Event-related Potential Method Research Articles

Study on averaging method of event related potentials under noise

Open offices that make effective use of limited space and encourage dialogue, interaction, and collaboration among employees, are becoming an increasingly. However, productive work-related conversation might actually decrease the performance of other employees within earshot more so than other random, meaningless noises. The presence of noise during the performance of cognitive tasks involving such as memory, commonly causes a subjective experience of annoyance, which can lead to a decline in performance. This tendency is stronger in response to meaningful noise, such as music and conversation, than for meaningless noise, such as the sound of traffic, and heating ventilating and air-conditioning noise. It is well known that the Event-Related Potential (ERP) in the brain wave elicited by internal or external stimuli are related to the operation of selective attention. The present experiment was designed to determine the effects of the noise on ERPs in the auditory odd-ball paradigms. In order to examined differences in the ERP components due to the noise, performance of algorithm for estimating waveform of ERPs such as averaging method is evaluated.

Electrophysiological analysis of signal detection outcomes emphasizes the role of decisional factors in recognition memory.

Event-related potential (ERP) studies have identified two time windows associated with recognition memory and interpreted them as reflecting two processes: familiarity and recollection. However, using relatively simple stimuli and achieving high recognition rates, most studies focused on hits and correct rejections. This leaves out some information (misses and false alarms) that according to Signal Detection Theory (SDT) is necessary to understand signal processing. We used a difficult visual recognition task with colored pictures of different categories to obtain enough of the four possible SDT outcomes and analyzed them with modern ERP methods. Non-parametric analysis of these outcomes identified a single time window (470 to 670 ms) which reflected activity within fronto-central and posterior-left clusters of electrodes, indicating differential processing. The posterior-left cluster significantly distinguished all STD outcomes. The fronto-central cluster only distinguished ERPs according to the subject's response: yes vs. no. Additionally, only electrophysiological activity within the posterior-left cluster correlated with the discrimination index (d'). We show that when all SDT outcomes are examined, ERPs of recognition memory reflect a single-time window that may reveal a bottom-up factor discriminating the history of items (i.e. memory strength), as well as a top-down factor indicating participants' decision.

Multivariate pattern analysis of EEG reveals nuanced impact of negation on sentence processing in the N400 and later time windows.

The neurocognitive mechanism underlying negation processing remains controversial. While negation is suggested to modulate the access of word meaning, no such evidence has been observed in the event-related potential (ERP) literature on sentence processing. In the current study, we applied both univariate ERP and multivariate pattern analysis (MVPA) methods to examine the processing of sentence negation. We investigated two types of negative congruent/incongruent sentence pairs with truth-value evaluation (e.g., "A robin is a/not a bird") and without (e.g., "The woman reads a/no book"). In the N400 time window, ERPs consistently showed increased negativity for negative and incongruent conditions. MVPA, on the other hand, revealed nuanced interactions between polarity and congruency. In the later P600 time window, MVPA but not the ERPs revealed an effect of congruency, which may be functionally distinct from the N400 window. We further used cross-decoding to show that the cognitive processes underlying the N400 window for both affirmative and negative sentences are comparable, whereas in the P600 window, only for the truth sentences, negative sentences showed a distinct pattern from their affirmative counterparts. Our results thus speak for a more interactive, but nevertheless serial and biphasic, and potentially construction-specific processing account of negation. We also discuss the advantage of applying MVPA in addition to the classical univariate methods for a better understanding of the neurobiology of negation processing and language comprehension alike.

Media Neuroscience on a Shoestring

Abstract: Event-related potentials (ERPs) capture neural responses to media stimuli with a split-second resolution, opening the door to examining how attention modulates the reception process. However, the relatively high cost and difficulty of incorporating ERP methods have prevented broader adoption. This study tested the potential of a new mobile, relatively easy-to-mount, and highly affordable device for electroencephalography (EEG) measurement – the Muse EEG system – combined with a free, open-source platform for ERP recording and analysis. Specifically, we compared ERPs with affective visual stimuli – representative of the kind of engaging content that pervades modern social media. Our results confirm that the Muse system provides robust visual ERPs, highly reliable across two samples. Although there was no difference between ERPs to moderately positive and neutral stimuli in the expected time windows (200–300 ms, 400–600 ms), an exploratory analysis provided some evidence for differential processing of positive versus neutral images at the right temporal sensor site (TP10). Additionally, a compliance-gaining manipulation in participant instructions significantly improved data quality. These results support the use of the Muse EEG system in large-scale studies examining brain responses to screen media. They also suggest an easy social influence tactic that can enhance data quality as communication neuroscience is scaled up. The availability of a mobile EEG system for 250 USD makes it possible to incorporate neuroimaging into various communication paradigms beyond visual communication.

A single-session behavioral protocol for successful event-related potential recording in children with neurodevelopmental disorders.

Event-related potentials (ERPs) are an ideal tool for measuring neural responses in a wide range of participants, including children diagnosed with neurodevelopmental disorders (NDDs). However, due to perceived barriers regarding participant compliance, much of this work has excluded children with low IQ and/or reduced adaptive functioning, significant anxiety symptoms, and/or sensory processing difficulties, including heterogeneous samples of children with autism spectrum disorder (ASD) and children with fragile X syndrome (FXS). We have developed a behavioral support protocol designed to obtain high-quality ERP data from children in a single session. Using this approach, ERP data were successfully collected from participants with ASD, FXS, and typical development (TD). Higher success rates were observed for children with ASD and TD than children with FXS. Unique clinical-behavioral characteristics were associated with successful data collection across these groups. Higher chronological age, nonverbal mental age, and receptive language skills were associated with a greater number of valid trials completed in children with ASD. In contrast, higher language ability, lower autism severity, increased anxiety, and increased sensory hyperresponsivity were associated with a greater number of valid trials completed in children with FXS. This work indicates that a "one-size-fits-all" approach cannot be taken to ERP research on children with NDDs, but that a single-session paradigm is feasible and is intended to promote increased representation of children with NDDs in neuroscience research through development of ERP methods that support inclusion of diverse and representative samples.

An Investigation of a Frontal Negative Slow Wave in a Virtual Hedonic Purchase Task.

There is a connection between the frontal negative slow wave (FNSW) and the arousal inhibition in the hedonic purchase context. To calculate the FNSW (400–800 ms), event-related potentials (ERPs) method was applied to depict the neural substrates on prudent and impulsive consumers’ behaviors within various states of promotion. Promotion types include the pure price promotion and the mixed promotion (a mixture of a charitable donation and a discount). Behaviorally, consumers response more quickly in the pure price promotion condition and they express a preference for the mixed promotion. More importantly, a larger FNSW emerged in the impulsive consumers than the prudent, suggesting that the former might tend to control their eagerness to consume hedonic items. Compared with the price promotion as the worse option, the mixed promotion as the better option caused more perceptual conflict, leading to an increase in N2 amplitude. It suggests that consumers incline to reject the worse offers. These results also reveal that people primarily have to search negative promotion information by their insight and subsequently impulsive consumers inhibit the responses to the promotion information. The method of ERPs and FNSW should be helpful for marketing researchers and professionals on hedonic consumption and sales promotion.

Investigation of Tactile Perception Evoked by Ridged Texture Using ERP and Non-linear Methods.

The triangular ridged surface can improve the grip reliability of products, but the sharp edge of triangular ridge induces sharp and uncomfortable feeling. To study the effect of edge shape (sharp, round, and flat shape) of triangular ridges on brain activity during touching, electroencephalograph (EEG) signals during tactile perception were evaluated using event-related potentials (ERP) and non-linear analysis methods. The results showed that the early component of P100 and P200, and the late component of P300 were successfully induced during perceiving the ridged texture. The edge shape features affect the electrical activity of brain during the tactile perceptions. The sharp shape feature evoked fast P100 latency and high P100 amplitude. The flat texture with complex (sharp and flat) shape feature evoked fast P200 latency, high P200 amplitude and RQA parameters. Both of the sharp shape and complex shape feature tended to evoke high peak amplitude of P300. The large-scale structures of recurrence plots (RPs) and recurrence quantification analysis (RQA) parameters can visually and quantitatively characterize the evolution regulation of the dynamic behavior of EEG system along with the tactile process. This study proved that RPs and RQA were protential methods for the feature extraction and state recognition of EEG during tactile perception of textured surface. This research contributes to optimize surface tactile characteristics on products, especially effective surface textures design for good grip.

Enhanced contralateral theta oscillations and N170 amplitudes in occipitotemporal scalp regions underlie attentional bias to fearful faces

Attending toward fearful faces and other threatening stimuli increase the chance of survival. The dot-probe task is a commonly used measure of spatial attention. Event-related potentials (ERPs) have been found to be a reliable measure of attentional bias. The dot-probe literature suggests that posterior contralateral N170 amplitudes are more enhanced by fearful faces compared to ipsilateral amplitudes. However, ERP methods remove non-phase locked frequencies, which provides additional information about neural activity. Specifically, theta oscillations (5–7 Hz) have been linked to attentional processing. The purpose of this study was to examine the relationship between posterior contralateral theta oscillations and N170 amplitudes in the dot-probe task. A modified dot-probe task was used with fear and neutral facial expressions and EEG data was recorded from 33 electrodes. The ERP and time-frequency data were extracted from the P7 and P8 electrodes (left and right occipitotemporal regions). This study found enhanced N170 amplitude and theta oscillations in the electrodes posterior contralateral to the fearful face. Contralateral N170 amplitudes and theta oscillations were related such that greater N170 amplitudes were associated with greater theta oscillations. The results indicated that increased contralateral N170 and theta oscillations are related to each other and underlie attentional bias to fearful faces.

From full calibration to zero training for a code-modulated visual evoked potentials for brain–computer interface

Objective. Typically, a brain–computer interface (BCI) is calibrated using user- and session-specific data because of the individual idiosyncrasies and the non-stationary signal properties of the electroencephalogram (EEG). Therefore, it is normal for BCIs to undergo a time-consuming passive training stage that prevents users from directly operating them. In this study, we systematically reduce the training data set in a stepwise fashion, to ultimately arrive at a calibration-free method for a code-modulated visually evoked potential (cVEP)-based BCI to fully eliminate the tedious training stage. Approach. In an extensive offline analysis, we compare our sophisticated encoding model with a traditional event-related potential (ERP) technique. We calibrate the encoding model in a standard way, with data limited to a single class while generalizing to all others and without any data. In addition, we investigate the feasibility of the zero-training cVEP BCI in an online setting. Main results. By adopting the encoding model, the training data can be reduced substantially, while maintaining both the classification performance as well as the explained variance of the ERP method. Moreover, with data from only one class or even no data at all, it still shows excellent performance. In addition, the zero-training cVEP BCI achieved high communication rates in an online spelling task, proving its feasibility for practical use. Significance. To date, this is the fastest zero-training cVEP BCI in the field, allowing high communication speeds without calibration while using only a few non-invasive water-based EEG electrodes. This allows us to skip the training stage altogether and spend all the valuable time on direct operation. This minimizes the session time and opens up new exciting directions for practical plug-and-play BCI. Fundamentally, these results validate that the adopted neural encoding model compresses data into event responses without the loss of explanatory power compared to using full ERPs as a template.

Event-related components are structurally represented by intrinsic event-related potentials

The detection of event-related potentials (ERPs) through electroencephalogram (EEG) analysis is a well-established method for understanding brain functions during a cognitive process. To increase the signal-to-noise ratio (SNR) and stationarity of the data, ERPs are often filtered to a wideband frequency range, such as 0.05–30 Hz. Alternatively, a natural-filtering procedure can be performed through empirical mode decomposition (EMD), which yields intrinsic mode functions (IMFs) for each trial of the EEG data, followed by averaging over trials to generate the event-related modes. However, although the EMD-based filtering procedure has advantages such as a high SNR, suitable waveform shape, and high statistical power, one fundamental drawback of the procedure is that it requires the selection of an IMF (or a partial sum of a range of IMFs) to determine an ERP component effectively. Therefore, in this study, we propose an intrinsic ERP (iERP) method to overcome the drawbacks and retain the advantages of event-related mode analysis for investigating ERP components. The iERP method can reveal multiple ERP components at their characteristic time scales and suitably cluster statistical effects among modes by using a tailored definition of each mode’s neighbors. We validated the iERP method by using realistic EEG data sets acquired from a face perception task and visual working memory task. By using these two data sets, we demonstrated how to apply the iERP method to a cognitive task and incorporate existing cluster-based tests into iERP analysis. Moreover, iERP analysis revealed the statistical effects between (or among) experimental conditions more effectively than the conventional ERP method did.

Electrophysiological investigation of reward anticipation and outcome evaluation during slot machine play

Slot machines are a popular form of gambling, offering a tractable way to experimentally model reward processes. This study used a 3-reel slot paradigm to assess psychologically distinct phases of reward processing, reflecting anticipation, and early- and late-stage outcome processing. EEG measures of winning, nearly missing (a losing outcome revealed at the final, third reel), and “totally” missing (a losing outcome revealed earlier, at the second reel) were collected from healthy adults (n=54). Condition effects were evaluated in: i) event-related potential (ERP) components reflecting anticipatory attention (stimulus preceding negativity, SPN) and outcome processing (reward positivity, RewP and late-positive potential, LPP) and ii) total power and phase synchrony of theta and delta band oscillations. Behaviorally, trial initiation was fastest after a near miss outcome and slowest after a winning outcome. As expected, a significant SPN was observed for possible wins (AA) vs. total misses (AB), consistent with reward anticipation. Larger win (AAA) vs. near miss (AAB) amplitudes were observed for the RewP; LPP amplitudes were largest for wins (AAA), intermediate for near misses (AAB), and smallest for total misses (ABC), reflecting significant early (RewP) and late-stage (LPP) outcome processing effects. There was an effect of reel position on the RewP, with larger amplitude in the final reel (AAA-AAB) relative to the 2nd-reel locked difference waves (AA-AB). Across all outcomes, near misses elicited the largest and most phase-synchronized theta responses, while wins elicited larger and more phase-synchronized delta responses than total misses, with delta band measures not distinguishing between near misses and wins. . Phase locking measures contrasting win vs. near miss delta and theta synchronization, within time windows corresponding to ERP measurements, covaried with RewP, but not SPN or LPP, amplitude. Lastly, EEG measures showed differential relationships with age and self-reported consummatory pleasure. In the context of slot machine play, where reward anticipation and attainment place minimal demands on effort and skill, ERP and time-frequency methods capture distinct neurophysiological signatures of reward anticipation and outcome processing.

Form and Motion in Biological Motion Perception: An Event-related Potential Paradigm

Point-light biological motion (PL-BM) is a complex stimulus that comprises interrelated form and motion cues. Despite the inherently dynamic nature of PL-BM, much remains to be understood about the temporal aspects of BM perception. The event-related potential (ERP) technique provides excellent temporal resolution, but typically involves time-locking to overall stimulus onset, which can make it challenging to explore subtler and ongoing aspects of processing, especially for dynamic stimuli. Here, we developed a novel variant of the ERP method, which features applying sparse visual events onto continuously presented, dynamic PL-BM stimuli. Subjects viewed PL-BM stimuli depicting locomotion with black dots corresponding to the joints of a moving body. A brief contrast reversal (i.e., change to white dots) is then applied to individual frames of the stimulus at an average rate of 3/s, with the goal of inducing a feed-forward wave of visual processing without disturbing the continuity of the ongoing motion. Each trial featured either an intact or a spatially scrambled PL-BM animation matched for local motion and motion energy. Evoked responses to the contrast-reversals showed the expected visual ERP componentry and distribution, indicating the feasibility of the approach. Furthermore, the occipital P1 (90-110ms) and parietooccipital N1 (150-170ms) components were enhanced for intact vs. scrambled PLWs. Frame-level analyses showed that while the response to the stimulus onset could dominate evoked potentials to dynamic stimuli, our ERP paradigm provides a promising approach to study the temporal aspects of BM processing by acting as a probe to “catch the visual system in action.” Follow-up experiments using this paradigm will aim to inform how form and motion cues are processed and integrated during biological motion perception.

Pearl and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian Psychophysiology and Cognitive Neuroscience Society on methodological limits and clinical reliability-part II.

This review focuses on new and/or less standardized event-related potentials methods, in order to improve their knowledge for future clinical applications. The olfactory event-related potentials (OERPs) assess the olfactory functions in time domain, with potential utility in anosmia and degenerative diseases. The transcranial magnetic stimulation-electroencephalography (TMS-EEG) could support the investigation of the intracerebral connections with very high temporal discrimination. Its application in the diagnosis of disorders of consciousness has achieved recent confirmation. Magnetoencephalography (MEG) and event-related fields (ERF) could improve spatial accuracy of scalp signals, with potential large application in pre-surgical study of epileptic patients. Although these techniques have methodological limits, such as high inter- and intraindividual variability and high costs, their diffusion among researchers and clinicians is hopeful, pending their standardization.

Pearls and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian Psychophysiology and Cognitive Neuroscience Society on methodological limits and clinical reliability-part I.

Event-related potentials (ERPs) are obtained from the electroencephalogram (EEG) or the magnetoencephalogram (MEG, event-related fields (ERF)), extracting the activity that is time-locked to an event. Despite the potential utility of ERP/ERF in cognitive domain, the clinical standardization of their use is presently undefined for most of procedures. The aim of the present review is to establish limits and reliability of ERP medical application, summarize main methodological issues, and present evidence of clinical application and future improvement. The present section of the review focuses on well-standardized ERP methods, including P300, Contingent Negative Variation (CNV), Mismatch Negativity (MMN), and N400, with a chapter dedicated to laser-evoked potentials (LEPs). One section is dedicated to proactive preparatory brain activity as the Bereitschaftspotential and the prefrontal negativity (BP and pN). The P300 and the MMN potentials have a limited but recognized role in the diagnosis of cognitive impairment and consciousness disorders. LEPs have a well-documented usefulness in the diagnosis of neuropathic pain, with low application in clinical assessment of psychophysiological basis of pain. The other ERP components mentioned here, though largely applied in normal and pathological cases and well standardized, are still confined to the research field. CNV, BP, and pN deserve to be largely tested in movement disorders, just to explain possible functional changes in motor preparation circuits subtending different clinical pictures and responses to treatments.

Динамика вызванных потенциалов в процессе становления грамотности

Literacy is a complex and multidimensional phenomenon that has been well studied in psychology and pedagogy. Neurophysiologists try to understand the mechanisms of writing and reading acquisition by analyzing different linguistic processes. In this paper, we review the data that were revealed by using the event-related potentials (ERPs) method in the light of spelling, lexical, semantic and syntactic aspects of literacy, as well as changes in the components of ERPs in children and adults during language acquisition and in dyslexia, the most studied reading disorder. The ERPs method can help to understand both the general, universal neural underpinnings of literacy development and the unique features of different languages.

Bringing the brain into personality assessment: Is there a place for event-related potentials?

Advances in technology have provided opportunities to assess physiological correlates and further our understanding of a number of constructs, including personality traits. Event-related potentials (ERPs), scalp-recorded measures of brain activity with millisecond temporal resolution, show properties that make them potential candidates for integrating neurophysiological methods into personality research. Several commonly used ERPs have trait-like properties including test-retest stability approaching .8 over two weeks. Additionally, ERP methods are relatively inexpensive and tolerable compared to other neurophysiological methods (e.g., functional magnetic resonance imaging [fMRI]) making them easier to obtain sample sizes required for individual differences research. Finally, the tasks that elicit ERPs are flexible enough to allow researchers to customize the tasks to the psychological constructs of interest. These factors suggest that ERPs could potentially be useful in the study of personality and individual differences. A baseline approach to this line of inquiry is to examine the properties of ERPs as neurophysiological individual differences markers and probe their links to personality traits as assessed by self-report questionnaires. This article does this for three well-studied ERPs. Techniques commonly used in personality assessment research-but rarely in ERP research-were applied to these candidate ERPs to examine their psychometric properties and personality correlates. Overall, although ERPs show promising properties as neurophysiological indicators of individual differences, they were only marginally related with existing personality traits. Further research clarifying the ERPs measurement properties and potential links with known personality processes is needed. Finally, we list some strategies to further integrate these two areas of research. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Awareness of Emotional Expressions in Cannabis Users: An Event-Related Potential Study.

Cannabis use has been associated with anxiogenic effects when used in low frequency for a short duration, but cannabis can also have anxiogenic effects when used heavily for a long duration. Animal studies have indicated the neurobiological mechanisms related to cannabis and anxiety; however, research has been limited on the related neurocognitive mechanisms. Previous research has indicated that cannabis use is associated with alterations in event-related potentials (ERPs). The purpose of the current study was to examine anxiety related attentional processing of emotional expressions using ERP methods. We used a backward masking paradigm to restrict awareness of facial expressions (i.e., fearful, happy, and neutral). The results indicated that cannabis use was associated with differences in emotional processing. Specifically, the results suggested cannabis users had increased P1 amplitudes toward happy facial expressions compared to fearful and neutral. Additionally, cannabis users seemed to have reduced N170 hemisphere lateralization.

ERP/MMR Algorithm for Classifying Topic‐Relevant and Topic‐Irrelevant Visual Shots of Documentary Videos

We propose and evaluate a video summarization method based on a topic relevance model, a maximal marginal relevance (MMR), and discriminant analysis to generate a semantically meaningful video skim. The topic relevance model uses event‐related potential (ERP) components to describe the process of topic relevance judgment. More specifically, the topic relevance model indicates that N400 and P600, which have been successfully applied to the mismatch process of a stimulus and the discourse‐internal reorganization and integration process of a stimulus, respectively, are used for the topic mismatch process of a topic‐irrelevant video shot and the topic formation process of a topic‐relevant video shot. To evaluate our proposed ERP/MMR‐based method, we compared the video skims generated by the ERP/MMR‐based, ERP‐based, and shot boundary detection (SBD) methods with ground truth skims. The results showed that at a significance level of 0.05, the ROUGE‐1 scores of the ERP/MMR method are statistically higher than those of the SBD method, and the diversity scores of the ERP/MMR method are statistically higher than those of the ERP method. This study suggested that the proposed method may be applied to the construction of a video skim without operational intervention, such as the insertion of a black screen between video shots.

A Comparative Study of the Brain Mechanism of Metaphor between Chinese and English

The purpose of this study is to reveal the unique law and mechanism of Chinese metaphorical processing. This study adopts Event-Related Potential (ERP) to further explore the mechanism of metaphorical processing in Chinese brains by using cognitive linguistic experimental paradigm and three kinds of grammatical structures, such as sentences, idioms and phrases. ERP method has been widely used in the research of brain cognitive function in recent years with the advantage of high time resolution. We can capture the changes of ERP waves of millisecond level by using ERP recorder. From the statistical analysis of SPSS, the average accuracy of metaphor is more than 90%, and the average accuracy of non-metaphor is more than 90% too. It is found that metaphorical processing is not only performed in any hemisphere, but also presents the dynamic distribution from left brain to right brain according to the standard level and semantic distance.

Sensory and cross-network contributions to response inhibition in patients with schizophrenia.

Patients with schizophrenia show response inhibition deficits equal to or greater than those seen in impulse-control disorders, and these deficits contribute to poor outcome. However, little is known about the circuit abnormalities underlying this impairment. To address this, we examined stop signal task performance in 21 patients with schizophrenia and 21 healthy controls using event related potential (ERP) and resting state functional connectivity. Patients showed prolonged stop signal reaction time (SSRT) and reduced N1, N2, and P3 amplitudes compared to controls. Across groups, P3 amplitudes were maximal after SSRT (i.e., after the time associated with the decision to stop occurred), suggesting that this component indexed response monitoring. Multiple regression analyses showed that longer SSRTs were independently related to 1) patient status, 2) reduced N1 amplitude on successful stop trials and 3) reduced anticorrelated resting state functional connectivity between visual and frontoparietal cortical networks. This study used a combined multimodal imaging approach to better understand the network abnormalities that underlie response inhibition in schizophrenia. It is the first of its kind to specifically assess the brain's resting state functional architecture in combination with behavioral and ERP methods to investigate response inhibition in schizophrenia.