European Union Seventh Framework Research Articles

Genome-wide association meta-analyses of drug-resistant epilepsy.

Genome-wide association meta-analyses of drug-resistant epilepsy.

Physio-fUS: a tissue-motion based method for heart and breathing rate assessment in neurofunctional ultrasound imaging.

Physio-fUS: a tissue-motion based method for heart and breathing rate assessment in neurofunctional ultrasound imaging.

FGF21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgery

FGF21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgery

Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region

Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region

Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum

Eosinophilic and neutrophilic asthma defined by high levels of blood and sputum eosinophils and neutrophils exemplifies the inflammatory heterogeneity of asthma, particularly severe asthma. We analysed the serum and sputum proteome to identify biomarkers jointly associated with these different phenotypes. Proteomic profiles (N=1129 proteins) were assayed in sputum (n=182) and serum (n=574) from two cohorts (U-BIOPRED and ADEPT) of mild-moderate and severe asthma by SOMAscan. Using least absolute shrinkage and selection operator (LASSO)-penalised logistic regression in a stability selection framework, we sought sparse sets of proteins associated with either eosinophilic or neutrophilic asthma with and without adjustment for established clinical factors including oral corticosteroid use and forced expiratory volume. We identified 13 serum proteins associated with eosinophilic asthma, including 7 (PAPP-A, TARC/CCL17, ALT/GPT, IgE, CCL28, CO8A1, and IL5-Rα) that were stably selected while adjusting for clinical factors yielding an AUC of 0.84 (95% CI: 0.83-0.84) compared to 0.62 (95% CI: 0.61-0.63) for clinical factors only. Sputum protein analysis selected only PAPP-A (AUC=0.81 [95% CI: 0.80-0.81]). 12 serum proteins were associated with neutrophilic asthma, of which 5 (MMP-9, EDAR, GIIE/PLA2G2E, IL-1-R4/IL1RL1, and Elafin) complemented clinical factors increasing the AUC from 0.63 (95% CI: 0.58-0.67) for the model with clinical factors only to 0.89 (95% CI: 0.89-0.90). Our model did not select any sputum proteins associated with neutrophilic status. Targeted serum proteomic profiles are a non-invasive and scalable approach for subtyping of neutrophilic and eosinophilic asthma and for future functional understanding of these phenotypes. U-BIOPRED has received funding from the Innovative Medicines Initiative (IMI) Joint Undertaking under grant agreement no. 115010, resources of which are composed of financial contributions from the European Union's Seventh Framework Programme (FP7/2007-2013), and European Federation of Pharmaceutical Industries and Associations (EFPIA) companies' in-kind contributions (www.imi.europa.eu). ADEPT was funded by Johnson & Johnson/Janssen pharmaceutical Company.

A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study

A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study

Diagnosis of childhood febrile illness using a multi-class blood RNA molecular signature

Appropriate treatment and management of children presenting with fever depend on accurate and timely diagnosis, but current diagnostic tests lack sensitivity and specificity and are frequently too slow to inform initial treatment. As an alternative to pathogen detection, host gene expression signatures in blood have shown promise in discriminating several infectious and inflammatory diseases in a dichotomous manner. However, differential diagnosis requires simultaneous consideration of multiple diseases. Here, we show that diverse infectious and inflammatory diseases can be discriminated by the expression levels of a single panel of genes in blood. A multi-class supervised machine-learning approach, incorporating clinical consequence of misdiagnosis as a "cost" weighting, was applied to a whole-blood transcriptomic microarray dataset, incorporating 12 publicly available datasets, including 1,212 children with 18 infectious or inflammatory diseases. The transcriptional panel identified was further validated in a new RNA sequencing dataset comprising 411 febrile children. We identified 161 transcripts that classified patients into 18 disease categories, reflecting individual causative pathogen and specific disease, as well as reliable prediction of broad classes comprising bacterial infection, viral infection, malaria, tuberculosis, or inflammatory disease. The transcriptional panel was validated in an independent cohort and benchmarked against existing dichotomous RNA signatures. Our data suggest that classification of febrile illness can be achieved with a single blood sample and opens the way for a new approach for clinical diagnosis. European Union's Seventh Framework no. 279185; Horizon2020 no. 668303 PERFORM; Wellcome Trust (206508/Z/17/Z); Medical Research Foundation (MRF-160-0008-ELP-KAFO-C0801); NIHR Imperial BRC.

Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial

Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial

Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study

Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study

In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy

SummaryBackgroundNon-invasive high-resolution imaging of the cerebral vascular anatomy and function is key for the study of intracranial aneurysms, stenosis, arteriovenous malformations, and stroke, but also neurological pathologies, such as degenerative diseases. Direct visualization of the microvascular networks in the whole brain remains however challenging in vivo.MethodsIn this work, we performed 3D ultrafast ultrasound localization microscopy (ULM) using a 2D ultrasound matrix array and mapped the whole-brain microvasculature and flow at microscopic resolution in C57Bl6 mice in vivo.FindingsWe demonstrated that the mouse brain vasculature can be imaged directly through the intact skull at a spatial resolution of 20 µm and over the whole brain depth and at high temporal resolution (750 volumes.s−1). Individual microbubbles were tracked to estimate the flow velocities that ranged from 2 mm.s−1 in arterioles and venules up to 100 mm.s−1 in large vessels. The vascular maps were registered automatically with the Allen atlas in order to extract quantitative vascular parameters such as local flow rates and velocities in regions of interest.InterpretationWe show the potential of 3D ULM to provide new insights into whole-brain vascular flow in mice models at unprecedented vascular scale for an in vivo technique. This technology is highly translational and has the potential to become a major tool for the clinical investigation of the cerebral microcirculation.FundingThis study was supported by the European Research Council under the European Union's Seventh Framework Program (FP/2007-2013) / ERC Grant Agreement n° 311025 and by the Fondation Bettencourt-Schueller under the program “Physics for Medicine”. We acknowledge the ART (Technological Research Accelerator) biomedical ultrasound program of INSERM.

NON-CHONDRAL MULTI-TISSUE PATHOLOGY AS ASSESSED BY MRI INCREASES RATES OF QUANTITATIVE MRI-DEFINED CARTILAGE THICKNESS LOSS OVER 24 MONTHS: THE APPROACH STUDY

NON-CHONDRAL MULTI-TISSUE PATHOLOGY AS ASSESSED BY MRI INCREASES RATES OF QUANTITATIVE MRI-DEFINED CARTILAGE THICKNESS LOSS OVER 24 MONTHS: THE APPROACH STUDY

MULTI‐TISSUE ASSESSMENT AND 24‐MONTH PROGRESSION OF SEMI‐QUANTITATIVE MRI BIOMARKERS OF KNEE OSTEOARTHRITIS IN THE IMI‐APPROACH COHORT

MULTI‐TISSUE ASSESSMENT AND 24‐MONTH PROGRESSION OF SEMI‐QUANTITATIVE MRI BIOMARKERS OF KNEE OSTEOARTHRITIS IN THE IMI‐APPROACH COHORT

QUANTITATIVE CT OF THE KNEE IN THE IMI-APPROACH OSTEOARTHRITIS COHORT: ASSOCIATION OF BONE MINERAL DENSITY WITH KELLGREN-LAWRENCE GRADES AND MENISCAL EXTRUSION

QUANTITATIVE CT OF THE KNEE IN THE IMI-APPROACH OSTEOARTHRITIS COHORT: ASSOCIATION OF BONE MINERAL DENSITY WITH KELLGREN-LAWRENCE GRADES AND MENISCAL EXTRUSION

THE POSSIBILITY OF AN OUTSIDE: THEORETICAL PREAMBLE

History and TheoryVolume 60, Issue 4 p. 3-19 Article THE POSSIBILITY OF AN OUTSIDE: THEORETICAL PREAMBLE ULRICH TIMME KRAGH, ULRICH TIMME KRAGH Adam Mickiewicz University in Poznań, PolandI wish to dedicate this theme issue of History and Theory to my dear friend and erudite guru Frank R. Ankersmit, a genuine intellectual. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013) / ERC Grant Agreement no. 615574, “Narrative Modes of Historical Discourse in Asia” (NAMO) hosted by Adam Mickiewicz University in Poznań, Poland.Search for more papers by this author ULRICH TIMME KRAGH, ULRICH TIMME KRAGH Adam Mickiewicz University in Poznań, PolandI wish to dedicate this theme issue of History and Theory to my dear friend and erudite guru Frank R. Ankersmit, a genuine intellectual. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013) / ERC Grant Agreement no. 615574, “Narrative Modes of Historical Discourse in Asia” (NAMO) hosted by Adam Mickiewicz University in Poznań, Poland.Search for more papers by this author First published: 15 December 2021 https://doi.org/10.1111/hith.12233 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume60, Issue4December 2021Pages 3-19 RelatedInformation

New Caledonian crows' planning behaviour: a reply to de Mahy et al .

New Caledonian crows' planning behaviour: a reply to de Mahy <i>et al</i> .

Urinary pH Warrants Therapeutic Window of EBL-1003 (Apramycin) in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis

Urinary pH Warrants Therapeutic Window of EBL-1003 (Apramycin) in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis

Incidental findings on brain MR imaging of asymptomatic term neonates in the Developing Human Connectome Project.

Incidental findings on brain MR imaging of asymptomatic term neonates in the Developing Human Connectome Project.

Liver zonation

Liver zonation

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study.

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study.

Genetic determinants of disease severity in the myotonic dystrophy type 1 OPTIMISTIC cohort.

In the article “Genetic determinants of disease severity in the myotonic dystrophy type 1 OPTIMISTIC cohort” by Cumming et al.,1 the study funding section should have read “Study funded by European Union's Seventh Framework Programme (FP7/2007–2013) under grant agreement number 305697 (the OPTIMISTIC project), the Wellcome Centre for Mitochondrial Research (ref 203105/Z/16/Z)), and donations to the DGM group from the Myotonic Dystrophy Support Group. The funders had no role in the study design, data collection, analysis, interpretation of data, writing the report, or decisions regarding when to submit publications.” The authors regret the error.