaviors; and 6) challenges to obtaining accurate health-related information. Key themes among caregivers included: 1) effects of the cancer experience on caregiver's lifestyle behaviors and 2) providing support to the survivor. Important considerations in adapting and developing lifestyle programming for border-dwelling cancer survivors include 1) access to content experts, 2) support with the management of physical symptoms, 3) inclusion of written materials, 4) incorporation of family in the program, and 5) inclusion of cancer survivor support groups. Conclusion: This study identified key concepts and themes important for the adaptation, development, and implementation of an evidence-based intervention supporting lifestyle behavior change to reduce the burden of cancer and comorbidities among cancer survivors and their caregivers living along the U.S./Mexico border. Citation Format: Samantha J. Werts, Melissa Lopez-Pentecost, Meghan Skiba, Rosi Vogel, Maia Ingram, Tatiana Enriquez, Lizzie Garcia, Cynthia Thomson. Qualitative analysis of the lifestyle programming preferences of Mexican-origin breast cancer survivors and cancer caregivers living on the U.S./Mexico border [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-033.

Exploring Interest in and Feasibility of a Lifestyle Intervention for Multiple Myeloma Patients

Exploring Interest in and Feasibility of a Lifestyle Intervention for Multiple Myeloma Patients